Chinasi aurora
Gli inibitori delle chinasi Aurora prendono di mira le chinasi Aurora, una famiglia di chinasi serina/treonina che svolgono un ruolo fondamentale nella regolazione della mitosi. Queste chinasi sono essenziali per il corretto allineamento, segregazione e citodieresi dei cromosomi durante la divisione cellulare. Un'attività anomala delle chinasi Aurora può portare a una proliferazione cellulare incontrollata e al cancro. Inibendo le chinasi Aurora, questi composti possono indurre l'arresto del ciclo cellulare e l'apoptosi nelle cellule tumorali, rendendoli strumenti preziosi nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle chinasi Aurora di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la mitosi e l'oncologia.
Trovati 121 prodotti per "Chinasi aurora".
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NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purezza:98.33%Colore e forma:SolidPeso molecolare:422.52Ref: TM-T16359
2mg39,00€5mg60,00€1mL*10mM (DMSO)67,00€10mg92,00€25mg177,00€50mg285,00€100mg414,00€200mg580,00€LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purezza:99.68%Colore e forma:SolidPeso molecolare:489.95TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormula:C28H32N4O3SPurezza:99.02% - 99.59%Colore e forma:Yellow SolidPeso molecolare:504.64Ref: TM-T2709
1mg34,00€5mg66,00€1mL*10mM (DMSO)74,00€10mg99,00€25mg192,00€50mg313,00€100mg497,00€200mg710,00€Tinengotinib
CAS:Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formula:C20H19ClN6OPurezza:99.05%Colore e forma:SolidPeso molecolare:394.86dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purezza:99.44%Colore e forma:Yellow SolidPeso molecolare:1071.93JB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:White SolidPeso molecolare:587.54Aurora kinase-IN-7
Aurora kinase-IN-7 (compound 4b) is an orally active inhibitor selectively targeting AURKB. It is utilized in the study of aggressive cancers.Formula:C26H21FN6OColore e forma:SolidPeso molecolare:452.48MS44
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.Colore e forma:Odour SolidSK2187
CAS:SK2187 is a selective degrader of AURKAPROTAC with a DC50 of approximately 10 nM. It exhibits growth-inhibitory effects on NGP cells, with an IC50 value of 101.5 nM. SK2187 is utilized in studies of MYCN-amplified neuroblastoma.Formula:C45H49ClFN7O11SColore e forma:SolidPeso molecolare:950.43AURKA-IN-4
CAS:AURKA-IN-4 is an AURKA inhibitor, which can inhibit the proliferation of tumor cells.Formula:C12H17NO3Purezza:99.98%Colore e forma:Brown SolidPeso molecolare:223.27GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurezza:99.73%Colore e forma:SolidPeso molecolare:507.63Aurora-A ligand 1
CAS:Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.Formula:C21H23N5O3Colore e forma:SolidPeso molecolare:393.439CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SoliddAURK-4
CAS:dAURK-4, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H52ClFN8O12Colore e forma:SolidPeso molecolare:1035.47PROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formula:C41H41N11O8SColore e forma:SolidPeso molecolare:847.90SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formula:C25H20FN7OPurezza:99.54%Colore e forma:White SolidPeso molecolare:453.47Ref: TM-T41256
1mg70,00€5mg152,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg401,00€50mg567,00€100mg802,00€200mg1.099,00€CAM2602
CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.Colore e forma:Odour SoliddAurAB2
dAurAB2 is a bifunctional PROTAC capable of effectively degrading Aurora-A and Aurora-B, with DC50 values of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and is valuable for neuroblastoma research.Colore e forma:Odour SolidTAS-119
CAS:TAS-119 (TAS-2104) is an orally available, selective and potent inhibitor of Aurora A with an IC50 of 1.0 nM.TAS-119 also inhibits Aurora B with an IC50 of 95Formula:C23H22Cl2FN5O3Purezza:99.65%Colore e forma:White SolidPeso molecolare:506.36Ref: TM-T34787
1mg92,00€5mg222,00€1mL*10mM (DMSO)248,00€10mg358,00€25mg710,00€50mg1.108,00€100mg1.558,00€
