Recettore Sigma
I recettori sigma sono siti di legame unici che, a differenza dei tradizionali GPCR, non rientrano nelle categorie classiche delle proteine recettoriali. Sono coinvolti nella modulazione dei sistemi di neurotrasmettitori e sono stati implicati in vari disturbi neurologici e psichiatrici. I recettori sigma sono anche associati alla sopravvivenza cellulare, e i loro ligandi vengono esplorati per applicazioni terapeutiche nella neuroprotezione, nel cancro e nella gestione del dolore. Presso CymitQuimica, offriamo una selezione di modulatori dei recettori sigma di alta qualità per supportare la tua ricerca in neuroscienze, oncologia e biologia dei recettori.
Trovati 46 prodotti di "Recettore Sigma"
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Siramesine hydrochloride
CAS:Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibitFormula:C30H32ClFN2OPurezza:99.72% - >99.99%Colore e forma:SolidPeso molecolare:491.04PRE-084 hydrochloride
CAS:PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).Formula:C19H28ClNO3Purezza:99.54%Colore e forma:SolidPeso molecolare:353.88BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Formula:C15H24Br2Cl2N2Purezza:97.81%Colore e forma:SolidPeso molecolare:463.08Dimemorfan phosphate
CAS:Dimemorfan phosphate (3,17-dimethylmorphinan) is a sigma 1 receptor agonist. Dimemorfan phosphate is used as a potent antitussive.Formula:C18H25N·H3O4PPurezza:99.65%Colore e forma:SolidPeso molecolare:353.4Blarcamesine hydrochloride
CAS:Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).Formula:C19H24ClNOPurezza:99.57% - 99.9%Colore e forma:SolidPeso molecolare:317.85BD-1047 dihydrobromide
CAS:<p>BD-1047 dihydrobromide (BD1047.2HBr) , a selective functional antagonist of sigma receptors, has antipsychotic activity in animal models predictive of efficacy</p>Formula:C13H22Br2Cl2N2Purezza:98.13% - 99.39%Colore e forma:SolidPeso molecolare:437.04Blarcamesine
CAS:<p>Blarcamesine (AVex-73) is a muscarinic M1 agonist potentially for the treatment of Alzheimer's disease.</p>Formula:C19H23NOPurezza:99.87%Colore e forma:SolidPeso molecolare:281.39Ditolylguanidine
CAS:Ditolylguanidine (Di-o-tolylguanidine) is an agonist of sigma receptor (σ1/σ2 receptor).Formula:C15H17N3Purezza:98.42%Colore e forma:White To Pinkish Solid PowderPeso molecolare:239.32S1RA hydrochloride
CAS:<p>S1RA hydrochloride (E-52862 hydrochloride) is an effective and specific sigma-1 receptor(σ1R, Ki: 17 nM) antagonist, and has good selectivity against σ2R (Ki ></p>Formula:C20H24ClN3O2Purezza:98% - 99.84%Colore e forma:SolidPeso molecolare:373.87KB-5492 free base
CAS:KB-5492 free base is an antiulcer agent that inhibits sigma receptors and can be used to study gastric lesions and gastric secretion.Formula:C23H30N2O6Purezza:97.10% - 97.94%Colore e forma:SolidPeso molecolare:430.49Opipramol
CAS:Opipramol (Ensidon) is a compound with antidepressant activity, a sigma (σ) receptor agonist, and anxiolytic activity.Formula:C23H29N3OPurezza:99.84% - 99.98%Colore e forma:SolidPeso molecolare:363.5S1RA
CAS:S1RA (E-52862)(E-52862) is a potent, selective antagonist of the sigma-1 receptor (σ1R, Ki=17 nM), demonstrating significant selectivity over the sigma-2Formula:C20H23N3O2Purezza:99.45%Colore e forma:SolidPeso molecolare:337.42PD 144418
CAS:PD 144418 displays potential antipsychotic activity.Formula:C18H22N2OPurezza:98%Colore e forma:SolidPeso molecolare:282.38Sigma-LIGAND-1
CAS:<p>Sigma-LIGAND-1 is a selective Sigma Receptor ligand with an IC50s of 16 nM, 19 nM at the DTG site and the PPP site, respectively.</p>Formula:C27H33NO4Purezza:99.89%Colore e forma:SolidPeso molecolare:435.56DuP 734
CAS:<p>DuP 734 is a potent and selective sigma receptor antagonist, functioning as a ligand for both sigma and 5-HT2 receptors, and exhibiting weak affinity towards D2 receptors. It possesses potential antipsychotic activity, potentially devoid of the motor side effects commonly observed with neuroleptics[1][2][3].</p>Formula:C17H23BrFNOColore e forma:SolidPeso molecolare:356.279NE-100 hydrochloride
CAS:NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity.Formula:C23H34ClNO2Purezza:99.76%Colore e forma:SolidPeso molecolare:391.98Sigma-1 receptor antagonist 3
CAS:Sigma-1 receptor antagonist 3 is a more potent and selective antagonist of Sigma-1 (σ1) receptor (Ki = 1.14 nM) than σ2 receptor(Ki = 1239 nM).Formula:C19H23ClFN3OPurezza:99.95%Colore e forma:SolidPeso molecolare:363.86WLB-89462
CAS:WLB-89462 (Compound 20c) is a selective σ2 receptor ligand with a K i of 13 nM, exhibiting neuroprotective properties and the ability to ameliorate Aβ peptide-Formula:C21H29N5O3Purezza:98%Colore e forma:SolidPeso molecolare:399.49Sigma-1 receptor antagonist 2
CAS:<p>Sigma-1 receptor antagonist 2 is a more potent and selective antagonist of sigma 1 receptor (σ1 R, Ki = 3.88 nM) than σ2 receptor (Ki = 1288 nM).</p>Formula:C20H26ClN3O2Purezza:99.6%Colore e forma:SolidPeso molecolare:375.89S1R agonist 1 hydrochloride
CAS:S1R Agonist 1 (Compound 6b) hydrochloride is a selective S1R agonist, displaying K i values of 0.93 nM for S1R and 72 nM for S2R, and has demonstratedFormula:C20H26ClNOPurezza:98%Colore e forma:SolidPeso molecolare:331.88
