Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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SJFα
CAS:SJFα (SJF alpha) degrades p38α and p38δ and can be used in cancer research.Formula:C59H67F2N7O11SPurezza:95.25%Colore e forma:SolidPeso molecolare:1120.27Mito-fisetin mF3
Mito-fisetin mF3 (compund mito-fisetin mF3) is a potent anticancer and anti-aging therapeutic agent that targets mitochondria.Formula:C52H42IO7PColore e forma:SolidPeso molecolare:936.76Cyclic MKEY
CAS:MKEY peptide inhibits CXCL4-CCL5, reduces atherosclerosis and aneurysm, neuroinflammatory effects unknown.Formula:C113H174N28O34S2Purezza:98%Colore e forma:SolidPeso molecolare:2532.89CXCR7 modulator 1
CAS:CXCR7 modulator 1 is an effective and orally bioavailable peptoid hybrid CXCR7 modulator with Ki of 9 nM.Formula:C48H57F2N7O7SPurezza:98%Colore e forma:SolidPeso molecolare:914.07PTX80
CAS:PTX80 is an antagonist of p62, with an IC50 value of 31.18 nM. It has been shown to reduce tumor volume in a HCT116 colorectal cancer mouse xenograft model.Formula:C26H26N4O3SColore e forma:SolidPeso molecolare:474.58OsMo
OsMo is a lysosomal-targeting hNEU1 inhibitor utilized in the study of myocardial injury.Colore e forma:Odour SolidNI-0801
NI-0801 (Anti-CXCL10 / IP-1) is a CHO-expressed humanized monoclonal antibody targeting CXCL10/IP-10 for the study of vitiligo and biliary cirrhosis.Purezza:97.9% (SDS-PAGE); 99.4% (SEC-HPLC) - 97.9% (SDS-PAGE); 99.4% (SEC-HPLC)Colore e forma:Odour LiquidPeso molecolare:144.81 kDaBRD4 degrader-5
<p>BRD4 degrader-5 (Compound 23) is a protein degrader utilizing a hydrophobic tag (HyTag) that targets BRD4 for degradation through endoplasmic reticulum stress and the autophagy-lysosome pathway (DC50 = 24.7 μM). It also inhibits the proliferation of 4T1 cancer cells, with an IC50 of 20.6 μM.</p>Formula:C35H42ClN7O2SColore e forma:SolidPeso molecolare:660.27ATG16L1 stabilizer-1
ATG16L1 stabilizer-1 (compound A3B) is an FKBP12-independent stabilizer of ATG16L1 that enhances cellular autophagy (Autophagy). Regardless of the presence of FKBP12, it has an inhibitory EC50 value of 12.1 μM for ATG16L1. When used alone, ATG16L1 stabilizer-1 can induce GFP-LC3 puncta formation, with an EC50 value of 12.0 μM.Formula:C45H62N14O5SColore e forma:SolidPeso molecolare:911.13BVT173187
CAS:BVT173187 is a neutrophil formyl peptide receptors (FPR1) inhibitor.Formula:C14H10Cl3NO2Colore e forma:SolidPeso molecolare:330.59CX4338
CAS:CX4338 is a CXCL8-mediated chemotaxis inhibitor.Formula:C22H24N2OSColore e forma:SolidPeso molecolare:364.50Salinomycin sodium salt
CAS:Salinomycin sodium salt (Sodium salinomycin), an antibiotic potassium ionophore, is an effective inhibitor of Wnt/β-catenin signaling.Formula:C42H69NaO11Purezza:98.76% - 99.11%Colore e forma:White Or Light Yellow Crystalline Powder With Special SmelPeso molecolare:772.98SJFδ
CAS:SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17 nM, but does not degrade p38α, p38β, or p38γ[1].Formula:C62H63F2N7O12SPurezza:98%Colore e forma:SolidPeso molecolare:1168.27Basic Blue 20
CAS:Basic Blue 20: Red-emitting DNA stain, peaks at 633/677 nm, high photobleaching resistance.Formula:C26H33Cl2N3Colore e forma:SolidPeso molecolare:458.47PBA-1105 TFA
<p>PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.</p>Formula:C41H49F3N2O8Colore e forma:SolidPeso molecolare:754.832Acetyl coenzyme A
CAS:Acetyl coenzyme A (Acetyl-CoA) is a pivotal molecule connecting multiple cellular metabolic pathways in the tricarboxylic acid cycle, fatty acid synthesisFormula:C23H38N7O17P3SColore e forma:SolidPeso molecolare:809.57Nictide
CAS:<p>Nictide, a peptide substrate for LRRK2 (leucine-rich repeat protein kinase-2), undergoes phosphorylation by the activated form of LRRK2[G2019S], exhibiting a Km value of 10 μM.</p>Formula:C123H193N45O28Colore e forma:SolidPeso molecolare:2750.13Tigecycline hydrochloride
CAS:Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formula:C29H40ClN5O8Purezza:98%Colore e forma:SolidPeso molecolare:622.11Atorvastatin Sodium
CAS:Atorvastatin Sodium (Lipitor) is a competitive inhibitor of HMG-CoA reductase and increases the expression of low density lipoprotein (LDL) receptors onFormula:C33H34FN2NaO5Purezza:99.88% - >99.99%Colore e forma:SolidPeso molecolare:580.63ALX 40-4C
CAS:ALX40-4C is a small peptide inhibitor of the chemokine receptor CXCR4 that can inhibit X4 strains of HIV-1.Formula:C56H113N37O10Purezza:98%Colore e forma:SolidPeso molecolare:1464.74CXM102
CXM102 is an activator of autophagy. This compound induces autophagy in aged BMSCs, rejuvenating them and promoting their preferential differentiation into osteoblasts. CXM102 enhances the nuclear translocation of transcription factor EB (TFEB) and the formation of osteoblasts. In middle-aged male mice, it stimulates bone anabolic metabolism, reduces marrow adipocytes, delays bone loss, lowers serum inflammation levels, reduces organ fibrosis, and extends lifespan.Formula:C28H27NO3Colore e forma:SolidPeso molecolare:425.52(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Formula:C16H18F6N5O5PColore e forma:SolidPeso molecolare:505.314Autophagy/REV-ERB-IN-1 hydrochloride
Autophagy/REV-ERB-IN-1 hydrochloride (Compound 24) is a dual inhibitor of autophagy and REV-ERB with anticancer properties. It enhances the efficacy of autophagy blockade and increases cytotoxicity against cancer cells. Autophagy/REV-ERB-IN-1 (hydrochloride) is applicable in melanoma research.Formula:C24H32Cl2F2N2Peso molecolare:456.19106Acetazolamide
CAS:<p>Acetazolamide (Diamox) is a Carbonic Anhydrase Inhibitor. The mechanism of action of acetazolamide is as a Carbonic Anhydrase Inhibitor. The chemical classification of acetazolamide is Sulfonamides.</p>Formula:C4H6N4O3S2Purezza:99.61% - 99.94%Colore e forma:Crystals From Water 1992)Peso molecolare:222.25Indomethacin-D4
CAS:Indomethacin-D4 is a deuterium labeled Indomethacin.Formula:C19H16ClNO4Purezza:98%Colore e forma:SolidPeso molecolare:361.81(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-OH is a conjugate of an E3 ligase ligand and a linker (E3LigaseLigand-Linker Conjugates), consisting of Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit the CRBN protein and serves as a crucial intermediate for synthesizing complete PROTAC molecules.</p>Formula:C27H32N8O5Peso molecolare:548.24957Autocamtide 2, amide
Autocamtide-2, an amide, is a selective CaMKII substrate for CAMK family assays at 100 μM.Formula:C65H119N23O19Purezza:98%Colore e forma:SolidPeso molecolare:1526.79(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3
<p>(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-CH2-COO-C(CH3)3 is an E3 ligase ligand-linker conjugate (E3LigaseLigand-Linker Conjugates) composed of thalidomide and its corresponding linker. This compound functions as a Cereblon ligand, facilitating the recruitment of CRBN protein, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C33H42N8O7Peso molecolare:662.31765(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH
(S)-Thalidomide-piperazine-pyrimidine-piperazine-C2-O-C2-OH is a conjugate combining an E3 ligase ligand with a linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding Linker. This compound functions as a Cereblon ligand, recruiting the CRBN protein and serving as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C29H36N8O6Peso molecolare:592.27578RCP168
RCP168 is a highly selective and potent CXCR4 receptor antagonist with an IC50 of 5 nM. It exhibits superior capacity to inhibit HIV-1 (Human Immunodeficiency Virus type 1) from entering host cells via the CXCR4 receptor compared to natural chemokines. RCP168 suppresses HIV-1 infection by blocking viral binding sites or inducing receptor internalization. It can be utilized in research to study interactions between the CXCR4 receptor and other chemokine receptors.Formula:C365H585N105O95S5Peso molecolare:8119.27766(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc
(1R,5S)-Thalidomide-3,8-diazabicyclo[3.2.1]octane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. This compound serves as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in the synthesis of complete PROTAC molecules.Formula:C31H41N5O6Peso molecolare:579.30568CXCR4-IN-3
<p>CXCR4-IN-3 (compound XVI) is an orally active inhibitor targeting the inflammation-related receptor CXCR4, with an IC50 of 3.2 nM. It exhibits potent anti-chemotactic effects, with an inhibition rate of 79.19±2.33%. Additionally, CXCR4-IN-3 possesses anti-inflammatory properties and can be utilized in research on IBD (inflammatory bowel disease).</p>CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Formula:C107H173N33O30Peso molecolare:2400.30261Antitumor agent-133
Antitumor agent-133 (compound 4d) is a bis-santine derivative that demonstrates activity against Huh1 (IC50 = 17.13 μM) and Huh7 (IC50 = 8.27 μM). It induces autophagy and inhibits tumor growth by modulating the levels of the LC3BII, ATG5, and p62 proteins.Formula:C27H24Br2N4O8Peso molecolare:689.99609PF-06835375
CAS:PF-06835375 is a humanized IgG1 antibody that selectively targets CXCR5 expressed on B cells, Tfh cells, and circulating Tfh-like cells (cTfh). It is applicable for research into systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).Colore e forma:LiquidALX 40-4C Trifluoroacetate
Alx40-4C trifluoroacetate inhibits CXCR4 and is an APJ antagonist with IC50 of 2.9M.Formula:C58H114F3N37O12Purezza:98%Colore e forma:SolidPeso molecolare:1578.76ATRA-biotin
CAS:ATRA-biotin is a biotin-conjugated form of all-trans retinoic acid (ATRA). It is utilized for the purpose of tracking ATRA within cells or specific tissues.Formula:C36H55N3O4SColore e forma:SolidPeso molecolare:625.91Tigecycline hydrate
CAS:Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.Formula:C29H39N5O8·xH2OColore e forma:SolidCCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Formula:C13H22N6OSPeso molecolare:310.15758Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Formula:C26H37N5O2Purezza:97.69% - 99.86%Colore e forma:White Crystalline SolidPeso molecolare:451.6AUTAC1
CAS:AUTAC1 is a MetAP2-targeted autophagy-mediated degradator (AUTAC) that degrades MetAP2 and FKBP12 proteins and can be used to synthesize PROTAC.Formula:C44H63FN8O11SPurezza:99.45% - 99.45%Colore e forma:SolidPeso molecolare:931.08H1k
<p>H1k is an eudistomin Y fluorescent derivative and lysosome-targeted antiproliferative agent that downregulates the expression of cell cycle protein B1.</p>Formula:C27H22N2OPurezza:98.13%Colore e forma:SoildPeso molecolare:390.48Autocamtide 2
CAS:<p>Autocamtide-2: Selective peptide for CaMKII, a CAMK Ser/Thr kinase.</p>Formula:C65H118N22O20Purezza:98%Colore e forma:White PowderPeso molecolare:1527.77MRL828
MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.Formula:C46H51FN14O5SColore e forma:SolidPeso molecolare:930.38716Deoxy-thalidomide-Pip-C-PIP-boc
CAS:Deoxy-thalidomide-Pip-C-PIP-boc, a conjugate of E3 ligase ligand and linker, comprises Thalidomide and the corresponding Linker. It functions as a Cereblon ligand to recruit CRBN protein and acts as a crucial intermediate in synthesizing complete PROTAC molecules.Formula:C28H39N5O5Colore e forma:SolidPeso molecolare:525.64CXCL-CXCR1/2-IN-1
CAS:CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.Formula:C14H8Cl2N4O3SPurezza:99.4%Colore e forma:SoildPeso molecolare:383.21E70K
E70K, a CXCL8 C-terminal peptide, features a lysine (K) substitution for glutamic acid (E) at position 70 and has demonstrated the ability to attenuateFormula:C108H178N34O28Purezza:98%Colore e forma:SolidPeso molecolare:2400.78Polyphyllin G
CAS:Polyphyllin G (Polyphyllin VII), the the main member of polyphyllin family, shows strong anticancer activity against several carcinomas.Formula:C51H84O22Purezza:98%Colore e forma:SolidPeso molecolare:1049.21LC3B recruiter 2
CAS:LC3B recruiter 2 (34R) is an LC3B recruiting agent incorporated into the autophagy-lysosome pathway degradation system (ATTEC, Autophagy-Tethering Compounds), with a direct binding affinity for LC3B. It connects via a linker to the CDK9 inhibitor SNS-032, creating an ATTEC capable of targeting and degrading the CDK9 and Cyclin T1 complex, while also inhibiting them. Consequently, LC3B recruiter 2 exerts its function through an LC3B-dependent autophagy-lysosome pathway, interfering with the cancer cell cycle progression, thereby demonstrating antitumor activity.Formula:C10H9ClN2O2Colore e forma:SolidPeso molecolare:224.644Autophagy agonist-1
Autophagyagonist-1 (compound 22) is an autophagy agonist. It exhibits significant anticancer activity against HepG2 cells and normal cells, with IC50 values of 8.8 μM and > 50 μM, respectively. The compound induces G1/S phase cell cycle arrest, suppresses the expression of CDK4 and CyclinD1, and upregulates P21. Additionally, Autophagyagonist-1 enhances autophagosome, LC3, and PINK1 accumulation, thereby promoting autophagy and mitophagy in HepG2 cells.Formula:C33H41N3O5Colore e forma:SolidPeso molecolare:559.7Manzamine A hydrochloride
CAS:Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.Formula:C36H45ClN4OColore e forma:SolidPeso molecolare:585.23ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formula:C25H30N2OSColore e forma:SolidPeso molecolare:406.58N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Formula:C15H21N5O4Purezza:97.13% - 99.69%Colore e forma:SolidPeso molecolare:335.36DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Formula:C59H68F3N13O6SColore e forma:SolidPeso molecolare:1144.31TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Formula:C145H238N34O44Colore e forma:SolidPeso molecolare:3161.64Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Colore e forma:SolidPeso molecolare:784.98LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Colore e forma:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Colore e forma:SolidPeso molecolare:426.47Syntide 2
CAS:Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).Formula:C68H122N20O18Purezza:98%Colore e forma:Lyophilized SolidPeso molecolare:1507.82YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Formula:C16H19NO2Purezza:98.31%Colore e forma:SoildPeso molecolare:257.33Ref: TM-T87944
1mg38,00€2mgPrezzo su richiesta5mg72,00€10mg105,00€25mg203,00€50mg328,00€100mg503,00€200mg769,00€SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formula:C34H32FeO6Colore e forma:SolidPeso molecolare:592.46(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C30H39N5O6Peso molecolare:565.29003Ch55-O-C3-NH2
CAS:Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.Formula:C27H35NO4Purezza:98%Colore e forma:SolidPeso molecolare:437.57Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Formula:C24H30F2N2Peso molecolare:384.23771MLCK inhibitor peptide 18
CAS:Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.Formula:C60H105N23O11Purezza:98%Colore e forma:SolidPeso molecolare:1324.64Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Formula:C28H33NO7Purezza:98%Colore e forma:Crystals From Acetone-Hexane White PowderPeso molecolare:495.56DOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFormula:C58H78N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1223.34SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purezza:98%Colore e forma:SolidPeso molecolare:7959.34p62-ZZ Ligand-Linker Conjugate 1
CAS:p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.Formula:C31H42N2O6Colore e forma:SolidPeso molecolare:538.68Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Formula:C27H48F3N9O7Colore e forma:SolidPeso molecolare:667.72Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Colore e forma:SolidPeso molecolare:902.1PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurezza:99.02%Colore e forma:SolidPeso molecolare:465.6Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Formula:C22H23N3O4Colore e forma:SolidPeso molecolare:399.397HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Colore e forma:Odour SolidFDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Formula:C22H24N6OPurezza:98.73% - 99.55%Colore e forma:SoildPeso molecolare:388.47Ref: TM-T77809
1mg70,00€5mg150,00€10mg227,00€25mg378,00€50mg547,00€100mg747,00€1mL*10mM (DMSO)166,00€Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Colore e forma:Odour SolidPHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Formula:C51H50F6N4O7Colore e forma:SolidPeso molecolare:944.96PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Formula:C41H42Br2IN7O5Peso molecolare:997.06589VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurezza:99.82%Colore e forma:SolidPeso molecolare:552.33Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purezza:97.74% - 99.99%Colore e forma:SolidPeso molecolare:401.84STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFormula:C19H10N2O3·C2H4O2Purezza:99.75%Colore e forma:SolidPeso molecolare:374.35Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Formula:C44H36Cl5FeN8Colore e forma:SolidPeso molecolare:909.92Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Formula:C20H24ClNO4Colore e forma:SolidPeso molecolare:377.86Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Colore e forma:SolidPeso molecolare:2505.83Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFormula:C32H38Cl3N7Colore e forma:SolidPeso molecolare:627.05Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formula:C90H141N33O18S2Colore e forma:SolidPeso molecolare:2037.42Insecticidal agent 364
CAS:<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formula:C23H18N4O3SPurezza:99.81%Colore e forma:SolidPeso molecolare:430.48Biotin-11-dCTP
Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .Formula:C28H43Li3N7O16P3SColore e forma:SolidPeso molecolare:879.49Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formula:C30H43N5O11SPurezza:98%Colore e forma:SolidPeso molecolare:681.75Desethyl chloroquine
CAS:Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.Formula:C16H22ClN3Purezza:99.56%Colore e forma:SolidPeso molecolare:291.82MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purezza:99.75%Colore e forma:SoildPeso molecolare:537.53Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Formula:C53H66N4O16S4Colore e forma:SolidPeso molecolare:1143.37cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Formula:C31H51ClN7O14PSColore e forma:SolidPeso molecolare:844.27ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formula:C94H82N4O2S4Purezza:98%Colore e forma:SolidPeso molecolare:1427.96D-CopA3
CAS:<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formula:C96H184N30O18S2Colore e forma:SolidPeso molecolare:2110.81Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Formula:C38H42Cl2N6O2Colore e forma:SolidPeso molecolare:685.69Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purezza:98%Colore e forma:SolidPeso molecolare:653.72NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Formula:C56H68ClN9O5S2Colore e forma:SolidPeso molecolare:1046.78Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Formula:C27H45NO3Colore e forma:SolidPeso molecolare:431.65Balixafortide
CAS:Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.Formula:C84H118N24O21S2Purezza:98%Colore e forma:SolidPeso molecolare:1864.14
