GPCR19
GPCR19, noto anche come GPR19, è un membro della famiglia dei recettori accoppiati alle proteine G, i cui ruoli sono ancora in fase di chiarimento in vari processi fisiologici. Sebbene meno caratterizzato rispetto ad altri GPCR, GPCR19 è di interesse nella ricerca focalizzata sulla scoperta di nuovi bersagli terapeutici per malattie metaboliche, cancro e disturbi neurologici. Presso CymitQuimica, offriamo una selezione di strumenti di ricerca e reagenti per supportare le vostre indagini sulle funzioni e le potenziali applicazioni terapeutiche di GPCR19.
Trovati 33 prodotti di "GPCR19"
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Hyodeoxycholic acid
CAS:<p>Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.</p>Formula:C24H40O4Purezza:97.29% - 98.82%Colore e forma:SolidPeso molecolare:392.57Deoxycholic acid
CAS:Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate.Formula:C24H40O4Purezza:99.91% - 99.91%Colore e forma:Crystals From Alc SolidPeso molecolare:392.57Ursodeoxycholic acid
CAS:Ursodeoxycholic acid (UDCA) is a potent inhibitor of liver-specific fatty acid transporter 5 (FATP5),inhibits cholesterol absorption. High-Quality, Low-Cost!Formula:C24H40O4Purezza:99.74% - ≥95%Colore e forma:White - Almost White Solid PowderPeso molecolare:392.57Cholic Acid 7-sulfate
CAS:Cholic acid 7-sulfate: a cholic acid metabolite with added sulfate at position 7, increased in feces of male mice with specific diets.Formula:C24H40O8SColore e forma:SolidPeso molecolare:488.64TGR5 agonist 1
Compound 18 (TGR5 agonist 1) is a potent agonist of TGR5, exhibiting an EC50 value of 0.31 µM [1].Formula:C28H48NNaO6SColore e forma:SolidPeso molecolare:549.74TGR5 agonist 4
TGR5 agonist 4 (compound 19), a derivative of cholic acid, selectively activates the TGR5 receptor with an effective concentration (EC50) of 4 μM [1].Formula:C24H38F2O5Colore e forma:SolidPeso molecolare:444.555-HT7R antagonist 1 free base
CAS:5-HT7R antagonist 1 (free base) is a G protein-biased antagonist for the 5-HT 7 R receptor, with a dissociation constant (K i) of 6.5 nM.Formula:C14H17ClN4Colore e forma:SolidPeso molecolare:276.77PEN (human)
CAS:PEN (human) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Formula:C97H159N27O32Purezza:98%Colore e forma:SolidPeso molecolare:2215.49PEN (rat)
CAS:PEN (rat) is an Endogenous peptide GPR83 agonist. ProSAAS-derived neuropeptide.Formula:C102H169N27O33Purezza:98%Colore e forma:SolidPeso molecolare:2301.62TGR5 agonist 2
TGR5 agonist 2 (compound 19) serves as a highly potent agonist of TGR5, demonstrating an EC50 value of 0.27 µM [1].Formula:C29H50NNaO6SColore e forma:SolidPeso molecolare:563.77TGR5 agonist 6
CAS:Compound 22b, also known as TGR5 agonist 6, is a non-systemic, intestine-targeted TGR5 agonist that demonstrates significant and sustained blood glucose-lowering effects with an acceptable safety profile.Formula:C42H48Cl2N6O6Colore e forma:SolidPeso molecolare:803.77TGR5 agonist 7
TGR5 agonist 7 (Compound 22-Na) is an intestine-restricted, orally active agonist of the G protein-coupled bile acid receptor TGR5 (GPBAR1 or GPR131) with an EC50 of less than 1 μM. In mouse models, it demonstrates blood glucose-lowering effects, making it useful for diabetes research.Formula:C37H59N2NaO9SColore e forma:SolidPeso molecolare:730.93Neuromedin S (human)
CAS:Neuromedin S (human) is a 33-amino acid neuropeptide identified as an endogenous ligand for the orphan G-protein coupled receptor (GPCR) FM-4/TGR-1, acting onTriamterene
CAS:Triamterene is a barosensitive epithelial sodium channel (ENaC) blocker with a diuretic effect. It can also act as an inhibitor of the TGR5 receptor, reducing GLP-1 secretion and cAMP level increases induced by TGR5 activation in a dose-dependent manner.Formula:C12H11N7Purezza:99.77%Colore e forma:Yellow Yellow SolidPeso molecolare:253.26Deoxycholic acid sodium salt
CAS:<p>Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates BAT thermogenic activity.</p>Formula:C24H39NaO4Purezza:97.88% - 99.75%Colore e forma:Cream Crystalline PowderPeso molecolare:414.56TC-G 1005
CAS:TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5).Formula:C25H25N3O2Purezza:98.60% - 99.78%Colore e forma:SolidPeso molecolare:399.48SBI-115
CAS:SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5Formula:C14H13ClN2O4SPurezza:99.53% - 99.78%Colore e forma:SolidPeso molecolare:340.78SB756050
CAS:SB756050 is a specific TGR5 agonist.Formula:C21H28N2O8S2Purezza:98.78% - >99.99%Colore e forma:SolidPeso molecolare:500.59BAR502
CAS:BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).Formula:C25H44O3Purezza:99.95%Colore e forma:SolidPeso molecolare:392.62TGR5 Receptor Agonist
CAS:TGR5 is a potent TGR5(GPCR19) agonist.Formula:C18H14Cl2N2O2Purezza:99.77% - ≥95%Colore e forma:SolidPeso molecolare:361.22BAR501
CAS:BAR501是高效选择性的 GPBAR1激动剂(EC50:1 μM)。Formula:C26H46O3Purezza:99.29% - 99.68%Colore e forma:SolidPeso molecolare:406.64PEN (human) aceate
PEN (human) aceate, one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83.Formula:C99H163N27O34Purezza:99.25%Colore e forma:SolidPeso molecolare:2275.51Ursodeoxycholic acid sodium
CAS:<p>Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities.</p>Formula:C24H40NaO4Purezza:99.66% - 99.96%Colore e forma:SolidPeso molecolare:415.56WB403
CAS:WB403 activates TGR5, lowers fasting/postprandial glucose and HbA1c, enhances glucose tolerance, and normalizes pancreatic α/β-cells in diabetic mice.Formula:C19H19BrN2OSPurezza:98%Colore e forma:SolidPeso molecolare:403.34CAY10789
CAS:CAY10789: potent CysLT1R antagonist (IC50 2.8 µM), GPBAR1 agonist (EC50 3 µM), reduces U937 cell adhesion, TNF-α, stable with promising pharmacokinetics.Formula:C17H15NO2Colore e forma:SolidPeso molecolare:265.31TGR5 agonist 3
CAS:Compound 8, a cholic acid derivative, functions as a selective TGR5 agonist and exhibits an EC50 value of 5 μM [1].Formula:C28H48O5Colore e forma:SolidPeso molecolare:464.68TGR5 Receptor Agonist 4
CAS:TGR5 Receptor Agonist 4, a selective agonist for the Bile Acid Receptor (TGR5), exhibits potent activity with an EC50 of 2 nM for human TGR5 (hTGR5) and 3 nMFormula:C25H27ClN2O5Colore e forma:SolidPeso molecolare:470.95INT-777 R-enantiomer
CAS:INT-777 is the R-enantiomer of INT-777, less potent than INT-777,EC50 of 4.79 μM for TGR5.Formula:C27H46O5Purezza:98%Colore e forma:SolidPeso molecolare:450.65RO5527239
CAS:RO5527239 is a potent, orally available GPBAR1 agonist agent.Formula:C28H31N3O3Purezza:98%Colore e forma:SolidPeso molecolare:457.56INT-777
CAS:INT-777 (S-EMCA) is a potent TGR5 agonist with an EC50 of 0.82 μM.Formula:C27H46O5Purezza:99.89%Colore e forma:SolidPeso molecolare:450.655-HT7R antagonist 1
5-HT7R antagonist 1 is a G protein-biased antagonist with Ki of 6.5 nM for 5-HT 7R.Formula:C14H18Cl2N4Colore e forma:SolidPeso molecolare:313.23TGR5 Receptor Agonist 3
CAS:TGR5 Receptor Agonist 3 is a GPBAR1 agonist with EC50 of 16.4 nM (hTGR5) & 209 nM (mTGR5), ensures gallbladder safety and reduces filling.Formula:C29H27N3O6Colore e forma:SolidPeso molecolare:513.54GPBAR1-IN-3
CAS:GPBAR1-IN-3 (Compound 14) is both a selective agonist for GPBAR1, with an EC50 value of 0.17 μM, and an antagonist for CysLT1R [1].Formula:C21H23NO2Colore e forma:SolidPeso molecolare:321.41
