Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1490 prodotti di "Autofagia"
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trifarotene
CAS:<p>Trifarotene (CD5789) is a RARγ agonist, 65x more selective than RARα and 16x than RARβ, with EC50 of 7.7 nM.</p>Formula:C29H33NO4Purezza:99.51%Colore e forma:SolidPeso molecolare:459.58Melatonin
CAS:<p>Melatonin (Melatonine) is a natural hormone that activates melatonin receptors. Melatonin regulates the biological clock. Cost-effective and quality-assured.</p>Formula:C13H16N2O2Purezza:98% - 99.89%Colore e forma:Pale Yellow Leaflets From Benzene SolidPeso molecolare:232.28Peiminine
CAS:<p>1. Peiminine (Raddeanine) is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury.</p>Formula:C27H43NO3Purezza:99.52% - ≥95%Colore e forma:White PowderPeso molecolare:429.64Ridaforolimus
CAS:<p>Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。</p>Formula:C53H84NO14PPurezza:90.00% - 98.55%Colore e forma:Off-White SolidPeso molecolare:990.21Oroxylin A
CAS:Oroxylin A fights tumors, aids RAS therapy, promotes CaCo-2 cell apoptosis, blocks MCF-7 cell invasion and enhances leukemia treatment.Formula:C16H12O5Purezza:98.72% - 99.55%Colore e forma:SolidPeso molecolare:284.26Ref: TM-T6S1315
1mg39,00€5mg74,00€10mg96,00€25mg156,00€50mg220,00€100mg325,00€200mg472,00€1mL*10mM (DMSO)88,00€SBI-0640756
CAS:SBI-0640756 (SBI-756) (SBI-756) is a first-in-class inhibitor that targets eIF4G1 and disrupts the eIF4F complex.Formula:C23H14ClFN2O2Purezza:99.75%Colore e forma:SolidPeso molecolare:404.82Enzalutamide
CAS:Enzalutamide (MDV3100) is an androgen receptor (AR) antagonist (IC50=36 nM in LNCaP).Formula:C21H16F4N4O2SPurezza:99% - 99.93%Colore e forma:SolidPeso molecolare:464.44Ref: TM-T6002
5mg48,00€10mg56,00€25mg74,00€50mg96,00€100mg154,00€200mg187,00€500mg274,00€1mL*10mM (DMSO)52,00€Arctigenin
CAS:(-)-Arctigenin ((-)-Arctigenin) is found in burdock.Formula:C21H24O6Purezza:98% - 99.51%Colore e forma:SolidPeso molecolare:372.41PRIMA-1
CAS:PRIMA-1 (NSC-281668) is a mutant p53 reactivator. It induces apoptosis and inhibits growth of human tumors with mutant p53.Formula:C9H15NO3Purezza:99.22%Colore e forma:SolidPeso molecolare:185.22Ref: TM-T6954
5mg51,00€10mg73,00€25mg140,00€50mg207,00€100mg368,00€200mg547,00€500mg877,00€1mL*10mM (DMSO)57,00€Fexaramine
CAS:Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity compared to natural compounds.Formula:C32H36N2O3Purezza:98.87% - 99.61%Colore e forma:SolidPeso molecolare:496.64GSK2656157
CAS:GSK2656157 is a highly specific and ATP-competitive PERK inhibitor (IC50: 0.9 nM) in a cell-free assay.Formula:C23H21FN6OPurezza:98.59% - >99.99%Colore e forma:SolidPeso molecolare:416.45Ref: TM-T2654
2mg35,00€5mg50,00€10mg81,00€25mg142,00€50mg259,00€100mg467,00€200mg632,00€1mL*10mM (DMSO)56,00€PD-166866
CAS:PD-166866 is a selective FGFR tyrosine kinase inhibitor.Formula:C20H24N6O3Purezza:98.29%Colore e forma:SolidPeso molecolare:396.44ICCB-19 hydrochloride
CAS:ICCB-19 hydrochloride (ICCB-19 HCl) is an inhibitor of TRADD (TNFRSF1A Associated Via Death Domain). It binds to a pocket on the TRADD-N.Formula:C12H22ClN3OSPurezza:99.3%Colore e forma:SolidPeso molecolare:291.84Ref: TM-T8931L
5mg35,00€10mg52,00€25mg96,00€50mg145,00€100mg210,00€200mg313,00€500mg495,00€1mL*10mM (DMSO)35,00€Pictilisib
CAS:Pictilisib (GDC-0941) (GDC-0941) is a potent pan inhibitor of class I catalytic subunits of PI3K (IC50s: 3/33/3/75 nM for p110α/β/δ/γ).Formula:C23H27N7O3S2Purezza:98.69% - 99.97%Colore e forma:SolidPeso molecolare:513.64SF1670
CAS:SF1670 (PTPase CD45 Inhibitor) is a specific PTEN inhibitor with IC50 of 2 μM.Formula:C19H17NO3Purezza:98.25% - 98.54%Colore e forma:SolidPeso molecolare:307.34Ref: TM-T6667
1mg44,00€2mg55,00€5mg88,00€10mg125,00€25mg273,00€50mg500,00€100mg740,00€1mL*10mM (DMSO)97,00€Thiamet G
CAS:Thiamet G is a selective O-GlcNAcase inhibitor (Ki=20 nM). The role of O-GlcNAcase is to remove O-GlcNAc from the modified protein. High-Quality, Low-Cost!Formula:C9H16N2O4SPurezza:99.06% - 99.98%Colore e forma:SolidPeso molecolare:248.3Ref: TM-T6056
2mg44,00€5mg63,00€10mg93,00€25mg188,00€50mg343,00€100mg510,00€500mg1.130,00€1mL*10mM (DMSO)63,00€Forskolin
CAS:Forskolin (Coleonol) is a natural product, an adenylate cyclase activator (EC50=0.5 μM).Formula:C22H34O7Purezza:98.83% - 99.96%Colore e forma:Less Crystalline Solid Colorless Crystalline SolidPeso molecolare:410.50Ref: TM-T2939
5mg43,00€10mg56,00€25mg86,00€50mg96,00€100mg144,00€200mg182,00€500mg306,00€1mL*10mM (DMSO)56,00€6-Thioguanine
CAS:6-Thioguanine (2-Amino-6-purinethiol) is an antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.Formula:C5H5N5SPurezza:98.75% - >99.99%Colore e forma:Odorless Or Almost Odorless Pale Yellow Crystalline PowderPeso molecolare:167.19Calcineurin substrate acetate
Calcineurin substrate acetate is from the regulatory RII subunit of cAMP-dependent protein kinase.Formula:C94H154N28O31Purezza:97.59%Colore e forma:SolidPeso molecolare:2172.4Cinobufagin
CAS:<p>Cinobufagin (Cinobufagine) is a selective Na+/K+-ATPase inhibitor. The activity of Cinobufagin is same as ouabain.</p>Formula:C26H34O6Purezza:97.77% - 99.97%Colore e forma:SolidPeso molecolare:442.54Fludrocortisone acetate
CAS:Fludrocortisone acetate (9α-Fludrocortisone acetate) , a glucocorticoid-receptor agonist, binds to cytoplasmic receptors, translocates to the nucleus, andFormula:C23H31FO6Purezza:96.92% - 98.03%Colore e forma:Crystalline SolidPeso molecolare:422.49Vinblastine sulfate
CAS:Vinblastine sulfate (Vincaleukoblastine sulfate salt) can inhibit the formation of microtubule, it also inhibits nAChR(IC50=8.9 uM).Formula:C46H58N4O9·H2SO4Purezza:97.81% - 99.82%Colore e forma:White PowderPeso molecolare:909.06Tacrolimus
CAS:<p>Tacrolimus (Fujimycin) can bind FKBP12 to form a high-affinity complex (Ki: 0.2 nM) which inhibits the activity of the calcium/calmodulin-dependent protein</p>Formula:C44H69NO12Purezza:98% - 99.94%Colore e forma:White Or Off-White Crystalline PowderPeso molecolare:804.02Glycycoumarin
CAS:Glycycoumarin is an estrogen agonist, it shows moderate inhibitory effects against CYP1A2 and CYP2B6.Formula:C21H20O6Purezza:97.64% - 99.78%Colore e forma:SolidPeso molecolare:368.38Ref: TM-TN1702
1mg42,00€5mg81,00€10mg122,00€25mg235,00€50mg348,00€100mg515,00€200mg743,00€1mL*10mM (DMSO)89,00€PTC-209
CAS:PTC-209 is a potent and selective BMI-1 inhibitor.Formula:C17H13Br2N5OSPurezza:99.43% - 99.887%Colore e forma:SolidPeso molecolare:495.19S29434
CAS:S29434 (NMDPEF) is a potent, competitiveinhibitor of quinone reductase 2 (QR2;IC50:5-16nM).Formula:C21H18N4O3Purezza:99.92%Colore e forma:SolidPeso molecolare:374.39PH-797804
CAS:PH-797804 is a pyridinone inhibitor of p38α (IC50: 26 nM, in a cell-free assay); 4-fold more selective versus p38β and does not inhibit JNK2.Formula:C22H19BrF2N2O3Purezza:97.90% - 98.27%Colore e forma:SolidPeso molecolare:477.3Ref: TM-T1974
1mg46,00€5mg94,00€10mg144,00€25mg255,00€50mg406,00€100mg628,00€500mg1.320,00€1mL*10mM (DMSO)97,00€Isradipine
CAS:Isradipine (PN 200-110), a dihydropyridine, is an antihypertensive calcium channel blocker that dilates arteries and reduces resistance.Formula:C19H21N3O5Purezza:99.84% - 99.95%Colore e forma:Yellow SolidPeso molecolare:371.39AM580
CAS:AM580 (CD336) is a retinoic acid receptor agonist that is selective for RARα( IC50 : 8 nM )Formula:C22H25NO3Purezza:98% - 99.84%Colore e forma:SolidPeso molecolare:351.44Ref: TM-T5854
2mg39,00€5mg57,00€10mg87,00€25mg164,00€50mg316,00€100mg469,00€500mg1.064,00€1mL*10mM (DMSO)64,00€Bakuchiol
CAS:Bakuchiol: anti-tumor, anti-helminthic, DNA polymerase1 inhibitor, cytotoxic, and anti-bacterial, may prevent dental caries.Formula:C18H24OPurezza:98.04% - 99.05%Colore e forma:Brownish Yellow Liquid ViscousPeso molecolare:256.38IKK 16
CAS:IKK 16 (IKK Inhibitor VII) is a selective IκB kinase (IKK) inhibitor for IKK-2, IKK complex and IKK-1 with IC50 of 40 nM, 70 nM and 200 nM, respectively.Formula:C28H29N5OSPurezza:98.76% - 99.61%Colore e forma:SolidPeso molecolare:483.63Ref: TM-T6176
1mg40,00€2mg52,00€5mg88,00€10mg139,00€25mg245,00€50mg406,00€100mg582,00€200mg825,00€1mL*10mM (DMSO)87,00€NL-1
CAS:NL-1 is a mitoNEET inhibitor with antileukemic effect.Formula:C18H25NO3SPurezza:98.64%Colore e forma:SolidPeso molecolare:335.46JH-II-127
CAS:JH-II-127 is an oral LRRK2 inhibitor with IC50s: 6.6 nM (WT), 2.2 nM (G2019S), 47.7 nM (A2016T).Formula:C19H21ClN6O3Purezza:98.32%Colore e forma:SolidPeso molecolare:416.86Ref: TM-T7155
2mg46,00€5mg70,00€10mg101,00€25mg170,00€50mg273,00€100mg386,00€200mg550,00€1mL*10mM (DMSO)77,00€Ruxolitinib
CAS:<p>Ruxolitinib (INCB018424) is a JAK1/2 inhibitor (IC50=3.3/2.8 nM) that is potent and selective.</p>Formula:C17H18N6Purezza:99.4% - >99.99%Colore e forma:SolidPeso molecolare:306.36Silibinin
CAS:Silibinin, main component in milk thistle, offers liver protection and shows anti-cancer potential in various human cells.Formula:C25H22O10Purezza:97.98% - 98.37%Colore e forma:SolidPeso molecolare:482.44Tozasertib
CAS:Tozasertib (MK-0457) is a pan-Aurora kinase inhibitor (Kis: 0.6/18/4.6 nM for Aurora A/Aurora B/Aurora C).Formula:C23H28N8OSPurezza:99.99%Colore e forma:SolidPeso molecolare:464.59Regorafenib Hydrochloride
CAS:Regorafenib HCl (BAY73-4506) is an oral inhibitor targeting angiogenic, stromal, and cancer kinases with strong antitumor effects.Formula:C21H16Cl2F4N4O3Purezza:99.56%Colore e forma:SolidPeso molecolare:519.28Aloe emodin
CAS:Aloe emodin (Rhabarberone) is an interferon-inducing agent, for JEV （IC50=1 μg/mL） and EV71（IC50=0.33 μg/mL ）.Formula:C15H10O5Purezza:97.00% - 99.61%Colore e forma:Orange SolidPeso molecolare:270.24GSK343
CAS:GSK343, a specific and effective EZH2 inhibitor (IC50=4 nM), exhibits 60 fold specificity activity against EZH1, and >1000 fold specificity activity againstFormula:C31H39N7O2Purezza:98% - 99.9%Colore e forma:SolidPeso molecolare:541.69LYN-1604 dihydrochloride
CAS:LYN-1604 is a novel ULK1 activator.It inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.Formula:C33H45Cl4N3O2Purezza:98.95% - 99.92%Colore e forma:SolidPeso molecolare:657.54Ref: TM-T8808L
1mg35,00€5mg78,00€10mg117,00€25mg212,00€50mg316,00€100mg447,00€200mg628,00€1mL*10mM (DMSO)101,00€OSU-T315
CAS:OSU-T315 (OSU-T315 (1,5-regioisomer)) (1,5-regioisomer) is a ILK inhibitor.Formula:C30H30F3N5OPurezza:98.69%Colore e forma:SolidPeso molecolare:533.59Ref: TM-T5485
1mg88,00€5mg187,00€10mg298,00€25mg533,00€50mg755,00€100mg1.008,00€200mg1.359,00€1mL*10mM (DMSO)220,00€Ixazomib
CAS:Ixazomib (MLN2238) is a boron-based peptide proteasome inhibitor targeting β5 site (IC50: 3.4 nM), also affecting β1 and β2 sites.Formula:C14H19BCl2N2O4Purezza:98% - 99.77%Colore e forma:SolidPeso molecolare:361.03SBE13 Hydrochloride
CAS:SBE13 Hydrochloride (SBE 13 HCl) is an effective and specific PLK1 inhibitor (IC50: 0.2 nM); no inhibition om Aurora A kinase, Plk2/3.Formula:C24H28Cl2N2O4Purezza:99.00% - ≥95%Colore e forma:SolidPeso molecolare:479.4Oxyphenisatin acetate
CAS:Oxyphenisatin acetate inhibits the growth of the breast cancer cell lines MCF7, T47D, HS578T, and MDA-MB-468.Formula:C24H19NO5Purezza:98% - 99.35%Colore e forma:SolidPeso molecolare:401.41Tenovin-6 Hydrochloride
CAS:Tenovin-6 HCl: Inhibits SIRT1 (21µM), SIRT2 (10µM), HDAC8; potent p53 activator.Formula:C25H35ClN4O2SPurezza:99.36%Colore e forma:SolidPeso molecolare:491.09Ref: TM-T8480
1mg39,00€2mg51,00€5mg70,00€10mg88,00€25mg140,00€50mg226,00€100mg376,00€1mL*10mM (DMSO)73,00€YM-201636
CAS:YM201636 (IC50=33 nM), a specific PIKfyve inhibitor, is less effective to p110α and insensitive to Fabl, which is yeast orthologue.Formula:C25H21N7O3Purezza:93.28% - 98.3%Colore e forma:SolidPeso molecolare:467.48Ref: TM-T6110
1mg48,00€2mg64,00€5mg96,00€10mg173,00€25mg359,00€50mg562,00€100mg802,00€500mg1.644,00€1mL*10mM (DMSO)97,00€Doramapimod
CAS:Doramapimod (BIRB 796) is a highly potent inhibitor of p38 MAPK (Kd: 0.1 nM), but weakly inhibits c-RAF, Fyn, Lck, ERK-1, SYK, IKK2, and ZAP-70.Formula:C31H37N5O3Purezza:97.14% - 98.80%Colore e forma:SolidPeso molecolare:527.66Ref: TM-T6277
1g532,00€5mg34,00€10mg52,00€25mg74,00€50mg96,00€100mg120,00€200mg213,00€500mg359,00€1mL*10mM (DMSO)42,00€Veliparib dihydrochloride
CAS:Veliparib dihydrochloride (ABT-888 dihydrochloride) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays, respectively.Formula:C13H18Cl2N4OPurezza:98% - 99.81%Colore e forma:SolidPeso molecolare:317.21Ambroxol hydrochloride
CAS:Ambroxol hydrochloride (Mucosolvan) is a metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract.Formula:C13H18Br2N2O·HClPurezza:99.70%Colore e forma:White To Yellowish Crystalline PowderPeso molecolare:414.56
