Gamma-secretasi
Gli inibitori della gamma-secretasi sono composti che prendono di mira il complesso enzimatico gamma-secretasi, coinvolto nella scissione della proteina precursore dell'amiloide (APP) per produrre peptidi beta-amiloidi. Questi peptidi possono aggregarsi per formare placche amiloidi, una caratteristica distintiva della malattia di Alzheimer. Inibendo la gamma-secretasi, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, diventando così un focus chiave nella ricerca sulla malattia di Alzheimer. Presso CymitQuimica, offriamo inibitori della gamma-secretasi per supportare la tua ricerca in biologia dell'amiloide, terapia dell'Alzheimer e malattie neurodegenerative.
Trovati 62 prodotti di "Gamma-secretasi"
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Demcizumab
CAS:<p>Demcizumab (OMP 21M18), an anti-DLL4 antibody, inhibits the Notch pathway and fights various cancers solo or with chemo.</p>Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.34 kDaCB-103
CAS:CB-103 is a orally active inhibitor of notch signaling pathway, with anti-tumor activity.Formula:C15H18N2OPurezza:99.44%Colore e forma:SolidPeso molecolare:242.32Rovalpituzumab
CAS:Rovalpituzumab: humanized antibody against DLL3, forms ADCs, treats small cell lung cancer.Purezza:> 95%Colore e forma:LiquidPeso molecolare:145.02 kDaBrontictuzumab
CAS:Brontictuzumab (OMP 52M5) is an anti-Notch1 monoclonal antibody with antitumor activity that inhibits tumor cell proliferation.Purezza:98.1% (SDS-PAGE); 97.6% (SEC-HPLC) - 98.1% (SDS-PAGE); 97.6% (SEC-HPLC)Colore e forma:LiquidNotch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Formula:C62H97N15O22S3Colore e forma:SolidPeso molecolare:1500.72Navicixizumab
CAS:Navicixizumab, a bispecific VEGF/DLL4 inhibitor, pairs with Paclitaxel in ovarian and other cancer research.Colore e forma:LiquidSAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Formula:C96H163N36F3O25SColore e forma:SolidPeso molecolare:2310.6CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Formula:C17H19N3O2SPurezza:99%Colore e forma:SolidPeso molecolare:329.42γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Formula:C25H23F3N4O2Colore e forma:SolidPeso molecolare:468.48SPL-707
CAS:SPL-707 is an effective and selective signal peptide peptidase-like 2a inhibitor (IC50: 80 nM).Formula:C27H28FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:505.54PSEN1-IN-1
PSEN1-IN-1 (Compound (+)-13b) functions as an inhibitor of PSEN1, displaying potent inhibition of the PSEN1-APH1A and PSEN1-APH1B complexes with respective IC50Formula:C20H19ClF3NO3SColore e forma:SolidPeso molecolare:445.88PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Formula:C20H18ClFN2O3SColore e forma:SolidPeso molecolare:420.88SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Formula:C94H162N36O23SPurezza:98%Colore e forma:SolidPeso molecolare:2196.58FRM-024
CAS:FRM-024 is a powerful gamma secretase modulator with the ability to penetrate the central nervous system (CNS), designed specifically for the treatment ofFormula:C22H22ClN5O2Colore e forma:SolidPeso molecolare:423.9Notch 1 TFA
Notch 1 TFA encodes a member of the NOTCH family of proteins.Formula:C64H98N15F3O25S3Purezza:98%Colore e forma:SolidPeso molecolare:1614.81BMS-906024
CAS:BMS-906024 (Osugacestat) is a gamma secretase inhibitor, a Notch inhibitor.BMS-906024 has broad-spectrum antitumour activity.Formula:C26H26F6N4O3Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:556.5RBPJ Inhibitor-1
CAS:RBPJ Inhibitor-1 (RIN1), a compound that impedes the functional interaction between RBPJ and SHARP, effectively inhibits NOTCH-dependent tumor cellFormula:C17H14FN3O2Purezza:99.79%Colore e forma:SoildPeso molecolare:311.315β-Cholanic acid
CAS:<p>5β-Cholanic acid (5beta-Cholanic acid) is a potent γ-secretase modulator used in Alzheimer's disease research.</p>Formula:C24H40O2Purezza:98.91% - 99.89%Colore e forma:SoildPeso molecolare:360.57Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Purezza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Colore e forma:LiquidLegumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Formula:C23H25N5O4SPurezza:98.14%Colore e forma:SolidPeso molecolare:467.54γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formula:C24H23FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:434.53FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purezza:99.81% - ≥98%Colore e forma:SolidPeso molecolare:438.52IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C13H11NO5S2Purezza:97.1% - 99.76%Colore e forma:SolidPeso molecolare:325.36JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Formula:C23H24N2O3Purezza:99.61%Colore e forma:SolidPeso molecolare:376.45IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purezza:97.96% - 98.38%Colore e forma:SolidPeso molecolare:353.41γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formula:C24H25ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColore e forma:SolidPeso molecolare:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formula:C25H28F3N7Purezza:99.50%Colore e forma:SolidPeso molecolare:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Formula:C20H14D3FO2SColore e forma:SolidPeso molecolare:343.43Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purezza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Colore e forma:LiquidTarextumab
CAS:<p>Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.</p>Purezza:95%Colore e forma:LiquidTarlatamab
CAS:"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."Colore e forma:LiquidAβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Formula:C29H26N4O2Purezza:98%Colore e forma:SolidPeso molecolare:462.54γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurezza:99.75% - 99.96%Colore e forma:SolidPeso molecolare:416.54ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurezza:99.69%Colore e forma:SolidPeso molecolare:471.8γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Formula:C23H19FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:402.42tCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Formula:C24H44O2Purezza:98%Colore e forma:SolidPeso molecolare:364.61γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Formula:C25H22F4N6O2Purezza:98%Colore e forma:SolidPeso molecolare:514.47LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Formula:C26H23F2N3O4Purezza:98%Colore e forma:SolidPeso molecolare:479.48ELN318463
CAS:ELN 318463 selectively inhibits γ-secretase; EC50: 12 nM (PS1), 656 nM (PS2); 51x more selective for PS1; targets APP.Formula:C19H20BrClN2O3SPurezza:98%Colore e forma:SolidPeso molecolare:471.8RR-11a analog
CAS:RR-11a (aza-peptide) inhibits asparaginyl endopeptidase: IC50 - 4.5 nM (T. Vaginalis, I. ricinus), 31 nM (S. mansoni).Formula:C22H29N5O8Purezza:98.80%Colore e forma:SolidPeso molecolare:491.49RR-11a
CAS:<p>RR-11a is a synthetic enzyme Legumain inhibitor.</p>Formula:C24H28N6O10Purezza:98%Colore e forma:SolidPeso molecolare:560.51CIA-1 hcl(452087-38-6 Free base)
CAS:CIA-1 inhibits the nuclear receptor COUP-TFII, with IC50s ranging from 1.2 μM to 7.6 μM in prostate cancer cell lines.CIA-1 inhibits the growth of a variety ofFormula:C17H20ClN3O2SPurezza:99.02%Colore e forma:SolidPeso molecolare:365.88BPN-15606
CAS:BPN-15606, an oral γ-secretase modulator, reduces Aβ42/Aβ40 with IC50 of 7/17 nM; promising PK/PD, lowers Aβ in rodent CNS.Formula:C23H23FN6OColore e forma:SolidPeso molecolare:418.47γ-Secretase modulator 11
CAS:5-{8-[(3,4'-Difluoro[1,1'-biphenyl]-4-yl)methoxy]-2-methylimidazo[1,2-a]pyridin-3-yl}-N-methylpyridine-2-carboxamide (1o) exhibited high in vitro potency andFormula:C28H22F2N4O2Colore e forma:SolidPeso molecolare:484.5Yhhu-3792
CAS:Yhhu-3792 activates Notch, boosts Hes3/Hes5, enhances NSC renewal, expands NSC pool, and may improve memory.Formula:C24H24N4O2Colore e forma:SolidPeso molecolare:400.47Aβ42-IN-2
CAS:Aβ42-IN-2 is a γ-secretase modulator. Aβ42-IN-2 has an IC 50 of 6.5 nM for Αβ 42. Aβ42-IN-2 can be used for the Alzheimer's disease research[1].Formula:C24H26N6O2Purezza:98.09% - 99.87%Colore e forma:SolidPeso molecolare:430.5JI051
CAS:JI051 has anti-tumor effects and can interact with PHB2 to inhibit the proliferation of HEK293 cells and pancreatic cancer cells.Formula:C22H24N2O3Purezza:≥98% - ≥98.0%Colore e forma:SolidPeso molecolare:364.44BT-GSI
BT-GSI: γ-secretase inhibitor targeting Notch, anti-myeloma & anti-resorptive for multiple myeloma/bone disease research.Formula:C26H46BrN5O10P2Colore e forma:SolidPeso molecolare:730.52BMS-932481
CAS:<p>BMS-932481 is a γ-secretase modulator.</p>Formula:C24H24FN7OColore e forma:SolidPeso molecolare:445.49Yhhu-3792 hydrochloride
CAS:Yhhu-3792 hydrochloride is a compound that bolsters the self-renewal capacity of neural stem cells (NSCs), catalyzes the Notch signaling pathway, and upregulates expression of Hes3 and Hes5. It augments the NSC pool, stimulates endogenous neurogenesis in the mouse hippocampal dentate gyrus (DG), and enhances mice's spatial and episodic memory skills. This compound shows promise for researching learning and memory impairments linked to DG dysfunction [1].Formula:C24H25ClN4O2Colore e forma:SolidPeso molecolare:436.93GSM-1
CAS:GSM-1 is a modulator of γ-Secretase.Formula:C26H31ClF3NO2Colore e forma:SolidPeso molecolare:481.98BMS-983970
CAS:BMS-983970 is an oral inhibitor of pan-Notch, and for the treatment of multiplecancers.Formula:C26H26F4N4O3Colore e forma:SolidPeso molecolare:518.5HDAC6-IN-9
CAS:HDAC6-IN-9 is a γ-secretase modulator that can significantly reduce the level of Aβ42 in mouse brain and can be used to study neurological diseases.Formula:C19H16N2O3Purezza:98.84%Colore e forma:SolidPeso molecolare:320.34γ-Secretase modulator 11 hydrochloride
CAS:<p>γ-Secretase modulator 11 hydrochloride is a potent, orally active γ-secretase modulator (IC50: 0.029 μM).</p>Formula:C28H23ClF2N4O2Colore e forma:SolidPeso molecolare:520.96DAPM
CAS:DAPM (gamma-Secretase Inhibitor XVI) is a Notch pathway inhibitor with anticancer activity and antiproliferative effects.Formula:C20H20F2N2O4Purezza:99.76%Colore e forma:SolidPeso molecolare:390.38PF-06442609
CAS:PF-06442609 is an orally active γ-secretase modulator with an IC50 value of 6 nM for Aβ42. It exhibits good CNS permeability.Formula:C24H24F4N4O3Peso molecolare:492.47BPN-15606 besylate
BPN-15606 besylate is a potent oral γ-secretase regulator reducing Aβ42 and Aβ40 with good pharmacokinetics. IC50: 7 nM (Aβ42), 17 nM (Aβ40).Formula:C29H29FN6O4SColore e forma:SolidPeso molecolare:576.64PF-06648671
CAS:PF-06648671 is a γ-secretase modulator for the treatment of neurodegenerative and/or neurological disorders.Formula:C25H23ClF4N4O3Purezza:98%Colore e forma:SolidPeso molecolare:538.92Notch inhibitor 1
CAS:Notch inhibitor 1 blocks Notch 1/3 (IC50: 7.8/8.5 nM) and aids cancer research.Formula:C26H25F7N4O3Purezza:98%Colore e forma:SolidPeso molecolare:574.49Aβ42-IN-1
CAS:Aβ42-IN-1, compound 1v, is a novel, potent and orally active γ-secretase modulator (GSM).Formula:C29H27ClN4O2Purezza:98%Colore e forma:SolidPeso molecolare:499
