ALK
Gli inibitori di ALK sono composti che mirano specificamente e inibiscono la chinasi del linfoma anaplastico (ALK), una tirosina chinasi recettoriale coinvolta nello sviluppo e nella progressione di alcuni tipi di cancro, inclusi il carcinoma polmonare non a piccole cellule e il neuroblastoma. Inibendo ALK, questi composti bloccano le vie di segnalazione che promuovono la crescita e la sopravvivenza delle cellule tumorali. Presso CymitQuimica, offriamo inibitori di ALK per supportare la tua ricerca in oncologia, terapie mirate contro il cancro e trasduzione del segnale.
Trovati 129 prodotti di "ALK"
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CEP-28122 mesylate salt (1022958-60-6 free base)
CEP-28122 mesylate salt (1022958-60-6 free base) is a highly selective orally active ALK inhibitor (IC50: 1.9 nM in an enzyme-based TRF assay).Formula:C29H39ClN6O6SPurezza:99.79%Colore e forma:SolidPeso molecolare:635.17ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:562.48Ref: TM-T10285
1mg52,00€5mg116,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)143,00€Ascrinvacumab
CAS:Ascrinvacumab (PF-03446962): humanized IgG2 anti-ALK-1 antibody, Kd 7 nM, inhibits TGF-β, for HCC research.Purezza:SDS-PAGE:95% SEC-HPLC:98.18%Colore e forma:LiquidPeso molecolare:150 kDaALK-IN-26
CAS:<p>ALK-IN-26 is an ALK inhibitor with potential anticancer activity.ALK-IN-26 shows antiproliferative activity against glioblastoma.</p>Formula:C24H23NO3SPurezza:99.91%Colore e forma:SoildPeso molecolare:405.51F-1
CAS:F-1: Potent ALK/ROS1 inhibitor with 2.1-3.9 nM IC50s; suppresses p-ALK signaling.Formula:C22H27ClN8O3SPurezza:97.66%Colore e forma:SolidPeso molecolare:519.02Ref: TM-T11254
1mg73,00€5mg140,00€10mg188,00€25mg316,00€50mg447,00€100mg620,00€200mg843,00€1mL*10mM (DMSO)168,00€ZX-29
CAS:ZX-29: Strong ALK inhibitor; IC50 - ALK 2.1 nM, L1196M 1.3 nM, G1202R 3.9 nM; triggers autophagy; anti-cancer.Formula:C23H28ClN7O3SPurezza:98.32%Colore e forma:SolidPeso molecolare:518.03Ref: TM-T13416
1mg92,00€5mg230,00€10mg364,00€25mg620,00€50mg848,00€100mg1.121,00€200mg1.510,00€1mL*10mM (DMSO)264,00€ALK inhibitor 2
CAS:ALK inhibitor 2 is a new-type and selective inhibitor for the ALK kinase.Formula:C23H28ClN7O3SPurezza:99.77% - >99.99%Colore e forma:SolidPeso molecolare:518.03LDN 193688
CAS:LDN 193688 is a BMP kinase inhibitor preferential for the ALK2 site, acting by binding to the ALK site,progressive osseous fibrodysplasia.Formula:C22H16N4OPurezza:99.48%Colore e forma:SoildPeso molecolare:352.39TL13-112
CAS:TL13-112 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.14 nM).Formula:C49H60ClN9O10SPurezza:98%Colore e forma:SolidPeso molecolare:1002.57Multi-kinase-IN-6
Multi-kinase-IN-6 (compound 10e) is a multikinase inhibitor that effectively impedes the activity of TrkA, ALK2, c-KIT, EGFR, PIM1, CK2α, CHK1, and CDK2.Purezza:98%Colore e forma:Odour SolidLDN-193189 2HCl
CAS:<p>LDN-193189 2HCl inhibits BMP signaling (ALK1/2/3/6), IC50: 0.8-16.7 nM; selective over TGF-β by 200-fold in C2C12 cells.</p>Formula:C25H24Cl2N6Purezza:99.78%Colore e forma:SolidPeso molecolare:479.4ALK-IN-9
CAS:ALK-IN-9 effectively inhibits cell growth with IC50 <0.2 nM for Ba/F3-EML4-ALK, KM12, KG-1.Formula:C20H21FN6O3Colore e forma:SolidPeso molecolare:412.425dALK-3
dALK-3 is a degrader of anaplastic lymphoma kinase (ALK) that effectively induces the degradation of EML4-ALK with a DC50 of 0.182 μM. It exhibits significant antiproliferative activity against H3122 cells and is applicable for tumor research.Formula:C39H45ClN7O5PColore e forma:SolidPeso molecolare:758.245M4K2234
CAS:M4K2234 (26b) inhibits ALK2/ALK5 (IC50: 5/2144 nM), used as a probe for ALK1/2 kinases in cancer research.Formula:C27H31FN4O2Purezza:99.99%Colore e forma:SolidPeso molecolare:462.56Ref: TM-T74660
1mgPrezzo su richiesta5mg120,00€10mg187,00€25mg376,00€1mL*10mM (DMSO)Prezzo su richiestaLAE-102
LAE-102 is a monoclonal antibody that acts as an antagonist of activin receptor II-A (ACTRIIA/ACVR2). It shows potential for research in the fields of endocrine and metabolic disorders, oncology, and respiratory diseases.Colore e forma:Odour LiquidALK protein ligand-1
CAS:ALK protein ligand-1 (Compound A1) is an ALK protein ligand, acting as a ligand for the target protein in PROTACs, demonstrating inhibitory effects on ALK. It is also useful in the synthesis of AP-1.Formula:C24H29ClN6O3SColore e forma:SolidPeso molecolare:517.043ALK-IN-13
CAS:<p>ALK-IN-13 is an ALK inhibitor.</p>Formula:C29H39ClN7O2PColore e forma:SolidPeso molecolare:584.12-Keto Crizotinib
CAS:2-Keto Crizotinib is an active lactam metabolite of crizotinib.Formula:C21H20Cl2FN5O2Purezza:98%Colore e forma:SolidPeso molecolare:464.32TL13-12
CAS:TL13-12 is a selective degrader of ALK-PROTAC and inhibits ALK activity (IC50: 0.69 nM).Formula:C45H53ClN10O10SPurezza:98%Colore e forma:SolidPeso molecolare:961.49TL13-110
CAS:Negative control for TL 13-112 . Displays no degradation of ALK in cell lines. Highly potent ALK inhibitor (IC50 = 0.34 nM).Formula:C49H62ClN9O9SColore e forma:SolidPeso molecolare:988.59INCB-000928
CAS:<p>Zilurgisertib (INCB-000928) is a selective and potent ALK 2 inhibitor for the study of cancer and MF anemia.</p>Formula:C30H38N4O3Purezza:98.93%Colore e forma:SolidPeso molecolare:502.65FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidKinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour SolidRef: TM-L1600
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaALK-IN-12
CAS:ALK-IN-12: potent ALK inhibitor (IC50: 0.18 nM), affects IGF1R and InsR (IC50: 20.3/90.6 nM), potential for cancer therapy.Formula:C24H30ClN6O2PColore e forma:SolidPeso molecolare:500.97ALK5 Inhibitor II (hydrochloride)
CAS:ALK5 Inhibitor II has IC50s: 4 nM (auto), 18 nM (TGF-β assay), 23 nM (binding, HepG2).Formula:C17H13N5·HClPurezza:98%Colore e forma:SolidPeso molecolare:323.8SIAIS164018 hydrochloride
SIAIS164018 hydrochloride is a PROTAC-based degrader targeting ALK and EGFR, exhibiting IC50 values of 2.5 nM for ALK and 6.6 nM for ALK G1202R.Formula:C43H49Cl2N10O7PPurezza:98%Colore e forma:SolidPeso molecolare:919.79CPD-1224
CAS:CPD-1224, an oral ALK inhibitor derivative, binds cereblon, targets EML4-ALK fusions, and degrades ALK plus L1196M/G1202R mutants.Formula:C43H47ClN8O7SColore e forma:SolidPeso molecolare:855.4ALK-IN-29
ALK-IN-29 (compound 4c) exhibits inhibitory effects on tyrosine protein kinases such as ALK, CDK2/CyclinE1, and FAK, with the strongest inhibition observed against ALK kinase, displaying a 40.63% inhibition rate at a concentration of 10 μM. ALK-IN-29 is applicable in cancer research.Formula:C29H32FN3OColore e forma:SolidPeso molecolare:457.58PROTAC ALK degrader-3
PROTAC ALK degrader-3 (4B) is an orally active PROTAC-based ALK degrader, efficiently inducing sustained degradation of ALK fusion protein and significant inhibition of downstream pathways in Karpas 299 cells with an IC50 of 119.33 nM. This compound exhibits antitumor activity.Formula:C50H60ClN9O7SColore e forma:SolidPeso molecolare:966.59TL13-22
CAS:TL13-22 is a potent inhibitor of ALK and does not lead to degradation of ALK proteins.TL13-22 is often used as a negative control for TL13-12 .Formula:C45H55ClN10O9SPurezza:99.13%Colore e forma:SolidPeso molecolare:947.5ALK/ROS1-IN-3
<p>ALK/ROS1-IN-3 (compound C01) is a dual inhibitor targeting ROS1 and ALK, with IC50 values of 42.3 nM for ROS1G2032R and 49.1 nM for ALKG1202R.</p>Formula:C32H32N4O2Peso molecolare:504.25253ALKBH5-IN-5
CAS:<p>ALKBH5-IN-5 is a highly selective, potent and covalently binding ALKBH5 inhibitor that alters m6A levels on mRNA, induces apoptosis, antitumo.</p>Formula:C13H13NO3Purezza:99.54%Colore e forma:SoildPeso molecolare:231.25Ref: TM-T203011
5mg35,00€10mg48,00€25mg88,00€50mg127,00€100mg188,00€200mg283,00€1mL*10mM (DMSO)52,00€ALK/ROS1-IN-5
<p>ALK/ROS1-IN-5 (compound X4) is a selective inhibitor of ALK and ROS1 kinases, with IC50 values of 0.512 μM for ALK and 0.766 μM for ROS1. It inhibits H2228 cells with an IC50 of 0.034 μM and induces apoptosis in cancer cells in a dose-dependent manner. Additionally, ALK/ROS1-IN-5 effectively suppresses the expression of p-ALK and p-ERK in cancer cells.</p>Formula:C32H28F2N4O3Colore e forma:SolidPeso molecolare:554.586LDN-193189 Tetrahydrochloride
CAS:LDN193189 is a BMPI receptor inhibitor, blocking ALK2 and ALK3 effectively, while weak on ALK4, ALK5, ALK7.Formula:C25H26Cl4N6Purezza:98.21%Colore e forma:SolidPeso molecolare:552.33EW-7195
CAS:<p>EW-7195 inhibits ALK5/TGFβR1 (>300x selective over p38α) with 4.83 nM IC50, blocking TGF-β1 signaling, EMT, and breast cancer lung metastasis.</p>Formula:C23H18N8Purezza:98.76%Colore e forma:SolidPeso molecolare:406.44ALK-IN-1
CAS:ALK-IN-1 is a potent ALK inhibitor, demonstrating the ability to overcome Crizotinib resistance mediated by an L1196M mutation.Formula:C26H34ClN6O2PPurezza:99.74% - 99.80%Colore e forma:SolidPeso molecolare:529.01SB-505124
CAS:SB505124 is a selective inhibitor of TGFβR for ALK4, ALK5.Formula:C20H21N3O2Purezza:97.19% - 99.92%Colore e forma:SolidPeso molecolare:335.4Ref: TM-T2462
1mg40,00€2mg52,00€5mg88,00€10mg127,00€25mg221,00€50mg374,00€100mg547,00€500mg1.159,00€1mL*10mM (DMSO)139,00€A 77-01
CAS:A 77-01 is a potent inhibitor of TGF-(beta) type I receptor superfamily activin-like kinase ALK5 with IC50 of 25 nM.Formula:C18H14N4Purezza:98.82% - ≥95%Colore e forma:SolidPeso molecolare:286.33Ref: TM-T2098
1mg43,00€2mg56,00€5mg90,00€10mg125,00€25mg210,00€50mg296,00€100mg416,00€200mgPrezzo su richiesta1mL*10mM (DMSO)90,00€GW788388
CAS:<p>GW788388 is a potent and selective inhibitor of ALK5, also inhibits TGF-(beta) type II receptor and activin type II receptor activities.</p>Formula:C25H23N5O2Purezza:98.03% - 99.58%Colore e forma:SolidPeso molecolare:425.48ML347
CAS:ML347 (LDN 193719)(DN193719) is a highly specific ALK1/2 inhibitor ( IC50: 46/32 nM), and the selectivity for ALK2 is >300-fold than ALK3.Formula:C22H16N4OPurezza:99.30% - ≥95%Colore e forma:SolidPeso molecolare:352.395-phenylthieno[2,3-d]pyrimidin-4-amine
CAS:5-phenylthieno[2,3-d]pyrimidin-4-amine is a heterocycle that inhibits enzymes like kinases, may treat diseases.Formula:C12H9N3SPurezza:97%Colore e forma:SolidPeso molecolare:227.29Ref: TM-T50042
2mg46,00€5mg64,00€10mg95,00€25mg145,00€50mg212,00€100mg319,00€200mg455,00€1mL*10mM (DMSO)64,00€RepSox
CAS:RepSox (ALK5 Inhibitor II) is a TGFβR-1/ALK5 inhibitor that selectively inhibits the binding of ATP to ALK5 and the autophosphorylation of ALK5 (IC50=23/4 nM).Formula:C17H13N5Purezza:98.8% - 99.73%Colore e forma:SolidPeso molecolare:287.32Ref: TM-T6337
1mg35,00€2mg48,00€5mg66,00€10mg85,00€25mg123,00€50mg172,00€100mg255,00€500mg630,00€1mL*10mM (DMSO)72,00€Brigatinib
CAS:<p>Brigatinib (AP-26113) is a highly potent and selective ALK inhibitor.</p>Formula:C29H39ClN7O2PPurezza:97.18% - >99.99%Colore e forma:SolidPeso molecolare:584.09SM 16
CAS:SM 16 is a ALK5/ALK4 kinase inhibitor (Ki: 10/1.5 nM).Formula:C25H26N4O3Purezza:99.72%Colore e forma:SolidPeso molecolare:430.5N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-bromoaniline
CAS:Compound 12d is a potent ALK5 inhibitor with an IC50 of 7nM.Formula:C22H18BrN7Purezza:99.935%Colore e forma:SolidPeso molecolare:460.33Ref: TM-T9837
1mg87,00€5mg192,00€10mg284,00€25mg452,00€50mg645,00€100mg867,00€200mg1.159,00€1mL*10mM (DMSO)226,00€CH5424802 analog
CAS:CH5424802 analog is a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.Formula:C28H30N4O2Purezza:98.96%Colore e forma:SolidPeso molecolare:454.56Ref: TM-T9224
1mg131,00€5mg286,00€10mg430,00€25mg710,00€50mg998,00€100mg1.349,00€1mL*10mM (DMSO)343,00€DMH-1
CAS:<p>DMH-1 is a BMP inhibitor that inhibits ALK1, ALK2, ALK3 and ALK6. DMH-1 promotes pluripotent stem cell differentiation. Cost-effective and quality-assured.</p>Formula:C24H20N4OPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:380.44ALK kinase inhibitor-1
CAS:SAR348830 is an ALK inhibitor, targeting anaplastic lymphoma kinase.Formula:C28H32FN5O3SPurezza:99.84%Colore e forma:SolidPeso molecolare:537.65A 83-01 sodium salt
CAS:A 83-01 sodium salt inhibits ALK5, ALK4, and ALK7 kinases with IC50s: 12, 45, 7.5 nM.Formula:C25H19N5NaSColore e forma:SolidPeso molecolare:444.51CEP-28122 mesylate salt
CEP-28122 mesylate, a diaminopyrimidine, selectively inhibits ALK with IC50 of 1.9 nM and exhibits antitumor effects.Formula:C29H39ClN6O6SColore e forma:SolidPeso molecolare:635.17Vactosertib Hydrochloride
CAS:Vactosertib Hydrochloride (EW-7197 Hydrochloride) is an ALK5 inhibitor, a TGF-β receptor I inhibitor with antimetastatic and anticancer effects.Formula:C22H19ClFN7Purezza:98.03%Colore e forma:SolidPeso molecolare:435.89Ref: TM-T15262
1mg35,00€5mg70,00€10mg97,00€25mg160,00€50mg243,00€100mg376,00€200mg550,00€1mL*10mM (DMSO)78,00€AZD-3463
CAS:AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.Formula:C24H25ClN6OPurezza:99.13%Colore e forma:SolidPeso molecolare:448.95LDN-193189 HCl
CAS:LDN-193189 HCl (LDN193189 Hydrochloride) is a selective BMP type I receptor kinases inhibitor.Formula:C25H22N6·HClPurezza:99.49% - 99.53%Colore e forma:SolidPeso molecolare:442.94Ref: TM-T6158
1mg35,00€2mg48,00€5mg70,00€10mg93,00€25mg156,00€50mg227,00€100mg378,00€200mg567,00€1mL*10mM (DMSO)86,00€Crizotinib acetate
CAS:Crizotinib is an oral c-met/HGFR tyrosine kinase inhibitor with potential cancer-fighting properties.Formula:C23H26Cl2FN5O3Colore e forma:SolidPeso molecolare:510.39SB 525334
CAS:SB-525334 is a potent and selective inhibitor of the TGF-β1R and ALK5 (IC50: 14.3 nM).Formula:C21H21N5Purezza:98.39% - ≥95%Colore e forma:SolidPeso molecolare:343.42Blu-782
CAS:<p>Blu-782 (ALK2-IN-1) is a activin receptor-like kinase-2 (ALK2) inhibitor ( IC50 of <10 nM)</p>Formula:C31H42N6O4Purezza:99.51%Colore e forma:SolidPeso molecolare:562.7K02288
CAS:<p>K 02288 is a novel small molecule inhibitor of ALK1/2/3/6.</p>Formula:C20H20N2O4Purezza:98% - 99.83%Colore e forma:SolidPeso molecolare:352.38LDN-212854
CAS:LDN-212854 (BMP Inhibitor III), a novel BMP inhibitor, exhibits greater selectivity for BMP versus the TGF-β type I receptors.Formula:C25H22N6Purezza:98% - 98.71%Colore e forma:SolidPeso molecolare:406.48Ref: TM-T1900
1mg49,00€2mg65,00€5mg97,00€10mg175,00€25mg309,00€50mg464,00€100mg697,00€200mg998,00€1mL*10mM (DMSO)107,00€SB-431542
CAS:SB-431542 is an inhibitor of ALK5/TGF-β type I Receptor (IC50=94 nM) and is selective.Formula:C22H16N4O3Purezza:99.035% - >99.99%Colore e forma:SolidPeso molecolare:384.39HG-14-10-04
CAS:<p>HG-14-10-04 is a potent and specific ALK inhibitor.</p>Formula:C29H34ClN7OPurezza:99.75% - >99.99%Colore e forma:SolidPeso molecolare:532.08CEP-28122
CAS:<p>CEP-28122 is a highly potent and selective orally active ALK inhibitor.</p>Formula:C28H35ClN6O3Purezza:99.87% - >99.99%Colore e forma:SolidPeso molecolare:539.07Vactosertib
CAS:Vactosertib (EW-7197) is an oral TGFBR1/ALK5 inhibitor with potential cancer-fighting properties.Formula:C22H18FN7Purezza:98.85% - 99.81%Colore e forma:SolidPeso molecolare:399.42Ensartinib
CAS:Ensartinib (X-396) is a potent and orally active dual ALK/MET inhibitor for the treatment of ALK-positive non-small cell lung cancer (NSCLC).Formula:C26H27Cl2FN6O3Purezza:99.92%Colore e forma:SolidPeso molecolare:561.44CAY10594
CAS:CAY10594, a PLD2 inhibitor, mitigates acetaminophen liver damage via the p-GSK-3β/JNK pathway.Formula:C26H28N4O2Purezza:98%Colore e forma:SolidPeso molecolare:428.53LDN-214117
CAS:<p>LDN-214117 is a potent and selective ALK2 inhibitor.</p>Formula:C25H29N3O3Purezza:98% - 99.82%Colore e forma:SolidPeso molecolare:419.52LDN193189
CAS:LDN193189 blocks BMP signaling by inhibiting ALK2/3; IC50: ALK1/2/3/6 = 0.8/0.8/5.3/16.7 nM.Formula:C25H22N6Purezza:98% - 99.86%Colore e forma:SolidPeso molecolare:406.48Crizotinib hydrochloride
CAS:Crizotinib hydrochloride (PF-02341066 hydrochloride) is a novel inhibitor of anaplastic lymphoma kinase and c-Met(IC50s of 20 and 8 nM)Formula:C21H23Cl3FN5OPurezza:98.73% - 98.87%Colore e forma:SolidPeso molecolare:486.8Ref: TM-T8399
5mg37,00€10mg52,00€25mg82,00€50mg99,00€100mg138,00€200mg171,00€500mg227,00€1mL*10mM (DMSO)59,00€Alectinib
CAS:Alectinib (RG-7853) is an ALK inhibitor that is selective, orally active, and ATP-competitive. Alectinib has antitumor activity. Cost-effective and quality-assured.Formula:C30H34N4O2Purezza:98% - 99.38%Colore e forma:SolidPeso molecolare:482.62Ref: TM-T1936
2mg47,00€5mg69,00€10mg87,00€50mg105,00€100mg168,00€200mg259,00€500mg437,00€1mL*10mM (DMSO)73,00€CEP-37440
CAS:CEP-37440 is an effective and specific Dual FAK/ALK inhibitor with IC50s of 120 nM(ALK cellular in 75% human plasma) and 2.3 nM (FAK).Formula:C30H38ClN7O3Purezza:98.86% - 99.98%Colore e forma:SolidPeso molecolare:580.12GSK1838705A
CAS:GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.Formula:C27H29FN8O3Purezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:532.57Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.61%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Ceritinib
CAS:Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.Formula:C28H36ClN5O3SPurezza:98.52% - 99.77%Colore e forma:SolidPeso molecolare:558.14BIBF0775
CAS:<p>BIBF0775 is a selective TGFβ type I receptor (Alk5) inhibitor (IC50: 34 nM).</p>Formula:C31H34N4O2Purezza:99.45% - 99.79%Colore e forma:SolidPeso molecolare:494.63R-268712
CAS:R-268712 is a potent ALK5 inhibitor with a 2.5 nM IC50, also targeting TGF-β type I receptor orally.Formula:C20H18FN5OPurezza:99.61%Colore e forma:SolidPeso molecolare:363.39Ref: TM-T16708
1mg47,00€5mg87,00€10mg137,00€25mg264,00€50mg399,00€100mg567,00€200mg805,00€1mL*10mM (DMSO)97,00€Lorlatinib
CAS:Lorlatinib (PF-6463922) is an orally available, ATP-competitive inhibitor of the receptor tyrosine kinases, anaplastic lymphoma kinase (ALK) and C-ros oncogeneFormula:C21H19FN6O2Purezza:99.77% - 99.95%Colore e forma:SolidPeso molecolare:406.41Ref: TM-T3061
1mg35,00€2mg44,00€5mg64,00€10mg94,00€25mg144,00€50mg225,00€100mg394,00€1mL*10mM (DMSO)70,00€Crizotinib
CAS:Crizotinib (PF-02341066) is an ATP-competitive small-molecule tyrosine kinases inhibitor of c-MET (IC50: 8 nM) and ALK (IC50: 20 nM) receptor.Formula:C21H22Cl2FN5OPurezza:99% - 99.87%Colore e forma:SolidPeso molecolare:450.34Ref: TM-T1661
2mgPrezzo su richiesta5mg34,00€10mg52,00€25mg58,00€50mg67,00€100mg93,00€500mg156,00€1mL*10mM (DMSO)52,00€Alectinib hydrochloride
CAS:Alectinib hydrochloride (RO5424802 Hydrochloride) is a selective, and orally available inhibitor of ALK( IC50 : 1.9 nM)Formula:C30H35ClN4O2Purezza:99.74% - 99.96%Colore e forma:SolidPeso molecolare:519.08A 83-01
CAS:A 83-01 (ALK5 Inhibitor IV) is a selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7.Formula:C25H19N5SPurezza:97% - 98.2%Colore e forma:SolidPeso molecolare:421.52SB-505124 hydrochloride
CAS:SB-505124 hydrochloride (SB505124 hydrochloride) is a TGF-β type I receptor (ALK4, ALK5, ALK7) inhibitor for the study of colorectal cancer.Formula:C20H22ClN3O2Purezza:98.71%Colore e forma:SolidPeso molecolare:371.86AZ 12799734
CAS:AZ 12799734 is an orally active, selective and potent dual inhibitor of TGFBR1 and ALK5 with inhibitory effects on BMP and TGFβ for the study of tumours.Formula:C18H18N4O3SPurezza:98.23%Colore e forma:SolidPeso molecolare:370.43Ref: TM-T35896
1mg49,00€5mg97,00€10mg155,00€25mg301,00€50mg472,00€100mg652,00€200mg908,00€1mL*10mM (DMSO)106,00€ALK5-IN-79
CAS:ALK5-IN-79 (compound 57), an ALK inhibitor, exhibits anticancer activity by inhibiting the TGF-β1/SMAD signaling pathway. It effectively reduces the production of extracellular matrix (ECM) and collagen deposition. Moreover, ALK5-IN-79 demonstrates satisfactory pharmacokinetic (PK) properties and favorable in vivo tolerance.Formula:C23H27N7OColore e forma:SolidPeso molecolare:417.51SMU-B
CAS:SMU-B is a well-tolerated c-Met/ALK dual inhibitor.Formula:C26H25Cl2FN4O2Purezza:98%Colore e forma:SolidPeso molecolare:515.41Ficonalkib
CAS:Ficonalkib is a potent antineoplastic agent that inhibits the Anaplastic Lymphoma Kinase (ALK) tyrosine kinase receptor.Formula:C29H39N7O3SColore e forma:SolidPeso molecolare:565.73Con B-1
CAS:ConB-1 is a potent and selective ALK inhibitor with low toxicity to normal cells .Formula:C38H52ClN7O6SColore e forma:SolidPeso molecolare:770.38RIPK2-IN-1
CAS:RIPK2-IN-1 (compound 18f) is a potent inhibitor of RIPK2 (IC50: 51 nM) and also inhibits ALK2 (IC50: 5 nM).Formula:C23H27N5O3SColore e forma:SolidPeso molecolare:453.56ALK5-IN-26
CAS:ALK5-IN-26 (EX-22) is an ALK (Activin receptor-like kinase) inhibitor. ALK5-IN-26 inhibits ALK5 (IC50 ≤ 1 nM).Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51OD36
CAS:OD36: Potent RIPK2 inhibitor, IC50=5.3 nM; hinders ALK2 signaling and osteogenesis, KD=37 nM; targets ALK2 ATP pocket.Formula:C16H15ClN4O2Purezza:99.45%Colore e forma:SolidPeso molecolare:330.77EML4-ALK kinase inhibitor 1
CAS:<p>Potent oral EML4-ALK inhibitor with a 1 nM IC50.</p>Formula:C31H48N8O3Purezza:99.62%Colore e forma:SolidPeso molecolare:580.76TRK/ALK-IN-1
TRK/ALK-IN-1: Potent dual TRK & ALK inhibitor; IC50s: 2.2nM (TRKA), 9.3nM (ALK WT), 38nM (ALK L1196M); cancer research potential.Formula:C31H35ClF2N8O2SColore e forma:SolidPeso molecolare:657.18ALK-IN-22
CAS:ALK-IN-22 suppresses ALK and mutants (IC50: 2.3-3.7 nM), hinders phosphorylation, and induces apoptosis in tumor studies.Formula:C24H24ClN7O2Colore e forma:SolidPeso molecolare:477.95WY-135
CAS:WY-135 is a dual inhibitor of ALK and ROS1 (IC50 of 1.4 nM and 1.1 nM, respectively).Formula:C28H34ClN9O3SPurezza:98%Colore e forma:SolidPeso molecolare:612.15ALK2-IN-2
CAS:ALK2-IN-2 is a potent and selective inhibitor of activin receptor-like kinase 2 (ALK2) (IC50: 9 nM), inhibiting ALK2 700-fold more than ALK3.Formula:C28H27N5O2SPurezza:99.86%Colore e forma:SolidPeso molecolare:497.61Ref: TM-T10287
1mg47,00€5mg95,00€10mg150,00€25mg229,00€50mg314,00€100mg434,00€200mg590,00€1mL*10mM (DMSO)104,00€OD36 hydrochloride
CAS:OD36 hydrochloride (OD-36 hydrochloride) is a potent RIPK2 inhibitor with an IC50 of 5.3 nM.OD36 hydrochloride is a macrocyclic inhibitor that binds efficientlyFormula:C16H16Cl2N4O2Purezza:99.85%Colore e forma:SolidPeso molecolare:367.23J-1048
CAS:J-1048, an activin receptor-like kinase 5 (ALK5) inhibitor, effectively suppresses TAA-induced liver fibrosis in mice through specific inhibition of the TGF-β/Formula:C23H17FN6S2Colore e forma:SolidPeso molecolare:460.55ALK2-IN-5
CAS:ALK2-IN-5, a pyrazolopyrimidine compound, serves as an inhibitor of ALK2 and FGFR, targeting disorders linked with their activity, including cancer [1].Formula:C24H32N8O2Colore e forma:SolidPeso molecolare:464.56ALK-IN-5
CAS:ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK, IC50: 2.9 nM).Formula:C24H25FN6O3Purezza:98%Colore e forma:SolidPeso molecolare:464.49CJ-2360
CAS:CJ-2360 is a potent ALK inhibitor, effective on wild-type and various mutants, with IC50 values ranging from 2.2 to 8.9 nM, also targeting 468 kinases.Formula:C27H30FN5O2Colore e forma:SolidPeso molecolare:475.56ALK5-IN-30
CAS:ALK5-IN-30 (EX-07) is a potent inhibitor of ALK with inhibitory effects on ALK5 (IC50< 10 nM) and TGFβ-R1 (IC50< 10 nM).Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51KRCA-0713
CAS:KRCA-0713 is a ALK inhibitor.Formula:C26H32ClN5O3SPurezza:98%Colore e forma:SolidPeso molecolare:530.08XST-14
CAS:XST-14 is a ULK1 inhibitor.XST-14 induces apoptosis and inhibits the growth of HCC cells.Formula:C16H21NO4Purezza:99.84% - 99.84%Colore e forma:SolidPeso molecolare:291.34ALK5-IN-29
CAS:ALK5-IN-29: selective ALK inhibitor, IC50 ≤ 10 nM, curbs tumor growth, aids in cancer research.Formula:C24H25FN8Colore e forma:SolidPeso molecolare:444.51ALK-IN-21
CAS:ALK-IN-21 (B10) inhibits ALK WT (IC50: 4.59nM), L1196M (2.07nM), G1202R (5.95nM); curbs Karpas299, H2228 cell growth; for ALCL research.Formula:C35H45ClN6O6S4Colore e forma:SolidPeso molecolare:809.48TGFBR1-IN-1
CAS:TGFBR1-IN-1 is an inhibitor of ALK5 (IC50 of 10-100 nM).Formula:C23H17N5O2SPurezza:98%Colore e forma:SolidPeso molecolare:427.48Conteltinib
CAS:Conteltinib (CT-707) is an enzyme inhibitor with antitumor activity targeting FAK, ALK and Pyk2. It can be used to study lymphoma.Formula:C32H45N9O3SPurezza:98.12% - 99.54%Colore e forma:SolidPeso molecolare:635.82Ref: TM-T14997
1mg73,00€5mg159,00€10mg229,00€25mg390,00€50mg547,00€100mg762,00€1mL*10mM (DMSO)215,00€MY10
CAS:MY10, a potent and orally active inhibitor of the receptor protein tyrosine phosphatase (RPTPβ/ζ), effectively reduces binge-like ethanol consumption andFormula:C15H10F6OS2Purezza:98.64%Colore e forma:SolidPeso molecolare:384.36Ref: TM-T61678
1mg62,00€5mg133,00€10mg207,00€25mg416,00€50mg663,00€100mg1.035,00€200mg1.388,00€1mL*10mM (DMSO)170,00€TP0427736 hydrochloride
CAS:TP0427736 hydrochloride is a novel and selective ALK5 inhibitor, capable of inhibiting Smad2/3 phosphorylation in A549 cells.Formula:C14H11ClN4S2Purezza:98.99%Colore e forma:SolidPeso molecolare:334.85ALK/EGFR-IN-2
CAS:ALK/EGFR-IN-2 is a potent dual inhibitor targeting ALK and EGFR, promoting apoptosis and G0/G1 cell cycle arrest in cancer cells.Formula:C27H34ClN7O3SColore e forma:SolidPeso molecolare:572.12GW-6604
CAS:GW-6604 is an ALK5 inhibitor and shows clear antifibrotic effects resulting in liver function improvement.Formula:C19H14N4Purezza:99.6%Colore e forma:SolidPeso molecolare:298.34Ref: TM-T9947
1mg35,00€5mg80,00€10mg116,00€25mg187,00€50mg279,00€100mg405,00€1mL*10mM (DMSO)Prezzo su richiestaALK/EGFR-IN-1
CAS:ALK/EGFR-IN-1 (Compound 8l) is a dual inhibitor targeting both ALK and EGFR, effectively blocking their phosphorylation.Formula:C27H34ClN7O3SPurezza:98%Colore e forma:SolidPeso molecolare:572.12ALK-IN-6
CAS:ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).Formula:C26H29ClD3N5O3SPurezza:98%Colore e forma:SolidPeso molecolare:533.1UNC5293
CAS:UNC5293: potent oral MERTK inhibitor, Ki=190 pM, IC50=0.9 nM; selective vs Axl/Tyro3/Flt3; good mouse PK; used in leukemia research.Formula:C30H42N6O2Colore e forma:SolidPeso molecolare:518.69ALK/ROS1-IN-1
CAS:ALK/ROS1-IN-1 is a potent and selective anti-crizotinib-resistant ALK/ROS1 dual inhibitor (IC50s: 0.530 μM and 0.174 μM for ROS1 and ALK enzyme).Formula:C30H35F3N6O3Purezza:98%Colore e forma:SolidPeso molecolare:584.63ALK/EGFR-IN-3
CAS:ALK/EGFR-IN-3 is a dual ALK and EGFR inhibitor that demonstrates potent anti-proliferative effects on various cancer cell lines, including H1975, PC9, and Baf3-Formula:C27H34ClN7O3SColore e forma:SolidPeso molecolare:572.12KER047
CAS:ALK2-IN-4, a highly effective ALK2 inhibitor.Formula:C26H30FN7OPurezza:98.49% - >99.99%Colore e forma:SolidPeso molecolare:475.56Ref: TM-T39764
1mg96,00€5mg227,00€10mg369,00€25mg753,00€50mg1.074,00€100mg1.644,00€1mL*10mM (DMSO)250,00€ALK-IN-27
CAS:Neladalkib (NVL-655) is an ALK inhibitor with antitumor activity for the study of non-small cell cancers.Formula:C23H22ClFN6OPurezza:99.71%Colore e forma:SolidPeso molecolare:452.91IN-1130
CAS:IN-1130: ALK5 inhibitor, IC50 - 5.3 nM (Smad3), 36 nM (casein), 4.3 μM (p38α MAPK).Formula:C25H20N6OPurezza:99.79%Colore e forma:SolidPeso molecolare:420.47DA-0157
CAS:DA-0157 is an orally active inhibitor targeting EGFR and ALK, designed to overcome resistance mutations in non-small cell lung cancer (NSCLC). It effectively inhibits the proliferation of Ba/F3-EGFR Del19/T790M/C797S (IC50= 6.9 nM), Ba/F3-EGFR WT (IC50= 0.83 μM), Ba/F3-EML4-ALK-L1196M (IC50= 5.5 nM), and Ba/F3-EML4-ALK (IC50= 7.4 nM). Additionally, DA-0157 inhibits CYP2D6 with an IC50 of 5.26 μM and demonstrates antitumor activity in mouse models.Formula:C31H43BrN7O2PColore e forma:SolidPeso molecolare:656.597ALK-IN-23
ALK-IN-23 inhibits ALK (IC50: 1.6-0.71 nM), hinders cancer cell spread, forms colonies in vitro, and reduces tumors in mice with low toxicity.Formula:C26H29ClN8O3SColore e forma:SolidPeso molecolare:569.08WZH-15-125
CAS:WZH-15-125 is a potent ALK inhibitor capable of overcoming resistance, particularly with complex ALK mutations. It exhibits an IC50 of 101.7 nM against the highly recalcitrant Lorlatinib-resistant G1202R/L1196M mutation. Additionally, WZH-15-125 can serve as a PROTAC target protein ligand for synthesizing PROTACWZH-17-002. This compound is applicable in non-small cell lung cancer research.Formula:C33H45BrN8O5SColore e forma:SolidPeso molecolare:745.73ALKBH5-IN-3
CAS:ALKBH5-IN-3 (Compound 20m) is a selective ALKBH5 inhibitor (IC50=21 nM), effectively stabilizes ALKBH5 in HepG2 cells and elevates m6A levels in intact cells.Formula:C11H7F3N2O3Purezza:98.32%Colore e forma:SolidPeso molecolare:272.18CDD-1115
CAS:<p>CDD-1115 is a potent and selective BMPR2 inhibitor, with an IC50 of 1.8 nM and a Kiapp of 6.2 nM. It effectively suppresses gene expression mediated by bone morphogenetic proteins (BMPs). BMPs regulate cellular processes in various tissue types, such as the kidneys, skeletal muscle, heart, and reproductive organs, and can induce ectopic bone formation.</p>Formula:C32H30N6O3Colore e forma:SolidPeso molecolare:546.619DDO-02267
CAS:<p>DDO-02267 is a selective lysine-targeted covalent inhibitor of ALKBH5, with an IC50 value of 0.49 μM. It increases levels of N6-methyladenosine (m6A) and targets the ALKBH5-AXL signaling axis. DDO-02267 serves as a probe for studying the biological function of mRNA demethylases.</p>Formula:C18H12N2O7SColore e forma:SolidPeso molecolare:400.362PF-06463922 acetate
CAS:PF-06463922 acetate: ALK/ROS1 inhibitor, brain- penetrable, active vs crizotinib-resistant mutants, in NSCLC trials.Formula:C23H23FN6O4Colore e forma:SolidPeso molecolare:466.46ALK ligand-Linker Conjugate 1
CAS:ALK ligand-Linker Conjugate 1 is an ALK ligand-connector conjugate used for the synthesis of PROTACALK degrader-4.Formula:C36H45N5O3Colore e forma:SolidPeso molecolare:595.77CEP-14083
CAS:CEP-14083: potent ALK inhibitor, effective in NPM/ALK T-cell lymphoma, binds ATP site; IC50=11 nmol/L, also inhibits insulin receptor, preclinical efficacy.Formula:C31H30N6O2Colore e forma:SolidPeso molecolare:518.61TGF-βRI inhibitor 3
CAS:<p>TGF-βRI inhibitor 3 (Compound 9ac) is a selective inhibitor of TGF-β that effectively suppresses the TGF-β signaling pathway. It exhibits IC50 values of 13 μM for c-Src kinase and 0.63 μM for ALK5 kinase.</p>Formula:C21H21NO4Colore e forma:SolidPeso molecolare:351.396W23-1006
CAS:W23-1006 is a selective covalent ALKBH5 inhibitor. It binds to the ALKBH5 C200 residue with an IC50 value of 3.848 μM. The inhibitory activity of W23-1006 is approximately 30 times stronger than that of FTO and 8 times greater than that of ALKBH3. W23-1006 is applicable for research in triple-negative breast cancer (TNBC).Formula:C17H12BrN3O5Colore e forma:SolidPeso molecolare:418.198Zotizalkib
CAS:TPX-0131: potent, selective, CNS-ready, oral ALK inhibitor (WT IC50: 1.4nM, G1202R/L1196M IC50: 0.3nM) with robust antitumor effects.Formula:C21H20F3N5O3Purezza:98.7%Colore e forma:SolidPeso molecolare:447.41Ref: TM-T9414
1mg127,00€5mg304,00€10mg487,00€25mg938,00€50mg1.473,00€100mg2.072,00€200mg2.802,00€1mL*10mM (DMSO)334,00€AZ12601011
CAS:AZ12601011 is a TGFBR1 kinase inhibitor that inhibits the growth of breast tumors.Formula:C19H15N5Purezza:98.81%Colore e forma:SolidPeso molecolare:313.36Ref: TM-T10426
1mg99,00€5mg235,00€10mg376,00€25mg728,00€50mg1.093,00€100mg1.510,00€1mL*10mM (DMSO)259,00€
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