Ricettore TAM
Gli inibitori dei recettori TAM prendono di mira la famiglia di recettori tirosina chinasi TAM, che comprende Tyro3, Axl e Mer. Questi recettori sono coinvolti nella regolazione delle risposte immunitarie, della sopravvivenza cellulare e della clearance delle cellule apoptotiche. La disregolazione dei recettori TAM è implicata nel cancro, nelle malattie autoimmuni e nelle infiammazioni croniche. Presso CymitQuimica, offriamo inibitori dei recettori TAM per supportare la tua ricerca in immunologia, oncologia e infiammazione.
Trovati 33 prodotti di "Ricettore TAM"
Ordinare per
Purezza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Formula:C31H29FN4O5Purezza:99.95% - 99.98%Colore e forma:SolidPeso molecolare:556.58ONO-7475
CAS:<p>ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase</p>Formula:C32H26N4O6Purezza:98.74%Colore e forma:SolidPeso molecolare:562.57DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Formula:C41H42FN5O7Purezza:99.75%Colore e forma:SolidPeso molecolare:735.8Dubermatinib
CAS:Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor.Formula:C24H30ClN7O2SPurezza:98.65% - 99.58%Colore e forma:SolidPeso molecolare:516.06RU-302
CAS:RU-302 is a pan inhibitor of TAM Receptor blocking the interface between the TAM Ig1 ectodomain and the Gas6 Lg domain.Formula:C24H24F3N3O2SPurezza:99.84%Colore e forma:SolidPeso molecolare:475.53R916562
CAS:R916562 is an orally active and selective Axl/VEGF-R2 inhibitor with IC50s of 136 nM and 24 nM, respectively. R916562 has anti-angiogenesis and anti-metastasis.Formula:C26H30ClN9SPurezza:98%Colore e forma:SolidPeso molecolare:536.09AXL-IN-15
CAS:AXL-IN-15 (cpd391) is a potent inhibitor of Axl, exhibiting both a dissociation constant (K i) and a half-maximal inhibitory concentration (IC50) of less than 1Formula:C26H32F3N9O3Purezza:98%Colore e forma:SolidPeso molecolare:575.59AXL-IN-14
CAS:AXL-IN-14: orally active, potent AXL inhibitor (IC50=0.8 nM); hinders Gas6/AXL migration, invasion; lowers p-AXL, p-AKT; anti-tumor.Formula:C32H24F2N4O4Purezza:98%Colore e forma:SolidPeso molecolare:566.55MerTK-IN-1
CAS:MerTK-IN-1 (compound 31) serves as an inhibitor of MerTK, with the capability to bind to the target in vivo.Formula:C23H26N8O4Colore e forma:SolidPeso molecolare:478.50Ligritinib
CAS:Ligritinib (AB801) is an orally active inhibitor of the AXL receptor tyrosine kinase. By inhibiting the kinase activity of AXL, Ligritinib blocks its downstream signaling pathways. It is utilized in cancer research, particularly in studies involving non-small cell lung cancer (NSCLC) in combination with chemotherapy.Formula:C33H32N6OColore e forma:SolidPeso molecolare:528.65Anticancer agent 109
CAS:Anticancer agent 109 (compound 6-15) acts as an inhibitor targeting the Gas6-Axl axis, demonstrating significant anti-cancer properties. This compound suppresses the expression of Gas6, Axl, p-PI3K, and p-AKT in cancer cells, thereby inducing G1 phase arrest and promoting apoptosis of cancer cells. Additionally, Anticancer agent 109 effectively inhibits tumor growth in nude mouse tumor-bearing models [1].Formula:C19H15N3O2Colore e forma:SolidPeso molecolare:317.34MerTK-IN-3
CAS:MerTK-IN-3 (compound 11) is an orally active, selective inhibitor of MerTK, exhibiting IC50 values of 21.5 nM for MerTK and 991.3 nM for Tyro3. It is applicable in colon cancer research.Formula:C36H31FN8O4Colore e forma:SolidPeso molecolare:658.68MerTK/Axl-IN-1
CAS:MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual inhibitor of MerTK/Axl, exhibiting IC50 values of 4.2 nM and 8.8 nM in Ba/F3 cells, and 0.2 nM and 0.9 nM in HTRF cells, respectively. It effectively inhibits pMerTK in vivo and possesses a long half-life and high oral bioavailability.Formula:C40H47FN6O4Colore e forma:SolidPeso molecolare:694.84
