DUB
Gli inibitori delle deubiquitinasi (DUB) mirano alle enzimi che rimuovono le molecole di ubiquitina dalle proteine, regolando così la stabilità, la localizzazione e l'attività delle proteine all'interno della cellula. Le deubiquitinasi svolgono ruoli essenziali in vari processi cellulari, tra cui la regolazione del ciclo cellulare, la riparazione del DNA e le risposte immunitarie. La disfunzione dell'attività delle DUB è legata al cancro, ai disturbi neurodegenerativi e alle infezioni virali. Gli inibitori delle DUB possono modulare questi processi, offrendo potenziali approcci terapeutici per queste condizioni. Presso CymitQuimica, forniamo inibitori delle DUB per supportare la tua ricerca in omeostasi proteica, oncologia e neurobiologia.
Trovati 89 prodotti di "DUB"
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LCAHA
CAS:LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.Formula:C24H41NO3Colore e forma:SolidPeso molecolare:391.59Capzimin
CAS:Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.Formula:C30H24N6O2S4Purezza:98.31% - 99.32%Colore e forma:SolidPeso molecolare:628.81Ref: TM-T10672
1mg48,00€2mgPrezzo su richiesta5mg95,00€10mg150,00€25mg300,00€50mg515,00€1mL*10mM (DMSO)131,00€XL-188
CAS:XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.Formula:C32H42N6O4Colore e forma:SolidPeso molecolare:574.71USP7-IN-4
CAS:USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .Formula:C29H34N6O3Purezza:98.27% - 99.09%Colore e forma:SolidPeso molecolare:514.628RK64
CAS:8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .Formula:C14H16N8O2SColore e forma:SolidPeso molecolare:360.4USP28-IN-2
CAS:USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.Formula:C23H20Cl2N2O3SColore e forma:SolidPeso molecolare:475.39HBX28258
CAS:HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.Formula:C26H30ClN3OPurezza:98%Colore e forma:SolidPeso molecolare:435.99BAP1-IN-1
CAS:BAP1-IN-1 is an inhibitor of the catalytic activity of BRCA1-associated protein 1 (BAP1), which is related to cancer and can be used to study cancer.Formula:C18H16N2O2Purezza:98.11%Colore e forma:SolidPeso molecolare:292.33I-138
CAS:I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.Formula:C26H23F3N6OPurezza:99.41%Colore e forma:SolidPeso molecolare:492.5Ref: TM-T73560
1mg170,00€5mg349,00€10mg492,00€25mg707,00€50mg982,00€100mg1.468,00€1mL*10mM (DMSO)384,00€USP28-IN-4
CAS:USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.Formula:C22H18Cl2N2O3SPurezza:98.48%Colore e forma:SolidPeso molecolare:461.36USP22-IN-1
CAS:USP22-IN-1 is a ubiquitin-specific peptidase 22 (USP22) inhibitor that can be used to treat proliferative diseases or cancer.Formula:C22H18N4Purezza:99.37%Colore e forma:SolidPeso molecolare:338.41GSK2643943A
CAS:GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.Formula:C17H12FN3Purezza:97.09%Colore e forma:SolidPeso molecolare:277.3Ref: TM-T11485
1mg39,00€2mg50,00€5mg82,00€10mg120,00€25mg236,00€50mg356,00€100mg537,00€200mg762,00€1mL*10mM (DMSO)90,00€6RK73
CAS:6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).Formula:C13H17N5O2SPurezza:99.91%Colore e forma:SolidPeso molecolare:307.37Ref: TM-T10188
1mg144,00€5mg298,00€10mg510,00€25mg825,00€50mg1.130,00€100mg1.510,00€500mg3.060,00€1mL*10mM (DMSO)328,00€P22074
CAS:P22074 is a USP7 inhibitor. It is not an active antagonist like its halogenated related compounds. p22074 has antitumour activity.Formula:C12H9NO3S2Purezza:>99.99%Colore e forma:SolidPeso molecolare:279.33Ref: TM-T28284
1mg144,00€5mg330,00€10mg452,00€25mg633,00€50mg842,00€100mg1.159,00€200mg1.549,00€1mL*10mM (DMSO)251,00€SJB3-019A
CAS:SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 timesFormula:C16H8N2O3Purezza:99.72%Colore e forma:SolidPeso molecolare:276.25Ref: TM-T12926
1mg77,00€2mg101,00€5mg168,00€10mg253,00€25mg416,00€50mg580,00€100mg783,00€200mg1.054,00€OTUB1/USP8-IN-1
CAS:OTUB1/USP8-IN-1 is an OTUB1/USP8 inhibitor with anticancer activity for the study of non-small cell lung cancer.Formula:C22H16ClFN2O4Purezza:98.59%Colore e forma:SoildPeso molecolare:426.83USP30 inhibitor 11
CAS:USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.Formula:C17H16N6O2SPurezza:98.84% - 99.59%Colore e forma:SolidPeso molecolare:368.41USP7-IN-12
CAS:USP7-IN-12 (compound 1) is a potent, orally active inhibitor of Usp7, exhibiting an IC50 of 3.67 nM and demonstrating antiproliferative activity [1].Formula:C29H28ClFN4O2SColore e forma:SolidPeso molecolare:551.07FT206
CAS:FT206 is a carboxamide inhibitor of ubiquitin-specific protease[1].Formula:C25H29N5OSColore e forma:SolidPeso molecolare:447.6USP1-IN-3
CAS:USP1-IN-3 is a selective inhibitor of USPI that inhibits USPI-UAFI (IC50<30 nM). USP1-IN-3 can be used to study cancer.Formula:C27H24F3N7OColore e forma:SolidPeso molecolare:519.52USP1-IN-5
CAS:USP1-IN-5 (compound 10) is a potent inhibitor of both USP1, with an IC50 of less than 50 nM, and MDA-MB-436 cells, where it also exhibits an IC50 of less thanFormula:C27H23F3N8OColore e forma:SolidPeso molecolare:532.52USP7-IN-13
CAS:USP7-IN-13 (Compound 101), a USP7 inhibitor, exhibits an IC50 range of 0.2-1 μM and is applicable in researching multiple myeloma [1].Formula:C24H28N4O3Colore e forma:SolidPeso molecolare:420.5DUB-IN-7
CAS:DUB-IN-7 (compound 43), a deubiquitinating enzyme (DUB) inhibitor, has utility in researching diseases driven by aberrant JAK2 activity, including leukemia [1].Formula:C17H19N5OColore e forma:SolidPeso molecolare:309.37FT671
CAS:FT671 is a non-covalent, selective USP7 inhibitor, disrupts the stability of USP7 substrates including MDM2, elevates p53, induces p21, inhibits tumor growth.Formula:C24H23F4N7O3Purezza:99.76%Colore e forma:SolidPeso molecolare:533.48Ref: TM-T12621L
1mgPrezzo su richiesta5mg131,00€10mgPrezzo su richiesta25mg464,00€50mg803,00€100mg1.388,00€USP7-IN-3
CAS:USP7-IN-3 is a potent and selective allosteric inhibitor of ubiquitin-specific protease 7 (USP7).Formula:C29H31F3N6O3Purezza:98%Colore e forma:SolidPeso molecolare:568.59LDN-91946
CAS:LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).Formula:C15H10N2O4SPurezza:97.12%Colore e forma:SolidPeso molecolare:314.32USP30 inhibitor 18
CAS:USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.Formula:C26H28FN3O4SPurezza:99.85%Colore e forma:SolidPeso molecolare:497.58Ref: TM-T36682
1mg137,00€5mg281,00€10mg447,00€25mg713,00€50mg1.018,00€100mg1.369,00€500mg2.673,00€1mL*10mM (DMSO)309,00€USP1-IN-6
CAS:USP1-IN-6 (Compound 11) functions as a potent USP1 inhibitor, exhibiting an IC50 value of less than 50 nM.Formula:C29H27F3N8OColore e forma:SolidPeso molecolare:560.57CT1113
CAS:CT1113, a potent inhibitor of both USP28 and USP25, effectively reduces MYC levels in vivo and demonstrates anti-tumor efficacy in a mouse pancreatic cancer CDXFormula:C25H29N5O2SColore e forma:SolidPeso molecolare:463.6USP7-IN-1
CAS:USP7-IN-1 is a selective and reversible ubiquitin-specific protease 7 (USP7) inhibitor (IC50 = 77 μM).Formula:C23H24ClN3O3Purezza:99.82%Colore e forma:SolidPeso molecolare:425.91Ref: TM-T13268
1mg92,00€5mg178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)207,00€IMP-1710
CAS:IMP-1710 is a selective UCH-L1 inhibitor with an IC50 value of 38 nM in a fluorescence polarization assay.[1]Cost-effective and quality-assured.Formula:C23H19N5OPurezza:99.3%Colore e forma:SolidPeso molecolare:381.43FT3967385
FT3967385: New USP30 inhibitor boosts mitochondrial ubiquitylation via PINK1-PARKIN.Formula:C21H19N5O2Colore e forma:SolidPeso molecolare:373.41USP7-IN-6
CAS:USP7-IN-6 is a potent inhibitor of ubiquitin-specific protease 7 (USP7, IC50: 6.8 nM).Formula:C41H43N7O4SPurezza:98%Colore e forma:SolidPeso molecolare:729.89USP7-797
CAS:USP7-797 is a selective non-covalent active site USP7 inhibitor, inhibiting USP7 and ubiquitin binding, with anti-tumor, oral and high efficiency properties.Formula:C27H28ClN3O3SPurezza:95.90%Colore e forma:SolidPeso molecolare:510.05USP7-IN-10
CAS:USP7-IN-10 is a potent inhibitor of ubiquitin-specific protease 7 (USP7), exhibiting an inhibition concentration half-maximal (IC50) value of 13.39 nM.Formula:C26H29ClN4O3SColore e forma:SolidPeso molecolare:513.05FT709
CAS:FT709 is a selective USP9X deubiquitinating enzyme inhibitor (IC50=82 nM) that reduces Makorin and ZNF598 levels, impairing ribosomal quality control pathways.Formula:C23H22N4O7SColore e forma:SolidPeso molecolare:498.51USP15-IN-1
CAS:USP15-IN-1 is a potent USP15 inhibitor (IC50 is 3.76 μM).
Formula:C22H23N3O3Purezza:99.509% - 99.81%Colore e forma:SolidPeso molecolare:377.44VCPIP1-IN-1
CAS:VCPIP1-IN-1 is a VCPIP1 inhibitor used in cancer research.Formula:C13H15ClN2O2Purezza:99.3%Colore e forma:SolidPeso molecolare:266.72Ref: TM-T88664
1mg49,00€5mg97,00€10mg154,00€25mg298,00€50mg472,00€100mg755,00€200mg1.017,00€1mL*10mM (DMSO)106,00€USP5-IN-1
USP5-IN-1, a powerful USP5 deubiquitinase inhibitor, selectively binds with 2.8 μM affinity, blocking USP5's di-ubiquitin cleavage.
Formula:C19H20ClN3O5SPurezza:99.76%Colore e forma:SoildPeso molecolare:437.9
