CaSR
Il recettore sensibile al calcio (CaSR) è un GPCR che svolge un ruolo vitale nel mantenimento dell'omeostasi del calcio regolando la secrezione dell'ormone paratiroideo e il riassorbimento del calcio nei reni. Il CaSR è anche coinvolto in vari altri processi fisiologici, tra cui il metabolismo osseo e la funzione vascolare. I modulatori del CaSR sono utilizzati nel trattamento di condizioni come l'iperparatiroidismo, l'osteoporosi e le malattie cardiovascolari. Presso CymitQuimica, offriamo una selezione di modulatori del CaSR di alta qualità per supportare la tua ricerca nel metabolismo del calcio, endocrinologia e salute delle ossa.
Trovati 34 prodotti di "CaSR"
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Strontium ranelate
CAS:<p>Strontium ranelate (S12911), a strontium (II) salt of the ranelic acid, is a medication for osteoporosis and can slow the course of osteoarthritis of the knee.</p>Formula:C12H6N2O8S·2SrPurezza:98.97%Colore e forma:Crystalline SolidPeso molecolare:513.49AC265347
CAS:<p>AC265347 is a potent calcium-sensitive receptor (CaSR) agonist and ago-PAM orthosteric modulator with antitumour activity for the study of neuroblastoma.</p>Formula:C17H17NOSPurezza:>99.99%Colore e forma:SolidPeso molecolare:283.39Evocalcet
CAS:Evocalcet (KHK7580) has an activating effect on the calcium-sensing receptor (CaSR).Formula:C24H26N2O2Purezza:98.88% - 99.68%Colore e forma:SolidPeso molecolare:374.48Etelcalcetide
CAS:<p>Etelcalcetide (AMG 416), a synthetic peptide CaSR activator, treats secondary hyperparathyroidism in hemodialysis patients.</p>Formula:C38H73N21O10S2Purezza:98%Colore e forma:SolidPeso molecolare:1048.26Poly-D-lysine hydrobromide (MW 1000-5000)
<p>Poly-D-lysine hydrobromide (PDLHB) (MW 1000-5000) is a synthetically produced polymeric substrate widely used in neural cell culture. Additionally, Poly-D-lysine hydrobromide acts as a CaSR agonist peptide.</p>Colore e forma:Odour SolidPoly-D-lysine hydrobromide (MW 150000-300000)
Poly-D-lysine hydrobromide (MW 150000-300000) enhances neural cell adhesion in culture and acts as a calcium-sensing receptor agonist peptide in research.Colore e forma:Odour SolidUpacicalcet HCl
Upacicalcet HCl, a calcium mimetic, reduces blood PTH by targeting parathyroid receptors; treats secondary hyperparathyroidism.Formula:C11H15Cl2N3O6SPurezza:98.56%Colore e forma:SoildPeso molecolare:388.22γ-Glu-Abu TFA
Gamma-Glu-AbuTFA is the TFA salt form of Gamma-Glu-Abu. This compound acts as an agonist for the calcium sensing receptor (CaSR), activating CaSR in HEK-293 cells with an EC50 of 0.21 μM.Formula:C11H17F3N2O7Colore e forma:SolidPeso molecolare:346.26G-Glu-Val
CAS:<p>G-Glu-Val (γ-glutamyl-L-valine, H-Glu-Val -OH), a flavour-regulating dipeptide, is a major contributor to "mellow".</p>Formula:C10H18N2O5Colore e forma:SolidPeso molecolare:246.26Calcium-Sensing Receptor Antagonists I
CAS:Calcium-Sensing Receptor Antagonists I functions as an antagonist to the parathyroid hormone receptors that sense calcium.Formula:C23H24N2O2Colore e forma:SolidPeso molecolare:360.45Cinacalcet
CAS:Cinacalcet (AMG 073) is an orally active, allosteric Ca receptor (CaR) agonist, treatment of cardiovascular disease .Formula:C22H22F3NPurezza:99.48%Colore e forma:Yellow OilPeso molecolare:357.41NPS-2143 hydrochloride
CAS:NPS-2143 hydrochloride (NPS-2143 HCL) is a selective potent calcium ion-sensing receptor antagonist.Formula:C24H25ClN2O2·HClPurezza:99.38% - 99.67%Colore e forma:SolidPeso molecolare:445.38TNCA
CAS:<p>TNCA (Lycoperodine-1) is a high-affinity CaSR ligand (CaSRL) with co-agonist activity.</p>Formula:C12H12N2O2Purezza:97.33% - 97.73%Colore e forma:SolidPeso molecolare:216.24Ligustroflavone
CAS:Ligustroflavone (Nuezhenoside) has anti-inflammatory activity.Formula:C33H40O18Purezza:98% - 99.92%Colore e forma:SolidPeso molecolare:724.66Gadolinium chloride
CAS:Gadolinium chloride is a calcium-sensing receptor (CaSR) agonistFormula:Cl3GdPurezza:98%Colore e forma:White Crystalline SolidPeso molecolare:263.61Cinacalcet hydrochloride
CAS:<p>Cinacalcet hydrochloride (AMG-073 hydrochloride) is a naphthalene derivative and CALCIMIMETIC AGENT that increases the sensitivity of PARATHYROID GLAND calcium-</p>Formula:C22H23ClF3NPurezza:99.96% - >99.99%Colore e forma:Off-White To Tan SolidPeso molecolare:393.87Etelcalcetide hydrochloride
CAS:<p>Etelcalcetide HCl, a synthetic peptide modulator of CaSR, lowers PTH in dialysis patients with secondary hyperparathyroidism.</p>Formula:C38H73N21O10S2HClPurezza:>99.99%Colore e forma:SolidPeso molecolare:1353.33NPS2390
CAS:<p>NPS2390 is a first generation quinoxaline derivative that acts as a noncompetitive antagonist of mGluR1 and mGluR5 (IC50 of 5.2 and 82 nM, respectively)</p>Formula:C19H21N3OPurezza:97.13%Colore e forma:SolidPeso molecolare:307.39Tecalcet Free Base
CAS:Tecalcet Free Base is an oral calcium receptor agonistFormula:C18H22ClNOColore e forma:SolidPeso molecolare:303.83SB-423562 HCl
CAS:SB-423562 is a calcium-sensing receptor antagonist.Formula:C26H33ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:473γ-L-Glutamyl-L-alanine
CAS:γ-L-Glutamyl-L-alanine, composed of gamma-glutamate and alanine, is the substrate of CRF21 (gamma-Glutamylcyclotransferase, GGCT).Formula:C8H14N2O5Purezza:99.49%Colore e forma:SolidPeso molecolare:218.21Poly-D-lysine hydrobromide (MW 30000-70000)
CAS:Poly-D-lysine hydrobromide (MW 30000-70000) (Poly-D-lysine HBr) is a peptide CaSR agonist that removes proteinase K-resistant PrP from SN56 neuroblastoma cells.Formula:(C6H14N2O2)x·xHBrColore e forma:SolidPeso molecolare:227.102NPS-2143
CAS:NPS-2143 (SB 262470A) is a novel potent and selective antagonist of Ca(2+) receptor.Formula:C24H25ClN2O2Purezza:99.56%Colore e forma:SolidPeso molecolare:408.92(Rac)-Upacicalcet
CAS:<p>(Rac)-Upacicalcet, a racemate, is an IV calcimimetic targeting parathyroid receptors to lower PTH, possibly treating SHPT.</p>Formula:C11H14ClN3O6SColore e forma:SolidPeso molecolare:351.76Calhex 231 hydrochloride
CAS:Calhex 231 hydrochloride a potent CaSR negative-conversion modulator that blocks the increase in [3H]inositol phosphate, inhibits mir-208a-mediated .Formula:C25H28Cl2N2OPurezza:99.36%Colore e forma:SolidPeso molecolare:443.41Tecalcet Hydrochloride
CAS:<p>Tecalcet Hydrochloride, an allosteric CaSR modulator, enhances extracellular Ca2+ sensitivity.</p>Formula:C18H23Cl2NOPurezza:99.97%Colore e forma:SolidPeso molecolare:340.29GSK3004774
CAS:<p>GSK3004774 is a nonabsorbable agonist of CaSR (pEC50: 7.3, 6.6, and 6.5 for human, mouse, and rat CaSR). GSK3004774 shows an EC50 of 50 nM for human CaSR.</p>Formula:C32H40N4O3Purezza:98%Colore e forma:SolidPeso molecolare:528.68Ronacaleret HCl
CAS:Ronacaleret HCl (SB-751689) is a small molecule CaSR antagonist for the treatment of endocrine and metabolic diseases, skin and musculoskeletal disorders.Formula:C25H32ClF2NO4Purezza:99.97%Colore e forma:SolidPeso molecolare:483.98CaSR antagonist-1
CAS:CaSR Antagonist-1 is a potent inhibitor of the calcium-sensing receptor (CaSR) with an inhibitory concentration (IC50) of 50 nM, suitable for the investigationFormula:C29H24FN3O2SPurezza:98%Colore e forma:SolidPeso molecolare:497.58Encaleret
CAS:Encaleret( JIT-305) is an antagonist of oral calcium-sensing receptor (CaSR), it is used for the treatment of osteoporosis.Formula:C29H33ClFNO4Colore e forma:SolidPeso molecolare:514.03Calindol hydrochloride
CAS:<p>Calindol (hydrochloride) is a positive allosteric modulator (PAM) of calcimimetic calcium-sensing receptor (CaSR) with an EC50 of 132 nM.</p>Formula:C21H21ClN2Purezza:99.47%Colore e forma:SolidPeso molecolare:336.86H-Glu-Thr-OH
CAS:H-Glu-Thr-OH (L-α-Glutamyl-L-threonine) is a dipeptide composed of two amino acids—glutamic acid (Glu) and threonine (Thr)—linked by a peptide bond and functions as an agonist of the extracellular calcium-sensing receptor (CaSR).Formula:C9H16N2O6Colore e forma:SolidPeso molecolare:248.23TAK-075
CAS:<p>TAK-075 is an orally active CaSR antagonist with an IC50 value of 0.94 nM. It transiently stimulates parathyroid hormone (PTH) secretion in rats and effectively prevents significant reduction in PTH secretion due to the accumulation of active metabolites, thereby maintaining a normal secretion pattern. TAK-075 is applicable in research related to metabolic diseases and osteoporosis.</p>Formula:C36H46N4O4SColore e forma:SolidPeso molecolare:630.84SB-423562
CAS:SB-423562 is a calcium-sensing receptor (CaSR) antagonist and can be used in studies about osteoporosis.Formula:C26H32N2O4Purezza:99.22%Colore e forma:SolidPeso molecolare:436.54
