Recettore del fattore di crescita dei fibroblasti (FGFR)
Gli inibitori dei recettori del fattore di crescita dei fibroblasti (FGFR) sono terapie mirate che bloccano l'attività dei FGFR, coinvolti nella proliferazione cellulare, differenziazione e angiogenesi. La segnalazione FGFR contribuisce alla formazione di nuovi vasi sanguigni nei tumori, promuovendo la loro crescita e sopravvivenza. Inibire i FGFR può quindi ridurre l'angiogenesi e la progressione del tumore. Presso CymitQuimica, offriamo una gamma di inibitori FGFR di alta qualità per supportare la tua ricerca in oncologia, biologia dello sviluppo e angiogenesi.
Trovati 169 prodotti di "Recettore del fattore di crescita dei fibroblasti (FGFR)"
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JK-P3
CAS:<p>JK-P3: a pyrazole inhibitor of VEGFR-2 (IC50: 7.8 μM), stalls FGFR 1/3 in vitro, halts HUVEC wound healing/tube formation, not cell growth.</p>Formula:C18H17N3O3Purezza:99.57%Colore e forma:SolidPeso molecolare:323.35PHA-680632
CAS:<p>PHA-680632 is potent inhibitor of Aurora A, Aurora B and Aurora C with IC50 of 27 nM, 135 nM and 120 nM, respectively.</p>Formula:C28H35N7O2Purezza:98.2%Colore e forma:SolidPeso molecolare:501.62Roblitinib
CAS:<p>Roblitinib (FGF-401), an FGFR4 inhibitor, potentially blocks tumor growth by halting cell proliferation and survival.</p>Formula:C25H30N8O4Purezza:97.27% - 99%Colore e forma:SolidPeso molecolare:506.56SU4984
CAS:<p>SU4984 is a cell-permeable, ATP-competitive and reversible inhibitor of the fibroblast growth factor receptor 1 (FGFR1).</p>Formula:C20H19N3O2Purezza:97.20%Colore e forma:SolidPeso molecolare:333.38BLU9931
CAS:<p>BLU9931 is the first selective small molecule inhibitor of FGFR4.</p>Formula:C26H22Cl2N4O3Purezza:96.958% - 99.85%Colore e forma:SolidPeso molecolare:509.38Heparan Sulfate
CAS:<p>Heparan sulfate is a natural product, a linear polysaccharide. Heparan sulfate occurs as a proteoglycan (HSPG). Cost effective and quality assured.</p>Formula:C12H19NO20S3(monomer)Purezza:98%Colore e forma:SolidPeso molecolare:593.47(monomer)EOC317
CAS:<p>EOC317 (ACTB-1003) is an oral kinase inhibitor (IC50: 6/2/4 nM, for FGFR1/VEGFR2/Tie-2).</p>Formula:C27H26F5N7O3Purezza:98.00% - 99.26%Colore e forma:SolidPeso molecolare:591.53Dovitinib lactate
CAS:<p>Dovitinib lactate (TKI-258 lactate)(TKI258) lactate is a potent inhibitor of fibroblast growth factor receptor 3 (FGFR3) (IC50 :5 nM).</p>Formula:C24H27FN6O4Purezza:99.54% - 99.77%Colore e forma:SolidPeso molecolare:482.51GW786034B
CAS:<p>Pazopanib HCl (Votrient) inhibits VEGFR1-3, PDGFR, FGFR, c-Kit, c-Fms with IC50 range 10-146 nM in cell-free assays.</p>Formula:C21H23N7O2S·HClPurezza:99.87%Colore e forma:SolidPeso molecolare:473.98PRN1371
CAS:<p>PRN1371 is a specific and potent FGFR1-4 and CSF1R inhibitor (IC50s: 0.6/1.3/4.1/19.3/8.1 nM for FGFR1/2/3/4 and CSF1R).</p>Formula:C26H30Cl2N6O4Purezza:98.65%Colore e forma:SolidPeso molecolare:561.46FIIN-3
CAS:<p>FIIN-3 is an irreversible inhibitor of FGFR.</p>Formula:C34H36Cl2N8O4Purezza:97.63% - 98.92%Colore e forma:SolidPeso molecolare:691.61Ponatinib
CAS:<p>Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively</p>Formula:C29H27F3N6OPurezza:98% - 99.60%Colore e forma:SolidPeso molecolare:532.56S49076
CAS:<p>S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.</p>Formula:C22H22N4O4SPurezza:95.35% - 97.4%Colore e forma:SolidPeso molecolare:438.5FGFR2-IN-3 hydrochloride
CAS:<p>FGFR2-IN-3 hydrochloride is a selective, orally active FGFR2 inhibitor.</p>Formula:C28H25ClFN7O2Colore e forma:SolidPeso molecolare:546.0Zoligratinib
CAS:<p>Zoligratinib (CH5183284) is a selective and orally available FGFR inhibitor, which is for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.</p>Formula:C20H16N6OPurezza:95.28% - 99.51%Colore e forma:SolidPeso molecolare:356.38PF 477736
CAS:<p>PF 477736 (PF-736,PF-00477736) is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (</p>Formula:C22H25N7O2Purezza:97.58% - 99.94%Colore e forma:SolidPeso molecolare:419.48Futibatinib
CAS:<p>Futibatinib (TAS-120) is an orally active, potent,and irreversible FGFR inhibitor of FGFR1, FGFR2, FGFR3, and FGFR4.Cost-effective and quality-assured.</p>Formula:C22H22N6O3Purezza:97.66% - 99.44%Colore e forma:SolidPeso molecolare:418.45Dovitinib lactate hydrate
CAS:<p>Dovitinib lactate hydrate (TKI258) is the Lactate of Dovitinib, which is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit).</p>Formula:C24H27FN6O4Purezza:99.82%Colore e forma:SolidPeso molecolare:482.51ENMD-2076
CAS:<p>ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.</p>Formula:C21H25N7Purezza:97.63% - ≥95%Colore e forma:SolidPeso molecolare:375.47Fisogatinib
CAS:<p>Fisogatinib (BLU-554) is a highly potent, selective, and orally active FGFR4 inhibitor.Cost-effective and quality-assured.</p>Formula:C24H24Cl2N4O4Purezza:99.27% - ≥95%Colore e forma:SolidPeso molecolare:503.38Masitinib mesylate
CAS:<p>Masitinib mesylate (AB-1010 mesylate) is a selective and orally bioavailable c-Kit inhibitor (IC50 of 200 nM,540/800 nM,510 nM for human recombinant c-Kit;</p>Formula:C29H34N6O4S2Purezza:97.67% - 98.44%Colore e forma:SolidPeso molecolare:594.75KHS 101
CAS:<p>KHS101 is a novel inhibitor of transforming acidic coiled-coil protein 3 (TACC3). It is a selective inducer of neuronal differentiation.</p>Formula:C18H21N5SPurezza:99.63%Colore e forma:SolidPeso molecolare:339.46Ferulic acid sodium
CAS:<p>Ferulic acid sodium (Sodium ferulic) is an agent used in the treatment of cardiovascular and cerebrovascular diseases and to prevent thrombosis.</p>Formula:C10H9NaO4Purezza:99.58%Colore e forma:White Crystalline PowderPeso molecolare:216.16S49076 HCl
CAS:<p>S49076 HCl (S-49076 Hydrochloride) is an effective inhibitor of MET, AXL/MER, and FGFR1/2/3.</p>Formula:C22H18ClN3O5Purezza:98%Colore e forma:SolidPeso molecolare:439.85R1530
CAS:<p>R1530 is a multikinase inhibitor with antineoplastic and antiangiogenesis activities.</p>Formula:C18H14ClFN4OPurezza:98.422%Colore e forma:SolidPeso molecolare:356.78KHS101 hydrochloride
CAS:<p>KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype.</p>Formula:C18H22ClN5SPurezza:99.6%Colore e forma:SolidPeso molecolare:375.92Alofanib
CAS:<p>Alofanib (RPT835) selectively inhibits FGFR2 in KATO III cells with IC50 <10 nM; doesn’t affect FGFR1/3 or FGF2-FGFR2 binding.</p>Formula:C19H15N3O6SPurezza:99.53% - 99.81%Colore e forma:SolidPeso molecolare:413.4Danusertib
CAS:<p>Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity.</p>Formula:C26H30N6O3Purezza:97.88% - 98.79%Colore e forma:White PowderPeso molecolare:474.55KW-2449
CAS:<p>KW-2449 is a multiple-targeted inhibitor, mostly for Flt3, modestly effective to Bcr-Abl, FGFR1, and Aurora A; little inhibitory on PDGFRβ, IGF-1R, EGFR.</p>Formula:C20H20N4OPurezza:98.43% - 99.69%Colore e forma:SolidPeso molecolare:332.4Nintedanib esylate
CAS:<p>Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β</p>Formula:C31H33N5O4·C2H6O3SPurezza:99.43% - 99.96%Colore e forma:SolidPeso molecolare:649.76FIIN-2
CAS:<p>FIIN-2, an irreversible, pan-FGFR inhibitor, inhibits FGFR1/2/3/4 with IC50 of 3.09 nM, 4.3 nM, 27 nM and 45.3 nM, respectively.</p>Formula:C35H38N8O4Purezza:97.82% - 99.65%Colore e forma:Crystalline SolidPeso molecolare:634.73ODM-203
CAS:<p>ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity</p>Formula:C26H21F2N5O2SPurezza:99.85%Colore e forma:SolidPeso molecolare:505.54LY2874455
CAS:<p>LY2874455 has been used in trials studying the treatment of Advanced Cancer.</p>Formula:C21H19Cl2N5O2Purezza:97.22% - 99.46%Colore e forma:SolidPeso molecolare:444.31Erdafitinib
CAS:<p>Erdafitinib (JNJ-42756493) is a quinoxaline derivative compound, acts on FGFR1/2/3/4.</p>Formula:C25H30N6O2Purezza:97.00% - 99.07%Colore e forma:SolidPeso molecolare:446.54ASP5878
CAS:<p>ASP5878 potently inhibited the tyrosine kinase activities of recombinant FGFR1, 2, 3, and 4 with IC50 values of 0.47, 0.60, 0.74, and 3.5 nmol/L.</p>Formula:C18H19F2N5O4Purezza:99.8% - 99.89%Colore e forma:SolidPeso molecolare:407.37AZD4547
CAS:<p>AZD4547 is an FGFR family inhibitor, and is able to act on FGFR1, FGFR2, FGFR3 and FGFR4. IC50:165 nM).Cost-effective and quality-assured.</p>Formula:C26H33N5O3Purezza:99.37% - 99.88%Colore e forma:SolidPeso molecolare:463.57CHIR-98014
CAS:<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formula:C20H17Cl2N9O2Purezza:97.25% - 99.59%Colore e forma:SolidPeso molecolare:486.31PD173074
CAS:<p>PD173074 inhibits FGFR1 (IC50: 25 nM) and VEGFR2 (100-200 nM); ~1000x more selective for FGFR1 over PDGFR/c-Src.</p>Formula:C28H41N7O3Purezza:98.15% - 98.21%Colore e forma:Yellow SolidPeso molecolare:523.67SU 5402
CAS:<p>SU 5402 is a potent multi-targeted receptor tyrosine kinase inhibitor with IC50 of 20 nM, 30 nM, and 510 nM for VEGFR2, FGFR1, and PDGF-Rβ, respectively.</p>Formula:C17H16N2O3Purezza:98.91% - 99.64%Colore e forma:Yellow-Green SolidPeso molecolare:296.32FGFR4-IN-1
CAS:<p>FGFR4-IN-1 is a potent FGFR4 inhibitor (IC50: 0.7 nM).</p>Formula:C24H27N7O5Purezza:98.96%Colore e forma:SolidPeso molecolare:493.52PD-161570
CAS:<p>PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM.</p>Formula:C26H35Cl2N7OPurezza:99.92%Colore e forma:SolidPeso molecolare:532.51Orantinib
CAS:<p>Orantinib (NSC 702827) , a excellent effective against PDGFR autophosphorylation with Ki of 8 nM, also highly inhibits Flk-1 and FGFR1 trans-phosphorylation.</p>Formula:C18H18N2O3Purezza:98.92% - 99.52%Colore e forma:SolidPeso molecolare:310.35Derazantinib
CAS:<p>Derazantinib (ARQ-087) is a potent, ATP-competitive, orally active tyrosine kinase inhibitor.Cost-effective and quality-assured.</p>Formula:C29H29FN4OPurezza:99.71%Colore e forma:SolidPeso molecolare:468.57PD-089828
CAS:<p>PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).</p>Formula:C18H18Cl2N6OPurezza:97.39%Colore e forma:SolidPeso molecolare:405.28XL 999
CAS:<p>Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）</p>Formula:C26H28FN5OPurezza:98.24% - 99.55%Colore e forma:SolidPeso molecolare:445.53Infigratinib
CAS:<p>Infigratinib (NVP-BGJ398) (BGJ398) is an orally bioavailable pan FGFR inhibitor (IC50: 0.9/1.4/1 nM for FGFR1/2/3), >40-fold selective for FGFR versus FGFR4 and</p>Formula:C26H31Cl2N7O3Purezza:98% - 98.97%Colore e forma:SolidPeso molecolare:560.48Masitinib
CAS:<p>Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.</p>Formula:C28H30N6OSPurezza:97.56% - >99.99%Colore e forma:SolidPeso molecolare:498.64DGY-06-116
CAS:<p>DGY-06-116 is an selective and irreversible covalent inhibitor of Src and FGFR1 with IC50 value of 3nM and 8340 nM, respectively.</p>Formula:C32H33ClN8O2Purezza:97.65%Colore e forma:SolidPeso molecolare:597.11Regorafenib
CAS:<p>Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orally</p>Formula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82SUN11602
CAS:<p>SUN11602, an aniline compound, mimics the neuroprotective mechanisms of basic fibroblast growth factor.</p>Formula:C26H37N5O2Purezza:99.36%Colore e forma:SolidPeso molecolare:451.6
