SGLT
I co-trasportatori sodio-glucosio (SGLT) sono proteine di membrana che facilitano il riassorbimento del glucosio nei reni accoppiando il trasporto del glucosio con gli ioni sodio. Gli inibitori degli SGLT sono una classe importante di farmaci utilizzati nel trattamento del diabete di tipo 2, in quanto aiutano a ridurre i livelli di glucosio nel sangue impedendo il riassorbimento del glucosio nei tubuli renali. Questi inibitori vengono anche studiati per i loro potenziali benefici nella protezione cardiovascolare e renale. Presso CymitQuimica, offriamo una gamma di modulatori SGLT di alta qualità per supportare la tua ricerca sul diabete, la fisiologia renale e i disturbi metabolici.
Trovati 34 prodotti per "SGLT".
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Sergliflozin A
CAS:Sergliflozin A is a selective SGLT2 inhibitor that induces diabetes in a dose-dependent manner. It reduces hyperglycemia.Formula:C20H24O7Purezza:99.71%Colore e forma:SolidPeso molecolare:376.4004KGA-2727
CAS:KGA-2727: potent, selective SGLT1 inhibitor (human Ki 97.4 nM, rat 43.5 nM), with high selectivity over SGLT2 for diabetes treatment.Formula:C26H40N4O8Purezza:98.46%Colore e forma:SolidPeso molecolare:536.6178O-Desethyl Dapagliflozin
CAS:O-Desethyl Dapagliflozin (Empagliflozin-4) is a SGLT2 inhibitor, IC50=33nM.Formula:C19H21ClO6Purezza:98.33%Colore e forma:Yellow OilPeso molecolare:380.819SGLT2-IN-4
SGLT2-IN-4 (Compound 1) is a selective and orally active inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2). It increases the proportion of α-helices in proteins and enhances the stability of the SGLT2-D201A mutant. SGLT2-IN-4 is applicable in research for type 2 diabetes.Empagliflozin-d8
CAS:Empagliflozin-d8 is the deuterium-labeled form of Empagliflozin. Empagliflozin (BI 10773) acts as a selective inhibitor of the sodium-glucose co-transporter-2 (SGLT-2), exhibiting an IC50 value of 3.1 nM for human SGLT-2.Formula:C23H27ClO7Peso molecolare:458.96Dapagliflozin (Standard)
CAS:Dapagliflozin (Standard) is the standard for Dapagliflozin (T2389). Dapagliflozin is a competitive sodium-glucose cotransporter 2 (SGLT2) inhibitor that can reduce renal glucose reabsorption and promote urinary glucose excretion. Dapagliflozin can also inhibit renal mesangial cell fibrosis by regulating the HO-1/TGF-β1/Smad2/3 axis, and is related to research on glucose transport, renal cell responses, and fibrosis signaling. Dapagliflozin can also be used in research on SGLT2 pharmacology and mechanisms of renal fibrosis-related pathways.Formula:C21H25ClO6Peso molecolare:408.87Canagliflozin (Standard)
CAS:Canagliflozin (Standard) is the standard substance of Canagliflozin, and it is applicable for quantitative analysis, quality control, and related research in biochemical experiments. Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor that inhibits CHO cells expressing mSGLT2, rSGLT2, and hSGLT2 (IC50=2/3.7/4.4 nM). Canagliflozin can be used for the treatment of type II diabetes mellitus (T2DM).Formula:C24H25FO5SColore e forma:SolidPeso molecolare:444.52T-1095
CAS:T-1095 is an inhibitor of renal glucose reabsorption and the expression of Na+-glucose cotransporters (SGLTs) and facilitative glucose transporter 2 (GLUT2).Formula:C26H28O11Purezza:99.78%Colore e forma:SolidPeso molecolare:516.4939Tofogliflozin (hydrate)
CAS:Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific inhibitor of SGLT2(Ki of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2).Formula:C22H28O7Purezza:97.03% - 98.78%Colore e forma:White SolidPeso molecolare:404.4535Phlorizin
CAS:Phlorizin (Phloridzin) is a non-selective SGLT inhibitor found in apple, for hSGLT1( Ki=300 nM) and hSGLT2( Ki=39 nM) .Formula:C21H24O10Purezza:99.73% - 99.77%Colore e forma:Solid CrystallinePeso molecolare:436.41Sotagliflozin
CAS:Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potentialFormula:C21H25ClO5SPurezza:99% - 99.86%Colore e forma:SolidPeso molecolare:424.938Dapagliflozin ((2S)-1,2-propanediol, hydrate)
CAS:Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) is a selective, orally active inhibitor of the renal sodium-glucose co-Formula:C24H35ClO9Purezza:99.88% - 99.94%Colore e forma:SolidPeso molecolare:502.98Mizagliflozin
CAS:Mizagliflozin is an orally active, selective SGLT1 inhibitor with a Ki value of 27 nM for human SGLT1.Cost-effective and quality-assured.Formula:C28H44N4O8Purezza:98.66% - 99.67%Colore e forma:SolidPeso molecolare:564.671Canagliflozin
CAS:Canagliflozin (JNJ 28431754AAA) is a selective SGLT2 inhibitor. Canagliflozin is used to treat type II diabetes mellitus. Cost-effective and quality-assured.Formula:C24H25FO5SPurezza:98.01% - >99.99%Colore e forma:White SolidPeso molecolare:444.52Ipragliflozin
CAS:Ipragliflozin (ASP1941) is under investigation in Type 2 Diabetes and Diabetes Mellitus, Type 2.Formula:C21H21FO5SPurezza:99.38% - 99.70%Colore e forma:White SolidPeso molecolare:404.45Phloretin
CAS:Phloretin (NSC-407292) inhibits eukaryotic urea transporters, has antioxidative properties, and can induce cancer cell apoptosis. Found in apples and apricots.Formula:C15H14O5Purezza:98.53% - >99.99%Colore e forma:White SolidPeso molecolare:274.2687Ertugliflozin
CAS:PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).Formula:C22H25ClO7Purezza:99.89% - 99.96%Colore e forma:SolidPeso molecolare:436.883Bexagliflozin
CAS:Bexagliflozin (EGT1442) is a potent, selective sodium glucose co-transporter 2 (SGLT2) inhibitor with IC50 values of 2 nM for human SGLT2.Formula:C24H29ClO7Purezza:98.99% - 99.89%Colore e forma:SolidPeso molecolare:464.936Empagliflozin
CAS:Empagliflozin (BI 10773) is an SGLT-2 inhibitor (IC50=3.1 nM) that is potent and selective, with more than 300-fold selectivity for SGLT-1/4/5/6.Formula:C23H27ClO7Purezza:98% - 99.98%Colore e forma:SolidPeso molecolare:450.91Trilobatin
CAS:Trilobatin (P-Phlorizin) has anti-oxidant effect, can increase superoxide dismutase (SOD) activity.Trilobatin has anti-inflammatory effect, it potentiallyFormula:C21H24O10Purezza:97.16%Colore e forma:SolidPeso molecolare:436.4093
