Cellule staminali
Gli inibitori delle cellule staminali sono composti che mirano specificamente alle cellule staminali e alle loro vie di segnalazione, influenzando la loro capacità di autorinnovarsi e differenziarsi. Questi inibitori sono cruciali nella ricerca focalizzata sul controllo del comportamento delle cellule staminali, sulla comprensione dei processi di sviluppo e sullo sviluppo di terapie per malattie come il cancro, dove si ritiene che le cellule staminali svolgano un ruolo chiave. Presso CymitQuimica, offriamo una varietà di inibitori delle cellule staminali per supportare la tua ricerca in medicina rigenerativa, biologia dello sviluppo e oncologia.
Trovati 129 prodotti per "Cellule staminali".
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HC-258
CAS:HC-258 is a direct TEAD inhibitor covalent Cys380, and reduces the transcriptional levels and inhibits the migration of CTGF, CYR61, AXL and NF2 MDA-MB-231.Formula:C20H24N2O2Colore e forma:Yellow SolidPeso molecolare:324.42MSC-1254
MSC-1254 is a reversible, selective, and covalent inhibitor of TEAD1, primarily utilized in cancer research.Formula:C25H22F2N4O4SColore e forma:SolidPeso molecolare:512.53LY2382770
LY2382770 is a human monoclonal antibody (mAb) that specifically targets TGFB1. It is utilized in the study of diabetic nephropathy.TGF-β1/Smad3-IN-1
CAS:TGF-β1/Smad3-IN-1 is an orally administrable dual inhibitor of TGF-β1/Smad3 with anti-fibrotic activity, idiopathic pulmonary fibrosis (IPF).Formula:C30H34N4O6SPurezza:99.83%Peso molecolare:578.68Depiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Formula:C21H14N4Purezza:99.69%Peso molecolare:322.36ALK5-IN-83
ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 μM. It suppresses TGF-β1-induced Smad2 phosphorylation and cell motility in A549 cells.Formula:C20H23N7O2SColore e forma:SolidPeso molecolare:425.51YAP/TAZ inhibitor-4
YAP/TAZ Inhibitor-4 (Compound 45) acts as an inhibitor of YAP/TAZ, exhibiting inhibitory activity on TEAD transcriptional activation by preventing the interaction between YAP or TAZ and TEAD.Formula:C28H28F3N3O3Colore e forma:SolidPeso molecolare:511.54Disitertide acetate
Disitertide acetate: a TGF-β1 and PI3K blocker, promotes apoptosis; inhibits receptor interaction.Formula:C70H113N17O24S2Purezza:95.77%Colore e forma:White SolidPeso molecolare:1640.88DC-TEADin02
CAS:DC-TEADin02 is an inhibitor of TEAD auto palmitoylation (IC50 = 197 nM). DC-TEADin02 can be in studies about development, regeneration, and tissue homeostasis.Formula:C19H17NO2SPurezza:99.83%Colore e forma:SolidPeso molecolare:323.41YAP-TEAD-IN-3
CAS:YAP-TEAD-IN-3 inhibitor YAP/TAZ-TEAD interactions Avi-human TEAD (4217-434) YAP-TEAD-IN-3 inhibits YAP reporter gene expression and NCI-H2052 cell proliferationFormula:C27H26ClF2N3O4Purezza:97.55% - 99.12%Colore e forma:SolidPeso molecolare:529.96Ref: TM-T77725
10mgPrezzo su richiesta50mgPrezzo su richiesta100mgPrezzo su richiesta1mg295,00€5mg705,00€SLLK, Control Peptide for TSP1 Inhibitor(TFA)
CAS:SLLK is a control peptide for LSKL.Formula:C21H41N5O6Purezza:98%Colore e forma:SolidPeso molecolare:459.58OPN-9652
CAS:OPN-9652 is a covalent TEAD inhibitor reversing drug resistance in BRAF-mutant tumors.Formula:C19H15F4NO2Purezza:99.78%Colore e forma:White SolidPeso molecolare:365.32Ref: TM-T212610
1mg49,00€5mg92,00€1mL*10mM (DMSO)104,00€10mg145,00€25mg255,00€50mg378,00€100mg573,00€TEAD-IN-16
TEAD-IN-16 (compound BC-011) is a potent inhibitor of TEAD, with an IC50 of 72.43 μM. This compound plays a significant role in cancer research.Formula:C16H14F3NO3Colore e forma:SolidPeso molecolare:325.09258YAP/TEAD-IN-1
YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.Formula:C32H30N8OColore e forma:SolidPeso molecolare:542.634YAP-TEAD-IN-1 acetate
YAP-TEAD-IN-1 acetate is an effective and competitive inhibitor of YAP–TEAD interaction with an IC50 of 25 nM.Formula:C95H148ClN23O23S2Purezza:98.11% - 99.98%Colore e forma:SoildPeso molecolare:2079.92TGFβRI-IN-7
TGFβRI-IN-7 (compound 16W) is a potent inhibitor of TGFβRI. It effectively inhibits the phosphorylation of SMAD2/3 and reduces the viability of H22 cells, with IC50 values of 12 nM and 65 nM, respectively. In an H22 cell xenograft model, TGFβRI-IN-7 exhibits antitumor efficacy with a TGI of 79.6%.Formula:C27H32N6O2Colore e forma:SolidPeso molecolare:472.582YAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Colore e forma:Odour SolidWnt/Hedgehog/Notch Compound Library
A unique collection of 237 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening;
Colore e forma:Odour SolidTubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Formula:C21H22N2O2Purezza:98.53%Colore e forma:SolidPeso molecolare:334.41Super-TDU (1-31) (TFA)
Super-TDU (1-31) TFA, a peptide, inhibits YAP-TEAD; it has strong anti-tumor effects in gastric cancer models.Formula:C141H218N40O48·C2HF3O2Colore e forma:SolidPeso molecolare:3355.5
