Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Colore e forma:Odour SolidcGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Formula:C31H51ClN7O14PSColore e forma:SolidPeso molecolare:844.27Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Colore e forma:SolidPeso molecolare:902.1SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purezza:98%Colore e forma:SolidPeso molecolare:7959.34Microcolin H
CAS:Microcolin H, a marine lipopeptide and phosphatidylinositol transfer protein ligand, targets PITPα/β. It enhances the conversion of LC3I to LC3II and decreases p62 levels in cancer cells, inducing autophagy cell death (Autophagy). Furthermore, Microcolin H effectively inhibits tumor growth and exhibits anti-proliferative activity in nude mouse subcutaneous tumor models [1].Formula:C38H63N5O9Colore e forma:SolidPeso molecolare:733.93Olaparib-d5
CAS:Olaparib D5 is a deuterium labeled Olaparib. Olaparib is a potent and oral inhibitor of PARP.Formula:C24H23FN4O3Purezza:98%Colore e forma:SolidPeso molecolare:439.49Regorafenib-d3
CAS:Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.Formula:C21H15ClF4N4O3Purezza:98%Colore e forma:SolidPeso molecolare:485.83Heparin Lithium
CAS:Heparin Lithium salt is an anticoagulant that reversibly binds to ATIII and enhances its inhibitory effect on coagulation factor(thrombin and factor Xa).Formula:C14H25NO20S3Colore e forma:SolidPeso molecolare:623.01321Imatinib D4
CAS:Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.Formula:C29H31N7OPurezza:98%Colore e forma:SolidPeso molecolare:497.63Bexarotene D4
CAS:Bexarotene D4 is a deuterium-labeled Bexarotene (LGD1069). Bexarotene is a selective RXR agonist used in the treatment of cutaneous T-cell lymphoma.Formula:C24H28O2Purezza:98%Colore e forma:SolidPeso molecolare:352.5Trimetazidine
CAS:Trimetazidine is a antianginal agent that selectively inhibits the mitochondrial enzyme LC 3-KAT, thereby preventing β-oxidation of free fatty acids.Formula:C14H22N2O3Purezza:99.9%Colore e forma:Hite Or Off-White Crystalline PowderPeso molecolare:266.34Binimetinib-13C-d3
Binimetinib-13C-d3 (MEK162) is an isotopically labelled compound of Binimetinib.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor melanoma.
Formula:C17H15BrF2N4O3Colore e forma:SolidPeso molecolare:445.24LG100268
CAS:LG100268 is a selective, and oral RXR agonist，inducing transcriptional activation in adipocytes; inhibits keratin 17 increases PD-L1 expression.Formula:C24H29NO2Purezza:99.83%Colore e forma:SolidPeso molecolare:363.49Enzalutamide-d3
CAS:Enzalutamide D3 is a deuterium labeled Enzalutamide . Enzalutamide is an androgen receptor (AR) antagonist with an IC50 of 36 nM in LNCaP prostate cells.Formula:C21H16F4N4O2SColore e forma:SolidPeso molecolare:467.45TRAF6 peptide TFA
TRAF6 peptide TFA, a specific inhibitor of the TRAF6-p62 interaction, significantly inhibits NGF-dependent ubiquitination of TrkA.Formula:C145H238N34O44·xC2HF3O2Purezza:98%Colore e forma:SolidPeso molecolare:3161.64 (free acid)Isoniazid-d4
CAS:Isoniazid-d4 is a deuterium isotope marker for Isoniazid.Isoniazid is a prodrug that must be activated by the bacterial peroxidase KatG, and is bactericidal.Formula:C6H3D4N3OColore e forma:SolidPeso molecolare:141.16Rapalink-1
CAS:Rapalink-1 is an mTOR inhibitor that inhibits the mTORC1-4E-BP1 pathway in mice.Formula:C91H138N12O24Purezza:98%Colore e forma:SolidPeso molecolare:1784.14Aliskiren
CAS:Aliskiren (CGP 60536) is a renin inhibitor (IC50: 1.5 nM) with antihypertensive activity and is used in the treatment of various cardiovascular diseases.Formula:C30H53N3O6Purezza:97.02%Colore e forma:SolidPeso molecolare:551.76Ref: TM-T22233
1mg35,00€5mg73,00€10mg105,00€25mg149,00€50mg187,00€100mg283,00€200mg419,00€1mL*10mM (DMSO)89,00€Erlotinib-d6 hydrochloride
CAS:Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.Formula:C22H24ClN3O4Purezza:98%Colore e forma:SolidPeso molecolare:435.93Ponatinib-d8
CAS:Ponatinib D8 is a deuterium-enriched, oral multi-kinase inhibitor (Abl, PDGFRα, VEGFR2, FGFR1, Src; IC50s: 0.37-5.4 nM).Formula:C29H27F3N6OPurezza:98%Colore e forma:SolidPeso molecolare:540.61ACT-1004-1239
CAS:ACT-1004-1239 is a CXCR7 antagonist with immunomodulatory and myelination-promoting effects, used for research on inflammatory demyelinating diseases.
Formula:C27H28F2N6O3Purezza:98.31%Colore e forma:SolidPeso molecolare:522.55KN-93 hydrochloride
CAS:KN-93 hydrochloride is a reversible, competitive CaMKII inhibitor inducing reversible G1 arrest, supporting cell cycle and signaling pathway studies.Formula:C26H30Cl2N2O4SPurezza:99.99%Colore e forma:SolidPeso molecolare:537.5ATI-2341
CAS:ATI-2341, pepducin targeting the CXCR4, is an allosteric agonist activating the Gi to promote inhibition of cAMP production and induce calcium mobilization.Formula:C104H178N26O25S2Colore e forma:SolidPeso molecolare:2256.82Rosuvastatin D3 Sodium
CAS:Rosuvastatin D3 Sodium is deuterium labeled Rosuvastatin, which is a competitive HMG-CoA reductase inhibitor(IC50 of 11 nM).Formula:C22H24D3FN3NaO6SPurezza:98%Colore e forma:SolidPeso molecolare:506.54Levomepromazine
CAS:Levomepromazine (Methotrimeprazine) is a Ca2+ release inducer with antiviral, anti-inflammatory, neuroprotective, sedative, and anti-nociceptive activities.Formula:C19H24N2OSPurezza:99.15%Colore e forma:SolidPeso molecolare:328.47CXCR2 antagonist 8
CAS:CXCR2 antagonist 8 is a selective CXCR2 antagonist, which can be used for the treatment and prevention of insulin resistance.Formula:C14H13N3O5Colore e forma:SolidPeso molecolare:303.27Motixafortide
CAS:Motixafortide (BKT140 4-fluorobenzoyl) is an antagonist of CXCR4 (IC50: 1 nM).Formula:C97H144FN33O19S2Purezza:98%Colore e forma:SolidPeso molecolare:2159.52Ezetimibe-d4
CAS:Ezetimibe D4, a deuterium-labeled variant of Ezetimibe, functions as an inhibitor of Niemann-Pick C1-like1 (NPC1L1) and is recognized for its potent activationFormula:C24H21F2NO3Purezza:98%Colore e forma:White SolidPeso molecolare:413.45Anti-LRRK2 Antibody (1C773)
Anti-LRRK2 Antibody (1C773) is an antibody targeting LRRK2. Anti-LRRK2 Antibody (1C773) can be used in ELISA, IHC.Colore e forma:Odour LiquidRapamycin-d3
CAS:Rapamycin-d3 is the deuterium labeled Rapamycin. Rapamycin is a potent and specific inhibitor of mTOR(IC50 of 0.1 nM in HEK293 cells).Formula:C51H79NO13Purezza:98%Colore e forma:SolidPeso molecolare:917.19Tetrahydrocurcumin D6
CAS:Tetrahydrocurcumin D6 is a deuterium labeled Tetrahydrocurcumin. Tetrahydrocurcumin displays inhibitory activity for CYP2C9 and CYP3A4.Formula:C21H24O6Purezza:98%Colore e forma:SolidPeso molecolare:378.45PS372424 hydrochloride
CAS:PS372424 hydrochloride,CXCR3 agonist. Anti-inflammatory. Inhibits T-cell migration.Formula:C33H45ClN6O4Purezza:95.03%Colore e forma:SolidPeso molecolare:625.2Manzamine A
CAS:Manzamine A, from marine sponges, blocks GSK-3, halts cancer growth, prevents bacterial infections, and reduces tau phosphorylation.Formula:C36H44N4OPurezza:98%Colore e forma:SolidPeso molecolare:548.775Idelalisib D5
CAS:Idelalisib D5, a version of Idelalisib marked with deuterium, is an orally bioavailable and highly selective inhibitor of p110δ.Formula:C22H18FN7OPurezza:98%Colore e forma:SolidPeso molecolare:420.45Ladarixin
CAS:Ladarixin (DF 2156A free base) is an orally active, non-competitive CXCR1/CXCR2 allosteric inhibitor that suppresses AKT, NF-κB, and angiogenesis.Formula:C11H12F3NO6S2Purezza:99.36%Colore e forma:SolidPeso molecolare:375.34Omeprazole-d3
CAS:Omeprazole D3 is deuterium labeled Omeprazole. Omeprazole is a proton pump inhibitor (PPI)Formula:C17H19N3O3SPurezza:98%Colore e forma:SolidPeso molecolare:348.44Desethyl chloroquine diphosphate
CAS:Desethyl chloroquine diphosphate is the active metabolite of Desethylchloroquine, an inhibitor of TLRs with antiplasmodial activity and inhibition of autophagy.Formula:C16H28ClN3O8P2Purezza:99.72%Colore e forma:SolidPeso molecolare:487.81Ambroxol hydrochloride (Standard)
CAS:Ambroxol hydrochloride (Standard) is the standard substance of Ambroxol hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Formula:C13H18Br2N2O·HClPeso molecolare:414.56Curcumin-d6
CAS:Curcumin D6 (difluoroformylmethane D6) is deuterium-labeled curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with various pharmacological effects, including anti-inflammatory, antioxidant, anti-proliferative and anti-aFormula:C21H20O6Purezza:98%Colore e forma:SolidPeso molecolare:374.422Vancomycin hydrochloride (Standard)
CAS:Vancomycin hydrochloride (Standard) is the standard substance of Vancomycin hydrochloride, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Vancomycin hydrochloride (Vancomycin HCl) is a glycopeptide antibiotic that targets Peptidoglycan in bacterial cell wall synthesis. Vancomycin hydrochloride is mainly used for the treatment of severe Gram-positive bacterial infections.Formula:C66H76Cl3N9O24Colore e forma:Off White PowderPeso molecolare:1485.71LY2510924
CAS:LY2510924 is an effective and selective CXCR4 antagonist. It blocks SDF-1 binding to CXCR4 (IC50: 0.079 nM).Formula:C62H88N14O10Colore e forma:SolidPeso molecolare:1189.45Imatinib-d8
CAS:Imatinib-d8 (STI571 D8) is a 2H-labeled form of Imatinib. Imatinib is a multi-target receptor tyrosine kinase inhibitor with antitumor activity.Formula:C29H23D8N7OPurezza:98%Colore e forma:SolidPeso molecolare:501.65THZ-P1-2
CAS:THZ-P1-2 is a PI5P4K inhibitor with anti-leukemic activity and can be used in the study of leukemia.Formula:C31H29N7O2Colore e forma:SolidPeso molecolare:531.61Ref: TM-T39459
1mg74,00€2mgPrezzo su richiesta5mg160,00€10mg216,00€25mg349,00€50mg494,00€100mg692,00€200mg934,00€1mL*10mM (DMSO)182,00€Br-DAPI
CAS:IST5-002 (N6-Benzyladenosine-5'-phosphate) is a Stat5a/b inhibitor with anticancer activity and is used in cancer research.Formula:C16H14BrN5Purezza:100%Colore e forma:SolidPeso molecolare:356.22Theophylline-d6
CAS:Theophylline-d6, an internal standard for theophylline quantification in GC/LC-MS, relaxes bronchial muscles and treats asthma/COPD.Formula:C7H2D6N4O2Colore e forma:SolidPeso molecolare:186.2OR-1855
CAS:OR-1855 is an active Levosimendan metabolite, has effect on human myometrial contractility.Formula:C11H13N3OPurezza:98%Colore e forma:Pale Yellow SolidPeso molecolare:203.24Loperamide-d6 hydrochloride
CAS:Loperamide D6 HCl: Deuterium-enriched opioid for diarrhea.Formula:C29H34Cl2N2O2Purezza:98%Colore e forma:SolidPeso molecolare:519.54Peptide R TFA
Peptide R (TFA) is a synthetic and specific CXCR4 antagonist. It demonstrates excellent tumor stroma remodeling capabilities and is applicable in research on solid tumors, such as glioblastoma.
Formula:C39H57N13O8S2·xC2HF3O2Colore e forma:SolidPeso molecolare:900.08 (free base)Pemetrexed disodium heptahydrate
CAS:Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits TS, DHFR and GARFT, inhibits precursor purine and pyrimidine nucleotides.Formula:C20H33N5Na2O13Purezza:99.783%Colore e forma:SolidPeso molecolare:597.49Pazopanib-d6
CAS:Pazopanib-d6 is a deuterated compound of Pazopanib.Formula:C21H17D6N7O2SColore e forma:SolidPeso molecolare:443.56
