Cellule staminali
Gli inibitori delle cellule staminali sono composti che mirano specificamente alle cellule staminali e alle loro vie di segnalazione, influenzando la loro capacità di autorinnovarsi e differenziarsi. Questi inibitori sono cruciali nella ricerca focalizzata sul controllo del comportamento delle cellule staminali, sulla comprensione dei processi di sviluppo e sullo sviluppo di terapie per malattie come il cancro, dove si ritiene che le cellule staminali svolgano un ruolo chiave. Presso CymitQuimica, offriamo una varietà di inibitori delle cellule staminali per supportare la tua ricerca in medicina rigenerativa, biologia dello sviluppo e oncologia.
Trovati 467 prodotti di "Cellule staminali"
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Trevogrumab
CAS:Trevogrumab is a human monoclonal antibody that inhibits myostatin (GDF8) to promote muscle growth, and is under research for treating age-related muscle loss (sarcopenia).Purezza:95% - 97.6% (SDS-PAGE); 95.9% (SEC-HPLC)Colore e forma:LiquidMetelimumab
CAS:Metelimumab (CAT-192) is a humanised monoclonal antibody targeting TGFβ1, which can be used to study diffuse systemic sclerosis (d-SSc).Purezza:95%Colore e forma:Liquid1-Azakenpaullone
CAS:1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.Formula:C15H10BrN3OPurezza:99.73%Colore e forma:Tan SolidPeso molecolare:328.16VT103
CAS:VT103, an oral TEAD1 palmitoylation inhibitor, shows promise against various cancers by disrupting YAP/TAZ-TEAD interactions.Formula:C18H17F3N4O2SPurezza:99.58%Colore e forma:SolidPeso molecolare:410.41TEAD-IN-6
CAS:TEAD-IN-6 (Example 11-1) is a TEAD modulator that inhibits the YAP1/TAZ-TEAD interaction, and has applications in cancer research [1].Formula:C19H17F3N4O3SPurezza:98%Colore e forma:SolidPeso molecolare:438.42TGFβRI-IN-1
CAS:TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII,Formula:C20H14D3N5O2Purezza:98%Colore e forma:SolidPeso molecolare:362.4CK2-IN-4
CAS:CK2-IN-4 is a protein kinase (CK2) inhibitor with an IC50 value of 8.6 µM.Formula:C18H11N3O4SPurezza:99.65%Colore e forma:SolidPeso molecolare:365.36CK2α-IN-1
CAS:CK2α-IN-1 is a selective non-ATP-competitive CK2α inhibitor with an IC50 of 7.0 µM and a Ki of 1.6 µM.CK2α-IN-1 exhibits potential anticancer activity and canFormula:C16H11N3O4SPurezza:98%Colore e forma:SolidPeso molecolare:341.34JA310
CAS:JA310 is a highly selective inhibitor of the MST3 kinase, demonstrating significant cellular potency with an EC50 value of 106 nM [1].Formula:C17H19N7OColore e forma:SolidPeso molecolare:337.38JAK1-IN-4
CAS:JAK1-IN-4 selectively blocks JAK1 (IC50 = 85 nM) over JAK2/JAK3 and halts STAT3 phosphorylation in NCI-H 1975 cells (IC50 = 227 nM).Formula:C26H32FN9O2Purezza:98%Colore e forma:SolidPeso molecolare:521.59ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurezza:99.69%Colore e forma:SolidPeso molecolare:471.8JAK-IN-11
CAS:JAK-IN-11 (R-348) is a potent and selective inhibitor of JAK, has the potential for the skin disorders treatment.Formula:C23H22FN5O4SPurezza:99.75%Colore e forma:SolidPeso molecolare:483.52H-1152
CAS:<p>H-1152 is a potent, specific, ATP-competitive, and cell permeable ROCK inhibitor (Ki = 1.6 nM).</p>Formula:C16H21N3O2SPurezza:98%Colore e forma:SolidPeso molecolare:319.42GSK3-IN-2
CAS:<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formula:C17H19N3OSPurezza:98.8%Colore e forma:SolidPeso molecolare:313.42CJJ300
CAS:<p>CJJ300 is a TGF-β inhibitor disrupting TGF-β-TβR complex formation, with an IC50 of 5.3 μM, and halts cell migration.</p>Formula:C30H33N3Purezza:99.80%Colore e forma:SolidPeso molecolare:435.6SD-1029
CAS:SD-1029 is a JAK2 inhibitor and a novel Stat3 activation inhibitor that inhibits Stat3 phosphorylation and JAK-STAT signaling.Formula:C25H32Br2Cl2N2O3Colore e forma:SolidPeso molecolare:639.25JAK-IN-30
CAS:<p>JAK-IN-30 (compound 31) is a water-soluble inhibitor of Janus kinases (JAKs), demonstrating inhibitory potency with half-maximal inhibitory concentration (IC50</p>Formula:C19H26N8SPurezza:98%Colore e forma:SolidPeso molecolare:398.53(Rac)-SIS3 free base
CAS:SIS3 free base is a potent and selective Smad3 phosphorylation inhibitor. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1.Formula:C28H27N3O3Purezza:98%Colore e forma:SolidPeso molecolare:453.53SB-772077B dihydrochloride
CAS:SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor (IC50s: 5.6 nM and 6 nM toward ROCK1 and ROCK2, respectively).Formula:C15H20Cl2N8O2Purezza:98%Colore e forma:SolidPeso molecolare:415.28inS3-54-A26
CAS:<p>inS3-54-A26 is an inhibitor of the DNA-binding domain of STAT3. inS3-54-A26 suppresses tumor growth, metastasis and the gene expression of STAT3.</p>Formula:C25H19ClN2O2Purezza:99.57%Colore e forma:SolidPeso molecolare:414.88PIMPC
CAS:PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibitsFormula:C21H19N5OPurezza:98%Colore e forma:SolidPeso molecolare:357.41JAK3/BTK-IN-2
CAS:<p>JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor.</p>Formula:C25H32N8O2Purezza:99.64% - 99.87%Colore e forma:SolidPeso molecolare:476.57Chromenone 1
CAS:Chromenone 1 is a potent potentiator of osteogenic bone morphogenetic protein (BMP).Formula:C18H10F3N3O2Purezza:99.83% - 99.93%Colore e forma:SolidPeso molecolare:357.29Aloisine B
CAS:<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formula:C15H14ClN3Purezza:95.15%Colore e forma:SolidPeso molecolare:271.74CAY10746
CAS:CAY10746 selectively inhibits ROCK I/II with IC50s: 0.014/0.003 μM, useful for diabetic retinopathy research.Formula:C26H23N3O5Purezza:99.71%Colore e forma:SolidPeso molecolare:457.48JAK3/BTK-IN-1
CAS:<p>JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important</p>Formula:C25H28N8OPurezza:97.89%Colore e forma:SolidPeso molecolare:456.54AF-2112
<p>AF-2112, a TEAD inhibitor derived from Flufenamic acid, significantly diminishes the expression of CTGF, Cyr61, Axl, and NF2.</p>Formula:C21H18FNO3Purezza:98%Colore e forma:SolidPeso molecolare:351.37SR-1277
CAS:SR-1277 is a potent, highly selective and ATP-competitive CK1δ/ε inhibitor, regulating Wee1 activity at the G2/M cell-cycle interface, and antiproliferative.Formula:C21H19N9O3SColore e forma:SolidPeso molecolare:477.5TEAD-IN-2
CAS:<p>TEAD-IN-2 is a potent and bifunctional TEAD inhibitor to induce TEAD protein degradation via the ubiquitination pathway, with anticancer potential.</p>Formula:C16H18BrF3N2OColore e forma:SolidPeso molecolare:391.23GSK-3β inhibitor 12
CAS:GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3βFormula:C14H13N3OSPurezza:98.58%Colore e forma:SolidPeso molecolare:271.34γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurezza:99.75% - 99.96%Colore e forma:SolidPeso molecolare:416.54JAK3i
CAS:<p>JAK3i selectively inhibits JAK3 kinase, targeting the second, vital wave of STAT5 phosphorylation for T cell growth.</p>Formula:C18H15FN4O3Purezza:98.61% - 99.81%Colore e forma:SolidPeso molecolare:354.34BRD0209
CAS:<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formula:C22H25N3OPurezza:99.92%Colore e forma:SolidPeso molecolare:347.45JAK-IN-28
CAS:JAK-IN-28 (Compound 111) is a Janus kinase (JAK) inhibitor potentially applicable in the research of cancer and inflammatory diseases [1].Formula:C20H18ClN7OPurezza:98%Colore e forma:SolidPeso molecolare:407.86JAK-IN-10
CAS:<p>JAK-IN-10 is a JAK inhibitor. JAK-IN-10 can be used for the research of dry eye disorders.</p>Formula:C20H18FN5O3SPurezza:99.53%Colore e forma:SolidPeso molecolare:427.45Aβ42-IN-2
CAS:<p>Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].</p>Formula:C24H26N6O2Purezza:98.09% - 99.87%Colore e forma:SolidPeso molecolare:430.5Wnt pathway activator 2
CAS:Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.Formula:C17H15NO4Purezza:99.41%Colore e forma:SolidPeso molecolare:297.31β-catenin/CBP-IN-1
CAS:β-catenin/CBP-IN-1 is a potent and selective inhibitor of CBP/β-cateninFormula:C33H35N6O7PPurezza:98%Colore e forma:SolidPeso molecolare:658.643F8
CAS:<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formula:C15H14N2O4Purezza:98.14% - 98.25%Colore e forma:SolidPeso molecolare:286.28ABC1183
CAS:<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formula:C18H14N4OSPurezza:98.92%Colore e forma:SolidPeso molecolare:334.39CRT0066854 hydrochloride
CAS:CRT0066854 HCl inhibits atypical PKCs; IC50: PKCι 132 nM, PKCζ 639 nM, ROCK-II 620 nM.Formula:C24H27Cl2N5SPurezza:99.63%Colore e forma:SolidPeso molecolare:488.48Rho-Kinase-IN-1
CAS:Rho-Kinase-IN-1: ROCK inhibitor, Ki of 30.5 nM (ROCK1) & 3.9 nM (ROCK2), used in research for diseases linked to cell overgrowth and inflammation.Formula:C20H24N4SPurezza:99.8%Colore e forma:SolidPeso molecolare:352.5XL413 xHCl
CAS:<p>BMS-863233 HCl is an ATP-competitive Cdc7 inhibitor (IC50: 3.4 nM) that is potent and selective.BMS-863233 HCl inhibited CK2 and PIM1 with IC50 values of 215</p>Formula:C14H12ClN3O2·xHClPurezza:99.37% - 99.67%Colore e forma:SolidPeso molecolare:326.18AS 1892802
CAS:AS 1892802, a ROCK inhibitor: IC50 - 52nM (hROCK2), 57nM (rROCK2), 122nM (hROCK1). Fast antinociceptive effect similar to Tramadol, Diclofenac.Formula:C20H19N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:333.38BIP-135
CAS:<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formula:C21H13BrN2O3Purezza:99.93%Colore e forma:SolidPeso molecolare:421.24Casein kinase 1δ-IN-1
CAS:Casein kinase 1δ-IN-1 (WAY-643895) is an inhibitor of casein kinase 1δ (CK1δ), which inhibits CK1δ.Formula:C11H7N3OSPurezza:99.89%Colore e forma:SolidPeso molecolare:229.26MSC-4106
CAS:<p>MSC-4106, an oral YAP/TAZ-TEAD inhibitor, blocks TEAD1/3 auto-palmitoylation and suppresses NCI-H226 tumors.</p>Formula:C18H12F3N3O2Purezza:99.89%Colore e forma:SoildPeso molecolare:359.3SJ000063181
CAS:<p>SJ000063181 activates BMP signaling (EC50 ≤1μM), usable as probe in zebrafish embryos.</p>Formula:C14H14ClFN2O2Purezza:99.94%Colore e forma:SolidPeso molecolare:296.72IHMT-MST1-58
CAS:<p>IHMT-MST1-58 is a STE20-like protein 1 kinase (MST1) inhibitor (IC50:23 nM) with high efficiency, selectivity and oral activity.</p>Formula:C21H22N6O3SPurezza:98.31% - 99.92%Colore e forma:SolidPeso molecolare:438.5FzM1
CAS:FzM1, a negative allosteric modulator (NAM) of the Frizzled receptor FZD4, diminishes WNT5A-dependent WNT responsive element (WRE) activity (log EC50inh=−6.2)Formula:C21H16N2O2SPurezza:99.37% - 99.89%Colore e forma:SolidPeso molecolare:360.43
