IGF-1R
Gli inibitori di IGF-1R sono composti che prendono di mira specificamente il recettore del fattore di crescita insulino-simile 1 (IGF-1R), una tirosina chinasi recettore coinvolta nella crescita, sviluppo e sopravvivenza cellulare. La segnalazione dell'IGF-1R svolge un ruolo significativo nella progressione del cancro, rendendo questi inibitori preziosi nella ricerca oncologica. Presso CymitQuimica, offriamo inibitori di IGF-1R per supportare la tua ricerca in biologia del cancro, endocrinologia e sviluppo di terapie mirate.
Trovati 91 prodotti di "IGF-1R"
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BRD7552
CAS:<p>BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.</p>Formula:C33H33N3O15Purezza:>99.99% - ≥98%Colore e forma:SolidPeso molecolare:711.63Sari 59-801
CAS:Sari 59-801 is a novel, orally effective hypoglycemic compound that appears to act largely by stimulation of insulin release.Formula:C18H23N3O2Purezza:99.92%Colore e forma:SolidPeso molecolare:313.39NT157
CAS:<p>NT157, a small tyrphostin, inhibits IRS, IGF-1R, and STAT3 in TME, reducing cancer cell survival.</p>Formula:C16H14BrNO5SPurezza:99.64%Colore e forma:SolidPeso molecolare:412.26Glymidine
CAS:Glycodiazine, a sulfadiazine derivative, reduces blood sugar by boosting insulin release and sensitivity.Formula:C13H15N3O4SColore e forma:SolidPeso molecolare:309.34NVP-ADW742
CAS:<p>NVP-ADW742 (ADW) is an IGF-1R inhibitor with IC50 of 0.17 μM, >16-fold more potent against IGF-1R than InsR; little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl</p>Formula:C28H31N5OPurezza:96.14% - 98.70%Colore e forma:SolidPeso molecolare:453.58PQ401 hydrochloride (196868-63-0(free base))
PQ401 inhibits autophosphorylation of IGF-1R domain with IC50 of <1 μM.Formula:C18H17Cl2N3O2Purezza:99.86%Colore e forma:SolidPeso molecolare:378.25NVP-AEW541
CAS:<p>NVP-AEW541 (AEW541), a potent inhibitor of IGF-1R(IC50=150 nM) and InsR(IC50=140 nM), exhibits excellent efficiency and specificity for IGF-1R in a cell-based</p>Formula:C27H29N5OPurezza:98.7% - 99.86%Colore e forma:SolidPeso molecolare:439.55MSDC 0160
CAS:<p>MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease.</p>Formula:C19H18N2O4SPurezza:98.11% - 99.53%Colore e forma:SolidPeso molecolare:370.42GSK1838705A
CAS:<p>GSK1838705A: IGF-1R inhibitor (IC50=2.0nM), IR (1.6nM), ALK (0.5nM), minimal other kinase impact.</p>Formula:C27H29FN8O3Purezza:98.89% - >99.99%Colore e forma:SolidPeso molecolare:532.57MAZ51
CAS:<p>MAZ51 is a VEGFR-3 (Flt-4) tyrosine kinase inhibitor.</p>Formula:C21H18N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:314.38XL228
CAS:XL228 is an inhibitor of multi-targeted tyrosine kinase (IC50s: 5, 3.1, 1.6, 6.1, 2 nM for Bcr-Abl, Aurora A, IGF-1R, Src, and Lyn, respectively).Formula:C22H31N9OPurezza:99.07%Colore e forma:SolidPeso molecolare:437.54Ceritinib dihydrochloride
CAS:<p>Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase with antitumour effect.</p>Formula:C28H38Cl3N5O3SPurezza:99.85% - 99.99%Colore e forma:SolidPeso molecolare:631.06Ceritinib
CAS:<p>Ceritinib (LDK378) is an ALK inhibitor with selective, ATP-competitive, and oral activity. Ceritinib has antitumor activity. Cost-effective and quality-assured.</p>Formula:C28H36ClN5O3SPurezza:98.52% - 99.77%Colore e forma:SolidPeso molecolare:558.14Picropodophyllin
CAS:<p>Picropodophyllin (PPP) is a selective IGF-1R inhibitor with IC50 of 1 nM, not affecting other growth factor receptors.</p>Formula:C22H22O8Purezza:98.88% - 99.62%Colore e forma:SolidPeso molecolare:414.41BMS-536924
CAS:<p>BMS-536924 (BMS 536924) is an ATP-competitive IGF-1R/IR inhibitor with IC50 of 100 nM/73 nM, modest activity for Mek, Fak, and Lck with very little activity for</p>Formula:C25H26ClN5O3Purezza:99.02%Colore e forma:SolidPeso molecolare:479.96NVP-TAE 226
CAS:<p>NVP-TAE 226: Potent FAK inhibitor, IC50=5.5nM, stronger vs Pyk2, IC50=3.5nM, weaker against IGF-1R, InsR, c-Met, ALK.</p>Formula:C23H25ClN6O3Purezza:98.07% - 98.78%Colore e forma:SolidPeso molecolare:468.94AZ7550
CAS:<p>AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).</p>Formula:C27H31N7O2Purezza:97.07% - 99.75%Colore e forma:SolidPeso molecolare:485.58AG1024
CAS:<p>AG1024 (Tyrphostin) suppresses IGF-1R autophosphorylation(IC50=7 μM), and is less potent for IR(IC50=57 μM).</p>Formula:C14H13BrN2OPurezza:98% - 99.37%Colore e forma:SolidPeso molecolare:305.17AZD-3463
CAS:<p>AZD-3463 (ALK/IGF1R inhibitor) , an orally bioavailable ALK inhibitor (Ki: 0.75 nM), can inhibit IGF1R with equivalent potency.</p>Formula:C24H25ClN6OPurezza:99.13%Colore e forma:SolidPeso molecolare:448.95Linsitinib
CAS:<p>OSI-906 (Linsitinib) is an oral inhibitor of IGF-1R with anti-cancer properties, potentially halting tumor growth and inducing cell death.</p>Formula:C26H23N5OPurezza:99.71% - ≥95%Colore e forma:SolidPeso molecolare:421.49NBI-31772 hydrate
<p>NBI-31772 hydrate blocks IGF and IGFBPs binding, freeing IGF-I with Ki 1-24 nM; it has anxiolytic and antidepressant effects.</p>Formula:C17H13NO8Colore e forma:SolidPeso molecolare:372.82Indirubin Derivative E804
CAS:Indirubin Derivative E804 is a potent insulin-like growth factor type 1 receptor (IGF1R) inhibitor with potential antitumor activity.Formula:C20H19N3O4Purezza:98.54%Colore e forma:SolidPeso molecolare:365.38GSK1904529A
CAS:<p>GSK1904529A (GSK 4529) is a specific inhibitor of IGF-1R (IC50=27 nM) and IR(IC50=25 nM) .</p>Formula:C44H47F2N9O5SPurezza:98.2% - 99.38%Colore e forma:SolidPeso molecolare:851.96Dusigitumab
CAS:<p>Dusigitumab (MEDI573) is a fully humanised monoclonal antibody targeting IGF1/IGF2, inhibiting IGF1/IGF2-induced IGF-1R phosphorylation.</p>Purezza:95% - 95%Colore e forma:LiquidFigitumumab
CAS:<p>Figitumumab is a potent anti-IGF1R mAb (IC50=1.8 nM) showing promise in advanced lung squamous cell carcinoma.</p>Purezza:95%Colore e forma:LiquidVeligrotug
CAS:<p>Veligrotug is an IV anti-IGF-1R antibody for thyroid eye disease, reducing diplopia and orbital inflammation, supporting autoimmune ophthalmopathy research.</p>Purezza:95% - 95%Colore e forma:LiquidAnti-IGFBP2 Antibody (M14)
<p>Anti-IGFBP2 Antibody (M14) is a human monoclonal antibody inhibitor that binds with high affinity to IGFBP2 and prevents its interaction with IGF1. Additionally, Anti-IGFBP2 Antibody (M14) can inhibit the recruitment of human endothelial cells, thereby obstructing tumor progression in human metastatic cancers.</p>Colore e forma:Odour LiquidS961
CAS:S961: High-affinity IR antagonist; IC50: HIR-A 0.048 nM, HIR-B 0.027 nM, HIGF-IR 630 nM.Formula:C211H297N55O71S2Purezza:98%Colore e forma:SolidPeso molecolare:4804.13BMS-754807
CAS:<p>BMS-754807 is an oral IGF-1R/InsR inhibitor with potential anti-cancer properties.</p>Formula:C23H24FN9OPurezza:99.69% - 99.94%Colore e forma:SolidPeso molecolare:461.49D-(+)-Sorbose
CAS:<p>D-(+)-Sorbose, an enantiomer inhibiting disaccharidase, lowers glucose and insulin post-meal in rats, possibly preventing diabetes.</p>Formula:C6H12O6Colore e forma:SolidPeso molecolare:180.16KU14R
CAS:<p>KU14R is a new I(3)-R antagonist, which selectively blocks the insulin secretory response to imidazolines.</p>Formula:C13H14N2OPurezza:98%Colore e forma:White SolidPeso molecolare:214.26BM-131246
CAS:<p>BM-131246 is an orally available and antidiabetic active thiazolidinedione derivative for the study of diabetes.</p>Formula:C22H20N2O4SPurezza:>99.99%Colore e forma:SolidPeso molecolare:408.47AZ12253801
CAS:<p>AZ12253801 is a type 1 insulin-like growth factor receptor (IGF-1R) inhibitor.</p>Formula:C21H22N8OPurezza:98%Colore e forma:SolidPeso molecolare:402.45Protonstatin-1
CAS:<p>Protonstatin-1: treats hypoglycemia & Alzheimer's, inhibits IGFIR kinase, used in cancer studies.</p>Formula:C8H5NO2S2Purezza:99.77%Colore e forma:SolidPeso molecolare:211.26NT219
CAS:NT219 is a dual inhibitor of insulin receptor substrate 1/2 (IRS1/2) and STAT3 that enhances the aggregation of misfolded prion proteins NT219 Effects.Formula:C16H14BrNO5SPurezza:98.06% - 99.72%Colore e forma:SolidPeso molecolare:412.26I-OMe-Tyrphostin AG 538
CAS:<p>I-OMe-Tyrphostin AG 538: IGF-1R & PI5P4Kα inhibitor, ATP-competitive, IC50 of 1 µM, targets IGF-1R pathway, cytotoxic in nutrient-poor PANC1 cells.</p>Formula:C17H12INO5Purezza:98.23%Colore e forma:SolidPeso molecolare:437.19BMS-695735
CAS:<p>BMS-695735: benzimidazole, inhibits IGF-1 receptor, broad antitumor effects, affects CYP3A4, low solubility, binds plasma proteins.</p>Formula:C26H31ClFN7OColore e forma:SolidPeso molecolare:512.02Tyrphostin AG 538
CAS:<p>Tyrphostin AG 538 is a chalcone compound, an IGF-1 receptor kinase inhibitor (IC₅0 : for 400 nM) that is potent, cell-permeable, reversible, and competitive.</p>Formula:C16H11NO5Purezza:98.75%Colore e forma:SoildPeso molecolare:297.26CL-A3-7
CAS:<p>CL-A3-7 is a viral-cell fusion inhibitor targeting the RSVF protein. It functions by blocking the interaction between the virus and the host's IGF1R, effectively inhibiting the infection of both wild-type and K394R mutant strains of RSV. This compound is suitable for use in antiviral drug development and resistance studies related to RSV.</p>Formula:C24H22Br2F2N2O3Colore e forma:SolidPeso molecolare:584.25IGF-1R inhibitor-4
CAS:<p>IGF-1Rinhibitor-4 (compound 22) is a potent inhibitor of IGF-1R, demonstrating an inhibition rate of 63% at a concentration of 10 μM. This compound plays a significant role in cancer research.</p>Formula:C13H15ClN4OColore e forma:SolidPeso molecolare:278.737AGL-2263
CAS:<p>AGL-2263 is a blocker of insulin receptor (IR)</p>Formula:C17H10N2O5Colore e forma:SolidPeso molecolare:322.27
