Chinasi aurora
Gli inibitori delle chinasi Aurora prendono di mira le chinasi Aurora, una famiglia di chinasi serina/treonina che svolgono un ruolo fondamentale nella regolazione della mitosi. Queste chinasi sono essenziali per il corretto allineamento, segregazione e citodieresi dei cromosomi durante la divisione cellulare. Un'attività anomala delle chinasi Aurora può portare a una proliferazione cellulare incontrollata e al cancro. Inibendo le chinasi Aurora, questi composti possono indurre l'arresto del ciclo cellulare e l'apoptosi nelle cellule tumorali, rendendoli strumenti preziosi nella ricerca e nella terapia del cancro. Presso CymitQuimica, offriamo una vasta gamma di inibitori delle chinasi Aurora di alta qualità per supportare la tua ricerca sulla regolazione del ciclo cellulare, la mitosi e l'oncologia.
Trovati 126 prodotti per "Chinasi aurora".
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NU6140
CAS:NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM).Formula:C23H30N6O2Purezza:98.33%Colore e forma:SolidPeso molecolare:422.52LY3295668
CAS:LY3295668 (AK-01) is a selective inhibitor of Aurora A with Kis of 0.8 nM and 1038 nM for Aurora A and B, respectively.Formula:C24H26ClF2N5O2Purezza:99.68%Colore e forma:SolidPeso molecolare:489.945TAK-901
CAS:TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among othersFormula:C28H32N4O3SPurezza:99.02% - 99.59%Colore e forma:Yellow SolidPeso molecolare:504.644Tinengotinib
CAS:Tinengotinib is a multikinase inhibitor that targets a series of kinases , including Aurora kinases A/B, JAK1/2, FGFR1/2/3, VEGFRs, and many other kinases.Formula:C20H19ClN6OPurezza:99.05%Colore e forma:SolidPeso molecolare:394.86dAURK-4 hydrochloride
dAURK-4 hydrochloride, a derivative of Alisertib, functions as a potent and selective degrader of AURKA (Aurora A), exhibiting anticancer properties [1].Formula:C52H53Cl2FN8O12Purezza:99.44%Colore e forma:Yellow SolidPeso molecolare:1071.93HLB-0532259
CAS:HLB-0532259 is a PROTAC degrader that targets the degradation of Aurora-A and N-Myc. In non-MYCN amplified MCF-7 cells, it degrades Aurora-A with a DC50 of 20.2 nM, and in MYCN amplified SK-N-BE and Kelly cells, it degrades N-Myc with DC50 values of 179 nM and 229 nM, respectively. HLB-0532259 has demonstrated antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligaseCereblon)Formula:C40H44N8O7Colore e forma:SolidPeso molecolare:748.827Barasertib
CAS:AZD1152 is a pro-drug of Barasertib (AZD1152)-hQPA. Which is a highly selective Aurora B inhibitor with IC50 of 0.37 nM in a cell-free assay.Formula:C26H31FN7O6PPurezza:99.92% - 99.97%Colore e forma:White SolidPeso molecolare:587.5398SP-96
CAS:SP-96: Aurora B inhibitor, IC50=0.316 nM, selectively hinders MDA-MD-468 growth, GI50=107 nM, for triple-negative breast cancer research.Formula:C25H20FN7OPurezza:99.54%Colore e forma:White SolidPeso molecolare:453.471PROTAC MPS1 degrader 1
PROTAC MPS1 degrader 1 (Compound 19) acts as a potent degrader of Monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB, with DC50 values of 17.7, 108.7, and 570.3 nM respectively. It is utilized in the study of acute myeloid leukemia. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase)Formula:C41H46N12O7Colore e forma:SolidPeso molecolare:818.88PROTAC MPS1 degrader 2
PROTAC MPS1 Degrader 2 (Compound 15) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA, and AURKB with DC50 values of 42.0, 2.1, and 154.0 nM respectively. It is utilized in the research of acute myeloid leukemia.Formula:C41H41N11O8SColore e forma:SolidPeso molecolare:847.90dAurAB2
dAurAB2 is a bifunctional PROTAC capable of effectively degrading Aurora-A and Aurora-B, with DC50 values of 59 nM and 39 nM, respectively. It reduces N-Myc levels in MYCN-amplified IMR32 neuroblastoma cells and is valuable for neuroblastoma research.Colore e forma:Odour SolidJB300
CAS:JB300 is a PROTAC-based compound that serves as a highly selective degrader of Aurora A, with a DC50 of 30 nM. It is utilized in cancer research. JB300 comprises the PROTAC target protein ligand MK-5108 [pink part], E3 ligase ligand Thalidomide-O-COOH [blue part], and PROTAC Linker Boc-NH-PEG2-C2-NH2 [black part]. The conjugate of the E3 ubiquitin ligase ligand and linker is Thalidomide-O-COOH-NH2-C2-PEG2-NH-Boc.Formula:C43H45ClFN7O10SColore e forma:SolidPeso molecolare:906.375MS44
MS44 is a potent degrader of aurora kinase B (AURKBPROTAC) with a degradation concentration (DC50) of 103 nM. It effectively and selectively degrades AURKB in a time- and ubiquitin-proteasome system (UPS)-dependent manner, showing specificity for AURKB over AURKA and AURKC. MS44 inhibits the proliferation of various cancer cell lines and strongly induces G2/M arrest. It is useful for studying AURKB-dependent tumors.Colore e forma:Odour SolidAurora-A ligand 1
CAS:Aurora-A ligand 1 is a potent and selective inhibitor of Aurora-A, exhibiting a dissociation constant (Kd) of 0.85 nM. It serves as a target protein ligand [PROTAC target protein ligand] in the development of PROTAC Aurora-A degraders with antitumor activity. Additionally, Aurora-A ligand 1 is utilized in the synthesis of HLB-0532259, which exhibits antitumor effects against neuroblastoma.Formula:C21H23N5O3Colore e forma:SolidPeso molecolare:393.439AurAP14
AurAP14 is an Aurora APROTAC degrader with a DC50 of 120 nM. It exhibits notable inhibitory activity against various tumor cell lines, with an IC50 of 0.294 μM in A549 cells and 0.534 μM in MCF-7 cells. AurAP14 induces apoptosis in A549 cells and causes cell cycle arrest in the S and G2/M phases. It demonstrates antitumor efficacy in both A549 and A549/PTR nude mouse xenograft models. AurAP14 is applicable for studying treatments for non-small cell lung cancer (NSCLC) with Aurora A overexpression.Retreversine
CAS:Retreversine serves as an inactive control counterpart to Reversine, a pioneering class of ATP-competitive Aurora kinase inhibitor.Formula:C21H27N7OColore e forma:SolidPeso molecolare:393.49GSK-1070916
CAS:GSK-1070916 (GSK-1070916A) is a reversible and ATP-competitive inhibitor of Aurora B/C with IC50 of 3.5 nM/6.5 nM.Formula:C30H33N7OPurezza:99.73%Colore e forma:SolidPeso molecolare:507.6293CD532 hydrochloride
CD532 hydrochloride, potent Aurora A inhibitor (IC50=45 nM), hampers MYCN protein, changes AURKA's shape, aids cancer research.Colore e forma:SolidCAM2602
CAM2602 is an inhibitor of Aurora A-TPX2 interaction, demonstrating a binding affinity of 19 nM with Aurora A. This compound has been shown to inhibit the growth of pancreatic cancer cells. In solid tumor xenograft models, CAM2602 increases the proportion of PH3-positive cells while decreasing the ratio of P-Thr288Aurora A-positive cells, ultimately inhibiting tumor growth.Colore e forma:Odour SolidAURKA-IN-4
CAS:AURKA-IN-4 is an AURKA inhibitor, which can inhibit the proliferation of tumor cells.Formula:C12H17NO3Purezza:99.98%Colore e forma:Brown SolidPeso molecolare:223.27
