IGF-1R
Gli inibitori di IGF-1R sono composti che prendono di mira specificamente il recettore del fattore di crescita insulino-simile 1 (IGF-1R), una tirosina chinasi recettore coinvolta nella crescita, sviluppo e sopravvivenza cellulare. La segnalazione dell'IGF-1R svolge un ruolo significativo nella progressione del cancro, rendendo questi inibitori preziosi nella ricerca oncologica. Presso CymitQuimica, offriamo inibitori di IGF-1R per supportare la tua ricerca in biologia del cancro, endocrinologia e sviluppo di terapie mirate.
Trovati 106 prodotti per "IGF-1R".
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MSDC-0602K
CAS:MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.Formula:C19H16KNO5SPurezza:99.42%Colore e forma:White SolidPeso molecolare:409.5Ganitumab
CAS:Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.Purezza:/ - > 95%Colore e forma:Transparent LiquidPeso molecolare:145.70 kDaRobatumumab
CAS:Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.Purezza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Colore e forma:Transparent LiquidPeso molecolare:145.56 kDaGIP (3-42), human
CAS:Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.Formula:C214H324N58O63SPurezza:95.73%Colore e forma:SolidPeso molecolare:4749.35HNMPA
CAS:HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.Formula:C11H11O4PPurezza:99.18%Colore e forma:SolidPeso molecolare:238.18Ref: TM-T21761
1mg48,00€2mg62,00€5mg88,00€1mL*10mM (DMSO)101,00€10mg137,00€25mg285,00€50mg427,00€100mg625,00€500mg1.324,00€NBI-31772
CAS:NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).Formula:C17H11NO7Purezza:99.79%Colore e forma:Yellow SolidPeso molecolare:341.27Teprotumumab
CAS:Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.Purezza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Colore e forma:Transparent LiquidPeso molecolare:145.62 kDaAZ7550 hydrochloride
CAS:AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).Formula:C27H32ClN7O2Purezza:99.65%Colore e forma:SolidPeso molecolare:522.04ALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:White SolidPeso molecolare:562.48Ref: TM-T10285
1mg50,00€5mg110,00€1mL*10mM (DMSO)136,00€10mg166,00€25mg323,00€50mg447,00€100mg610,00€GIP (human) acetate
GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.Purezza:98.65%Colore e forma:SolidCixutumumab
CAS:Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impedingPurezza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:LiquidPeso molecolare:146.32 kDaInsulin sensitizer C59
CAS:Insulin sensitizer C59 is an orally available insulin sensitizer that improves glucose uptake and can be used to study insulin-stimulated GLUT4 translocation.Formula:C16H18Cl2N2OPurezza:99.98%Colore e forma:White SolidPeso molecolare:325.23Xenin-8
CAS:neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effectsFormula:C51H79N15O9Purezza:98%Colore e forma:SolidPeso molecolare:1046.27Gastric Inhibitory Peptide (1-42) (porcine) TFA
Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.Formula:C225H342N60O66S·XCF3COOHColore e forma:White SolidPeso molecolare:4975.55GIP (1-39)
CAS:Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP.Formula:C210H316N56O61SPurezza:98%Colore e forma:SolidPeso molecolare:4633.21PQ401
CAS:PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79Valanafusp alfa
CAS:Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.Colore e forma:LiquidIGF-I (30-41)
CAS:IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).Formula:C51H83N19O19Purezza:98%Colore e forma:SolidPeso molecolare:1266.34C-Peptide 2, rat
CAS:C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion.Formula:C135H222N38O49Colore e forma:SolidPeso molecolare:3161.478Proinsulin C-peptide (human)
CAS:C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.Formula:C129H211N35O48Purezza:98%Colore e forma:SolidPeso molecolare:3020.26Insulin Aspart
CAS:Insulin Aspart is a rapid-acting insulin analog with faster absorption than human insulin, improving postprandial glycemic control.Purezza:99.86%Colore e forma:White Solid[Pro3]-GIP (Mouse)
GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.Formula:C225H342N62O64SPurezza:98%Colore e forma:SolidPeso molecolare:4971.62AVE1642
AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.Colore e forma:Odour LiquidLDD39
LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.Formula:C55H59F2N11O6Colore e forma:SolidPeso molecolare:1008.12Insulin glulisine
CAS:Insulin glulisine (HMR 1964), a rapid-acting analogue, mimics human insulin; used in diabetes research.Formula:C258H384N64O78S6Colore e forma:SolidPeso molecolare:5822.57OI338
OI338 is an orally available, ultralong-acting insulin analogue.Formula:C260H403N65O84S6Colore e forma:SolidPeso molecolare:5971.76CPF-7
CAS:CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulationFormula:C118H193N33O32Colore e forma:SolidPeso molecolare:2586[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Formula:C72H110N19O33P3Purezza:98%Colore e forma:SolidPeso molecolare:1862.67TLK19781
CAS:TLK19781 is an insulin receptor modulator.Formula:C33H24Cl2N4O13S4Purezza:98%Colore e forma:SolidPeso molecolare:883.73[D-Ala2]-GIP (human)
CAS:Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.58cis-NVP-ADW742
CAS:NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.Formula:C28H31N5OColore e forma:SolidPeso molecolare:453.59Insulin α-chain (1-13)
CAS:Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.Formula:C66H118N20O22S3Purezza:98%Colore e forma:SolidPeso molecolare:1639.96IGF-1R inhibitor-2
CAS:IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.Formula:C24H24FN7O2Colore e forma:SolidPeso molecolare:461.501TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Formula:C24H28NO7PSPurezza:98%Colore e forma:SolidPeso molecolare:505.52GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Formula:C162H240N40O47SPurezza:98%Colore e forma:SolidPeso molecolare:3531.94WAY-270250
CAS:WAY-270250 is an IGF-1R/SRC inhibitor.Formula:C18H16N2O2Purezza:99.97%Colore e forma:Green SolidPeso molecolare:292.33LAGIPRA peptide
LAGIPRA peptide is a long-acting agonist of GIP1R. It improves insulin sensitivity by enhancing glucose handling and reduces circulating branched-chain amino acids (BCAA) and keto acids. LAGIPRA peptide holds potential for research in type 2 diabetes.Proinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Formula:C153H259N49O52Purezza:98%Colore e forma:SolidPeso molecolare:3616.99ZIGIR
ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.Formula:C39H40N6O3Purezza:98.34% - 99.32%Colore e forma:Pink SolidPeso molecolare:640.77GIP, human
CAS:Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.6Acetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Formula:C228H340N60O67SColore e forma:SolidPeso molecolare:5025.6Insulin peglispro
CAS:Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Formula:C370H566N104O110S4Colore e forma:SolidPeso molecolare:8359.32(Pro3) GIP, human
CAS:(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.Formula:C226H338N60O64SColore e forma:SolidPeso molecolare:4951.53DA-JC4
CAS:DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.Formula:C225H346N56O65Colore e forma:SolidPeso molecolare:4875.49Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Colore e forma:SolidGIP (1-30) amide, porcine TFA
GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.Colore e forma:SolidXenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Formula:C53H83N15O11Purezza:99.98%Colore e forma:SolidPeso molecolare:1106.32IGF-I (24-41)
CAS:IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.Formula:C88H133N27O28Purezza:98%Colore e forma:SolidPeso molecolare:2017.16GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPurezza:98%Colore e forma:SolidINSR agonist 1
INSR agonist 1, an insulin receptor (INSR) agonist, effectively elevates INSR pY1355/1361 levels and exhibits synergistic effects with insulin.Formula:C36H47BrN4O6Colore e forma:SolidPeso molecolare:711.69
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