GRK
Le chinasi dei recettori accoppiati alle proteine G (GRK) sono una famiglia di enzimi che fosforilano i GPCR attivati, portando alla desensibilizzazione dei recettori e alla regolazione della segnalazione dei recettori. Le GRK svolgono un ruolo cruciale nel controllo dell'intensità e della durata della segnalazione dei GPCR, rendendole importanti nella regolazione di vari processi fisiologici, tra cui la funzione cardiovascolare, la risposta immunitaria e la neurotrasmissione. Gli inibitori e gli attivatori delle GRK sono studiati per le loro potenziali applicazioni terapeutiche nell'insufficienza cardiaca, nel cancro e nei disturbi neurologici. Presso CymitQuimica, offriamo una gamma di modulatori delle GRK di alta qualità per supportare la tua ricerca nella trasduzione del segnale, nella regolazione dei recettori e nello sviluppo terapeutico.
Trovati 41 prodotti per "GRK".
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GSK180736A
CAS:GSK180736A: GRK2 inhibitor (IC50 0.77µM), >100x selectivity vs GRKs, weak at PKA (IC50 30µM), strong vs ROCK1 (IC50 100nM).Formula:C19H16FN5O2Purezza:98.98% - 99.51%Colore e forma:SolidPeso molecolare:365.36Ref: TM-T3513
1mg39,00€2mg50,00€1mL*10mM (DMSO)62,00€5mg70,00€10mg94,00€25mg161,00€50mg290,00€100mg538,00€500mg1.161,00€GRK6-IN-2
CAS:GRK6-IN-2 is a potent G protein-coupled receptor kinase 6 (GRK6) inhibitor with potential antitumor activity.GRK6-IN-2 has been studied in multiple myeloma.Formula:C21H21FN6Purezza:99.65%Colore e forma:SolidPeso molecolare:376.43GRK6-IN-3
CAS:GRK6-IN-3 is an inhibitor of G protein-coupled receptor kinase 6 (GRK6) with an IC50 of 1.03 μM [1].Formula:C17H20N4O2Peso molecolare:312.37GRK5-IN-3
CAS:GRK5-IN-3 is a covalent inhibitor of G protein-coupled receptor kinase 5 (GRK5).GRK5-IN-3 significantly inhibits GRK5 (IC50: 0.22 μM) and GRK6 (IC50: 0.41 μM).Formula:C23H21N7O3Colore e forma:SolidPeso molecolare:443.46CCG-273220
CAS:CCG-273220 covalently inhibits GRK5 at Cys474 with 220 nM IC50; more selective over GRK2.Formula:C26H24ClFN4O3Colore e forma:SolidPeso molecolare:494.95GSK466317A
CAS:GSK466317A is a GRK2 inhibitor.Formula:C21H16ClF3N4O2Purezza:98%Colore e forma:SolidPeso molecolare:448.83CCG-271423
CAS:CCG-271423: potent GRK5 inhibitor (IC50: 0.0021 μM), less on GRK2 (IC50: 44 μM); lowers Ca2+ events and heart cell contractility.Formula:C28H26N4O3Colore e forma:SolidPeso molecolare:466.53CCG-224406
CAS:CCG-22440 is a Highly Selective and Potent Inhibitor of G Protein-Coupled Receptor Kinase 2.Formula:C29H27FN6O5Colore e forma:SolidPeso molecolare:558.56GRK5-IN-4
CAS:GRK5-IN-4: potent, selective covalent inhibitor of GRK5 (IC50=1.1 μM), 90x more specific than GRK2, useful for heart failure research.Formula:C26H25N7O3Colore e forma:SolidPeso molecolare:483.52CCG-273463
CAS:CCG-273463: Potent GRK5 inhibitor (IC50: 9 nM), used for researching heart failure, hypertrophy, cancer.Formula:C26H25BrN4O3Colore e forma:SolidPeso molecolare:521.41GSK317354A
CAS:GSK317354A is a GRK2 inhibitor.Formula:C25H18F4N6OColore e forma:SolidPeso molecolare:494.44GSK299115A
CAS:GSK299115A (GSK-299115A) is a selective ROCK1 Inhibitor. GSK299115A exhibits IC50 of 8nM, 620nM, 560nM for ROCK1, RSK1, p70S6K, respectively.Formula:C20H16Cl2N4O2Purezza:99.69%Colore e forma:SolidPeso molecolare:415.27Ref: TM-T27471
1mg303,00€5mg732,00€1mL*10mM (DMSO)895,00€10mg1.018,00€25mg1.513,00€50mg2.035,00€100mg2.673,00€GSK2163632A
CAS:GSK2163632A is an insulin-like growth factor 1 receptor inhibitor that acts by binding to a novel region of the GRK active site cleft.Formula:C27H32N8O3SColore e forma:SolidPeso molecolare:548.66KR-39038
CAS:KR-39038 is an oral GRK5 inhibitor for heart failure research; blocks HDAC5 pathway, IC50: 0.02 μM, fights cardiac hypertrophy.Formula:C24H32ClFN6OColore e forma:SolidPeso molecolare:475.00Ro 32-0432 hydrochloride
CAS:Ro 32-0432 is a selective, ATP-competitive, oral pan-PKC inhibitor exhibiting inhibitory effects on PKCα, PKCβI, PKCβII, PKCγ, and PKCε.Formula:C28H28N4O2Purezza:98%Colore e forma:Red SolidPeso molecolare:452.55DS-1558
CAS:DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDFFormula:C21H21F3O4Colore e forma:SolidPeso molecolare:394.38GRK5-IN-5
CAS:GRK5-IN-5 (Compound 4a) is a selective inhibitor of G protein-coupled receptor kinase 5 (GRK5) with an IC50 value of 0.03 μM. It shows an IC50 of 2.2 μM for GRK2 and 0.036 μM for GRK6. GRK5-IN-5 exhibits potent anti-hypertrophic activity in cardiac muscle and inhibits the proliferation of non-cardiac cells. It blocks pathological cardiac remodeling by inhibiting the abnormal upregulation of hypertrophic marker genes Nppa and Nppb. GRK5-IN-5 is useful for research in myocardial hypertrophy.Formula:C30H27FN4O5Peso molecolare:542.57LAS195319
CAS:LAS195319 is a potent and selective inhaled PI3Kδ Inhibitor (IC50 = 0.5 nM) for the Treatment of Respiratory Diseases.Formula:C29H26N10O3SColore e forma:SolidPeso molecolare:594.65CCG258208
CAS:GRKs-IN-1 has remarkable potency against and selectivity for G protein-coupled receptor kinase 2 GRK2 (IC50: 130 nM) and GRK5 (IC50: 7.1 μM).Formula:C24H25FN4O4Purezza:98%Colore e forma:SolidPeso molecolare:452.48GRK6-IN-5
CAS:GRK6-IN-5 is an inhibitor of the GRK6 polypeptide, with an IC50 of 4.48 μM. GRK6-IN-5 is utilized in research focused on hematological malignancies, inflammatory diseases, and autoimmune disorders.Formula:C23H21N3O2Colore e forma:SolidPeso molecolare:371.432
