Glutaminasi
Gli inibitori della glutaminasi sono composti che inibiscono la glutaminasi, un enzima che catalizza la conversione della glutamina in glutammato, un passaggio cruciale nel metabolismo cellulare, specialmente nelle cellule tumorali. La glutaminasi svolge un ruolo chiave nel fornire energia e precursori biosintetici per le cellule in rapida proliferazione. Gli inibitori della glutaminasi sono importanti per esplorare le dipendenze metaboliche nelle cellule tumorali e sviluppare potenziali strategie terapeutiche. Presso CymitQuimica, offriamo inibitori della glutaminasi per supportare la tua ricerca nel metabolismo del cancro, nella bioenergetica cellulare e nella scoperta di nuove terapie.
Trovati 43 prodotti di "Glutaminasi"
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LDN-27219
CAS:LDN-27219 is a potent hTGase inhibitor with IC50 of 0.6 uM.Formula:C20H16N4O2S2Purezza:99.01% - 99.38%Colore e forma:SolidPeso molecolare:408.5BJJF078
CAS:BJJF078, an aminopiperidine, inhibits human/mouse TG2 (IC50: 41/54 nM) and TG1 (IC50: 0.16 μM), may be used in MS studies.Formula:C27H29N3O6SPurezza:99.56%Colore e forma:SoildPeso molecolare:523.6PROTAC TG2 degrader-2
PROTAC TG2 degrader-2 (compound 7) is a selective competitive degrader of Transglutaminase 2 (TG2), exhibiting a dissociation constant (Kd) greater than 100 μM.Formula:C47H57N9O6SPurezza:98%Colore e forma:SolidPeso molecolare:876.08GLS1 Inhibitor-7
GLS1 Inhibitor-7 (compound 4d) serves as a GLS1 antagonist with an IC50 value of 46.7 μM, demonstrating potential applications in anticancer, antiaging, andFormula:C20H17F3N4O3S2Purezza:98%Colore e forma:SolidPeso molecolare:482.5LM11
<p>LM11 is a transglutaminase 2 (TG2) inhibitor that exhibits activity against glioblastoma cells by maintaining TG2 in a cytotoxic conformational state.</p>Formula:C26H18Cl2N4O5Peso molecolare:536.065436-Diazo-5-oxo-L-nor-Leucine
CAS:6-Diazo-5-oxo-L-nor-Leucine (L-6-Diazo-5-oxonorleucine) is an antagonist of glutaminases (Ki : 6 μM).Formula:C6H9N3O3Purezza:98.04% - 98.93%Colore e forma:SolidPeso molecolare:171.15PROTAC TG2 degrader-1
PROTAC TG2 Degrader-1 (Compound 11) is a VHL-based PROTAC that targets tissue transglutaminase (TG2) and exhibits a binding affinity with a K D of 68.9 μM.Formula:C55H73N9O10SPurezza:98%Colore e forma:SolidPeso molecolare:1052.29Glutaminase C-IN-2
<p>Glutaminase C-IN-2 (compound 11), an allosteric inhibitor of glutaminase C (GAC), exhibits potent inhibitory activity with an IC50 of 10.64 nM.</p>Formula:C24H23N7O2SPurezza:98%Colore e forma:SolidPeso molecolare:473.55HB-2-30
CAS:HB-2-30 is a far-red fluorescent transglutaminase 2 (TG2) probe for in vitro and in vivo endocytosis imaging. HB-2-30 complexes with TG2 and α2-macroglobulin for efficient endocytosis via the LRP1 pathway.Formula:C66H86N10O14S2Peso molecolare:1307.58Trivalent hydroxyarsinothricn
Trivalent hydroxyarsinothricn (R-AST-OH) is a covalent and irreversible inhibitor of kidney-type glutaminase (KGA). It binds to the glutamine binding site and forms a covalent bond with the cysteine residue at the active site. This compound selectively kills triple-negative breast cancer (TNBC) cells without being cytotoxic to control cell lines. KGA is an enzyme that regulates glutamine metabolism and is associated with tumor malignancy.Formula:C4H10AsNO4Peso molecolare:210.98258L-Methionine-DL-sulfoximine
CAS:MSO blocks glutamine synthetase, impacts astroglia, and is used in convulsant research.Formula:C5H12N2O3SPurezza:99.56% - ≥98%Colore e forma:White Crystalline PowderPeso molecolare:180.23Glutaminase-IN-1
CAS:Glutaminase-IN-1 (CB839 derivative), a glutaminase (KGA) inhibitor, has antitumor activity in an aggressive H22 hepatocellular carcinoma xenograft model.Formula:C26H24F3N7O3SePurezza:98.65% - 98.65%Colore e forma:SolidPeso molecolare:618.47Glutaminase-IN-3
CAS:<p>Glutaminase-IN-3 is a potent Glutaminase 1 inhibitor with potential antitumor activity and inhibits GLS1 for cancer research.</p>Formula:C19H19F3N6O2SPurezza:98.51%Colore e forma:SolidPeso molecolare:452.45Telaglenastat
CAS:Telaglenastat (CB 839) (IC50 of 24 nM), an effective, specific, and oral inhibitor, which is bioavailable glutaminase, for recombinant human GAC.Formula:C26H24F3N7O3SPurezza:97.57% - 99.89%Colore e forma:SolidPeso molecolare:571.57L-Albizziin
CAS:L-Albizziin (L-beta-Ureidoalanine) is a glutamase inhibitor and is a glutaminyl-tRNA synthetase inhibitor.Formula:C4H9N3O3Purezza:99.98%Colore e forma:White PowderPeso molecolare:147.13Glutaminase C-IN-1
CAS:Glutaminase C-IN-1 (Compound 968) is a Glutaminase C allosteric inhibitor.Formula:C27H27BrN2OPurezza:99.68% - >99.99%Colore e forma:SolidPeso molecolare:475.42GK921
CAS:GK921 is a transglutaminase 2 (TGase) inhibitor.Formula:C21H20N4OPurezza:97.44% - 99.49%Colore e forma:SolidPeso molecolare:344.41BPTES
CAS:<p>BPTES(IC50 of 0.16 μM) is an effective and specific GlutamiN/Ase GLS1 (KGA) inhibitor.</p>Formula:C24H24N6O2S3Purezza:95.83% - 99.64%Colore e forma:SolidPeso molecolare:524.68Zampilimab
CAS:<p>Zampilimab (UCB-7858) is a humanised monoclonal antibody targeting TGM2, inhibits the cross-linking transamidase activity of TG2, renal fibrosis.</p>Purezza:95%Colore e forma:LiquidIrbesartan-d4
CAS:Irbesartan-d4 (Irbesartan D4), a deuterated compound of Irbesartan, is an angiotensin receptor blocker and is used in the study of cardiovascular disease.Formula:C25H28N6OPurezza:>99.99%Colore e forma:SolidPeso molecolare:432.55Duazomycin
CAS:Duazomycin, an antitumor substance and glutamine antagonist, is used as a chemotherapeutic agent.Formula:C8H11N3O4Colore e forma:SolidPeso molecolare:213.19JHU-083
CAS:JHU-083 is a glutaminase antagonist that improves cognition and normalizes aberrant hippocampal glutaminase activity in APOE4 mice.Formula:C14H24N4O4Purezza:97.89% - 99.53%Colore e forma:SolidPeso molecolare:312.37GLS1 Inhibitor
CAS:GLS1 inhibitor blocks glutaminase 1 (IC50=0.021 μM), hinders NCI H1703 NSCLC cell growth in vitro (GI50=0.011 μM), and suppresses tumors in mice.Formula:C19H21N7O2SColore e forma:SolidPeso molecolare:411.48NC9 TG2 inhibitor
CAS:NC9 is an irreversible inhibitor of transglutaminase 2 (TG2) and also inhibits Factor XIIIA (FXIIIA).Formula:C35H47N5O8SPurezza:98%Colore e forma:SolidPeso molecolare:697.84AA9 TG2 inhibitor
CAS:<p>AA9 is a novel transglutaminase (TG2) inhibitor.</p>Formula:C32H36N4O5Colore e forma:SolidPeso molecolare:556.65AA10 TG2 inhibitor
CAS:<p>AA10 is an irreversible inhibitor of transglutaminase 2 (TG2).</p>Formula:C32H36N4O5Colore e forma:SolidPeso molecolare:556.65GLS1 Inhibitor-3
CAS:GLS1 Inhibitor-3 (compound C147) is a potent inhibitor of GLS1 (IC50: 27.98 nM) and exhibits anti-proliferative effects.Formula:C30H32N10O2SColore e forma:SolidPeso molecolare:596.71VA4 TG2 inhibitor
CAS:VA4 is a novel irreversible TG2 transamidase site-specific inhibitor.Formula:C33H41N5O6SColore e forma:SolidPeso molecolare:635.77α-Glucosidase-IN-5
CAS:α-Glucosidase-IN-5 (compound 8) is isolated from a twig extract of Polyalthia cinnamomea which is a potent α-glucosidase inhibitor with an IC50 of 57.9 µM.Formula:C15H13NO3Colore e forma:SolidPeso molecolare:255.27Glutaminase-IN-4
CAS:<p>Glutaminase-IN-4 (compound 2a) is a glutaminase (GLS) inhibitor (IC50: 2.3 μM).</p>Formula:C23H22N6O2S2Colore e forma:SolidPeso molecolare:478.59CP4d inhibitor
CAS:CP4d is a novel reversible tg2 transamidase site-specific inhibitorFormula:C18H13N5O5Colore e forma:SolidPeso molecolare:379.33THDP-17
CAS:THDP-17 is a inhibitor of glutaminase. THDP-17 shows a partial uncompetitive inhibition in vitro.Formula:C12H16N2SPurezza:98%Colore e forma:SolidPeso molecolare:220.33UPGL00004
CAS:<p>UPGL00004: potent GAC inhibitor, IC50=29 nM, Kd=27 nM, suppresses triple-negative breast cancer cell growth.</p>Formula:C25H26N8O2S2Purezza:97.93%Colore e forma:SolidPeso molecolare:534.66IPN60090
CAS:IPN60090: potent oral GLS1 inhibitor, IC50 of 31 nM, potential for anticancer and immunomodulation.Formula:C24H27F3N8O3Purezza:99.76%Colore e forma:SolidPeso molecolare:532.52Sirpiglenastat
CAS:<p>Sirpiglenastat (DRP-104) is a glutamine antagonist, a prodrug of DON, with antitumor activity that acts by suppressing the adaptive immune system.</p>Formula:C22H27N5O5Purezza:98.01% - 98.37%Colore e forma:SolidPeso molecolare:441.48TG2-IN-3h
CAS:TG2-IN-3h is a highly selective, potent, cell-permeable fluorescent irreversible tissue transglutaminase (tg2) inhibitorFormula:C21H26N4O4SPurezza:99.34% - 99.76%Colore e forma:SolidPeso molecolare:430.52TG-2-IN-1
CAS:TG-2-IN-1 (Compound D003) is a transglutaminase-2 ( TGM-2 ) inhibitor. TG-2-IN-1 can be used in myopia research[1].Formula:C8H13ClN2OSPurezza:98.43%Colore e forma:SolidPeso molecolare:220.72KCC009
CAS:KCC009 is a potent and selective Transglutaminase 2 Inhibitor.Formula:C21H22BrN3O5Colore e forma:SolidPeso molecolare:476.32ZED-1227
CAS:<p>ZED-1227 (TAK-227) is a TG2 inhibitor with anticancer activity that blocks inflammation-induced TG2 expression and activation for the treatment of Celiac Diseas</p>Formula:C26H36N6O6Purezza:99.04%Colore e forma:SolidPeso molecolare:528.6TGase2-IN-1
CAS:TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 µM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 µM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.Formula:C23H25N3O3Colore e forma:SolidPeso molecolare:391.46TG-2-IN-4
CAS:TG-2-IN-4 (compound 8), an inhibitor of transglutaminase 2 (TG2) with an IC 50 value of less than 0.5 mM, is utilized in the study of inflammatory disorders [1].Formula:C34H40N6O5Colore e forma:SolidPeso molecolare:612.72GLS-1-IN-1
<p>GLS-1-IN-1 (compound 1d) is a GLS-1 inhibitor that inhibits Hep G2, MCF 7 and MCF 10A cells.</p>Formula:C26H25FN4OSColore e forma:SolidPeso molecolare:460.57IPN60090 dihydrochloride
CAS:IPN-60090 dihydrochloride is a potent and specific inhibitor of glutaminase 1 (GLS1) with a remarkable inhibition constant (IC50) of 31 nM. It does not exhibit any inhibitory activity against GLS-2. Furthermore, IPN-60090 dihydrochloride possesses outstanding physicochemical properties and pharmacokinetic characteristics in vivo. Therefore, it is a valuable compound for researching solid tumors, including lung and ovarian cancers.Formula:C24H29Cl2F3N8O3Colore e forma:SolidPeso molecolare:605.44
