GTPase
Le GTPasi sono una famiglia di enzimi che idrolizzano il guanosina trifosfato (GTP) in guanosina difosfato (GDP), svolgendo un ruolo cruciale nelle vie di trasduzione del segnale, comprese quelle mediate dai GPCR. Le GTPasi agiscono come interruttori molecolari in vari processi cellulari, come la divisione cellulare, la crescita e la differenziazione. La disregolazione dell'attività delle GTPasi è implicata in numerose malattie, tra cui il cancro e i disturbi genetici. Presso CymitQuimica, offriamo una selezione di modulatori di GTPasi di alta qualità per supportare la tua ricerca nella segnalazione cellulare, biologia del cancro e vie correlate ai GPCR.
Trovati 22 prodotti di "GTPase"
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PT-129
PT-129 is a PROTAC degrader targeting the NTF2 domain of G3BP1/2, degrading stress granules in stressed cells, suppressing proliferation.Formula:C46H48N8O12SColore e forma:SolidPeso molecolare:936.98RGS2-Galpha-q interaction-IN-1
RGS2–Galpha-q interaction-IN-1 (Compound AJ-3) is an inhibitor of the RGS2-Galpha-q interaction. It inhibits the growth of cancer cell lines that express RGS2 and has anti-cell migration properties.Formula:C30H30ClN7O3Colore e forma:SolidPeso molecolare:572.06Myristoylated ARF6 (2-13)
Myristoylated ARF6 (2-13) inhibits the MyD88–ARNO–ARF6 signaling axis by inactivating ARF6.Formula:C74H128N16O18Peso molecolare:1528.95925CID-1067700
CAS:CID-1067700 is one of the first identified competitive inhibitors of nucleotide binding by Ras-related GTPases（Rab7 with a Ki of 13 nM).Formula:C18H18N2O4S2Purezza:99.46%Colore e forma:SolidPeso molecolare:390.48Ref: TM-T7558
1mg35,00€2mg52,00€5mg74,00€10mg111,00€25mg188,00€50mg246,00€100mg319,00€1mL*10mM (DMSO)82,00€Exo-1
CAS:Exo-1 (Methyl 3-(4-fluorobenzoyl)-6-methyl-2-pyridinecarboxylate) is a synthetic compound that has been shown to affect the metabolism of various nutrients, asFormula:C15H12FNO3Purezza:99.45%Colore e forma:SolidPeso molecolare:273.26Ref: TM-T9200
5mg55,00€10mg82,00€25mg126,00€50mg182,00€100mg273,00€200mg409,00€500mg677,00€1mL*10mM (DMSO)69,00€BQU57
CAS:BQU57 shows selective inhibition for Ral relative to Ras or Rho and inhibit xenograft tumor growth.Formula:C16H13F3N4OPurezza:97.45% - 98.72%Colore e forma:SolidPeso molecolare:334.3CCG-50014
CAS:CCG-50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.Formula:C16H13FN2O2SPurezza:98.53%Colore e forma:SolidPeso molecolare:316.35Exo1
CAS:Exo1 is an inhibitor of the exocytic pathwayFormula:C15H12FNO3Purezza:98.75%Colore e forma:SolidPeso molecolare:273.26MLS-573151
CAS:MLS-573151 is a selective inhibitor of GTPase Cdc42(EC50 of 2 μM).Formula:C21H19N3O2SPurezza:98.80%Colore e forma:SolidPeso molecolare:377.46Ref: TM-T22106
2mg35,00€5mg52,00€10mg90,00€25mg170,00€50mg259,00€100mg383,00€200mg545,00€1mL*10mM (DMSO)58,00€NAV-2729
CAS:NAV-2729 inhibits six ArfGEFs (human ARNO, EFA6, BIG1, and BRAG2 and Legionella and Rickettsia RalF), the strongest effects being against BRAG2, Arf1 and Arf6.Formula:C25H17ClN4O3Purezza:98.83% - 98.91%Colore e forma:SolidPeso molecolare:456.88Ref: TM-T5142
2mg46,00€5mg66,00€10mg96,00€25mg205,00€50mg303,00€100mg454,00€500mg938,00€1mL*10mM (DMSO)74,00€RBC8
CAS:RBC8 is a specific GTPases RalA/RalB inhibitor by inhibiting the binding of Ral to its effector RALBP1, no inhibition on the GTPases RhoA and Ras.Formula:C25H20N4O3Purezza:98.44% - 99.81%Colore e forma:SolidPeso molecolare:424.45Ref: TM-T6634
1mg48,00€5mg92,00€10mg156,00€25mg298,00€50mg472,00€100mg687,00€200mg938,00€1mL*10mM (DMSO)97,00€ML-097
CAS:ML-097 (CID-2160985) is a pan activator of Ras-related GTPasesFormula:C14H11BrO3Purezza:99.12%Colore e forma:SolidPeso molecolare:307.139Ref: TM-T21970
5mg65,00€10mg95,00€25mg140,00€50mg202,00€100mg303,00€500mg725,00€1mL*10mM (DMSO)71,00€Dynamin inhibitory peptide Acetate
Dynamin inhibitory peptide Acetate is a peptide with the sequence Gln-Val-Pro-Ser-Arg-Pro-Asn-Arg-Ala-Pro that inhibit the GTPase dynamin.Formula:C49H84N18O16Purezza:97.28%Colore e forma:SolidPeso molecolare:1181.3Ref: TM-T21798L
1mg115,00€5mg350,00€10mg517,00€25mg822,00€50mg1.130,00€100mg1.501,00€1mL*10mM (DMSO)833,00€QS11
CAS:QS11, a GTPase ARFGAP1, modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation.Formula:C36H33N5O2Purezza:98.59%Colore e forma:SolidPeso molecolare:567.68Ref: TM-T4022
2mg35,00€5mg52,00€10mg85,00€25mg156,00€50mg226,00€100mg340,00€200mg465,00€1mL*10mM (DMSO)65,00€Bragsin1
CAS:Bragsin1 is a potent and selective and noncompetitive ArfGEF BRAG2 inhibitor, inhibits Arf GTPase activation(IC50 : 3 μM),and with anti-cancer activity.Formula:C11H6F3NO4Colore e forma:SolidPeso molecolare:273.16CCG-4986
CAS:CCG-4986 is the first small molecule RGS inhibitor reported that directly bound to an RGS protein.Formula:C13H11ClN2O5S2Colore e forma:SolidPeso molecolare:374.82CCG-2046
CAS:CCG-2046 is a chemical inhibitor targeting RGS4, demonstrating an inhibition concentration (IC50) of 4.3 μM for the interaction between RGS4 and Gαo signal.Formula:C11H10N4Colore e forma:SolidPeso molecolare:198.22Compound C108
CAS:<p>Compound C108 is an inhibitor of GTPase-activating protein SH3 domain-binding protein 2 (G3BP2).</p>Formula:C15H14N2O3Purezza:99.77%Colore e forma:SolidPeso molecolare:270.28CCG-63808
CAS:CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins.Formula:C25H15FN4O2SPurezza:90%Colore e forma:SolidPeso molecolare:454.48RBC10
CAS:RBC10 inhibits the binding of Ral to its effector RALBP1, as well as inhibiting Ral-mediated cell spreading of murine embryonic fibroblasts and anchorage-Formula:C24H25ClN2O2Purezza:99.71%Colore e forma:SolidPeso molecolare:408.92Ref: TM-T24706
1mg34,00€2mg52,00€5mg80,00€10mg116,00€25mg259,00€50mg374,00€100mg545,00€200mg740,00€1mL*10mM (DMSO)86,00€CCG-63802
CAS:CCG-63802 is a reversible small-molecule inhibitor of regulator of G protein signaling (RGS) proteins.Formula:C26H18N4O2SPurezza:90%Colore e forma:SolidPeso molecolare:450.51RGS10 modulator-1
CAS:RGS10 modulator-1 (compound 15) is an effective regulator of RGS10. It significantly reverses IFNγ-induced expression of both RGS10 protein and mRNA, as well as COX-2 mRNA and iNOS expression triggered by IFNγ.Formula:C16H15BrN2O3S2Colore e forma:SolidPeso molecolare:427.336
