PDGFR
Gli inibitori del recettore del fattore di crescita derivato dalle piastrine (PDGFR) sono composti che bloccano la segnalazione del PDGFR, un recettore coinvolto nella crescita cellulare, nella proliferazione e nell'angiogenesi. Il PDGFR svolge un ruolo significativo nello sviluppo dei vasi sanguigni che riforniscono i tumori. Inibendo il PDGFR, è quindi possibile prevenire l'angiogenesi, rendendo questi inibitori preziosi nella terapia del cancro. Presso CymitQuimica, offriamo una selezione di inibitori del PDGFR di alta qualità per supportare la tua ricerca in oncologia, biologia vascolare e angiogenesi.
Trovati 127 prodotti di "PDGFR"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CHIR-124
CAS:CHIR-124 is an effective Chk1 inhibitor (IC50: 0.3 nM). It has 2, 000-fold selectivity against Chk2, 500- to 5, 000-fold less activity against Cdc2 and CDK2/4.Formula:C23H22ClN5OPurezza:96.33% - 98.35%Colore e forma:SolidPeso molecolare:419.91Ref: TM-T6350
1mg42,00€2mg51,00€5mg81,00€10mg104,00€25mg170,00€50mg240,00€100mg359,00€1mL*10mM (DMSO)87,00€Ponatinib
CAS:Ponatinib (AP24534) is an orally available, multitargeted kinase inhibitor (IC50s: 0.37/1.1/1.5/2.2/5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectivelyFormula:C29H27F3N6OPurezza:98% - 99.60%Colore e forma:SolidPeso molecolare:532.56Regorafenib
CAS:Regorafenib (BAY 73-4506) is a multi-targeted receptor tyrosine kinase inhibitor that inhibits RET, C-RAF, VEGFR2, c-Kit, VEGFR1, and PDGFRβ and is orallyFormula:C21H15ClF4N4O3Purezza:98% - 99.95%Colore e forma:SolidPeso molecolare:482.82Ref: TM-T1792
5mg35,00€10mg51,00€25mg80,00€50mg96,00€100mg144,00€200mg185,00€500mg309,00€1mL*10mM (DMSO)57,00€Ripretinib
CAS:Ripretinib (DCC-2618) is an orally bioavailable inhibitor of KIT and PDGFRA.Formula:C24H21BrFN5O2Purezza:99.07% - 99.62%Colore e forma:SolidPeso molecolare:510.36Ref: TM-T8482
1mg74,00€2mg97,00€5mg165,00€10mg274,00€25mg432,00€50mg692,00€100mg1.121,00€200mg1.539,00€1mL*10mM (DMSO)202,00€XL 999
CAS:Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）Formula:C26H28FN5OPurezza:98.24% - 99.55%Colore e forma:SolidPeso molecolare:445.53Regorafenib Hydrochloride
CAS:<p>Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.</p>Formula:C21H16Cl2F4N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:519.28Flumatinib mesylate
CAS:Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.Formula:C30H33F3N8O4SPurezza:99.82%Colore e forma:SolidPeso molecolare:658.69Ref: TM-T7861
1mg37,00€5mg88,00€10mg133,00€25mg250,00€50mg393,00€100mg628,00€500mg1.301,00€1mL*10mM (DMSO)139,00€Nintedanib
CAS:<p>Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/</p>Formula:C31H33N5O4Purezza:98% - 99.92%Colore e forma:SolidPeso molecolare:539.62CP-673451
CAS:CP-673451 is a specific inhibitor of PDGFRα/β (IC50: 10/1 nM) with antiangiogenic and antitumor activity and the selectivity is higher 450-fold than otherFormula:C24H27N5O2Purezza:99.62% - 99.88%Colore e forma:SolidPeso molecolare:417.5Ref: TM-T6091
1mg52,00€2mg66,00€5mg96,00€10mg180,00€25mg354,00€50mg540,00€100mg778,00€500mg1.605,00€1mL*10mM (DMSO)114,00€NVP-ACC789
CAS:<p>ACC-789 (NVP-ACC789 (ZK202650); ZK-202650) is an effective, specific and orally active inhibitor of the VEGF receptor tyrosine kinases.</p>Formula:C21H17BrN4Purezza:99.44% - 99.63%Colore e forma:SolidPeso molecolare:405.29Dovitinib
CAS:<p>Dovitinib is an orally active, multi-targeted tyrosine kinase (RTK) inhibitor with anti-tumor effects.Cost-effective and quality-assured.</p>Formula:C21H21FN6OPurezza:99.35% - 99.92%Colore e forma:SolidPeso molecolare:392.43ENMD-2076
CAS:ENMD-2076, a multi-targeted kinase inhibitor, has specific activity against Aurora A, Flt3, KDR/VEGFR2, Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα.Formula:C21H25N7Purezza:97.63% - ≥95%Colore e forma:SolidPeso molecolare:375.47PD-089828
CAS:PD 089828 inhibits FGFR1, PDGFRβ, EGFR (IC50s: 0.15-5.47 μM), and c-Src (IC50: 0.18 μM).Formula:C18H18Cl2N6OPurezza:97.39%Colore e forma:SolidPeso molecolare:405.28PDGFR Tyrosine Kinase Inhibitor III
CAS:PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III) is a multikinase inhibitor thatFormula:C27H27N5O4Purezza:99.50%Colore e forma:SoildPeso molecolare:485.53Ref: TM-T60108
5mg52,00€10mg78,00€25mg160,00€50mg225,00€100mg325,00€200mg445,00€1mL*10mM (DMSO)50,00€Toceranib
CAS:Toceranib phosphate, orally active, inhibits RTK, PDGFR, VEGFR, Kit; Kis 5 nM PDGFRβ, 6 nM KDR; has antitumor effects.Formula:C22H25FN4O2Purezza:97.62%Colore e forma:SolidPeso molecolare:396.46Tovetumab
CAS:Tovetumab (MEDI-575) is an anti-PDGFRα mAb inhibiting its signaling, in trials for glioblastoma and NSCLC.Purezza:95%Colore e forma:LiquidPDGFRα kinase inhibitor 1
CAS:PDGFRα kinase inhibitor 1 is a type II PDGFRα kinase inhibitor that inhibits both PDGFRα and PDGFRβ.Formula:C34H34N8O2Purezza:99.78%Colore e forma:SolidPeso molecolare:586.69DMPQ dihydrochloride
CAS:PDGFRβ inhibitorFormula:C16H16Cl2N2O2Purezza:99.51%Colore e forma:SolidPeso molecolare:339.22AC710 Mesylate
CAS:AC710 Mesylate is a potent PDGFR inhibitor (Kds: 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ).Formula:C32H46N6O7SPurezza:98%Colore e forma:SolidPeso molecolare:658.81AC710
CAS:<p>AC710 is a potent PDGFR inhibitor (Kds: 0.6, 1, 1.57, 1.3, 1 nM for FLT3, KIT, CSF1R, PDGFRα and PDGFRβ).</p>Formula:C31H42N6O4Purezza:99.67%Colore e forma:SolidPeso molecolare:562.7E-4177
CAS:E-4177 is an angiotensin II type 1 receptor (AT1R) antagonist and can be used to study cardiovascular diseases.Formula:C24H21N3O2Purezza:98.67% - 99.57%Colore e forma:SolidPeso molecolare:383.44Chiauranib
CAS:<p>Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.</p>Formula:C27H21N3O3Purezza:99.22%Colore e forma:SolidPeso molecolare:435.47SU16f
CAS:SU16f, a 3-substituted indolin-2-one, is a selective PDGFRβ inhibitor; IC50: 10 nM (PDGFRβ), 140 nM (PDGFR1), 2.29 μM (PDGFR2), halts GC cell growth.Formula:C24H22N2O3Purezza:97.69%Colore e forma:SolidPeso molecolare:386.44BMS-605541
CAS:<p>BMS-605541 is a potent and selective inhibitor of vascular endothelial growth factor receptor-2 (VEGFR-2) kinase activity(Ki=49 nM).</p>Formula:C19H17F2N5OSPurezza:98.07%Colore e forma:SolidPeso molecolare:401.43Tyrphostin AG1433
CAS:Tyrphostin AG1433 (AG1433) is an inhibitor of tyrosine kinases and also a dual inhibitor of PDGFRβ(IC50s = 5.0 μM) and VEGFR-2 (Flk-1/KDR)(IC50s = 9.3 μM).Formula:C16H14N2O2Purezza:98.47%Colore e forma:SolidPeso molecolare:266.29Ref: TM-T13238
1mg52,00€5mg97,00€10mg160,00€25mg271,00€50mg416,00€100mg620,00€500mg1.283,00€1mL*10mM (DMSO)111,00€TG 100572 Hydrochloride
CAS:<p>TG 100572 Hydrochloride is a inhibitor of multi-targeted kinase which inhibits receptor tyrosine kinases and Src kinases(IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.</p>Formula:C26H27Cl2N5O2Purezza:98%Colore e forma:SolidPeso molecolare:512.432-Methyl-3-phenylquinoxaline
CAS:2-Methyl-3-phenylquinoxaline (compound 38) serves as an effective inhibitor of the Platelet-Derived Growth Factor Receptor Tyrosine Kinase (PDGF-RTK), exhibiting significant inhibitory activity against the full-length PDGFR kinase in intact cells (IC50 greater than 100 μM).Formula:C15H12N2Colore e forma:SolidPeso molecolare:220.27
