Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1490 prodotti di "Autofagia"
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CXCR4 antagonist 5
CAS:CXCR4 antagonist with IC50 of 8.8 nM, inhibits CXCL12-induced calcium increase and chemotaxis, with good safety and minimal CYP, hERG impact.Formula:C21H30N6Colore e forma:SolidPeso molecolare:366.5p38 MAPK-IN-2
CAS:p38 MAPK-IN-2 is an inhibitor of p38 kinase.Formula:C20H19ClFN5O2Purezza:98%Colore e forma:SolidPeso molecolare:415.85SMYD3-IN-2
SMYD3-IN-2, a cancer research chemical, inhibits SMYD3 (IC50 0.81 μM) and BGC823 (IC50 0.75 μM), inducing fatal autophagy in gastric cancer.Formula:C26H21BrN2O4Colore e forma:SolidPeso molecolare:505.36CXCR4 modulator-2
CAS:CXCR4 modulator-2 (Z7R) has high potency (IC50: 1.25 nM), stable in mouse serum (t1/2=77.1 min), and anti-inflammatory in mice.Formula:C21H32N8O2Colore e forma:SolidPeso molecolare:428.53NSC 33994
CAS:NSC 33994 is a selective inhibitor of JAK2 (IC50 = 60 nM). It also shows no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM.Formula:C28H42N2O2Purezza:98%Colore e forma:SolidPeso molecolare:438.65Ambroxol-d5
CAS:Ambroxol-d5 is a standard for quantifying ambroxol in GC/LC-MS, an expectorant metabolite of bromhexine improving mucociliary functions.Formula:C13H13Br2D5N2OPeso molecolare:383.13Olacaftor
CAS:Olacaftor, also known as VX-440, is a protein modulator of cystic fibrosis transmembrane regulator (CFTR).Formula:C29H34FN3O4SColore e forma:SolidPeso molecolare:539.66SR 3677 dihydrochloride
CAS:Potent and selective Rho-kinase inhibitor (IC50 values are 3 and 56 nM for ROCK-II and ROCK-I respectively).Formula:C22H26Cl2N4O4Colore e forma:SolidPeso molecolare:481.37Lamotrigine isethionate
CAS:Water-soluble salt of lamotrigine . Displays anticonvulsant effects and inhibits glutamate release, possibly through inhibition of Na+, K+ and Ca2+ currents.Formula:C11H13Cl2N5O4SColore e forma:SolidPeso molecolare:382.22PF-06371900
CAS:PF-06371900 is a potent and highly selective inhibitor of leucine-rich repeat kinase 2 (LRRK2).Formula:C17H16N6O2SColore e forma:SolidPeso molecolare:368.41Ralimetinib
CAS:Ralimetinib blocks MK2 phosphorylation at Thr334 without affecting p38α MAPK or JNK. It is an ATP-competitive inhibitor of p38 MAPK α/β (IC50 5.3/3.2 nM).Formula:C24H29FN6Purezza:99.16% - 99.21%Colore e forma:SolidPeso molecolare:420.53Ivacaftor benzenesulfonate
CAS:Ivacaftor benzenesulfonate used for cystic fibrosis treatment. is an orally bioavailable CFTR potentiator.Formula:C30H34N2O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.67Glaucocalyxin B
CAS:Glaucocalyxin B is a diterpenoid isolated from Rabdosia japonica with anticancer and antitumor activity. It decreases the growth of HL-60 cells (IC50: 5.86 μM).Formula:C22H30O5Purezza:99.13% - 99.35%Colore e forma:SolidPeso molecolare:374.47Ref: TM-TQ0309
1mg97,00€5mg235,00€10mg354,00€25mg582,00€50mgPrezzo su richiesta1mL*10mM (DMSO)243,00€Methophenazine diethanesulfonate
CAS:Methophenazine diethanesulfonate is a Calmodulin antagonist.Formula:C35H48ClN3O11S3Colore e forma:SolidPeso molecolare:818.41Xantocillin
CAS:Xanthocillin is a marine agent. Xanthocillin also induces autophagy through inhibition of the MEK/ERK pathway.Formula:C18H12N2O2Purezza:98%Colore e forma:SolidPeso molecolare:288.3PF-06455943
CAS:PF-06455943: LRRK2 inhibitor, IC50=3nM, PET radioligand, used for ADME/neuro PK & Parkinson's research.Formula:C17H14FN5OColore e forma:SolidPeso molecolare:323.32Poloppin
CAS:Poloppin modulates polo-like kinases, targets mutant KRAS, and enhances Crizotinib's effects against KRAS-mutant cancers.Formula:C20H15BrF3NO2Purezza:98%Colore e forma:SolidPeso molecolare:438.24GSK3-IN-3
CAS:<p>GSK3-IN-3 is a mitochondrial autophagy (mitophagy) inducer and GSK-3 inhibitor (IC50: 3.01 μM) that induces parkin-dependent mitochondrial autophagy.</p>Formula:C24H35N3O4Purezza:99.37%Colore e forma:SolidPeso molecolare:429.55AMD 3465
CAS:AMD 3465 (GENZ-644494) blocks CXCR4, hinders X4 HIV replication (IC50: 1-10 nM), ineffective against R5 viruses, IC50: 0.75 nM (12G5 mAb), 18 nM (CXCL12AF647).Formula:C24H38N6Purezza:98%Colore e forma:SolidPeso molecolare:410.60Fluoxetine oxalate
CAS:Fluoxetine oxalate, an SSRI, treats depression, OCD, bulimia, panic, and PMS.Formula:C19H20F3NO5Colore e forma:SolidPeso molecolare:399.36
