Gamma-secretasi
Gli inibitori della gamma-secretasi sono composti che prendono di mira il complesso enzimatico gamma-secretasi, coinvolto nella scissione della proteina precursore dell'amiloide (APP) per produrre peptidi beta-amiloidi. Questi peptidi possono aggregarsi per formare placche amiloidi, una caratteristica distintiva della malattia di Alzheimer. Inibendo la gamma-secretasi, questi composti mirano a ridurre la produzione di beta-amiloide e la sua accumulazione nel cervello, diventando così un focus chiave nella ricerca sulla malattia di Alzheimer. Presso CymitQuimica, offriamo inibitori della gamma-secretasi per supportare la tua ricerca in biologia dell'amiloide, terapia dell'Alzheimer e malattie neurodegenerative.
Trovati 62 prodotti di "Gamma-secretasi"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Formula:C24H23FN4OSPurezza:98%Colore e forma:SolidPeso molecolare:434.53FLI-06
CAS:FLI-06 is a Notch signaling inhibitor (EC50: 2.3 μM).Formula:C25H30N2O5Purezza:99.81% - ≥98%Colore e forma:SolidPeso molecolare:438.52Ref: TM-T3075
1mg35,00€2mg52,00€5mg74,00€10mg99,00€25mg172,00€50mg311,00€100mg542,00€500mg1.188,00€1mL*10mM (DMSO)82,00€IMR-1A
CAS:IMR-1A is the metabolite of IMR-1 which is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C13H11NO5S2Purezza:97.1% - 99.76%Colore e forma:SolidPeso molecolare:325.36Ref: TM-T3540
1mg49,00€5mg97,00€10mg154,00€25mg311,00€50mg502,00€100mg755,00€200mg1.017,00€1mL*10mM (DMSO)104,00€JI130
CAS:JI130 hinders Hes1 transcription repression; notably shrinks pancreatic tumor volume in mice.Formula:C23H24N2O3Purezza:99.61%Colore e forma:SolidPeso molecolare:376.45IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Formula:C15H15NO5S2Purezza:97.96% - 98.38%Colore e forma:SolidPeso molecolare:353.41γ-secretase modulator 1 hydrochloride
CAS:gamma-secretase inhibitior-1 is a gamma-secretase modulator that is useful to Alzheimer's disease [1].Formula:C24H25ClN4OSPurezza:98%Colore e forma:SolidPeso molecolare:453MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Formula:C21H21ClF2NaO4SColore e forma:SolidPeso molecolare:465.89LY900009
CAS:LY900009 is a small molecule inhibitor of Notch signalling via selective inhibition of the γ-secretase protein.Formula:C23H27N3O4Purezza:97.07%Colore e forma:SolidPeso molecolare:409.48Ref: TM-T9015
1mg38,00€5mg85,00€10mg118,00€25mg207,00€50mg306,00€100mg444,00€200mg622,00€1mL*10mM (DMSO)93,00€RO7185876
CAS:RO7185876 is a selective gamma secretase modulator, which can be used in the study of Alzheimer's disease.Formula:C25H28F3N7Purezza:99.50%Colore e forma:SolidPeso molecolare:483.532Sulindac EP Impurity C-d3
CAS:Sulindac EP Impurity C-d3 is a deuterated compound of Sulindac EP Impurity C. Sulindac EP Impurity C has a CAS number of 32004-67-4. (E/Z)-Sulindac sulfide is a potent γ-secretase modulator (GSM) that selectively reduces Aβ42 production in favor of shorter Aβ species. (E/Z)-Sulindac sulfide can be used for researching Alzheimer's disease [1].Formula:C20H14D3FO2SColore e forma:SolidPeso molecolare:343.43Dilpacimab
CAS:Dilpacimab (ABT165) is a dual-variable antibody that targets DLL4 and VEGF pathways, showing potential in cancer research by blocking angiogenesis and Notch.Purezza:95% - 97.7% (SDS-PAGE); 95.6% (SEC-HPLC)Colore e forma:LiquidTarextumab
CAS:Tarextumab is an anti-Notch2/3 mAb, a promising candidate for breast, lung, ovarian, and pancreatic cancers.Purezza:95%Colore e forma:LiquidTarlatamab
CAS:"Tarlatamab (AMG-757), a BiTE antibody, targets DLL3, prevalent in SCLC tumors with scant normal tissue expression, and shows promise for SCLC research."Colore e forma:LiquidAβ42-IN-1 free base
CAS:Aβ42-IN-1 free base (compound 1v), an orally active γ-secretase modulator with high brain exposure, effectively lowers Aβ42 levels, exhibiting an IC 50 of 0.091Formula:C29H26N4O2Purezza:98%Colore e forma:SolidPeso molecolare:462.54γ-secretase modulator 1
CAS:gamma-secretase modulator 1 is a modulator of γ secretase and can be used in studies about the treatment of Alzheimer's disease.Formula:C24H24N4OSPurezza:99.75% - 99.96%Colore e forma:SolidPeso molecolare:416.54ELN318463 racemate
CAS:ELN318463 racemate (ELN 318463 racemate) is the racemate of ELN318463 which is an amyloid precursor protein (APP) selective γ-secretase inhibitor.Formula:C19H20BrClN2O3SPurezza:99.69%Colore e forma:SolidPeso molecolare:471.8Ref: TM-T11178L
1mg162,00€5mg391,00€10mg615,00€25mg907,00€50mg1.235,00€100mg1.663,00€1mL*10mM (DMSO)447,00€γ-Secretase modulator 4
CAS:γ-Secretase modulator 4 is a potent γ-secretase modulator, reduces the Aβ42 level with IC50s of 0.017 μM and 0.014 μM in mouse and human, respectively.Formula:C23H19FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:402.42tCFA15
CAS:tCFA15: A trimethylated long-chain fatty alcohol with a 15-carbon side chain; may regulate Notch signaling and neuron differentiation.Formula:C24H44O2Purezza:98%Colore e forma:SolidPeso molecolare:364.61γ-secretase modulator 2
CAS:Gamma-secretase modulator 2 selectively targets Alzheimer's by reducing Aβ(1-42), aiding in prevention and treatment.Formula:C25H22F4N6O2Purezza:98%Colore e forma:SolidPeso molecolare:514.47LY-411575 isomer 1
CAS:LY-411575 isomer 1 is a potent γ-secretase inhibitor. LY-411575 isomer 1 is an isomer of LY411575.Formula:C26H23F2N3O4Purezza:98%Colore e forma:SolidPeso molecolare:479.48
