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Recettore del fattore di crescita dei fibroblasti (FGFR)

Recettore del fattore di crescita dei fibroblasti (FGFR)

Gli inibitori dei recettori del fattore di crescita dei fibroblasti (FGFR) sono terapie mirate che bloccano l'attività dei FGFR, coinvolti nella proliferazione cellulare, differenziazione e angiogenesi. La segnalazione FGFR contribuisce alla formazione di nuovi vasi sanguigni nei tumori, promuovendo la loro crescita e sopravvivenza. Inibire i FGFR può quindi ridurre l'angiogenesi e la progressione del tumore. Presso CymitQuimica, offriamo una gamma di inibitori FGFR di alta qualità per supportare la tua ricerca in oncologia, biologia dello sviluppo e angiogenesi.

Trovati 169 prodotti di "Recettore del fattore di crescita dei fibroblasti (FGFR)"

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  • Logo CymitQuimica
    Targetmol
    + Info

    FGFR4-IN-9

    <p>FGFR4-IN-9 is a selective inhibitor of FGFR4 (IC50: 75.3 nM) that effectively inhibits the growth and angiogenesis of hepatocellular carcinoma cells.</p>
    Formula:C24H22ClF3N4O4
    Colore e forma:Solid
    Peso molecolare:522.9

    Ref: TM-T63662

  • FGFR-IN-5
    Targetmol
    + Info

    FGFR-IN-5

    CAS:
    <p>FGFR-IN-5 is a potent inhibitor of FGFR. FGFR-IN-5 has potential for research in cancer diseases.</p>
    Formula:C25H22N6O3
    Colore e forma:Solid
    Peso molecolare:454.48

    Ref: TM-T62794

  • Logo CymitQuimica
    Targetmol
    + Info

    FGFR4-IN-6

    <p>FGFR4-IN-6: covalent, reversible FGFR4 blocker, 5.4 nM IC50, good oral bioavailability, reduces Hep3B2.1-7 tumors in mice, low toxicity.</p>
    Formula:C31H33N7O4
    Colore e forma:Solid
    Peso molecolare:567.64

    Ref: TM-T64015

  • E7090 succinate
    Targetmol
    + Info

    E7090 succinate

    CAS:
    <p>E7090 succinate inhibits FGFR1, FGFR2, and FGFR3 with IC50: 0.71, 0.50, 1.2 nM; less so FGFR4 at 120 nM.</p>
    Formula:C76H92N10O24
    Colore e forma:Solid
    Peso molecolare:1529.60

    Ref: TM-T72749

  • Logo CymitQuimica
    Targetmol
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    FGFR1 inhibitor-6

    <p>FGFR1 inhibitor-6, IC50: 16.31 nM, blocks cell cycle at pro-G1/G2/M and induces apoptosis.</p>
    Formula:C27H19N5O4S2
    Colore e forma:Solid
    Peso molecolare:541.6

    Ref: TM-T63816

  • CEP-11981
    Targetmol
    + Info

    CEP-11981

    CAS:
    <p>CEP-11981 is an orally active TIE2/pan-VEGFR inhibitor with broad tyrosine kinase inhibitory activity, antitumour and anti-angiogenic, refractory solid tumours.</p>
    Formula:C28H27N7O
    Purezza:99.58%
    Colore e forma:Solid
    Peso molecolare:477.56

    Ref: TM-T68539

  • Logo CymitQuimica
    Targetmol
    + Info

    FGFR4-IN-10

    <p>FGFR4-IN-10 (compound 5a) is a potent, selective FGFR4 inhibitor with IC50 of 70.7 nM, sparing FGFR1-3.</p>
    Formula:C20H19F3N6O3
    Colore e forma:Solid
    Peso molecolare:448.4

    Ref: TM-T62682

  • FGFR1 inhibitor-17
    Targetmol
    + Info

    FGFR1 inhibitor-17

    CAS:
    <p>FGFR1inhibitor-17 (Compound 92) is a potent inhibitor of FGFR1, with promising applications in cancer research.</p>
    Formula:C16H13ClN2O3
    Colore e forma:Solid
    Peso molecolare:316.739

    Ref: TM-T205365

  • FGFR1 inhibitor-16
    Targetmol
    + Info

    FGFR1 inhibitor-16

    CAS:
    <p>FGFR1inhibitor-16 (Compound 89) functions as an FGFR1 inhibitor, demonstrating an inhibition rate of 53.00% at a concentration of 50 μM and 24.95% at 10 μM. It is utilized in tumor research.</p>
    Formula:C16H9N5O3S
    Colore e forma:Solid
    Peso molecolare:351.339

    Ref: TM-T205114

  • FGFR2/3-IN-2
    Targetmol
    + Info

    FGFR2/3-IN-2

    CAS:
    <p>FGFR2/3-IN-2 (compound 10) is an orally active inhibitor targeting FGFR2 and FGFR3. It exhibits IC50 values of 3.7 nM for FGFR2 and 31.2 nM for FGFR3, with a pre-incubation time of 1 hour. FGFR2/3-IN-2 demonstrates selectivity over FGFR1/4 and other kinases, and does not cause diarrhea or increased serum phosphate in vivo. In the SNU-16 gastric cancer model, FGFR2/3-IN-2 can induce tumor stasis or regression.</p>
    Formula:C29H23FN6O3
    Colore e forma:Solid
    Peso molecolare:522.53

    Ref: TM-T205706

  • FGFR-IN-6
    Targetmol
    + Info

    FGFR-IN-6

    CAS:
    <p>FGFR-IN-6 (Compound 5) is an FGFR inhibitor.</p>
    Formula:C23H22N6O3
    Colore e forma:Solid
    Peso molecolare:430.46

    Ref: TM-T62391

  • FGFR1 inhibitor-15
    Targetmol
    + Info

    FGFR1 inhibitor-15

    CAS:
    <p>FGFR1inhibitor-15 (Compound 23) is an FGFR1 inhibitor with an IC50 value of 27 μM, useful for tumor research.</p>
    Formula:C17H13FN4O
    Colore e forma:Solid
    Peso molecolare:308.31

    Ref: TM-T205729

  • AZ8010
    Targetmol
    + Info

    AZ8010

    CAS:
    AZ8010 (AZ12908010) serves as an effective inhibitor of FGFR1-3 and exhibits antiproliferative properties, making it useful for cancer research.
    Formula:C27H34N4O3
    Colore e forma:Solid
    Peso molecolare:462.58

    Ref: TM-T89951

  • FGFR-IN-16
    Targetmol
    + Info

    FGFR-IN-16

    CAS:
    <p>FGFR-IN-16 (compound 7N) is a potent inhibitor of FGFR1, FGFR2, and FGFR4, exhibiting IC50 values of 8 nM, 4 nM, and 3.8 nM respectively. It plays a crucial role in cancer research.</p>
    Formula:C30H27Cl2N7O4
    Colore e forma:Solid
    Peso molecolare:620.49

    Ref: TM-T201714

  • FGFR-IN-15
    Targetmol
    + Info

    FGFR-IN-15

    <p>FGFR-IN-15 (compound 18i) acts as a pan-FGFR inhibitor, exhibiting potent inhibitory activity against FGFR1-4.</p>
    Formula:C22H23N5O5S
    Colore e forma:Solid
    Peso molecolare:469.51

    Ref: TM-T201821

  • FGFR4-IN-4
    Targetmol
    + Info

    FGFR4-IN-4

    CAS:
    <p>FGFR4-IN-4 is a FGFR4 inhibitor with anti-tumor activity.</p>
    Formula:C28H32Cl2N6O5
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:603.5

    Ref: TM-T11280

  • PNU-145156E
    Targetmol
    + Info

    PNU-145156E

    CAS:
    <p>PNU-145156E is a noncytotoxic molecule inhibiting growth and angiogenic factors, suppress tumor angiogenesis, support anti-angiogenic research strategies.</p>
    Formula:C45H40N10O17S4
    Colore e forma:Solid
    Peso molecolare:1121.12

    Ref: TM-T70412

  • Fanregratinib
    Targetmol
    + Info

    Fanregratinib

    CAS:
    Fanregratinib is a fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor.
    Formula:C27H33ClN6O2
    Colore e forma:Solid
    Peso molecolare:509.04

    Ref: TM-T201139

  • FGFR1 inhibitor-10
    Targetmol
    + Info

    FGFR1 inhibitor-10

    CAS:
    <p>FGFR1 inhibitor-10 (Compound 4i), with an IC50 of 28 nM, effectively inhibits FGFR1 phosphorylation.</p>
    Formula:C26H30F3N7O2S
    Purezza:98%
    Colore e forma:Solid
    Peso molecolare:561.62

    Ref: TM-T79686

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