Recettore Trk
Gli inibitori dei recettori Trk prendono di mira le chinasi recettoriali della tropomiosina (Trk), una famiglia di tirosina chinasi recettoriali che svolgono un ruolo significativo nello sviluppo e nella funzione del sistema nervoso. I recettori Trk sono coinvolti nella segnalazione delle neurotrofine, essenziale per la sopravvivenza, la differenziazione e la crescita dei neuroni. La disregolazione della segnalazione Trk è associata a disturbi neurologici e ad alcuni tipi di cancro. Presso CymitQuimica, offriamo inibitori dei recettori Trk per supportare la tua ricerca in neurobiologia, oncologia e malattie neurodegenerative.
Trovati 70 prodotti per "Recettore Trk".
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Adimanebart
CAS:Adimanebart is a humanized agonist monoclonal antibody targeting MuSK that stabilizes the neuromuscular junction and is used in neuromuscular disease research.Purezza:95%Colore e forma:LiquidPeso molecolare:~150 kDaTRK-IN-23
CAS:TRK-IN-23 is a potent oral TRK inhibitor (IC50=0.5 nM); overcomes G595R mutation; used for NTRK-fusion cancer research.Formula:C20H17FN4O2Purezza:97.01%Colore e forma:Brown SolidPeso molecolare:364.37Povovetug
CAS:Povovetug is a humanized chimeric IgG1κ monoclonal antibody inhibitor that targets NGF/bNGF. It exhibits significant analgesic activity and is applicable in research on central nervous inflammation, such as chronic root pain.Trk-IN-4
CAS:Trk-IN-4 (PF-6683324) is a potent pan-Trk inhibitor and antinociceptive. It is also a selective type II PTK6 inhibitor antitumor.Formula:C24H23F4N5O4Purezza:98.13%Colore e forma:White SolidPeso molecolare:521.4641TrkA-IN-3
CAS:TrkA-IN-3 is a selective small-molecule inhibitor with an IC₅₀ value of 22.4 nM.Formula:C24H17F3N4O3Purezza:98.37%Colore e forma:White SolidPeso molecolare:466.41Anti-Human NGF/bNGF Antibody (AS2886401-00)
Anti-NGF/bNGF Antibody (AS2886401-00) is a human monoclonal antibody (mAb) targeting NGF/bNGF. It inhibits intracellular calcium (Ca2+) influx and provides sustained analgesic effects during movement in an osteoarthritis (OA) rat model. This antibody is applicable for research in osteoarthritis.Colore e forma:Odour LiquidTavilermide
CAS:Tavilermide (MIM-D3) is a selective TrkA agonist, a cyclic mimetic, which can be used to study dry keratoconjunctivitis and dry eye syndrome.Formula:C24H32N6O11Purezza:98.98%Colore e forma:SolidPeso molecolare:580.5445MNAC13
MNAC13 is a chimeric mouse IgG1 antibody targeting human TrkA. By specifically binding to the TrkA receptor, MNAC13 inhibits NGF-dependent signaling pathways. It demonstrates effective and lasting analgesic properties, making MNAC13 suitable for research on inflammation and chronic pain.CRB-0089
CRB-0089 is a human monoclonal antibody targeting NGF/bNGF. It is used in the study of analgesia.Colore e forma:Odour LiquidProtein kinase inhibitor 5
CAS:Protein kinase inhibitor 5 is a potent inhibitor of TRK-A, demonstrating an IC50 of 1.8 nM, and effectively suppresses cell viability [1].Formula:C29H31F2N7OPurezza:98%Colore e forma:SolidPeso molecolare:531.6ZEB85
ZEB85 is a human monoclonal antibody (mAb) that targets TrkB. It activates TrkB and its downstream signaling cascade, enhancing neuronal activity. ZEB85 can prevent β-amyloid toxicity in cultured hippocampal neurons and is useful for Alzheimer's disease (AD) research.TrkA-IN-1
CAS:TrkA-IN-1 is a potent and selective inhibitor of Tropomyosin-related kinase A (TrkA) (IC50: 99 nM in a cell-based assay) with analgesic activity.Formula:C25H20N4OPurezza:98%Colore e forma:SolidPeso molecolare:392.4525TRK-IN-24
CAS:TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L,Formula:C39H45N7O3Purezza:98%Colore e forma:SolidPeso molecolare:659.82ENT-C225
CAS:ENT-C225 is a potent TrkB neurotrophin receptor (TrkBR) activator with neuroprotective activity for the study of Alzheimer's disease and Parkinson's disease.Formula:C26H40N4O5Purezza:99.36% - 99.40%Colore e forma:SolidPeso molecolare:488.62PF-06733804
CAS:PF-06733804 is a potent inhibitor of pan-Trk in cell-based assays (IC50s: 8.4 nM, 6.2 nM, and 2.2 nM for TrkA, TrkB, and TrkC) with anti-hyperalgesic effect.Formula:C20H19F5N4O4Purezza:98%Colore e forma:SolidPeso molecolare:474.38Type II TRK inhibitor 1
CAS:Type II TRK Inhibitor 1 is a potent inhibitor targeting multiple tropomyosin receptor kinase (TRK) fusion protein variants as well as the wild type.Formula:C35H33F3N8O3Purezza:98%Colore e forma:SolidPeso molecolare:670.68TrkA-IN-4
CAS:TrkA-IN-4 is a highly potent, orally active TrkA allosteric inhibitor that is metabolized in vivo as a prodrug to its active form, TrkA-IN-3.Formula:C27H21F3N4O5Purezza:99.97%Colore e forma:White SolidPeso molecolare:538.48Paltimatrectinib
CAS:Paltimatrectinib (PBI-200) is a tyrosine kinase inhibitor with anticancer activity, and is used in the study of bladder, breast, and colorectal cancers.Formula:C20H15F5N6Purezza:99.96%Colore e forma:Yellow SolidPeso molecolare:434.3653AZ-23
CAS:AZ-23 is an inhibitor of ATP-competitive and Trk kinase A/B/C.Formula:C17H19ClFN7OPurezza:99.4% - 99.85%Colore e forma:White SolidPeso molecolare:391.83(R,S)-Selitrectinib
CAS:(R,S)-Selitrectinib (compound 17) is a Trk inhibitor that shows activity against cancers with NTRK1, NTRK2, or NTRK3 gene mutations that confer resistance to other Trk inhibitors. It is suitable for research involving Trk inhibitor-resistant cancers.Formula:C20H21FN6OPeso molecolare:380.42
