Ricettore TAM
Gli inibitori dei recettori TAM prendono di mira la famiglia di recettori tirosina chinasi TAM, che comprende Tyro3, Axl e Mer. Questi recettori sono coinvolti nella regolazione delle risposte immunitarie, della sopravvivenza cellulare e della clearance delle cellule apoptotiche. La disregolazione dei recettori TAM è implicata nel cancro, nelle malattie autoimmuni e nelle infiammazioni croniche. Presso CymitQuimica, offriamo inibitori dei recettori TAM per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 33 prodotti di "Ricettore TAM"
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Tilvestamab
CAS:Tilvestamab (BGB149) is a humanized monoclonal antibody targeting AXL with anti-tumor and anti-fibrotic activities, inhibiting Gas6-induced AXL activation.Purezza:>95%Colore e forma:LiquidTAM-IN-2
CAS:TAM-IN-2 is an inhibitor of TAM.Formula:C31H27F2N7O3Purezza:98.09% - 99.74%Colore e forma:SolidPeso molecolare:583.59UNC 569 hydrochloride
UNC 569 hydrochloride: reversible ATP-competitive Mer inhibitor, IC50 2.9 nM, Ki 4.3 nM, also inhibits Axl/Tyro3; used in leukemia, teratoid tumor studies.Formula:C22H30ClFN6Purezza:99.93%Colore e forma:SolidPeso molecolare:432.96SGI-7079
CAS:<p>SGI-7079: selective Axl inhibitor; hinders tumor growth dose-dependently; may target EGFR inhibitor resistance.</p>Formula:C26H26FN7Purezza:95.51% - 99.26%Colore e forma:SolidPeso molecolare:455.53LDC1267
CAS:LDC1267 is a excellently specific TAM(Tyro3, Axl and Mer) kinase inhibitor, for Mer( IC50<5 nM), Tyro3(IC50=8 nM), and Axl(IC50=29 nM).Formula:C30H26F2N4O5Purezza:99.38% - 99.88%Colore e forma:SolidPeso molecolare:560.55NPS-1034
CAS:NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Formula:C31H23F2N5O3Purezza:98.48%Colore e forma:SolidPeso molecolare:551.54UNC2541
CAS:<p>UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor.</p>Formula:C24H34FN7O2Purezza:98.33%Colore e forma:SolidPeso molecolare:471.572-D08
CAS:2-D08 is a synthetic flavone that inhibits sumoylation, also inhibits Axl with an IC50 of 0.49 nM.2-D08 showed anti-aggregatory and neuroprotective effect.Formula:C15H10O5Purezza:98.58% - 98.95%Colore e forma:SolidPeso molecolare:270.24Bemcentinib
CAS:Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC.Formula:C30H34N8Purezza:97% - 99.8%Colore e forma:SolidPeso molecolare:506.64RU-301
CAS:RU-301 is a novel pan-tam inhibitorFormula:C21H19F3N4O4SPurezza:98.87%Colore e forma:SolidPeso molecolare:480.46UNC569
CAS:UNC569 selectively inhibits kidney URAT1, regulating uric acid excretion and aiding gout patient's uric balance.Formula:C22H29FN6Purezza:98.91% - 99.67%Colore e forma:SolidPeso molecolare:396.5BMS 777607
CAS:<p>BMS 777607 (BMS 817378) is a Met-related inhibitor for c-Met/Axl/Ron/Tyro3. BMS-777607 has been investigated for the basic science of Malignant Solid Tumour.</p>Formula:C25H19ClF2N4O4Purezza:98.30% - >99.99%Colore e forma:SolidPeso molecolare:512.89UNC2250
CAS:<p>UNC2250 is an effective and specific Mer inhibitor (IC50=1.7 nM).</p>Formula:C24H36N6O2Purezza:98.57% - 99.87%Colore e forma:SolidPeso molecolare:440.58Cabozantinib hydrochloride
CAS:<p>Cabozantinib hydrochloride (XL184) is a potent pan-tyrosine kinases inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt4 (IC50s: 0.035, 1.3, 4.6, 7 and 6</p>Formula:C28H25ClFN3O5Purezza:99.97%Colore e forma:SolidPeso molecolare:537.96Cabozantinib
CAS:<p>Cabozantinib (XL184) is a multi-targeted tyrosine kinase receptor inhibitor that inhibits VEGFR2, c-Met, Kit, Axl, and Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM).</p>Formula:C28H24FN3O5Purezza:99.68% - 99.88%Colore e forma:SolidPeso molecolare:501.51CEP-40783
CAS:<p>CEP-40783 (RXDX-106) is an effective, specific and orally active AXL/c-Met inhibitor (IC50: 7/12 nM). It also inhibits MER and TYRO3 (IC50: 29/19 nM).</p>Formula:C31H26F2N4O6Purezza:99.76% - 99.84%Colore e forma:SolidPeso molecolare:588.56Ningetinib Tosylate
CAS:Ningetinib Tosylate is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formula:C38H37FN4O8SPurezza:99.93%Colore e forma:SolidPeso molecolare:728.79Gilteritinib
CAS:<p>Gilteritinib (ASP2215) is a potent inhibitor at the FMS-related tyrosine kinase 3 (FLT3) and AXL tyrosine kinase receptors (IC50 = 0.29 nM and <1 nM,</p>Formula:C29H44N8O3Purezza:97.75% - 99.90%Colore e forma:SolidPeso molecolare:552.71XL092
CAS:<p>XL092 (JUN04542) is an Axl Mer cMet KDR inhibitor for the treatment of Axl and Mer receptor tyrosine kinase- dependent disorders.</p>Formula:C29H25FN4O5Purezza:98.60%Colore e forma:SolidPeso molecolare:528.53UNC2881
CAS:UNC2881 is a specific Mer tyrosine kinase inhibitor (IC50: 4.3 nM). It is about 83- and 58-fold higher selectivity than Axl and Tyro3, respectively.Formula:C25H33N7O2Purezza:98.97% - 99.85%Colore e forma:SolidPeso molecolare:463.58Ningetinib
CAS:<p>Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.</p>Formula:C31H29FN4O5Purezza:99.95% - 99.98%Colore e forma:SolidPeso molecolare:556.58ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formula:C32H26N4O6Purezza:98.74%Colore e forma:SolidPeso molecolare:562.57DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.75%Colore e forma:SolidPeso molecolare:735.8Dubermatinib
CAS:Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.Formula:C24H30ClN7O2SPurezza:98.65% - 99.58%Colore e forma:SolidPeso molecolare:516.06RU-302
CAS:RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.Formula:C24H24F3N3O2SPurezza:99.84%Colore e forma:SolidPeso molecolare:475.53R916562
CAS:R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.Formula:C26H30ClN9SPurezza:98%Colore e forma:SolidPeso molecolare:536.09AXL-IN-15
CAS:AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1Formula:C26H32F3N9O3Purezza:98%Colore e forma:SolidPeso molecolare:575.59AXL-IN-14
CAS:AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.Formula:C32H24F2N4O4Purezza:98%Colore e forma:SolidPeso molecolare:566.55MerTK-IN-1
CAS:MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.Formula:C23H26N8O4Colore e forma:SolidPeso molecolare:478.50Ligritinib
CAS:Ligritinib (AB801) is an orally active inhibitor of the AXL receptor tyrosine kinase. By inhibiting the kinase activity of AXL, Ligritinib blocks its downstream signaling pathways. It is utilized in cancer research, particularly in studies involving non-small cell lung cancer (NSCLC) in combination with chemotherapy.Formula:C33H32N6OColore e forma:SolidPeso molecolare:528.65Anticancer agent 109
CAS:Anticancer agent 109 (compound 6-15) acts as an inhibitor targeting the Gas6-Axl axis, demonstrating significant anti-cancer properties. This compound suppresses the expression of Gas6, Axl, p-PI3K, and p-AKT in cancer cells, thereby inducing G1 phase arrest and promoting apoptosis of cancer cells. Additionally, Anticancer agent 109 effectively inhibits tumor growth in nude mouse tumor-bearing models [1].Formula:C19H15N3O2Colore e forma:SolidPeso molecolare:317.34MerTK-IN-3
CAS:MerTK-IN-3 (compound 11) is an orally active, selective inhibitor of MerTK, exhibiting IC50 values of 21.5 nM for MerTK and 991.3 nM for Tyro3. It is applicable in colon cancer research.Formula:C36H31FN8O4Colore e forma:SolidPeso molecolare:658.68MerTK/Axl-IN-1
CAS:<p>MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.</p>Formula:C40H47FN6O4Colore e forma:SolidPeso molecolare:694.84
