Proteina Hedgehog/Smoothened
La via di segnalazione Hedgehog/Smoothened è una via correlata ai GPCR cruciale, coinvolta nello sviluppo embrionale, nella rigenerazione dei tessuti e nel mantenimento delle cellule staminali. Smoothened (SMO) è una proteina transmembrana chiave che trasduce i segnali dai ligandi Hedgehog (Hh) per attivare le cascate di segnalazione a valle. La disregolazione della via Hedgehog/Smoothened è implicata in vari tumori e disturbi dello sviluppo, rendendola un bersaglio significativo per l'intervento terapeutico. Presso CymitQuimica, offriamo una gamma di modulatori di alta qualità per la via Hedgehog/Smoothened per supportare la tua ricerca in biologia dello sviluppo, oncologia e medicina rigenerativa.
Trovati 49 prodotti di "Proteina Hedgehog/Smoothened"
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ALLO-2
CAS:ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.Formula:C18H12F3N5OPurezza:99.19%Colore e forma:SolidPeso molecolare:371.32Dynarrestin
CAS:Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.Formula:C22H23F2N3O2SPurezza:99.64%Colore e forma:SolidPeso molecolare:431.5GANT 58
CAS:GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).Formula:C24H16N4SPurezza:99.53%Colore e forma:SolidPeso molecolare:392.48SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Formula:C28H30Cl3N3OSPurezza:>99.99%Colore e forma:SoildPeso molecolare:562.98HSP70-IN-3
HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.Formula:C48H78N6O7SColore e forma:SolidPeso molecolare:883.23GI-560192
CAS:GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.Formula:C20H16N2O2Purezza:99.53%Colore e forma:SoildPeso molecolare:316.35GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Colore e forma:Odour SolidHPP-9
HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BETFormula:C49H52N6O11Colore e forma:SolidPeso molecolare:900.97HL2-m5
CAS:HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.Formula:C70H101N15O24S3Colore e forma:SolidPeso molecolare:1632.83WAY-313170
CAS:WAY-313170 Inhibits hedgehog signaling and phosphodiesterase.Formula:C19H17ClN2O2S2Purezza:97.92%Colore e forma:SolidPeso molecolare:404.93CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Formula:C31H43ClN4O5Purezza:94.05%Colore e forma:SolidPeso molecolare:587.15SANT 2
CAS:SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.Formula:C26H26ClN3O4Purezza:99.23%Colore e forma:SolidPeso molecolare:479.96MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Formula:C24H23N3O5SPurezza:99.73%Colore e forma:SolidPeso molecolare:465.52Sonidegib
CAS:Sonidegib (Erismodegib), a Smoothened (Smo) antagonist, inhibits Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively.Formula:C26H26F3N3O3Purezza:98% - 99.97%Colore e forma:SolidPeso molecolare:485.5JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Formula:C19H18N4OSPurezza:98.93% - 99.89%Colore e forma:SolidPeso molecolare:350.44Glasdegib
CAS:Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.Formula:C21H22N6OPurezza:98.72%Colore e forma:SolidPeso molecolare:374.44SANT-1
CAS:SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).Formula:C23H27N5Purezza:99.93% - >99.99%Colore e forma:SolidPeso molecolare:373.49HhAntag
CAS:HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activityFormula:C24H23ClN4O3Purezza:95.73%Colore e forma:SolidPeso molecolare:450.92Taladegib
CAS:Taladegib (LY2940680), an oral Smo receptor antagonist, targets Hedgehog signaling for cancer treatment.Formula:C26H24F4N6OPurezza:98.75% - >99.99%Colore e forma:SolidPeso molecolare:512.5SAG hydrochloride (912545-86-9(free base))
CAS:SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.Formula:C28H29Cl2N3OSPurezza:99.19% - 99.97%Colore e forma:SolidPeso molecolare:526.52MRT-81
CAS:MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.Formula:C31H29N3O5SPurezza:99.72%Colore e forma:SolidPeso molecolare:555.64SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Formula:C28H28ClN3OSPurezza:97.37% - 98.88%Colore e forma:SolidPeso molecolare:490.06Ciliobrevin A
CAS:Ciliobrevin A (HPI-4) is an inhibitor of hedgehog signaling pathway with an IC50 <10 μM.Formula:C17H9Cl2N3O2Purezza:98.54% - 99.57%Colore e forma:SolidPeso molecolare:358.18HPI 1
CAS:HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.Formula:C27H29NO6Purezza:97.6%Colore e forma:SolidPeso molecolare:463.52Neurodazine
CAS:Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Formula:C27H21ClN2O3Purezza:98.01%Colore e forma:SolidPeso molecolare:456.925-LOX inhibitor
CAS:5-LOX inhibitor (1-(sec-Butyl)-4-(4-(4-(4-hydroxyphenyl)piperazin-1-yl)phenyl)-1H-1,2,4-triazol-5(4H)-one) is an itraconazole impurity, a LOX-5 inhibitor.Formula:C22H27N5O2Purezza:98.01%Colore e forma:SolidPeso molecolare:393.48MS-0022
CAS:MS-0022: SMO antagonist, inhibits Hh signaling in nM-µM ranges, curbs tumor cell growth, and delays tumor progression in vivo.Formula:C21H16BrN3OColore e forma:SolidPeso molecolare:406.28SMANT hydrochloride
CAS:SMANT hydrochloride (N-(4-bromophenyl)-3-(3,5-dimethylpiperidin-1-yl)propanamide hydrochloride) is an antagonist of Smoothened accumulation.Formula:C16H24BrClN2OPurezza:99.81%Colore e forma:SolidPeso molecolare:375.733-epi-Vitamin D3
CAS:3-epi-Vitamin D3 (Epicholecalciferol), an analogue of Vitamin D3, serves as a Hedgehog pathway inhibitor, exhibiting potency with an IC50 value of 39.2 μM inFormula:C27H44OColore e forma:SolidPeso molecolare:384.64RUSKI-201 dihydrochloride
CAS:RUSKI-201 dihydrochloride: potent Hhat inhibitor (IC50: 0.20 μM), blocks Hh signaling, and inhibits Hh palmitoylation.Formula:C20H29Cl2N3OSColore e forma:SolidPeso molecolare:430.43Hedgehog Antagonist VIII
CAS:Hh antagonist VIII is a quinazolinyl-urea that inhibits Gli transcription in the Hh pathway, linked to cancer, with an IC50 of 70 nM.Formula:C23H15ClF4N4O2Colore e forma:SolidPeso molecolare:490.84SMO-IN-3
CAS:SMO-IN-3: Strong SMO blocker, disrupts Hh pathway (IC50=34.09 nM), hinders Daoy cell growth, has anticancer properties.Formula:C27H25F4N3O2Colore e forma:SolidPeso molecolare:499.5RUSKI-201
CAS:RUSKI-201 is the first selective Hedgehog acyltransferase (Hhat) chemical probe in cells.Formula:C20H27N3OSColore e forma:SolidPeso molecolare:357.51SANT-2
CAS:SANT-2 is a potent inhibitor of Shh signaling pathway.Formula:C23H20ClN3O4Colore e forma:SolidPeso molecolare:437.88Hedgehog IN-3
CAS:Hedgehog IN-3 (compound 3), with an IC50 value of 0.01 µM, serves as a hedgehog pathway inhibitor, proving beneficial for cancer research applications [1].Formula:C18H13ClF3N5OColore e forma:SolidPeso molecolare:407.78M-25
CAS:M-25 is a Smoothened antagonist and inhibitor of the Hedgehog pathway.Formula:C23H29N3O2Colore e forma:SolidPeso molecolare:379.5LEQ-506
CAS:LEQ506, an oral Smoothened antagonist, may inhibit cancer growth by blocking the Hedgehog signaling pathway.Formula:C27H29N5OColore e forma:SolidPeso molecolare:439.55SMO-IN-2
CAS:<p>SMO-IN-2 is a SMO inhibitor with antiproliferative activity and anticancer activity and inhibits Hh signaling.SMO-IN-2 can be used in the study of cancer.</p>Formula:C25H25F4N5O2Purezza:98.64%Colore e forma:SolidPeso molecolare:503.49AZD8542
CAS:AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic.Formula:C25H24N4O2Purezza:99.96%Colore e forma:SolidPeso molecolare:412.48Hedgehog IN-2
CAS:Hedgehog IN-2 (Compound 20) functions as an inhibitor of the Hedgehog signaling pathway, exhibiting an IC50 of <0.003 μM in C3H10T1/2 cells [1].Formula:C24H22N4O2Colore e forma:SolidPeso molecolare:398.46GSA-10
CAS:<p>GSA-10 is a potent Smoothened (Smo) receptor agonist with an EC50 of 1.2 μM.</p>Formula:C26H30N2O5Purezza:99.71%Colore e forma:SolidPeso molecolare:450.53Hh-Ag1.5
CAS:Hh-Ag1.5 is a dual Hedgehog/Smo agonist (EC50/Ki: 0.5-2.3 nM), reprograms hepatic stem cells, and differentiates hiPSCs into neural/skin cells.Formula:C28H26ClF2N3OSPurezza:99.8%Colore e forma:SolidPeso molecolare:526.04Robotnikinin
CAS:Robotnikinin is an Shh signaling inhibitor in a concentration-dependent manner. It acts by exhibiting significant repression of Shh-induced Gli1/Gli2.Formula:C25H27ClN2O4Purezza:98%Colore e forma:SolidPeso molecolare:454.95SAG 21k
CAS:<p>SAG 21k is an orally bioactive and potent Hedgehog signaling activator that crosses the blood-brain barrier for the study of cartilage regeneration.</p>Formula:C29H28ClF2N3O2SPurezza:99.51%Colore e forma:SolidPeso molecolare:556.07TAK-441
CAS:TAK-441: oral Hedgehog signal blocker, potent anticancer, IC50=4.4 nM, reduces Gli1 mRNA & tumor growth.Formula:C28H31F3N4O6Purezza:99.82%Colore e forma:SolidPeso molecolare:576.56IMP-1575
CAS:IMP-1575 is a highly effective inhibitor of hedgehog acyltransferase (HHAT), with an IC50 of 0.75 μM when inhibiting purified HHAT. IMP-1575 has potential applications in cancer research.Formula:C19H25N3OSPeso molecolare:343.49MRT-92
CAS:MRT-92 is an antagonist of Smoothened (Smo) with anti-cancer activity, featuring a binding affinity (Ki) of 0.7 nM. It inhibits the Hedgehog signaling pathway by obstructing the overlapping binding sites within the transmembrane domain of the Smoothened receptor and suppresses the proliferation of cerebellar granule cells in rodents (IC50=0.4 nM). MRT-92 is utilized for research into cerebellar gliomas.Formula:C33H34N4O5Colore e forma:SolidPeso molecolare:566.65BRD50837
CAS:BRD50837 is a potent and selective inhibitor of Sonic Hedgehog (Shh).Formula:C26H32ClN3O6SPurezza:98%Colore e forma:SolidPeso molecolare:550.07LAB687
CAS:LAB687 (Compound 2a) is an inhibitor of microsomal triglyceride transfer protein (MTP) with an IC50 of 0.9 nM for inhibiting the secretion of apolipoprotein B (apoB) in HepG2 cells. Additionally, LAB687 acts as a Smoothened (Smo) antagonist, exhibiting IC50 values of 2.48 μM and 3.42 μM for mouse and human Smo receptors, respectively. This compound is effective in reducing triglyceride and low-density lipoprotein cholesterol (LDL-C) levels and in inhibiting the Hedgehog signaling pathway.Formula:C26H23F3N2O3Colore e forma:SolidPeso molecolare:468.47
