Recettore della dopamina
I recettori della dopamina sono un gruppo di recettori accoppiati alle proteine G (GPCR) che rispondono al neurotrasmettitore dopamina, svolgendo un ruolo chiave nella regolazione del movimento, della motivazione, della ricompensa e di diverse funzioni cognitive. Questi recettori sono divisi in famiglie simili a D1 e D2, ognuna con funzioni e profili farmacologici distinti. I modulatori dei recettori della dopamina sono ampiamente studiati per le loro applicazioni nel trattamento del morbo di Parkinson, della schizofrenia, della dipendenza e di altri disturbi neuropsichiatrici. Presso CymitQuimica, offriamo una vasta gamma di modulatori dei recettori della dopamina di alta qualità per supportare la tua ricerca in neuroscienze, salute mentale e segnalazione GPCR.
Trovati 443 prodotti di "Recettore della dopamina"
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PD 128907
CAS:PD 128907 - potent, selective dopamine D2/D3 agonist for researching receptor roles in the brain.Formula:C14H19NO3Purezza:98%Colore e forma:SolidPeso molecolare:249.31UWA-101 hydrochloride
CAS:UWA-101 hydrochloride is a selective, non-cytotoxic inhibitor of DAT/SERT, demonstrating EC50 values of 3.6 µM for DAT and 2.3 µM for SERT inhibition. It mitigates motor disorders and other side effects associated with dopaminergic agent use (e.g., L-DOPA) without exhibiting psychotropic effects. This compound is utilized in research focused on neurodegenerative conditions like Parkinson's disease [1] [2].Formula:C13H18ClNO2Colore e forma:SolidPeso molecolare:255.74Sonepiprazole
CAS:Sonepiprazole (PNU-101387G) is a chemical compound known for its selective antagonistic properties toward D4 dopamine receptors, exhibiting dissociationFormula:C21H27N3O3SPurezza:99.81%Colore e forma:SolidPeso molecolare:401.52Desethoxy Quetiapine hydrochloride
CAS:Desethoxy quetiapine, an active metabolite of the atypical antipsychotic quetiapine, primarily forms through the action of the cytochrome P450 (CYP) isoform CYP3A5. This compound binds to dopamine D2 receptors with an IC50 value of 1,330 nM. In vivo, desethoxy quetiapine at dosages of 20 and 40 mg/kg mitigates dopamine receptor agonist apomorphine-induced climbing behavior and ameliorates swimming deficits in mice, showcasing its potential modulatory effects on dopamine-mediated behaviors.Formula:C19H21N3OSHClColore e forma:SolidPeso molecolare:412.38Quinpirole dihydrochloride
CAS:Quinpirole dihydrochloride is an agonist of the D2-like dopamine receptor.Formula:C13H23Cl2N3Purezza:98%Colore e forma:SolidPeso molecolare:292.25Carmoxirole hydrochloride
CAS:Carmoxirole hydrochloride (EMD 45609 hydrochloride) is a selective dopamine D2 receptor agonist with antihypertensive activity in vivo.Formula:C24H27ClN2O2Purezza:99.37% - 99.62%Colore e forma:SolidPeso molecolare:410.94Ref: TM-T10683
1mg44,00€5mg90,00€10mg130,00€25mg215,00€50mg316,00€100mg434,00€200mg585,00€1mL*10mM (DMSO)94,00€LY-368975
CAS:LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents.Formula:C17H21NOSColore e forma:SolidPeso molecolare:287.42FAUC-312
CAS:FAUC-312 is a potent and selective agonist of the dopamine D4 receptor.Formula:C21H26N4Purezza:98%Colore e forma:SolidPeso molecolare:334.46Pentiapine
CAS:Pentiapine (CGS 10746) is a novel inhibitor of dopamine release.Formula:C15H17N5SPurezza:99.35%Colore e forma:SolidPeso molecolare:299.39Ref: TM-T12405
1mg487,00€5mg753,00€10mg1.216,00€25mg1.691,00€50mg2.262,00€100mg3.068,00€1mL*10mM (DMSO)938,00€Piribedil N-oxide
CAS:Piribedil N-oxide, a metabolite of the dopamine receptor agonist piribedil, represents a chemical compound involved in the metabolic processing of its parent compound, piribedil.Formula:C16H18N4O3Colore e forma:SolidPeso molecolare:314.34SB-414796
CAS:SB-414796 is a selective antagonist of the dopamine D3 receptor.Formula:C29H36N4O4SPurezza:98%Colore e forma:SolidPeso molecolare:536.69CP-293019
CAS:CP-293019 is a potent, selective antagonist of dopamine D4 receptor.Formula:C19H22F2N4OPurezza:98%Colore e forma:SolidPeso molecolare:360.4(+)-Dihydrexidine hydrochloride
CAS:(+)-Dihydrexidine hydrochloride is an agonist of dopamine D1 receptor(EC50 of 72± 21 nM).Formula:C17H18ClNO2Purezza:98%Colore e forma:SolidPeso molecolare:303.78Naxagolide free base
CAS:Naxagolide is a sustained release formulation. It is a dopamine agonist.Formula:C15H21NO2Purezza:98%Colore e forma:SolidPeso molecolare:247.33Timiperone
CAS:Timiperone exhibits a high affinity for cerebral dopamine D2 receptors, demonstrating antipsychotic activity as it mitigates stereotyped behavior.Formula:C22H24FN3OSPurezza:98%Colore e forma:SolidPeso molecolare:397.514-Amino-PPHT Hydrobromide
CAS:4-Amino-PPHT Hydrobromide is a precursor for fluorescent labeled Dopamine D2 receptors agonist.Formula:C21H28N2OPurezza:98%Colore e forma:SolidPeso molecolare:324.46NMI 8739
CAS:<p>NMI 8739 (n-docosahexaenoyl dopamine) is an agonist of D2 autoreceptor.</p>Formula:C30H41NO3Purezza:98.51%Colore e forma:SolidPeso molecolare:463.65PAOPA
CAS:dopamine D2 receptor modulatorFormula:C11H18N4O3Purezza:>99.99%Colore e forma:SolidPeso molecolare:254.29Lumateperone
CAS:<p>Lumateperone (ITI 722) is a 5HT2A receptor antagonist and a dopamine receptor phosphoprotein modulator (DPPM).</p>Formula:C24H28FN3OPurezza:99.68% - 99.91%Colore e forma:SolidPeso molecolare:393.5NMDAR antagonist 5
CAS:NMDAR antagonist 5 (Compound A17) is a multi-target antagonist that acts on NMDAR and monoamine transporters (SERT, DAT, and NET). It demonstrates strong NMDAR antagonistic efficacy (IC50= 0.3 μM) and effective activity on monoamine transporters (SERT IC50= 1.1 μM, DAT IC50= 0.7 μM, NET IC50= 2.7 μM). NMDAR antagonist 5 exhibits high safety with low toxicity (hepatic and renal toxicity IC50> 100 μM; cardiac toxicity IC50= 24.5 μM). It has antidepressant properties and is useful for depression research.Formula:C17H21N3Colore e forma:SolidPeso molecolare:267.369RG-15
CAS:RG-15 is an orally active dopamine receptor antagonist with high affinity for the human D2 receptor (pKi of 8.23) and human D3 receptor (pKi of 10.49). It inhibits dopamine-stimulated [35S]GTPγS binding with IC50 values of 21.2 nM in rat striatal membranes, 36.7 nM in mouse A9 cells expressing human D2L receptors, and 7.2 nM in CHO cells expressing human D3 receptors. RG-15 enhances dopamine turnover and synthesis in the striatum and olfactory bulb of mice, exhibiting antipsychotic activity.Formula:C25H32Cl2F3N5O2SColore e forma:SolidPeso molecolare:594.52Dopamine D3 receptor ligand-1
Dopamine D 3 receptor ligand is a potent, selective, high-affinity dopamine D3 receptor ligand that is 89 times more selective for D3 (Ki: 8 nM) than D2 (Ki:Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55CM699
CAS:CM699 is an effective dual inhibitor of the dopamine transporter (DAT) and Sigma receptor (σR), with IC50 values of 311 nM and 14.1 nM, respectively.Formula:C24H29N3O2Colore e forma:SolidPeso molecolare:391.519-Methyl-β-carboline
CAS:9-Methyl-β-carboline is a cognitive enhancer with neuroprotective, neurorestorative, and anti-inflammatory properties. Its behavioral effects may be linked to hippocampal dopamine levels and the stimulation of dendritic and synaptic proliferation.Formula:C12H10N2Colore e forma:SolidPeso molecolare:182.221Dopamine D3 receptor antagonist-1
Dopamine D3 receptor antagonist-1 is a dopamine D3 receptor selective or multi-targeting ligand with a Ki value of 1.58 nM that has demonstrated therapeuticFormula:C31H35Cl2N3O3Colore e forma:SolidPeso molecolare:568.53U91356
CAS:U91356 is an agonist of the dopamine receptors.Formula:C13H17N3OPurezza:98%Colore e forma:SolidPeso molecolare:231.29UNC10099984A
CAS:UNC10099984A (Compound 6) is a functionally selective ligand for the dopamine D2 receptor, exhibiting a Ki value of 4.6 nM and an EC50 of 6.2 nM for β-arrestin. This compound is useful for research into central nervous system diseases related to the D2 receptor.Formula:C24H29Cl2N3O2Colore e forma:SolidPeso molecolare:462.41D4R antagonist-1
Potent, selective D4R antagonist; IC50 = 6.87 µM; potential in Parkinson’s disease research.Formula:C21H25F2NO2Colore e forma:SolidPeso molecolare:361.43Cendifensine
CAS:Cendifensine functions as a monoamine reuptake inhibitor, targeting the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT).Formula:C14H17Cl2NOColore e forma:SolidPeso molecolare:286.197Disulergine
CAS:Disulergine is a dopamine receptor agonist. It also prolactin release-inhibiting 8 alpha-amino-ergoline.Formula:C17H24N4O2SPurezza:98%Colore e forma:SolidPeso molecolare:348.46LY3154207
CAS:LY3154207: selective, potent oral human dopamine D1 receptor PAM, low agonist activity, EC50=3 nM.Formula:C24H29Cl2NO3Colore e forma:SolidPeso molecolare:450.4Lisuride
CAS:Lisuride: an oral D2 dopamine agonist, ergot derivative, used in Parkinson's, migraine, and high prolactin research.Formula:C20H26N4OColore e forma:SolidPeso molecolare:338.45RS 12254
CAS:RS 12254 is a dopamine agonist and antihypertensive agent.Formula:C28H40N2O4Purezza:98%Colore e forma:SolidPeso molecolare:468.63Quinagolide Free Base
CAS:Quinagolide Free Base is a non-ergot dopamine D(2)-agonist.Formula:C20H33N3O3SColore e forma:SolidPeso molecolare:395.56Dopamine D4 receptor ligand 3
CAS:Dopamine D4 receptor ligand 3 (Compound 16) functions as a dopamine D4 receptor (D4R) antagonist with a pKi of 8.86. In HEK-293T cells, it shows pIC50 values of 5.78, 5.55, and 6.17 for Go, Gi, and βArr2 sensors, respectively. This compound inhibits the activity of human glioma cell lines U87 MG, T98G, and U251 MG, and it induces ROS production and mitochondrial dysfunction in these glioma cells.Formula:C28H31N3O5Colore e forma:SolidPeso molecolare:489.56Neflumozide
CAS:Neflumozide (HRP 913) is an orally effective derivative of benzisoxazole, characterized by its potent dopamine antagonist properties and antipsychotic activity. It is utilized in research related to psychiatric disorders.Formula:C22H23FN4O2Colore e forma:SolidPeso molecolare:394.44PD-147693
CAS:PD-147693 (compound II) is an active metabolite of the presynaptic dopamine autoreceptor agonist CI-1007, and it exhibits antipsychotic activity similar to CI-1007.Formula:C24H27NOPeso molecolare:345.477Dopamine D3 receptor antagonist-2
Dopamine D3 receptor antagonist-2 is a dopamine D3 receptor selective (Ki=2.16 nM) or multi-targeting dual ligand that shows potential effects in CNS disorders.Formula:C23H27Cl2N3O3Colore e forma:SolidPeso molecolare:464.38D4R antagonis-2
Potent D4R antagonist-2: selective, IC50=6.52 μM, good in vitro PK and brain penetration, potential for Parkinson's research.Formula:C21H23ClF2N2O2Colore e forma:SolidPeso molecolare:408.87D1R antagonist 1
CAS:Compound 12a (D1R antagonist 1) is a D1R antagonist that participates in both G-protein-coupled and β-arrestin-mediated signaling pathways [1].Formula:C22H26BrNO4Purezza:98%Colore e forma:SolidPeso molecolare:448.353-Hydroxybenzylamine
CAS:3-Hydroxybenzylamine is a useful organic compound for research related to life sciences. The catalog number is T124305 and the CAS number is 73604-31-6.Formula:C7H9NOColore e forma:SolidPeso molecolare:123.1556-Chloro-5-(2-chloroethyl)indolin-2-one
CAS:6-Chloro-5-(2-chloroethyl)indolin-2-one is a useful organic compound for research related to life sciences. The catalog number is T64862 and the CAS number is 118289-55-7.Formula:C10H9Cl2NOColore e forma:SolidPeso molecolare:230.09GR 218,231
CAS:GR 218,231 is a selective antagonist of D3 dopamine receptor.Formula:C24H33NO3SPurezza:98%Colore e forma:SolidPeso molecolare:415.59Ref: TM-T27431
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