Autofagia
Gli inibitori dell'autofagia mirano al processo cellulare di autofagia, che comporta la degradazione e il riciclo dei componenti cellulari attraverso i lisosomi. L'autofagia è un meccanismo critico per mantenere l'omeostasi cellulare, ma la sua disfunzione è implicata in varie malattie, tra cui il cancro, la neurodegenerazione e le infezioni. Gli inibitori dell'autofagia possono bloccare questo processo, rendendoli strumenti preziosi per studiare il ruolo dell'autofagia nelle malattie e sviluppare strategie terapeutiche. Presso CymitQuimica, offriamo inibitori dell'autofagia per supportare la tua ricerca in biologia cellulare, oncologia e malattie neurodegenerative.
Trovati 1489 prodotti di "Autofagia"
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Manzamine A hydrochloride
CAS:Manzamine A hydrochloride: oral beta-carboline inhibiting GSK-3β & CDK-5; blocks autophagy in cancer; antimalarial; fights HSV-1.Formula:C36H45ClN4OColore e forma:SolidPeso molecolare:585.23ACKR3 agonist 1
ACKR3 agonist 1 (compound 27), exhibiting selective agonistic properties for ACKR3 (EC 50 =69 nM, E max =82%), demonstrates the capability to inhibit platelet aggregation and shows potential in mitigating platelet-mediated thrombosis. This compound is characterized by its metabolic stability and non-cytotoxic nature.Formula:C25H30N2OSColore e forma:SolidPeso molecolare:406.58N6-Isopentenyladenosine
CAS:N6-Isopentenyladenosine, an end product of the mevalonate pathway, is an autophagy inhibitor with anti-melanoma activity.Formula:C15H21N5O4Purezza:97.13% - 99.69%Colore e forma:SolidPeso molecolare:335.36DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Formula:C59H68F3N13O6SColore e forma:SolidPeso molecolare:1144.31TRAF6 peptide
CAS:TRAF6 peptide inhibits TRAF6-p62, blocks TrkA ubiquitination, and shows promise for neurological disease research.Formula:C145H238N34O44Colore e forma:SolidPeso molecolare:3161.64Fumagilin-105
CAS:<p>Fumagilin-105, an autophagy-targeting chimera (AUTOTAC), induces self-oligomerization of p62 and exhibits a DC50 of 0.7 μM against MetAP2 in HEK293 cells.</p>Formula:C46H60N2O9Colore e forma:SolidPeso molecolare:784.98LC3in-C42
LC3in-C42 is a covalent inhibitor of LC3A/B and autophagy active within cells. Selectively inhibiting the binding of P62 to LC3A/B both in vitro and at the cellular level, LC3in-C42 functions similarly to D5 and is effective at lower concentrations.Colore e forma:Odour SolidSQA1
CAS:SQA1 is a derivative of a phthalamide (SQA) and acts as a CCR6 antagonist with a Kd of 250 nM, as well as a CXCR2 inhibitor. It occupies an intracellular pocket that overlaps with the G protein binding site, stabilizing the pocket's closed conformation.Formula:C22H26N4O5Colore e forma:SolidPeso molecolare:426.47Syntide 2
CAS:Syntide-2 is a synthetic peptide recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII; Km = 12 µM).Formula:C68H122N20O18Purezza:98%Colore e forma:Lyophilized SolidPeso molecolare:1507.82YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Formula:C16H19NO2Purezza:98.31%Colore e forma:SoildPeso molecolare:257.33Ref: TM-T87944
1mg38,00€2mgPrezzo su richiesta5mg72,00€10mg105,00€25mg203,00€50mg328,00€100mg503,00€200mg769,00€SHP2-IN-35
<p>SHP2-IN-35 (Compound 3f) functions as an inhibitor of SHP2. It exhibits antiproliferative activity in cancer cell lines RKO, SW480, and CT26, with IC50 values of 5.72 μM, 3.71 μM, and 1.42 μM, respectively. SHP2-IN-35 inhibits the PI3K-Akt signaling pathway, regulates the expression of cell cycle-related genes, and induces mitochondrial autophagy (autophagy). Within the tumor microenvironment (TME), SHP2-IN-35 suppresses the expression of certain cytokines and chemokines, thereby modulating tumor progression.</p>Formula:C34H32FeO6Colore e forma:SolidPeso molecolare:592.46(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Formula:C30H39N5O6Peso molecolare:565.29003Ch55-O-C3-NH2
CAS:Ch55-O-C3-NH2, also known as RAR ligand 1, is a ligand derived from the Ch55 compound that specifically targets RAR.Formula:C27H35NO4Purezza:98%Colore e forma:SolidPeso molecolare:437.57Autophagy/REV-ERB-IN-1
Autophagy/REV-ERB-IN-1 is a dual inhibitor of autophagy and REV-ERB. It exhibits antitumor activity, with a CC50 value of 2.3 μM in BTB-474 cells.Formula:C24H30F2N2Peso molecolare:384.23771MLCK inhibitor peptide 18
CAS:Myosin light chain kinase inhibitor; IC50=50 nM; 4000x more selective over CaM kinase II; no PKA inhibition; cell-permeable.Formula:C60H105N23O11Purezza:98%Colore e forma:SolidPeso molecolare:1324.64Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Formula:C28H33NO7Purezza:98%Colore e forma:Crystals From Acetone-Hexane White PowderPeso molecolare:495.56DOTA-CXCR4-L
DOTA-CXCR4-L, a peptide targeting the CXCR4 receptor, is utilized in cancer research, notably in the contexts of glioblastoma and triple-negative breast cancerFormula:C58H78N16O14Purezza:98%Colore e forma:SolidPeso molecolare:1223.34SDF-1α (human)
CAS:SDF-1α (human) serves as a chemotactic agent for mononuclear cells through its interaction with the CXCR4 receptor, facilitating critical biological processesFormula:C356H578N106O93S4Purezza:98%Colore e forma:SolidPeso molecolare:7959.34p62-ZZ Ligand-Linker Conjugate 1
CAS:p62-ZZ Ligand-Linker Conjugate 1 is a conjugate of the p62-ZZ domain ligand and linker. This compound is utilized in the synthesis of AUTOTACVinclozolinM2-2204.Formula:C31H42N2O6Colore e forma:SolidPeso molecolare:538.68Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Formula:C27H48F3N9O7Colore e forma:SolidPeso molecolare:667.72Peptide R
CAS:Peptide R, a cyclic CXCR4 antagonist, remodels tumor stroma, aiding cancer research.Formula:C39H59N13O8S2Colore e forma:SolidPeso molecolare:902.1PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Formula:C27H31NO4SPurezza:99.02%Colore e forma:SolidPeso molecolare:465.6Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Formula:C22H23N3O4Colore e forma:SolidPeso molecolare:399.397HDAC6-IN-58
HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).Colore e forma:Odour SolidFDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Formula:C22H24N6OPurezza:98.73% - 99.55%Colore e forma:SoildPeso molecolare:388.47Ref: TM-T77809
1mg70,00€5mg150,00€10mg227,00€25mg378,00€50mg547,00€100mg747,00€1mL*10mM (DMSO)166,00€Beclin1-Bcl-2 interaction inhibitor 1
Beclin1-Bcl-2 Interaction Inhibitor 1 effectively disrupts the binding of Beclin 1 to Bcl-2, and is utilized in cancer and neurodegeneration research [1].Colore e forma:Odour SolidPHTPP-1304
CAS:PHTPP-1304, a chimeric autophagy-targeting compound (AUTOTAC) based on PHTPP, induces p62 self-oligomerization and degrades estrogen receptor ERβ (DC50: ~2 nM, HEK293T). Additionally, PHTPP-1304 facilitates the formation of p62+ERβ+ puncta in a dose-dependent manner, influencing autophagic flux.Formula:C51H50F6N4O7Colore e forma:SolidPeso molecolare:944.96PDEδ autophagic degrader 1
PDEδ autophagic degrader 1 (compound 12c) is an autophagosome-tethering compound (ATTEC) and a potent autophagic degrader of PDEδ. This compound effectively reduces PDEδ protein levels through lysosome-mediated autophagy without affecting PDEδ mRNA expression. Additionally, PDEδ autophagic degrader 1 inhibits the growth of KRAS mutant pancreatic cancer cells.Formula:C41H42Br2IN7O5Peso molecolare:997.06589VUF-11222
CAS:VUF-11222 is an agonist of high affinity non-peptide CXCR3 agonist (pKi = 7.2).Formula:C25H31BrINPurezza:99.82%Colore e forma:SolidPeso molecolare:552.33Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Formula:C21H20ClNO5Purezza:97.74% - 99.99%Colore e forma:SolidPeso molecolare:401.84STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFormula:C19H10N2O3·C2H4O2Purezza:99.75%Colore e forma:SolidPeso molecolare:374.35Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Formula:C44H36Cl5FeN8Colore e forma:SolidPeso molecolare:909.92Corydalmine hydrochloride
CAS:Corydalmine hydrochloride: antifungal, oral analgesic, soothes neuropathic pain by blocking NF-κB/CXCL1/CXCR2.Formula:C20H24ClNO4Colore e forma:SolidPeso molecolare:377.86Zn-DPA-maytansinoid conjugate 1
Zn-DPA-maytansinoid 1 targets checkpoints, shrinks tumors, and heats TME.Formula:C115H145ClN18O31S2Zn2Colore e forma:SolidPeso molecolare:2505.83Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFormula:C32H38Cl3N7Colore e forma:SolidPeso molecolare:627.05Polyphemusin II-Derived Peptide
CAS:T140, a Polyphemusin II-derived peptide, inhibits HIV-1 entry and blocks anti-CXCR4 antibody (12G5) binding.Formula:C90H141N33O18S2Colore e forma:SolidPeso molecolare:2037.42Insecticidal agent 364
CAS:<p>Insecticidal agent 364 is a selective small molecule inhibitor of rapamycin kinase target protein.</p>Formula:C23H18N4O3SPurezza:99.81%Colore e forma:SolidPeso molecolare:430.48Biotin-11-dCTP
Biotin-11-dCTP is a fluorescent dye for DNA labeling [1] .Formula:C28H43Li3N7O16P3SColore e forma:SolidPeso molecolare:879.49Tigecycline mesylate
CAS:Tigecycline mesylate is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Formula:C30H43N5O11SPurezza:98%Colore e forma:SolidPeso molecolare:681.75Desethyl chloroquine
CAS:Desethyl chloroquine (Monodesethylchloroquine) is a major metabolite of Chloroquine which is a TLR inhibitor. Desethyl chloroquine shows antiplasmodic activity.Formula:C16H22ClN3Purezza:99.56%Colore e forma:SolidPeso molecolare:291.82MRT 67307 dihydrochloride
CAS:<p>MRT 67307 dihydrochloride inhibits IKKε/TBK-1, ULK1/2, and blocks autophagy, with IC50s of 160/19, 45/38 nM respectively.</p>Formula:C26H38Cl2N6O2Purezza:99.75%Colore e forma:SoildPeso molecolare:537.53Cy5.5-SE (DIPEA)
Cy5.5-SE DIPEA is a water-soluble CY dye often used for labeling proteins and antibodies, with simple mixing for conjugation. Store protected from light.Formula:C53H66N4O16S4Colore e forma:SolidPeso molecolare:1143.37cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Formula:C31H51ClN7O14PSColore e forma:SolidPeso molecolare:844.27ITIC
CAS:"ITIC, a non-fullerene acceptor with high Tg of 180°C, shows excellent thermal stability and a low glass-crystal transition, plus unique crystallization."Formula:C94H82N4O2S4Purezza:98%Colore e forma:SolidPeso molecolare:1427.96D-CopA3
CAS:<p>D-CopA3 is an inhibitor of MDM2 and an activator of the p53 signaling pathway. It exhibits cytotoxicity in colorectal cancer cells HCT-116, LoVo, and RKO with IC50 values of 15-18 μM and induces JNK/Beclin-1 mediated autophagy. D-CopA3 downregulates the expression of the cell cycle inhibitor protein p21Cip1/Waf1, enhances mucosal barrier function, and reduces infiltration of inflammatory mediators. It shows anti-inflammatory properties in mouse models of acute enteritis induced by C. difficile toxin A and chronic colitis induced by DSS. Additionally, D-CopA3 demonstrates antitumor activity in a mouse HCT-116 xenograft model.</p>Formula:C96H184N30O18S2Colore e forma:SolidPeso molecolare:2110.81Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Formula:C38H42Cl2N6O2Colore e forma:SolidPeso molecolare:685.69Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Formula:C23H26ClI2NO3Purezza:98%Colore e forma:SolidPeso molecolare:653.72NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Formula:C56H68ClN9O5S2Colore e forma:SolidPeso molecolare:1046.78Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Formula:C27H45NO3Colore e forma:SolidPeso molecolare:431.65Balixafortide
CAS:Balixafortide (POL6326), a potent CXCR4 blocker with IC50 < 10 nM, mobilizes HSPCs and is anti-cancer, 1000x more selective than CXCR7.Formula:C84H118N24O21S2Purezza:98%Colore e forma:SolidPeso molecolare:1864.14
