IGF-1R
Gli inibitori di IGF-1R sono composti che prendono di mira specificamente il recettore del fattore di crescita insulino-simile 1 (IGF-1R), una tirosina chinasi recettore coinvolta nella crescita, sviluppo e sopravvivenza cellulare. La segnalazione dell'IGF-1R svolge un ruolo significativo nella progressione del cancro, rendendo questi inibitori preziosi nella ricerca oncologica. Presso CymitQuimica, offriamo inibitori di IGF-1R per supportare la tua ricerca in biologia del cancro, endocrinologia e sviluppo di terapie mirate.
Trovati 92 prodotti di "IGF-1R"
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MSDC-0602K
CAS:<p>MSDC-0602K, a Ps-TZD, targets PPARγ (IC50: 18.25 μM) and MPC, may help study fatty liver, lipid imbalance, inflammation, and insulin issues.</p>Formula:C19H16KNO5SPurezza:99.42%Colore e forma:SolidPeso molecolare:409.5Ganitumab
CAS:<p>Ganitumab (AMG 479) is a potent monoclonal antibody targeting IGF1R with 0.22 nM affinity; used in cancer research.</p>Purezza:100% (SEC-HPLC) - > 95%Colore e forma:LiquidPeso molecolare:145.70 kDaALK inhibitor 1
CAS:ALK inhibitor 1 is a selective ALK kinase inhibitor.Formula:C23H28BrN7O3SPurezza:98.27%Colore e forma:SolidPeso molecolare:562.48Robatumumab
CAS:<p>Robatumumab (Sch 717454) is a fully humanized anti-IGF-1R monoclonal antibody with antitumor activity and antiproliferative activity.</p>Purezza:96.9% (SDS-PAGE); 98.1% (SEC-HPLC) - 96.9% (SDS-PAGE); 98.1% (SEC-HPLC)Colore e forma:LiquidGIP (human) acetate
<p>GIP (human) acetate boosts insulin, limits gastric acid, affects lipid metabolism, and obesity development.</p>Purezza:98.65%Colore e forma:SoildAZ7550 hydrochloride
CAS:<p>AZ7550 hydrochloride (AZ7550 hydrochloride ), an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H32ClN7O2Purezza:99.65%Colore e forma:SolidPeso molecolare:522.04GIP (3-42), human
CAS:<p>Human GIP (3-42) is a peptide antagonist of GIP receptors, affecting insulin regulation and diabetes research.</p>Formula:C214H324N58O63SPurezza:95.73%Colore e forma:SolidPeso molecolare:4749.35Proinsulin C-peptide (human)
CAS:<p>C-peptide, a 31-amino acid, links Proinsulin A & B chains for correct folding and function.</p>Formula:C129H211N35O48Purezza:98%Colore e forma:SolidPeso molecolare:3020.26Gastric Inhibitory Peptide (1-42) (porcine) TFA
<p>Gastric Inhibitory Peptide (1-42) (porcine) TFA is a glucose-dependent insulinotropic polypeptide released by intestinal K-cells.</p>Formula:C225H342N60O66S·XCF3COOHColore e forma:SolidPeso molecolare:4975.55IGF-I (24-41)
CAS:<p>IGF-I (24-41) is a fragment of IGF-I, affecting GH activities with anabolic, antioxidant, anti-inflammatory, and cytoprotective properties.</p>Formula:C88H133N27O28Purezza:98%Colore e forma:SolidPeso molecolare:2017.16TLK19781
CAS:<p>TLK19781 is an insulin receptor modulator.</p>Formula:C33H24Cl2N4O13S4Purezza:98%Colore e forma:SolidPeso molecolare:883.73cis-NVP-ADW742
CAS:<p>NVP-ADW742 is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.</p>Formula:C28H31N5OColore e forma:SolidPeso molecolare:453.59IGF-I (30-41)
CAS:<p>IGF-I (30-41) is amino acids 30 to 41 fragment of Insulin-like Growth Factor I (IGF-I).</p>Formula:C51H83N19O19Purezza:98%Colore e forma:SolidPeso molecolare:1266.34GIP, human
CAS:<p>Insulinotropic hormone from K-cells, binds GIP receptors, boosts insulin, affects lipids, and has antiapoptotic properties.</p>Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.6TAK-778
CAS:TAK-778, a derivative of ipriflavone, demonstrates the ability to stimulate bone growth in both in vitro and in vivo models.Formula:C24H28NO7PSPurezza:98%Colore e forma:SolidPeso molecolare:505.52LDD39
<p>LDD39, a PROTAC targeting the degradation of RET protein, effectively and persistently degrades total RET (tRET) protein in vivo and inhibits phosphorylated RET (pRET) signaling.</p>Formula:C55H59F2N11O6Colore e forma:SolidPeso molecolare:1008.12[Pro3]-GIP (Mouse)
<p>GIP receptor blocker, 2.6μM IC50, hinders insulin release, regulates glucose in ob/ob mice, and enhances glucose tolerance.</p>Formula:C225H342N62O64SPurezza:98%Colore e forma:SolidPeso molecolare:4971.62AVE1642
<p>AVE1642 is a human IgG monoclonal antibody (mAb) that specifically targets CD221/IGF1R. It has the ability to slow the growth of tumor xenografts and extend the survival of tumor-bearing nude mice. AVE1642 is applicable in the study of advanced solid tumors. Recommended isotype control: HumanIgG1kappa, Isotype Control.</p>Colore e forma:Odour LiquidOI338
OI338 is an orally available, ultralong-acting insulin analogue.Formula:C260H403N65O84S6Colore e forma:SolidPeso molecolare:5971.76Insulin efsitora alfa
CAS:<p>Insulin efsitora alfa(LY-3209590) is an IR agonist and a fusion protein that binds a novel single-chain insulin variant to the structural domain of human IgG Fc</p>Purezza:98.3% (SDS-PAGE); 98.1% (SEC-HPLC) - 98.3% (SDS-PAGE); 98.1% (SEC-HPLC)Colore e forma:Liquid[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153)
CAS:Insulin Receptor (1142-1153) binds insulin, is a substrate for its kinase, and has research/medical potential.Formula:C72H110N19O33P3Purezza:98%Colore e forma:SolidPeso molecolare:1862.67Cixutumumab
CAS:<p>Cixutumumab (IMC-A12), a humanized monoclonal antibody targeting IGF-1R, exhibits high affinity and inhibits ligand-dependent receptor activation, impeding</p>Purezza:98.5% (SDS-PAGE); 97.5% (SEC-HPLC) - 98.5% (SDS-PAGE); 97.5% (SEC-HPLC)Colore e forma:Liquid[D-Ala2]-GIP (human)
CAS:<p>Potent GIP receptor agonist with 630 pM EC50; enhances cAMP, glucose control, insulin, cognition in diabetic/obese animals; neuroprotective in PD model.</p>Formula:C226H338N60O66SPurezza:98%Colore e forma:SolidPeso molecolare:4983.58HNMPA
CAS:<p>HNMPA blocks insulin receptor kinase, halting autophosphorylation; no impact on cAMP protein kinase or PKC.</p>Formula:C11H11O4PPurezza:99.18%Colore e forma:SolidPeso molecolare:238.18Teprotumumab
CAS:<p>Teprotumumab: human antibody, inhibits IGF-1R, used for thyroid eye diseases.</p>Purezza:SDS-PAGE:95.2%;SEC-HPLC:99.6%Colore e forma:LiquidPeso molecolare:145.62 kDaIGF-1R inhibitor-2
CAS:<p>IGF-1R inhibitor-2 blocks the insulin-like growth factor-1 receptor, potentially reversing tumor cell transformation and increasing apoptosis susceptibility.</p>Formula:C24H24FN7O2Colore e forma:SolidPeso molecolare:461.501GIP (1-30) amide,human
CAS:GIP (1-30) amide (Human) is a glucose-dependent insulinotropic polypeptide that stimulates insulin secretion, reducing postprandial glycemic issues.Formula:C162H240N40O47SPurezza:98%Colore e forma:SolidPeso molecolare:3531.94Valanafusp alfa
CAS:<p>Valanafusp alfa (AGT-181) is a fusion protein targeting HIR and IDUA for MPS I research.</p>Colore e forma:LiquidWAY-270250
CAS:<p>WAY-270250 is an IGF-1R/SRC inhibitor.</p>Formula:C18H16N2O2Purezza:99.77%Colore e forma:SoildPeso molecolare:292.33NBI-31772
CAS:<p>NBI-31772 (NBI 31772) is the potent inhibitor of insulin-like growth factor-1 binding protein (IGFBP, Ki = 47 nM).</p>Formula:C17H11NO7Purezza:99.79%Colore e forma:SolidPeso molecolare:341.27GIP (1-30) amide, porcine TFA
<p>GIP (1-30) amide, porcine TFA: a full GIP receptor agonist, similar to natural GIP(1-42), stimulates insulin, mildly inhibits gastric acid.</p>Colore e forma:LiquidZIGIR
<p>ZIGIR enables insulin-based sorting of pure alpha and beta cells, revealing zinc(II) in human delta cell granules.</p>Formula:C39H40N6O3Purezza:98.34% - 99.32%Colore e forma:SolidPeso molecolare:640.77Macupatide
CAS:Macupatide is a gastric inhibitory polypeptide (GIP) receptor agonist, utilized in research related to antidiabetic applications.Colore e forma:SolidAcetyl Gastric Inhibitory Peptide (human)
CAS:Acetyl Gastric Inhibitory Peptide: improved insulinotropic, antihyperglycemic, for diabetes/obesity research.Formula:C228H340N60O67SColore e forma:SolidPeso molecolare:5025.6(Pro3) GIP, human
CAS:<p>(Pro3) GIP, human: stable hGIPR full agonist, high affinity (Ki/Kd=0.90nM), for obesity-related diabetes research.</p>Formula:C226H338N60O64SColore e forma:SolidPeso molecolare:4951.53Insulin peglispro
CAS:Insulin peglispro (BIL) is a basal insulin with a stable, extended activity and may offer improved blood sugar control.Formula:C370H566N104O110S4Colore e forma:SolidPeso molecolare:8359.32DA-JC4
CAS:<p>DA-JC4: dual GLP-1/GIP agonist, for neurological disease research and insulin pathway studies.</p>Formula:C225H346N56O65Colore e forma:SolidPeso molecolare:4875.49PQ401
CAS:<p>PQ401 (IGF-1R Inhibitor II) suppresses autophosphorylation of IGF-1R domain(IC50<1 μM).</p>Formula:C18H16ClN3O2Purezza:99.77%Colore e forma:SolidPeso molecolare:341.79GIP (3-42), human acetate
GIP (3-42), human acetate is an antagonist of a glucose-dependent insulinotropic polypeptide (GIP) receptor and regulates insulin secretion and GIP metabolismPurezza:98%Colore e forma:LiquidProinsulin C-Peptide (55-89), human
CAS:Proinsulin, insulin's precursor, has A and B chains linked by a 31 amino acid C-peptide. Enzymes cleave it, yielding insulin and C-peptide.Formula:C153H259N49O52Purezza:98%Colore e forma:SolidPeso molecolare:3616.99Xenin 8 acetate
Xenin 8 acetate is a biologically active fragment of Xenin in the neurotensin/xenopsin family.Formula:C53H83N15O11Purezza:95.54%Colore e forma:SoildPeso molecolare:1106.32Insulin α-chain (1-13)
CAS:<p>Insulin alpha-chain peptide, amino acids 1-13, T cell-recognized, posttranslationally modified.</p>Formula:C66H118N20O22S3Purezza:98%Colore e forma:SolidPeso molecolare:1639.96IGF1R/CD221 Protein, Human, Recombinant (His & Avi)
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Colore e forma:Lyophilized PowderPeso molecolare:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa(alpha subunit) and 52-55 kDa(beta subunit) based on Tris-Bis PAGE result.HNMPA-(AM)3
CAS:<p>HNMPA-(AM)3 抑制 ERK 磷酸化的激活以及促促胸腺激素 (PTTH) 刺激蜕皮类固醇产生。 此外，HNMPA-(AM)3 对蜕皮类固醇产生 (IC50=14.2 μM) 和胰岛素受体活性 (IC50=14.2 μM 和 200 μM，在蚊子和哺乳动物中分别) 具有抑制作用。</p>Formula:C20H23O10PPurezza:97.22%Colore e forma:SolidPeso molecolare:454.36IGF1R/CD221 Protein, Human, Recombinant (aa 31-932, His & Avi), Biotinylated
<p>The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis</p>Colore e forma:Lyophilized PowderPeso molecolare:105.8 kDa (alpha subunit) and 23 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 110-120 kDa (alpha subunit) and 52-55 kDa (beta subunit) based on Tris-Bis PAGE result.IGF1R/CD221 Protein, Mouse, Recombinant (His)
IGF1R/CD221 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Purezza:> 95% as determined by Bis-Tris PAGE > 90% as determined by HPLC - > 95% as determined by Bis-Tris PAGE > 90% as determined by HPLCColore e forma:Lyophilized PowderPeso molecolare:80.72+23.0 kDa (predicted); 110-140 kDa and 50-65 kDa, corresponding to the α subunit and β subunit respectively (reducing condition, due to glycosylation)IGF1R/CD221 Protein, Cynomolgus, Recombinant (His)
The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosisColore e forma:Lyophilized PowderPeso molecolare:80.59 kDa (alpha subunit) and 19.28 kDa (beta subunit) (predicted). Due to glycosylation, the protein migrates to 48-58 kDa (beta subunit) and 100-115 kDa (alpha subunit) and 130-150 kDa based on Tris-Bis PAGE result.MID-1
CAS:<p>MID-1 is an inhibitor of MG53-IRS-1 (Mitsugumin 53-Insulin Receptor Substrate-1) interaction.</p>Formula:C12H11N3O4SPurezza:99.39%Colore e forma:SolidPeso molecolare:293.3Ginsenoside Rg5
CAS:<p>Ginsenoside Rg5 shows promise for Alzheimer's, reduces inflammation, and aids vascular health without side effects.</p>Formula:C42H70O12Purezza:98% - 99.65%Colore e forma:SolidPeso molecolare:767BRD7552
CAS:<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Formula:C33H33N3O15Purezza:>99.99% - ≥98%Colore e forma:SolidPeso molecolare:711.63
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