Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1494 prodotti di "Autofagia"
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SHS206
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that decreases triglyceride levels in the liver. Demonstrating in vivo efficacy in a GAN mouse model, SHS206 also exhibits inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH).Formula:C14H7F6N3OColore e forma:SolidPeso molecolare:347.22SH498
CAS:SH498 is a novel Bmi-1-mediated anti-tumor agent with significant anti-proliferative effects.
Formula:C27H25F3N2O4Colore e forma:SolidPeso molecolare:498.49SORT1-IN-2
CAS:SORT1-IN-2 (compound 6) is an inhibitor of SORT1.Formula:C21H29N3O4Colore e forma:SolidPeso molecolare:387.47QW24
CAS:QW24 down-regulates BMI-1, exhibits potent antitumour effects and is used as an effective therapeutic agent in the treatment of clinical colorectal cancer.Formula:C27H28N2O4Colore e forma:SolidPeso molecolare:444.52ATG12-IN-1
CAS:ATG12-IN-1 (compound 4) acts as an autophagy inhibitor targeting the ATG12-ATG3 protein-protein interaction (IC50= 9 μM), suitable for research in cancer studies.Formula:C23H15ClN4O2Colore e forma:SolidPeso molecolare:414.84SW063058
CAS:SW063058 is an autophagy inducer that specifically disrupts the interaction between Beclin 1 and Bcl-2 without affecting the interactions of Bcl-2 with pro-apoptotic members (such as Bax and BIM). By inhibiting the negative regulation of Beclin 1 (key to autophagy initiation) by Bcl-2, SW063058 enhances autophagic activity without inducing cytotoxicity, apoptosis, or other forms of cell death in vitro.Formula:C22H15BrFIN2O2Colore e forma:SolidPeso molecolare:565.17HDAC10-IN-2
HDAC10-IN-2, a selective HDAC10 inhibitor (IC50=20nM), modulates autophagy in FLT3-ITD+ acute myeloid leukemia.Formula:C19H22N2O2Colore e forma:SolidPeso molecolare:310.39CXCR4 antagonist 3
CXCR4 antagonist 3, aka compound 12a, has 11 nM IC50, shares TIQ15 traits, and is promising in HIV research.Formula:C22H31N5Colore e forma:SolidPeso molecolare:365.52Hesperadin hydrochloride
Hesperadin hydrochloride is an ATP-competitive indolone inhibitor of Aurora A and B, with an IC50 value of 250 nM for Aurora B.Formula:C29H33ClN4O3SColore e forma:SolidPeso molecolare:553.12LRRK2-IN-4
CAS:LRRK2-IN-4: Potent, selective LRRK2 inhibitor, oral, BBB-penetrating, IC50=2.6 nM, potential for Parkinson's.Formula:C25H29ClF2N6O2Colore e forma:SolidPeso molecolare:518.99DQ661
CAS:DQ661 is a potent inhibitor of PPT1 and a dimeric quinacrine autophagy (autophagy) inhibitor. It effectively suppresses the activity of mTORC1 and reduces protein expression levels of pS6K T389 and pS6 S240-244. Additionally, DQ661 exhibits anticancer properties.Formula:C41H47Cl2N5O2Colore e forma:SolidPeso molecolare:712.75Rosiglitazone sodium
CAS:Rosiglitazone sodium is an effective and selective PPARγ activator, with EC50 values of 30 nM for PPARγ1, 100 nM for PPARγ2, and 60 nM for PPARγ. It also has an approximate Kd of 40 nM for PPARγ. Additionally, Rosiglitazone sodium acts as a regulator of TRP channels, inhibiting the activities of TRPM2 and TRPM3, while activating TRPC5.Formula:C18H18N3NaO3SColore e forma:SolidPeso molecolare:379.41ST-539
CAS:ST-539 is an inhibitor of the deubiquitinating enzyme USP30, with an IC50 of 0.37 μM. It enhances the ubiquitination of mitochondrial proteins and induces mitophagy (autophagy), thereby regulating mitochondrial homeostasis. ST-539 is applicable for research in neurodegenerative diseases.Formula:C30H31N3O4SColore e forma:SolidPeso molecolare:529.65LRRK2-IN-5
LRRK2-IN-5 is an oral, BBB-penetrating selective inhibitor for LRRK2 with IC50s: 1.2μM (GS) and 16μM (WT); halts LRRK2 autophosphorylation.Formula:C24H26F2N4O2SColore e forma:SolidPeso molecolare:472.55SRI-31255
CAS:SRI-31255 is an orally active LRRK2 inhibitor, with IC50 values of 520 nM for human wild-type (WT) and 427 nM for the G2019S mutant. It inhibits kinase activity by binding to the ATP-binding pocket of LRRK2, providing neuroprotective effects. SRI-31255 serves as a lead compound for developing LRRK2-targeted therapies for Parkinson’s disease research.Formula:C15H14N4Colore e forma:SolidPeso molecolare:250.30CCX662
CAS:CCX662 is a CXCR7 antagonist. It inhibits the binding of 125I-CXCL12 to CXCR7 with an IC50 of 9 nM. This compound is suitable for use in cancer research.Formula:C28H37N5O4SColore e forma:SolidPeso molecolare:539.69Anle138b-F105
CAS:Anle138b-F105 is an autophagy-targeting chimera (AUTOTAC) with a DC50 value of 3 nM. It targets tauP301L for lysosomal degradation.Formula:C36H37FN4O5Colore e forma:SolidPeso molecolare:624.7LC3B recruiter 1
CAS:LC3B recruiter 1 (compound 33R) is an LC3B recruiting fragment. It directly interacts with LC3B, exhibiting a Kd value of 2.87 µM.Formula:C14H10ClN3O2Colore e forma:SolidPeso molecolare:287.701ACT-672125
CAS:ACT-672125: Potent CXCR3 blocker, may treat autoimmunity, safe with dose-dependent efficacy in lung inflammation.Formula:C25H25F3N10O2SColore e forma:SolidPeso molecolare:586.59PARL-IN-1
PARL-IN-1: Strong PARL blocker, IC50 28 nM, boosts PINK1/Parkin mitophagy.Formula:C40H58N6O7Colore e forma:SolidPeso molecolare:734.92ACT-777991
CAS:ACT-777991: oral CXCR3 blocker, stable in microsomes/hepatocytes, inhibits T-cell migration to CXCL11.Formula:C20H20F6N8O2SColore e forma:SolidPeso molecolare:550.48CXCR2 antagonist 4
CXCR2 antagonist 4 inhibits CXCR2 (IC50: 0.13 μM) and CXCL8-induced calcium rise (IC50: 27 μM), promising for cancer research.Formula:C15H14F2N4OS2Colore e forma:SolidPeso molecolare:368.424-FPBUA
CAS:4-FPBUA, a semi-synthetic analog of lichen acid, enhances the functionality of cell-based blood-brain barriers (BBB) and increases the transport of β-amyloid (Aβ) in monolayer cells. Additionally, it acts as an inhibitor of mTOR, enhancing cellular autophagy (Autophagy) which can reverse BBB disruption in vivo, making it relevant for research in Alzheimer's disease.Formula:C31H23FO7Colore e forma:SolidPeso molecolare:526.51LRRK2-IN-2
CAS:LRRK2-IN-2: selective, potent LRRK2 inhibitor, IC50 of 0.6 nM, oral, crosses blood-brain barrier, for Parkinson's research.Formula:C23H23Cl2F3N6O2Colore e forma:SolidPeso molecolare:543.37(R)-SCH 546738
CAS:(R)-SCH 546738, the R-isomer of SCH 546738, is a non-competitive, orally active antagonist targeting the CXCR3 receptor, exhibiting a K_i of 0.4 nM for the human CXCR3 receptor.Formula:C23H31Cl2N7OColore e forma:SolidPeso molecolare:492.45CXCR7 antagonist-1 hydrochloride
CAS:CXCR7 antagonist-1 hydrochloride, Inhibits SDF-1 (CXCL12) or I-TAC binding to CXCR7, used for tumor and inflammation research.Formula:C21H20ClFN6OPurezza:99.84%Colore e forma:SolidPeso molecolare:426.87HDAC10-IN-1
HDAC10-IN-1 is a potent, selective HDAC10 inhibitor (IC50=58 nM) affecting autophagy in FLT3-ITD+ acute myeloid leukemia cells.Formula:C18H23N3O2Colore e forma:SolidPeso molecolare:313.39CXCR4 antagonist 10
CAS:CXCR4 antagonist10 (compound 21) is an effective CXCR4 inhibitor with an IC50 value of 7.8 nM. It plays a significant role in cancer research.Formula:C18H18N4O4Colore e forma:SolidPeso molecolare:354.36Stauprimide
CAS:Stauprimide inhibits MYC by blocking NME2, reducing MYC transcription in ESCs.Formula:C35H28N4O5Purezza:98%Colore e forma:SolidPeso molecolare:584.62SCH 563705
CAS:SCH 563705 is a CXCR2 and CXCR1 antagonist used in the study of acute respiratory syndrome, chronic obstructive pulmonary disease, and inflammation.Formula:C23H27N3O5Purezza:98.03%Colore e forma:SolidPeso molecolare:425.48BRD1991
CAS:BRD1991 is a chemical compound that specifically disrupts the interaction between Beclin 1 and Bcl-2, thereby inducing autophagy.Formula:C33H35Cl2N3O4Colore e forma:SolidPeso molecolare:608.55CXCR4 modulator-1
CAS:CXCR4 modulator-1 (ZINC72372983) is potent (EC50=100nM) with uses in anti-inflammatory, anticancer, and anti-HIV research.Formula:C23H27N5O2Colore e forma:SolidPeso molecolare:405.49LRRK2-IN-3
CAS:LRRK2-IN-3: potent, selective oral LRRK2 blocker, BBB-penetrant, IC50 of 0.6 nM in hPBMCs, for Parkinson's research.Formula:C25H29ClF2N6O2Colore e forma:SolidPeso molecolare:518.99Gepotidacin mesylate dihydrate
CAS:Gepotidacin mesylate dihydrate (GSK2140944 mesylate dihydrate) is an antibiotic and an inhibitor of bacterial type II topoisomerase.Formula:C25H36N6O8SPurezza:99.85%Colore e forma:SolidPeso molecolare:580.65DCC-3116
CAS:DCC-3116 is an orally active, selective and potent ULK1/2 inhibitor with anticancer activity.DCC-3116 inhibits autophagy and can be used in cancer research.Formula:C26H36F3N7O2Purezza:98.55%Colore e forma:SoildPeso molecolare:535.61Ref: TM-T86167
1mg69,00€5mg147,00€10mg224,00€25mg358,00€50mgPrezzo su richiesta1mL*10mM (DMSO)170,00€VUF11207 trifluoroacetate salt
CAS:VUF11207 trifluoroacetate salt is a useful organic compound for research related to life sciences. The catalog number is T66657 and the CAS number is 1378524-41-4.Formula:C29H36F4N2O6Colore e forma:SolidPeso molecolare:584.609Dusquetide
CAS:Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.Formula:C25H47N9O5Purezza:98%Colore e forma:SolidPeso molecolare:553.709Pepstatin Ammonium
Pepstatin Ammonium is a specific inhibitor of aspartic proteaseproduced by actinomycetes(hemoglobin-pepsin, hemoglobin-proctase, casein-pepsin, casein-proctase, casein-acid protease and hemoglobin-acid protease with IC50s of 4.5 nM, 6.2 nM, 150 nM, 290 nMFormula:C34H66N6O9Purezza:98%Colore e forma:SolidPeso molecolare:702.92Dihydrocelastrol
CAS:Dihydrocelastrol is synthesized by hydrogenation of celastrol, a treterpene isolated from Chinese medicinal plant Tripterygium regelii. Dihydrocelastrol could inhibit cell proliferation and promote apoptosis through caspase-dependent way in vitro. DHCE coFormula:C29H40O4Colore e forma:SolidPeso molecolare:452.63Salvianolic acid B
CAS:Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.
Formula:C36H30O16Purezza:99.75% - 99.86%Colore e forma:Yellow SolidPeso molecolare:718.61FR 167653
CAS:FR 167653 sulfate, an orally active and selective inhibitor of p38 MAPK, is effective in treating inflammation, trauma, and ischemia-reperfusion injury in vivo. It acts as a potent suppressor of TNF-α and IL-1β production through specific inhibition of p38 MAPK activity.Formula:C24H20FN5O6SPurezza:98%Colore e forma:SolidPeso molecolare:525.51EIPA hydrochloride
CAS:EIPA hydrochloride also inhibits Na+/H+-exchanger (NHE) and macropinocytosisEIPA hydrochloride (L593754 hydrochloride) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM.Formula:C11H19Cl2N7OPurezza:98%Colore e forma:SolidPeso molecolare:336.22CXCR4-IN-1
CAS:CXCR4-IN-1 (Example C5), with an IC50 of 20 nM, is a potent inhibitor of CXCR4, applicable for the research of various conditions such as cancer, HIV, diabetic
Formula:C23H32N6Purezza:98%Colore e forma:SolidPeso molecolare:392.54Ref: TM-T79059
Prodotto fuori produzioneVISTA-IN-2
CAS:VISTA-IN-2 (Compound 1) is a V-domain Ig suppressor of T-cell activation (VISTA) inhibitor that promotes the degradation of VISTA in cells via autophagy,
Formula:C23H23N3OPurezza:98%Colore e forma:SolidPeso molecolare:357.45Ref: TM-T79653
Prodotto fuori produzione
