Recettore del glucagone
I recettori del glucagone sono GPCR che mediano gli effetti del glucagone, un ormone coinvolto nella regolazione dell'omeostasi del glucosio promuovendo la degradazione del glicogeno e il rilascio di glucosio dal fegato. Questi recettori sono fondamentali nella gestione dei livelli di zucchero nel sangue e sono di particolare interesse nello studio del diabete e dei disturbi metabolici. Gli antagonisti dei recettori del glucagone sono studiati come potenziali trattamenti per l'iperglicemia nel diabete di tipo 2. Presso CymitQuimica, offriamo una varietà di modulatori dei recettori del glucagone di alta qualità per supportare la tua ricerca in endocrinologia, diabete e regolazione metabolica.
Trovati 204 prodotti per "Recettore del glucagone".
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Glucagon receptor antagonists-3
CAS:Glucagon receptor antagonist -3 is a highly effective glucagon receptor antagonist.Formula:C22H30FNO2Purezza:98%Colore e forma:SolidPeso molecolare:359.48GLP-1 receptor agonist 3
CAS:GLP-1 receptor agonist 3 is a GLP-1 receptor agonist,Example 4A-1, has EC50s of 1.1 nM and 13 nM in Clone H6 and Clone C6 cell lines assay, respectively.Formula:C31H30FN5O4Purezza:98%Colore e forma:SolidPeso molecolare:555.6Retagliptin hydrochloride
CAS:Retagliptin (SP2086) hydrochloride serves as a potent inhibitor of dipeptidyl peptidase-4 (DPP-4) and beta-amino acids. This compound aids in the management of type 2 diabetes and enhances glycemic control by extending the activity of intestinal hormones, notably glucagon-like peptide-1 (GLP-1) .Formula:C19H19ClF6N4O3Colore e forma:SolidPeso molecolare:500.82GLP-1R agonist 3
CAS:GLP-1R agonist 3 is a GLP-1R agonist, an imidazole derivative.GLP-1R agonist 3 can be used to study diabetes and obesity.Formula:C31H28FN5O4Purezza:97.19%Colore e forma:Yellow SolidPeso molecolare:553.58Lotiglipron
CAS:Lotiglipron (PF-07081532) is a GLP-1R agonist that lowers blood glucose and may be used in the study of type 2 diabetes mellitus (T2DM) and excess obesity.Formula:C31H31ClN4O5Purezza:98.3%Colore e forma:SolidPeso molecolare:575.05Ref: TM-T77781
1mg66,00€5mg133,00€1mL*10mM (DMSO)170,00€10mg197,00€25mg394,00€50mg512,00€100mg670,00€LGD-6972
CAS:LGD-6972 is an antagonist of glucagon receptor.Formula:C43H46N2O5SPurezza:98.8% - 99.62%Colore e forma:SolidPeso molecolare:702.9Ref: TM-T11845
1mg84,00€5mg177,00€10mg260,00€1mL*10mM (DMSO)268,00€25mg447,00€50mg655,00€100mg888,00€Adomeglivant
CAS:Adomeglivant (LY2409021) is a potent and selective glucagon receptor antagonist. Which is used in clinical trial for type 2 diabetes mellitus.Formula:C32H36F3NO4Purezza:99.51%Colore e forma:SolidPeso molecolare:555.63GLP-1 receptor agonist 15
CAS:GLP-1 receptor agonist 15 (Example 4) is a GLP receptor agonist with an EC50 of 0.74 nM. It exhibits an IC50 of 10.1 μM against the hERG potassium ion channel. This compound is applicable for research in the diabetes field.Formula:C32H31ClFN3O5Colore e forma:SolidPeso molecolare:592.057DA-302168S
CAS:DA-302168S is an orally active, selective GLP-1R agonist with an EC50 value of 1.32 nM. It promotes insulin secretion and has a hypoglycemic effect. Additionally, DA-302168S reduces food intake. It primarily activates GLP-1R in humans and monkeys, with minimal effect on GLP-1R in rats, mice, and dogs. DA-302168S can be used for research in type 2 diabetes and obesity.Formula:C33H24ClF2N3O5Colore e forma:SolidPeso molecolare:616.011Naperiglipron
CAS:Naperiglipron (LY3549492) (Example 2) is a glucagon-like peptide-1 receptor (GLP-1R) agonist with an EC50 of 1.14 nM for hGLP-1R. It markedly reduces blood glucose levels in GLP-1R gene knock-in mouse models. Additionally, Naperiglipron inhibits PDE10A1 enzyme activity (IC50: 7.43 μM) and exhibits weak hERG inhibitory activity. This compound is applicable in research on Type II diabetes mellitus (T2DM) and obesity.Formula:C33H26F2N4O4Peso molecolare:580.59GLP-1 receptor agonist 12
CAS:Compound 20A, known as GLP-1 receptor agonist 12, acts as an agonist of the GLP receptor. It is utilized in researching diseases like diabetes [1].Formula:C31H31FN6O4Colore e forma:SolidPeso molecolare:570.61Glucagon receptor antagonist-11
CAS:Glucagon receptor antagonist-11 (Compound 14) is a glucagon receptor antagonist with a pIC50 value of 6.677. This compound, along with Glucagon receptor antagonist-10, is applicable in glucose homeostasis research.Formula:C21H13FN4Peso molecolare:340.36GLP-1 receptor agonist 10
CAS:GLP-1 Receptor Agonist 10 (Compound 42), an agonist of the GLP receptor, reduces glucose excursions and inhibits food intake in mice. It is useful for research into type 2 diabetes (T2DM) and obesity [1].Formula:C30H28F4N6O5Colore e forma:SolidPeso molecolare:628.57GLP-1R agonist 8
CAS:GLP-1R agonist 8 is a potent agonist of GLP-1R (EC50 < 2 nM).Formula:C33H32N4O5Colore e forma:SolidPeso molecolare:564.63PF-06372222
CAS:PF-06372222: a small-molecule that modulates GCGR and antagonizes GLP-1R, affecting insulin and glucagon.Formula:C26H28F3N5O3Purezza:98%Colore e forma:SolidPeso molecolare:515.53GLP-1R modulator-1
CAS:GLP-1R modulator-1 (Compound 384) is a potent and orally active selective agonist of the glucagon-like peptide-1 receptor (GLP-1R). It activates G protein-coupled signaling, leading to increased intracellular cAMP levels, enhanced insulin secretion, delayed gastric emptying, and reduced appetite. GLP-1R modulator-1 holds potential for research in type 2 diabetes, obesity, and non-alcoholic steatohepatitis (NASH).Formula:C41H38ClFN6O4Colore e forma:SolidPeso molecolare:733.23GLP-1 receptor agonist 16
CAS:GLP-1 receptoragonist 16 (Example 53) is a GLP-1 agonist applicable for research in diabetes, obesity, or diseases related to non-alcoholic steatohepatitis.Formula:C33H31ClFN3O4Colore e forma:SolidPeso molecolare:588.068LXT34
CAS:LXT34 (Example 2) is a GPR120 agonist with anti-inflammatory properties. This compound enhances GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreatic cells. LXT34 is applicable in studies related to inflammatory conditions, such as type 2 diabetes, obesity, and non-alcoholic fatty liver disease.Formula:C18H21NO3SColore e forma:SolidPeso molecolare:331.43DS79932728
CAS:DS79932728 is an orally active inhibitor of G9a and GLP, with IC50 values of 12.6 nM and 75.7 nM, respectively. It induces the production of γ-globin, thereby increasing fetal hemoglobin (HbF) levels. In cynomolgus monkey models, DS79932728 enhances the proportion of F-reticulocytes (F-rets) and shows good oral absorption characteristics.Formula:C19H25N3OColore e forma:SolidPeso molecolare:311.421GLP-1R agonist 32
CAS:GLP-1R agonist 32 (Compound 111) is an orally active and potent GLP-1R agonist with an EC50 value of 0.017 nM. It stimulates the production of cyclic adenosine monophosphate (cAMP) by activating GLP-1R, which enhances insulin secretion, suppresses glucagon release, and delays gastric emptying to regulate blood glucose levels. GLP-1R agonist 32 shows potential for research in type 2 diabetes, obesity, and related metabolic disorders.Formula:C32H31ClFN3O5Colore e forma:SolidPeso molecolare:592.06
