Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1495 prodotti di "Autofagia"
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AZD-8055
CAS:AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.
Formula:C25H31N5O4Purezza:98% - 99.69%Colore e forma:SolidPeso molecolare:465.54ARRY-797
CAS:ARRY-797 (ARRY-371797) is a potent and selective p38α inhibitor and inhibits LPS-Induced IL-6.
Formula:C22H26F2N4O2Purezza:98.97% - 99.81%Colore e forma:SolidPeso molecolare:416.46Sulfosuccinimidyl oleate sodium
CAS:Sulfosuccinimidyl oleate sodium is a long-chain fatty acid that inhibits fatty acid transport into cells.Cost-effective and quality-assured.Formula:C22H36NNaO7SPurezza:96.53%Colore e forma:SolidPeso molecolare:481.58Ref: TM-T13036L
1mg38,00€5mg72,00€10mg117,00€25mg187,00€50mg299,00€100mg472,00€200mg607,00€500mg938,00€Lamotrigine hydrate
CAS:Lamotrigine hydrate: oral anticonvulsant, blocks Na+ channels, stabilizes neurons, inhibits glutamate, treats epilepsy, focal seizure.Formula:C9H9Cl2N5OColore e forma:SolidPeso molecolare:274.11Entrectinib
CAS:Entrectinib (RXDX-101) is an orally Trk, ROS1, and ALK inhibitor. Entrectinib exhibits antitumor activity. Cost-effective and quality-assured.Formula:C31H34F2N6O2Purezza:98.03% - 99.61%Colore e forma:SolidPeso molecolare:560.64Ref: TM-T3678
2mg42,00€5mg59,00€10mg88,00€25mg111,00€50mg168,00€100mg283,00€500mg692,00€1mL*10mM (DMSO)69,00€Quercetin
CAS:Quercetin (Sophoretin) is a natural flavonoid and is an agonist of SIRT1.Formula:C15H10O7Purezza:96.29% - 98.05%Colore e forma:Sensitive To Exposure To Air And Light Insoluble In Water Alcoholic Solutions Taste Very Bitter (Ntp 1992)Peso molecolare:302.24Dronedarone
CAS:Dronedarone (SR 33589) is an amiodarone analogue which has an effective and promising treatment for Atrial fibrillation.Formula:C31H44N2O5SPurezza:98.85% - 99.99%Colore e forma:SolidPeso molecolare:556.76PF-04457845
CAS:PF-04457845 is a greatly and effctive FAAH inhibitor, and for hFAAH(IC50=7.2±0.63 nM) and rFAAH(IC50=7.4±0.62 nM).Formula:C23H20F3N5O2Purezza:>99.99%Colore e forma:SolidPeso molecolare:455.43Ref: TM-T4323
2mg34,00€5mg50,00€10mg84,00€25mg155,00€50mg222,00€100mg396,00€200mg515,00€1mL*10mM (DMSO)55,00€MRT68921
CAS:MRT68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively.Formula:C25H34N6OPurezza:99.23%Colore e forma:SolidPeso molecolare:434.58KU-55933
CAS:KU-55933 (ATM Kinase Inhibitor) is an ATM inhibitor that is selective and ATP-competitive. KU-55933 has antitumor effects. Cost-effective and quality-assured.
Formula:C21H17NO3S2Purezza:97.21% - >99.99%Colore e forma:SolidPeso molecolare:395.49CGI-1746
CAS:CGI1746 is a potent and highly selective small-molecule Btk inhibitor with IC50 of 1.9 nM.Formula:C34H37N5O4Purezza:97.69% - 97.88%Colore e forma:SolidPeso molecolare:579.69Tolvaptan
CAS:Tolvaptan (OPC-41061) is an orally bioavailable, selective, arginine vasopressin receptor 2 (V2, AVPR2) antagonist that can be used to treat hyponatremia.
Formula:C26H25ClN2O3Purezza:99.78% - >99.99%Colore e forma:SolidPeso molecolare:448.94Telaglenastat hydrochloride
CAS:Telaglenastat (CB-839) HCl: First-in-class, oral GLS1 inhibitor, targets KGA/GAC, IC50 23-28 nM, triggers autophagy, anticancer.Formula:C26H25ClF3N7O3SColore e forma:SolidPeso molecolare:608.04SBE13
CAS:SBE13 is a selective and potent inhibitor of Plk1 (IC50: 200 pM). SBE13 has a weak effect on Plk2 or Plk3 with IC50 values of >66 μM and 875 nM respectively.Formula:C24H27ClN2O4Colore e forma:SolidPeso molecolare:442.94Biochanin A
CAS:Biochanin A: an isoflavone from red clover with anticancer properties and inhibits FAAH.Formula:C16H12O5Purezza:97.1% - 98.97%Colore e forma:SolidPeso molecolare:284.26Nur77 modulator 1
CAS:Nur77 modulator 1: binds at 3.58 μM, boosts expression, alters location, triggers ER stress/autophagy, induces apoptosis, and fights hepatoma.Formula:C28H25N5O2SPurezza:99.62%Colore e forma:SolidPeso molecolare:495.6Ref: TM-T40130
1mg64,00€5mg140,00€10mg226,00€25mg373,00€50mg509,00€100mg702,00€200mg944,00€1mL*10mM (DMSO)153,00€KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFormula:C19H17Cl2N3O2SPurezza:98.86%Colore e forma:SolidPeso molecolare:422.33Pirarubicin HCl
CAS:Pirarubicin HCl, a less cardiotoxic doxorubicin analogue, hinders DNA replication and repairs by intercalating into DNA and inhibiting topoisomerase II.Formula:C32H38ClNO12Colore e forma:SolidPeso molecolare:664.1Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Formula:C14H18ClN3O2SPurezza:99.54% - ≥95%Colore e forma:White SolidPeso molecolare:327.83NUCC-390 dihydrochloride
CAS:NUCC-390, a selective CXCR4 agonist, promotes nerve repair by inducing CXCR4 internalization, opposite to AMD3100.Formula:C23H35Cl2N5OColore e forma:SolidPeso molecolare:468.46Venetoclax
CAS:Venetoclax (ABT-199) is a selective inhibitor of Bcl-2 (Ki < 0.010 nM), binding over 3 orders of magnitude less avidly to Bcl-xL, and Bcl-W (Kis = 48/245 nM).Formula:C45H50ClN7O7SPurezza:98.00% - 99.97%Colore e forma:SolidPeso molecolare:868.44EIPA
CAS:EIPA (L593754) is a TRPP3 channel inhibitor and an inhibitor of Na+/H+ exchange (NHE). EIPA inhibits megacytosis, promotes autophagy. Cost-effective and quality-assured.Formula:C11H18ClN7OPurezza:96.62% - 99.981%Colore e forma:Off-White To Yellow SolidPeso molecolare:299.76Ref: TM-TQ0157
2mg35,00€5mg49,00€10mg74,00€25mg106,00€50mg172,00€100mg245,00€200mg360,00€1mL*10mM (DMSO)50,00€Troglitazone
CAS:Troglitazone (Romglizone) is a PPARγ agonist with anti-inflammatory and anti-tumor activity.Formula:C24H27NO5SPurezza:98% - 99.8%Colore e forma:Yellow SolidPeso molecolare:441.54Ref: TM-T3170
2mg42,00€5mg62,00€10mg88,00€25mg172,00€50mg305,00€100mg558,00€500mg1.169,00€1mL*10mM (DMSO)85,00€Glyphosate
CAS:Glyphosate (Atila) is an herbicide. It also is a possible carcinogen to humans.Formula:C3H8NO5PPurezza:99.12% - 99.91%Colore e forma:White Crystals (Darkens) Ph (1% Solution In Water) 2 5 (Ntp 1992)Peso molecolare:169.07GNE-7915 tosylate
CAS:GNE-7915 tosylate is a potent, selective, and brain-penetrant LRRK2 inhibitor, boasting an IC50 value of 9 nM.Formula:C26H29F4N5O6SColore e forma:SolidPeso molecolare:615.6Lapatinib tosylate
CAS:Lapatinib tosylate (GW572016) is an oral ErbB-2/EGFR inhibitor with IC50s of 10.2 nM (EGFR) & 9.8 nM (ErbB-2).Formula:C36H34ClFN4O7S2Colore e forma:SolidPeso molecolare:753.26FIPI HCl
CAS:FIPI: Selective phospholipase D inhibitor, blocks mercury-induced lipid signals, protects aortic cells.Formula:C23H25ClFN5O2Colore e forma:SolidPeso molecolare:457.93Fasudil hydrochloride hydrate
CAS:Fasudil HCl hydrate is a ROCK inhibitor that hinders mature CCM development and lowers portal pressure in cirrhotic rats.Formula:C28H38Cl2N6O5S2Colore e forma:SolidPeso molecolare:673.67Retro-2
CAS:Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, it protects HeLa cells against Ricin, Stx1 and Stx2.
Formula:C19H16N2OSPurezza:98.15%Colore e forma:SolidPeso molecolare:320.41PHA-665752
CAS:PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.Formula:C32H34Cl2N4O4SPurezza:97.05% - 98.82%Colore e forma:SolidPeso molecolare:641.61Tacrolimus monohydrate
CAS:Tacrolimus monohydrate (LCP-Tacro) is a macrolide from the culture broth of a strain of Streptomyces tsukubaensis, binds to FKBP to form a complex.Formula:C44H71NO13Purezza:97.07% - 98.05%Colore e forma:SolidPeso molecolare:822.05Dorsomorphin
CAS:Dorsomorphin (BML-275) is an AMPK inhibitor (Ki=109 nM) that is selective and ATP-competitive.Formula:C24H25N5OPurezza:98% - 99.06%Colore e forma:SolidPeso molecolare:399.49Glucosamine sulfate
CAS:Glucosamine sulfate (D-Glucosaminesulfate) was extracted from synthetic product;Store the product in sealed, cool and dry condition.Formula:C6H13NO5·H2SO4Purezza:99.64%Colore e forma:White CrystalPeso molecolare:277.25Lucanthone hydrochloride
CAS:Lucanthone hydrochloride is a novel acridine derivative which supresses autophagic degradation and triggers apoptosis in colon cancer cells.Formula:C20H25ClN2OSColore e forma:SolidPeso molecolare:376.94Cucurbitacin E
CAS:Cucurbitacin E, from Cucumic melo, inhibits cyclin B1/CDC2, and has neuroprotective, anti-proliferative, anti-cancer, and pain relief properties.Formula:C32H44O8Purezza:98.88% - 99.87%Colore e forma:SolidPeso molecolare:556.69Ref: TM-T5S1467
1mg56,00€5mg109,00€10mg168,00€25mg284,00€50mg423,00€100mg610,00€1mL*10mM (DMSO)133,00€Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formula:C25H30N6O3Purezza:97.08% - 99.06%Colore e forma:SolidPeso molecolare:462.54Ref: TM-T1961
1mg37,00€5mg74,00€10mg117,00€25mg173,00€50mg236,00€100mg378,00€200mg558,00€1mL*10mM (DMSO)84,00€Paris saponin VII
CAS:Paris saponin VII (Dioscini) shows inhibitory effects on cell proliferation.
Formula:C51H82O21Purezza:99.51% - 99.63%Colore e forma:SolidPeso molecolare:1031.18DBEQ
CAS:DBEQ (JRF 12) is a selective, potent, reversible, and ATP-competitive p97 inhibitor.Formula:C22H20N4Purezza:98.93% - ≥95%Colore e forma:SolidPeso molecolare:340.42Ref: TM-T1969
2mg34,00€5mg52,00€10mg85,00€25mg152,00€50mg264,00€100mg334,00€200mg494,00€1mL*10mM (DMSO)52,00€UBCS039
CAS:UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)Formula:C16H13N3Purezza:98.31%Colore e forma:SolidPeso molecolare:247.29Ref: TM-T7679
1mg38,00€5mg77,00€10mg110,00€25mg215,00€50mg306,00€100mg429,00€200mg600,00€1mL*10mM (DMSO)95,00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Formula:C15H9FN2O3Purezza:99.16% - 99.84%Colore e forma:SolidPeso molecolare:284.24Ref: TM-T1805
5mg35,00€10mg54,00€25mg88,00€50mg117,00€100mg178,00€200mg213,00€500mg359,00€1mL*10mM (DMSO)46,00€SRT 1720
CAS:SRT 1720 is a selective activator of human SIRT1 (EC1.5: 0.16 μM) and is >230-fold less potent for SIRT2 and SIRT3.Formula:C25H23N7OSPurezza:98.84%Colore e forma:SolidPeso molecolare:469.56BAY 11-7082
CAS:BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that inhibits TNFα-induced IκBα phosphorylation (IC50=10 μM).Formula:C10H9NO2SPurezza:98% - 99.92%Colore e forma:SolidPeso molecolare:207.25Ref: TM-T1902
5mg50,00€10mg57,00€25mg96,00€50mg170,00€100mg265,00€200mg399,00€500mg662,00€1mL*10mM (DMSO)52,00€L-779450
CAS:L-779450, an effective, ATP-competitive Raf kinase inhibitor (IC50: 10 nM) , displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively.Formula:C20H14ClN3OPurezza:≥95%Colore e forma:SolidPeso molecolare:347.8Gemcitabine hydrochloride
CAS:Gemcitabine hydrochloride (LY 188011 hydrochloride) is a synthetic cytosine nucleoside derivative and an inhibitor of DNA synthesis.Formula:C9H11F2N3O4·HClPurezza:99.28% - 99.98%Colore e forma:White Crystalline Granular OdorlessPeso molecolare:299.66BL-918
CAS:BL-918 is a potent activator of UNC-51-like kinase 1 (ULK1) with an EC50 of 24.14 nM.Formula:C23H15F8N3OSPurezza:99.4% - 99.89%Colore e forma:SolidPeso molecolare:533.44Ref: TM-T8322
1mg50,00€2mg66,00€5mg99,00€10mg147,00€25mg269,00€50mg432,00€100mg708,00€500mg1.423,00€1mL*10mM (DMSO)120,00€TPEN
CAS:TPEN (TPEDA) is a specific cell-permeable heavy metal chelator.Formula:C26H28N6Purezza:98% - 99.72%Colore e forma:White Crystalline PowderPeso molecolare:424.54RSVA405
CAS:RSVA405 is an AMPK activator (EC50 = 1 μM), and is STAT3 inhibitorFormula:C17H20N4O2Purezza:99.30%Colore e forma:SolidPeso molecolare:312.37Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purezza:99.04% - >99.99%Colore e forma:SolidPeso molecolare:228.2Cryptotanshinone
CAS:Cryptotanshinone: STAT3 inhibitor, IC50 4.6 μM; blocks STAT3 Tyr705 phosphorylation, minor effect on Ser727, no impact on STAT1/5.Formula:C19H20O3Purezza:97.94% - ≥95%Colore e forma:Orange Needle CrystalPeso molecolare:296.36Idarubicin hydrochloride
CAS:Idarubicin hydrochloride (Zavedos), a hydrochloride salt form of Idarubicin, is a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells ( IC50: 3.3 ng/mL).Formula:C26H27NO9·HClPurezza:98.91% - 99.96%Colore e forma:SolidPeso molecolare:533.95
