Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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FMK 9a
CAS:FMK 9a is an irreversible inhibitor of ATG4B with IC50 values of 80 and 73 nM in the TR-FRET and cellular-based LRA assays.Formula:C23H21FN2O3Purezza:98.97%Colore e forma:SolidPeso molecolare:392.42Ref: TM-T15303
1mg111,00€5mg274,00€10mg406,00€25mg655,00€50mg929,00€100mg1.216,00€200mg1.673,00€1mL*10mM (DMSO)284,00€Dactolisib Tosylate
CAS:Dactolisib Tosylate (BEZ235 Tosylate) is a dual kinase inhibitor that targets PI3K and mTOR.Formula:C37H31N5O4SPurezza:99.91%Colore e forma:SolidPeso molecolare:641.74ITX5061
CAS:ITX5061 is a type II inhibitor of p38 MAPK and scavenger receptor B1 (SRB1) antagonist for the study of hepatitis C virus infection.Formula:C30H38ClN3O7SPurezza:98.35%Colore e forma:SolidPeso molecolare:620.16Ref: TM-T15603
1mg202,00€5mg512,00€10mg753,00€25mg1.264,00€50mg1.786,00€100mg2.375,00€1mL*10mM (DMSO)677,00€Cytarabine hydrochloride
CAS:Cytarabine hydrochloride (Ara-C hydrochloride) is a nucleoside analog that causes S phase cell cycle arrest and inhibits DNA polymerase.
Formula:C9H14ClN3O5Purezza:98.46%Colore e forma:White PowderPeso molecolare:279.68Elubrixin
CAS:Elubrixin (SB-656933) inhibits neutrophil CD11b upregulation (IC50 of 260.7 nM) and shape change (IC50 of 310.5 nM).Formula:C17H17Cl2FN4O4SPurezza:98.65% - 99.78%Colore e forma:SolidPeso molecolare:463.31Ref: TM-T11179
1mg115,00€5mg249,00€10mg369,00€25mg562,00€50mg787,00€100mg1.054,00€200mg1.406,00€1mL*10mM (DMSO)266,00€LRRK2-IN-7
CAS:LRRK2-IN-7: potent, selective CNS-active LRRK2 inhibitor, IC50 0.9 nM, >1000x selectivity vs kinases/channels/CYPs.Formula:C24H26N6OPurezza:99.26%Colore e forma:SolidPeso molecolare:414.5NUCC-390
CAS:NUCC-390, a novel small-molecule CXCR4 receptor agonist, selectively induces CXCR4 receptor internalization while acting antagonistically to AMD3100.Formula:C23H33N5OPurezza:97.08%Colore e forma:SolidPeso molecolare:395.54Ref: TM-T12269
1mg115,00€5mg274,00€10mg432,00€25mg772,00€50mg1.074,00€100mg1.444,00€200mg1.882,00€1mL*10mM (DMSO)283,00€MAPK13-IN-1
CAS:MAPK13-IN-1 is a potent MAPK13 (p38δ) inhibitor (IC50: 620 nM).Formula:C20H23N5O2Purezza:99.62%Colore e forma:SolidPeso molecolare:365.43Ref: TM-T11943
1mg94,00€2mg137,00€5mg222,00€10mg334,00€25mg578,00€50mg838,00€100mg1.224,00€500mg2.448,00€1mL*10mM (DMSO)245,00€CP-312
CAS:CP-312 activates antioxidant defense, induces HMOX1, and shields human iPSC-derived cardiomyocytes from oxidative stress.Formula:C16H12ClN3OS2Purezza:99.89%Colore e forma:SolidPeso molecolare:361.87Apostatin-1
CAS:Apostatin-1 (Apt-1) is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.Formula:C19H27N3OSPurezza:99.31%Colore e forma:SolidPeso molecolare:345.5Ref: TM-T9079
1mg34,00€2mg49,00€5mg74,00€10mg113,00€25mg222,00€50mg358,00€100mg530,00€500mg1.153,00€1mL*10mM (DMSO)82,00€AZD8309
CAS:AZD8309 is an oral CXCR2 antagonist, curbing neutrophil movement, lowering MPO in lungs/pancreas, and trypsin/elastase activity.
Formula:C15H14F2N4O2S2Purezza:98.35% - 99.67%Colore e forma:SolidPeso molecolare:384.42Atg4B-IN-2
CAS:Atg4B-IN-2 is an Atg4B inhibitor with anticancer activity that inhibits Atg4B and PLA2 and resists the anticancer activity of resistant prostate cancer drugs.Formula:C21H30O3Purezza:98.86%Colore e forma:SolidPeso molecolare:330.46XRK3F2
CAS:XRK3F2 inhibits p62-ZZ, counters MM's Runx2 suppression in vitro, and prompts bone growth and remodeling in vivo with tumors.Formula:C23H24ClF2NO3Purezza:98.91% - 99.12%Colore e forma:SolidPeso molecolare:435.89Mavorixafor
CAS:Mavorixafor (AMD-070) is an effective and selective antagonist of CXCR4, with an IC50 value of 13 nM against CXCR4 125I-SDF binding.
Formula:C21H27N5Purezza:98.56%Colore e forma:SolidPeso molecolare:349.47Acetazolamide sodium
CAS:Acetazolamide sodium (OT-302 sodium) is a potent carbonic anhydrase (CA) IX inhibitor used for indications such as epilepsy and altitude sickness.Formula:C4H5N4NaO3S2Purezza:99.71% - 99.87%Colore e forma:SolidPeso molecolare:244.23AZD8797
CAS:AZD8797 (KAND567) is a CX3CR1 antagonist with potential protective effects against neuronal damage and prevents nociceptive hypersensitivity in rats.Formula:C19H25N5OS2Purezza:98.73% - 99.68%Colore e forma:SolidPeso molecolare:403.56Ref: TM-T14384
1mg80,00€5mg170,00€10mg253,00€25mg442,00€50mg620,00€100mg845,00€1mL*10mM (DMSO)187,00€AC-73
CAS:AC-73, an oral CD147 inhibitor, blocks ERK1/2/STAT3/MMP-2 pathway, reducing liver cancer progression and leukemia cell growth.Formula:C21H21NO2Purezza:99.36%Colore e forma:SolidPeso molecolare:319.4Ref: TM-T14091
1mg50,00€5mg92,00€10mg170,00€25mg289,00€50mg487,00€100mg862,00€500mg1.728,00€1mL*10mM (DMSO)103,00€Cysmethynil
CAS:Cysmethynil is an indole-based Icmt inhibitor with antitumor activity, induces cell cycle arrest in G1 phase, and can be used for the study of solid tumors.Formula:C25H32N2OPurezza:99%Colore e forma:SolidPeso molecolare:376.53Ref: TM-T36082
1mg47,00€2mg60,00€5mg87,00€10mg140,00€25mg274,00€50mg439,00€100mg707,00€500mg1.415,00€Cosalane
CAS:Cosalane (NSC 658586) is an HIV replication inhibitor and an inhibitor of chemokine receptor 7 (CCR7) signalling in humans and mice.Formula:C45H60Cl2O6Purezza:99.53% - 99.78%Colore e forma:SolidPeso molecolare:767.86MTK458
CAS:MTK458 (EP-0035985) is a PINK1 activator with antidepressant activity for the study of Parkinson;s disease.
Formula:C17H15F3N4Purezza:98.36%Colore e forma:SolidPeso molecolare:332.32IT1t dihydrochloride
CAS:IT1t dihydrochloride inhibits CXCL12/CXCR4 interaction with IC50 of 2.1 nM. IT1t dihydrochloride is an antagonist of CXCR4.Formula:C21H36Cl2N4S2Purezza:99.91%Colore e forma:SolidPeso molecolare:479.57Ref: TM-T11693L
2mg35,00€5mg52,00€10mg96,00€25mg170,00€50mg305,00€100mg444,00€200mg615,00€1mL*10mM (DMSO)59,00€XIE62-1004
CAS:XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62.Formula:C23H25NO3·HClColore e forma:SolidPeso molecolare:399.91Butylate
CAS:Butylate is a herbicide of thiocarbamate.Formula:C11H23NOSColore e forma:Less Liquid Which Darkens Upon Exposure To Light Air And Moisture Colorless Liquid Which Darkens Upon Exposure To Light Air And MoisturePeso molecolare:217.37NUCC-390 dihydrochloride (1060524-97-1 free base)
NUCC-390 dihydrochloride is selective agonist of small-molecule CXCR4 receptor.Formula:C23H35Cl2N5OPurezza:98%Colore e forma:SolidPeso molecolare:468.46Calmidazolium chloride
CAS:Calmidazolium chloride blocks calmodulin, hinders phosphodiesterase (IC50=0.15µM), Ca2+-ATPase (IC50=0.35µM), and can induce cancer cell apoptosis.Formula:C31H23Cl7N2OPurezza:98.53%Colore e forma:SolidPeso molecolare:687.7Ref: TM-T10667
5mg63,00€10mg87,00€25mg145,00€50mg215,00€100mg320,00€200mg467,00€1mL*10mM (DMSO)95,00€(3R,5R)-Rosuvastatin
CAS:(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor (IC50: 11 nM).Formula:C22H28FN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:481.54SLLN-15
CAS:SLLN-15: oral, potent autophagy enhancer; targets macroautophagy in TNBC.Formula:C19H23N7Se2Purezza:98%Colore e forma:SolidPeso molecolare:507.35AGN-195183
CAS:AGN 195183: RARα agonist, Kd=3 nM, selective, no RARβ/γ effect, inhibits breast cancer cells, in Phase I/II clinical trials, non-irritant.Formula:C22H22ClF2NO4Colore e forma:SolidPeso molecolare:437.86CXCR4 antagonist 6
CAS:CXCR4 antagonist 6 blocks CXCR4 (IC50: 79 nM), hinders calcium flux (IC50: 0.25 nM), reduces cell migration, and is effective in cancer metastasis mice.Formula:C21H30N6Purezza:100%Colore e forma:SolidPeso molecolare:366.5Cisd2 agonist 1
CAS:Cisd2 agonist 1 is a CISD2) agonist (EC50: 34 nM) with potential anticancer activity and can be used to study non-alcoholic fatty liver disease (NAFLD).Formula:C14H13FN2O3SPurezza:99.06%Colore e forma:SolidPeso molecolare:308.33Ref: TM-T78093
1mg74,00€5mg160,00€10mg250,00€25mg512,00€50mg847,00€100mg1.159,00€500mg2.327,00€1mL*10mM (DMSO)170,00€AGN 194310
CAS:AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].Formula:C28H24O2SColore e forma:SolidPeso molecolare:424.55(R,R)-CXCR2-IN-2
CAS:'(R,R)-CXCR2-IN-2 is a brain-penetrating diastereoisomer and CXCR2 antagonist with pIC50 of 9 (Tango) and 6.8 (HWB Gro-α/CD11b).'Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9(±)-AMG 487
AMG 487 is an effective and selective antagonist of chemokine receptor 3.Formula:C32H28F3N5O4Purezza:98%Colore e forma:SolidPeso molecolare:603.59CXCR2 antagonist 3
CAS:Compound 11h, a CXCR2 antagonist, inhibits neutrophil/MDSCs and boosts CD3+ T cells in Pan02 tumors.Formula:C17H15FN2O4SColore e forma:SolidPeso molecolare:362.38CC214-1
CAS:CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.Formula:C20H21N7O2Purezza:97.16%Colore e forma:SolidPeso molecolare:391.43AMD-3329 free base
CAS:AMD-3329 is a potent anti-HIV agent that blocks virus replication by targeting CXCR4, a key receptor for X4 viruses' entry.Formula:C34H50N8Colore e forma:SolidPeso molecolare:570.81Pentixafor
CAS:Pentixafor is a peptide that selectively targets the CXCR4 receptor and can be labeled with Gallium-68 (68Ga) for visualization using positron emission
Formula:C60H80N14O14Purezza:98%Colore e forma:SolidPeso molecolare:1221.36AEW541 HCl
CAS:AEW541 (CAS# 475489-16-8) is a selective IGF-IR kinase inhibitor (IC50: IGF-IR=0.086μM, InsR=2.3μM), blocking IGF-I effects and colony formation.Formula:C27H31Cl2N5OColore e forma:SolidPeso molecolare:512.47CXCR2-IN-2
CAS:CXCR2-IN-2, Selective CXCR2 antagonist (IC50=5.2 nM), BBB penetration, oral bioavailability, inhibits Gro-α-induced CD11b expression in blood.Formula:C18H23ClN2O5SColore e forma:SolidPeso molecolare:414.9AZD0233
CAS:AZD0233, Oral CX3CR1 antagonist, modulates CX3CR1/CX3CL1 axis, improves cardiac function in DCM models.Formula:C19H29FN6O4SPeso molecolare:456.54TIQ-15
CAS:TIQ-15 is an effective and selective CXCR4 antagonist. It has good drug-like properties.Formula:C23H32N4Purezza:98%Colore e forma:SolidPeso molecolare:364.53Antitumor agent-82
Antitumor agent-82: potent, anti-proliferative, induces autophagy via ATG5/ATG7.Formula:C32H42N6Colore e forma:SolidPeso molecolare:510.72Ruxolitinib sulfate
CAS:Ruxolitinib sulfate, a potent JAK1/2 inhibitor (IC50: 3.3/2.8 nM), is >130x more selective for JAK1/2 than JAK3.Formula:C17H20N6O4SColore e forma:SolidPeso molecolare:404.456CEPN
CAS:6CEPN is a Cyclooxygenase-1 inhibitor that acts by suppressing colorectal cancer growth.Formula:C23H18O5Colore e forma:SolidPeso molecolare:374.39KN-93 Phosphate
CAS:KN-93 (Phosphate) can competitively block the binding of calmodulin to the corresponding kinase.Cost-effective and quality-assured.Formula:C26H32ClN2O8PSPurezza:99.58% - 99.93%Colore e forma:SolidPeso molecolare:599.03Ref: TM-T2606
1mg52,00€5mg97,00€10mg144,00€25mg283,00€50mg525,00€100mg758,00€500mg1.510,00€1mL*10mM (DMSO)139,00€SR10067
CAS:SR10067 is a potent, selective and brain penetrant agonist of Rev-Erbβ(IC50 = 160 nM) and Rev-Erbα(IC50 = 170 nM) with anxiolytic activity.Formula:C31H31NO3Purezza:99.57%Colore e forma:SolidPeso molecolare:465.58Ref: TM-T12998
1mg58,00€5mg134,00€10mg207,00€25mg353,00€50mg510,00€100mg658,00€200mg905,00€1mL*10mM (DMSO)144,00€Ladarixin Sodium
CAS:Ladarixin Sodium, an Chemokine CXCR antagonist, is used potentially for the treatment of type I diabetes.Formula:C11H12F3NNaO6S2Colore e forma:SolidPeso molecolare:398.32AMD-3329 hydrobromide
CAS:AMD-3329 hydrobromide: strong, selective anti-HIV agent, blocks virus replication by targeting CXCR4 co-receptor.Formula:C34H58Br8N8Colore e forma:SolidPeso molecolare:1218.13INT-767
CAS:INT-767 is a highly potent farneson X receptor (FXR)/TGR5 dual agonist that prevents NASH and promotes visceral fat brown lipogenesis and mitochondrial functionFormula:C25H43NaO6SPurezza:98%Colore e forma:SolidPeso molecolare:494.66AGN 194078
CAS:AGN 194078 is a selective RARα agonist (Kd: 3 nM; EC50: 112 nM).Formula:C22H23F2NO4Colore e forma:SolidPeso molecolare:403.42
