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Recettore del fattore di crescita dei fibroblasti (FGFR)

Recettore del fattore di crescita dei fibroblasti (FGFR)

Gli inibitori dei recettori del fattore di crescita dei fibroblasti (FGFR) sono terapie mirate che bloccano l'attività dei FGFR, coinvolti nella proliferazione cellulare, differenziazione e angiogenesi. La segnalazione FGFR contribuisce alla formazione di nuovi vasi sanguigni nei tumori, promuovendo la loro crescita e sopravvivenza. Inibire i FGFR può quindi ridurre l'angiogenesi e la progressione del tumore. Presso CymitQuimica, offriamo una gamma di inibitori FGFR di alta qualità per supportare la tua ricerca in oncologia, biologia dello sviluppo e angiogenesi.

Trovati 169 prodotti di "Recettore del fattore di crescita dei fibroblasti (FGFR)"

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  • PD168393
    Targetmol
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    PD168393

    CAS:
    <p>PD168393 is an irreversible EGFR inhibitor (IC50: 0.70 nM), irreversibly alkylate Cys-773; inactive against PKC, FGFR, PDGFR, and insulin.</p>
    Formula:C17H13BrN4O
    Purezza:99.13% - 99.83%
    Colore e forma:Solid
    Peso molecolare:369.22

    Ref: TM-T6932

  • Lenvatinib mesylate
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    Lenvatinib mesylate

    CAS:
    Lenvatinib mesylate (E7080 (mesylate)) is an oral and multi-targeted inhibitor of VEGFR1-3, FGFR1-4, PDGFR, KIT, and RET, with potent antitumor activities.
    Formula:C22H23ClN4O7S
    Purezza:99.03% - 99.79%
    Colore e forma:Solid
    Peso molecolare:522.96

    Ref: TM-T8541

  • SSR128129E
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    SSR128129E

    CAS:
    SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 μM), but not affecting other related RTKs.
    Formula:C18H15N2O4·Na
    Purezza:98.79% - ≥95%
    Colore e forma:Solid
    Peso molecolare:346.31

    Ref: TM-T6082

  • H3B-6527
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    H3B-6527

    CAS:
    <p>H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma, with antineoplastic activity.</p>
    Formula:C29H34Cl2N8O4
    Purezza:97.45%
    Colore e forma:Solid
    Peso molecolare:629.54

    Ref: TM-T7738

  • FGFR2-IN-3
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    FGFR2-IN-3

    CAS:
    <p>FGFR2-IN-3 is an orally active selective FGFR2 inhibitor[1].</p>
    Formula:C28H24FN7O2
    Purezza:99.63%
    Colore e forma:Soild
    Peso molecolare:509.53

    Ref: TM-T60185

  • TG 100801
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    TG 100801

    CAS:
    <p>TG 100801 is a dual inhibitor of VEGFr2 and Src family kinases and is a candidate compound for the treatment of age-related macular degeneration (AMD).</p>
    Formula:C33H30ClN5O3
    Purezza:99.28% - 99.61%
    Colore e forma:Solid
    Peso molecolare:580.08

    Ref: TM-T13157

  • MAX-40279 hydrochloride
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    MAX-40279 hydrochloride

    CAS:
    <p>MAX-40279 HCl: potent FLT3/FGFR inhibitor; potential in AML research.</p>
    Formula:C22H24ClFN6OS
    Colore e forma:Solid
    Peso molecolare:474.98

    Ref: TM-T63094

  • CP-547632 hydrochloride
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    CP-547632 hydrochloride

    CAS:
    <p>CP-547632 hydrochloride: oral VEGFR-2/FGF inhibitor (IC50: 11/9 nM), well-tolerated, antitumor.</p>
    Formula:C20H25BrClF2N5O3S
    Colore e forma:Solid
    Peso molecolare:568.86

    Ref: TM-T10870

  • FGFR4-IN-11
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    FGFR4-IN-11

    CAS:
    <p>FGFR4-IN-11: selective, covalent FGFR4 inhibitor; IC50=2.1 nM; blocks FGF19 pathway; anticancer.</p>
    Formula:C29H29N5O5
    Colore e forma:Solid
    Peso molecolare:527.57

    Ref: TM-T63704

  • FGFR3-IN-1
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    FGFR3-IN-1

    CAS:
    <p>FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor that inhibits FGFR1 (IC50: 40 nM), FGFR2 (IC50: 5.1 nM) and FGFR3 (IC50: 12 nM).</p>
    Formula:C28H39N9O3S
    Colore e forma:Solid
    Peso molecolare:581.73

    Ref: TM-T64107

  • SSR128129E free acid
    Targetmol
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    SSR128129E free acid

    CAS:
    SSR128129E free acid is an orally available and allosteric inhibitor of FGFR(IC50 of 1.9 μM for FGFR1).
    Formula:C18H16N2O4
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:324.33

    Ref: TM-T13003

  • FGFR4-IN-5
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    FGFR4-IN-5

    CAS:
    <p>FGFR4-IN-5: potent, selective FGFR4 inhibitor, IC50 6.5 nM, strong in vivo anti-tumor effect, for liver cancer research.</p>
    Formula:C23H23Cl2N5O5
    Colore e forma:Solid
    Peso molecolare:520.37

    Ref: TM-T37425

  • FGFR3-IN-2
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    FGFR3-IN-2

    CAS:
    <p>FGFR3-IN-2 (compound 18b) is a potent and selective FGFR3 inhibitor that inhibits FGFR3 (IC50: 4.1 nM) and VEGFR2 (IC50: 570 nM).</p>
    Formula:C28H39N9O4S
    Colore e forma:Solid
    Peso molecolare:597.73

    Ref: TM-T64215

  • FGFR-IN-9
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    FGFR-IN-9

    <p>FGFR-IN-9: oral FGFR inhibitor, IC50: 17.1 nM (FGFR4 WT), 29.6 (FGFR3), 30.7 (V550L), 46.7 (FGFR2), 64.3 nM (FGFR1).</p>
    Formula:C25H28N6O3S
    Colore e forma:Solid
    Peso molecolare:492.59

    Ref: TM-T73316

  • FGFR-IN-3
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    FGFR-IN-3

    CAS:
    <p>FGFR-IN-3: potent, oral FGFR modulator, BBB-penetrating, neuroprotective, potential in neurodegeneration study.</p>
    Formula:C18H27F2N5O2
    Colore e forma:Solid
    Peso molecolare:383.44

    Ref: TM-T61660

  • Derazantinib Racemate
    Targetmol
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    Derazantinib Racemate

    CAS:
    <p>Derazantinib Racemate is an oral ATP competitive kinase inhibitor targeting FGFR1/2/3 (IC50s: 4.5/1.8/4.5 nM).</p>
    Formula:C29H29FN4O
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:468.57

    Ref: TM-T10997

  • SUN13837
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    SUN13837

    CAS:
    <p>SUN13837, an oral FGFR modulator, crosses the BBB and shows neuroprotective promise.</p>
    Formula:C21H29N5O2
    Colore e forma:Solid
    Peso molecolare:383.49

    Ref: TM-T61666

  • MAX-40279
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    MAX-40279

    CAS:
    <p>MAX-40279 is a potent, dual FLT3 kinase and FGFR kinase inhibitor. MAX-40279 has potential for acute myeloid leukemia (AML) studies.</p>
    Formula:C22H23FN6OS
    Colore e forma:Solid
    Peso molecolare:438.52

    Ref: TM-T62513

  • Rogaratinib
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    Rogaratinib

    CAS:
    <p>Rogaratinib (BAY1163877) is an aberrant inhibitor of fibroblast growth factor receptor (FGFR).</p>
    Formula:C23H26N6O3S
    Purezza:99.54%
    Colore e forma:Solid
    Peso molecolare:466.56

    Ref: TM-T16781

  • FGFR-IN-7
    Targetmol
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    FGFR-IN-7

    CAS:
    <p>FGFR-IN-7: Oral FGFR modulator, crosses blood-brain barrier, neuroprotective, phospholipidosis-resistant, useful for neurodegeneration study.</p>
    Formula:C16H21ClF2N4O2
    Colore e forma:Solid
    Peso molecolare:374.81

    Ref: TM-T61528