Wnt/beta-catenina
Gli inibitori della via Wnt/beta-catenina sono composti che inibiscono la via di segnalazione Wnt/beta-catenina, cruciale per la regolazione dello sviluppo embrionale, della proliferazione cellulare e del mantenimento delle cellule staminali. La disfunzione di questa via è legata a vari tipi di cancro e malattie degenerative. Gli inibitori della segnalazione Wnt/beta-catenina sono preziosi per la ricerca volta a comprendere il ruolo di questa via nelle malattie e a sviluppare terapie mirate. Presso CymitQuimica, offriamo inibitori di Wnt/beta-catenina per supportare la tua ricerca in biologia delle cellule staminali, biologia dello sviluppo e ricerca sul cancro.
Trovati 65 prodotti per "Wnt/beta-catenina".
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Tegatrabetan
CAS:Tegatrabetan (BC2059) is a small molecule inhibitor of the Wnt/beta-catenin pathway with potential antineoplastic activity.Formula:C28H36N4O6S2Purezza:98.47% - 99.95%Colore e forma:SolidPeso molecolare:588.74Ref: TM-T5642
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)92,00€10mg117,00€25mg198,00€50mg316,00€100mg535,00€Fz7-21
CAS:Fz7-21, a peptide antagonist of FZD7, inhibits Wnt/β-catenin signaling (IC50=50-100nM) in cells with WNT3A.Formula:C83H114N18O23S2Purezza:99.8%Colore e forma:White SolidPeso molecolare:1796.03KYA1797K
CAS:KYA1797K is a highly potent and selective inhibitor. Wnt/β-catenin IC50 is 0.75 μM through TOPflash assay.Formula:C17H11N2O6S2·KPurezza:97.57% - 99.33%Colore e forma:SolidPeso molecolare:442.51Ref: TM-T6868
2mg39,00€5mg56,00€1mL*10mM (DMSO)62,00€10mg92,00€25mg178,00€50mg301,00€100mg485,00€200mg690,00€IQ 1
CAS:IQ 1 has multiple roles, such as maintaining the multifunctionality of mouse ESCs, decreasing Wnt-stimulated phosphorylation, blocking PP2A/Nkd interactions.Formula:C21H22N4O2Purezza:98.57% - ≥95%Colore e forma:Orange SolidPeso molecolare:362.42Ref: TM-T3635
5mg49,00€1mL*10mM (DMSO)54,00€10mg73,00€25mg133,00€50mg185,00€100mg333,00€200mg474,00€500mg767,00€BML-284 hydrochloride
CAS:BML-284 hydrochloride (Wnt agonist 1 HCL) is a potent, selective Wnt canonical signaling activator and tubulin polymerization inhibitor.Formula:C19H19ClN4O3Purezza:99.80%Colore e forma:SolidPeso molecolare:386.84Ref: TM-T8820
1mg34,00€5mg64,00€10mg84,00€1mL*10mM (DMSO)94,00€25mg142,00€50mg253,00€100mg439,00€200mg615,00€500mg964,00€WAY-262611
CAS:WAY262611 is a Wnt/β-catenin agonist and an inhibitor of Dkk1. It increases bone formation rate with EC50 of 0.63 μM in TCF-luciferase assay.Formula:C20H22N4Purezza:98.09% - 99.09%Colore e forma:SolidPeso molecolare:318.42MSAB
CAS:MSAB inhibits Wnt/β-catenin by binding to β-catenin and inducing its breakdown.Formula:C15H15NO4SPurezza:99.76%Colore e forma:SolidPeso molecolare:305.35Ref: TM-T8710
1mg34,00€2mg47,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg113,00€25mg222,00€50mg334,00€100mg507,00€500mg1.063,00€IWP-4
CAS:IWP-4 (Inhibitor of Wnt Production-4) is a potent Wnt inhibitor.Formula:C23H20N4O3S3Purezza:98% - 99.59%Colore e forma:Yellow SolidPeso molecolare:496.62PRI-724
CAS:PRI-724 is a second-generation, selective small molecule inhibitor of the β-catenin/CBP interaction.Cost-effective and quality-assured.Formula:C33H35N6O7PPurezza:98.25% - 98.38%Colore e forma:White SolidPeso molecolare:658.64Setrusumab
CAS:Setrusumab (BPS 804) is a sclerostin-targeting antibody used in bone remodeling and Wnt signaling research.Purezza:95% - >95% (SDS-PAGE); 97.8% (SEC-HPLC)Colore e forma:Liquidβ-catenin/CBP-IN-1
CAS:β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFormula:C33H35N6O7PPurezza:98%Colore e forma:SolidPeso molecolare:658.64ZW4864 free base
CAS:ZW4864 (free base) is an orally active and selective β catenin/B-Cell lymphoma 9 protein protein interaction ( β catenin/BCL9 PPI ) inhibitor.Formula:C33H42N6O3Purezza:99.81%Colore e forma:SolidPeso molecolare:570.72Ref: TM-T9642
1mg152,00€5mg371,00€1mL*10mM (DMSO)409,00€10mg557,00€25mg887,00€50mg1.198,00€100mg1.611,00€500mg3.232,00€TNIK-IN-1
CAS:TNIK-IN-1 is a potent TNIK inhibitor (IC50 = 65 nM). It exerts antitumor effects by disrupting the Wnt signaling pathway, utilized in research for colorectal cancer and cancer stemness mechanisms.Formula:C19H17N5O3SPurezza:99.01%Colore e forma:SolidPeso molecolare:395.43FJ9
CAS:FJ9 is an FZD7 inhibitor that disrupts the protein interaction between Frz7 and the DVL PDZ domain and induces apoptosis in melanoma and non-small cell lung cancer cell lines.Formula:C23H27NO3Purezza:99.41% - 99.60%Colore e forma:White SolidPeso molecolare:365.47Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purezza:99.41%Colore e forma:White SolidPeso molecolare:297.31GB1874
CAS:GB1874 is an inhibitor of the Wnt pathway targeting β-catenin-TCF4 protein-protein interaction (PPI), affecting proliferation in Wnt-dependent CRC cells.Formula:C24H27N3O2SColore e forma:Yellow SolidPeso molecolare:421.56TNKS-IN-1
CAS:TNKS-IN-1 is a tankyrase inhibitor used in Wnt/β-catenin signaling and colorectal cancer research models.Formula:C18H18N2OPurezza:99.98%Colore e forma:SolidPeso molecolare:278.35Wnt/β-catenin agonist 4
CAS:Wnt/β-catenin agonist 4 is an agonist of Wnt that activates Wnt/β-catenin signaling and directs signaling.Formula:C16H15FN4O2Purezza:99.96%Colore e forma:SolidPeso molecolare:314.31Ref: TM-T60803
1mg34,00€5mg66,00€1mL*10mM (DMSO)77,00€10mg98,00€25mg172,00€50mg295,00€100mg485,00€200mg682,00€FzM1.8
CAS:FzM1.8: allosteric FZD4 agonist, pEC50=6.4; boosts TCF/LEF, activates WNT/β-catenin with no WNT needed.Formula:C18H14N2O4Purezza:99.89%Colore e forma:SolidPeso molecolare:322.31Ref: TM-T15363
2mg38,00€5mg55,00€1mL*10mM (DMSO)60,00€10mg87,00€25mg165,00€50mg264,00€100mg411,00€200mg593,00€FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formula:C21H16N2O2SPurezza:99.37% - 99.89%Colore e forma:Yellow SolidPeso molecolare:360.43Ref: TM-T24076
1mg39,00€1mL*10mM (DMSO)58,00€5mg60,00€10mg94,00€25mg178,00€50mg310,00€100mg500,00€500mg1.071,00€
