Recettore dei cannabinoidi
I recettori dei cannabinoidi sono GPCR che mediano gli effetti dei cannabinoidi endogeni (endocannabinoidi) e fitocannabinoidi, come quelli presenti nella cannabis. I due principali tipi di recettori dei cannabinoidi, CB1 e CB2, sono coinvolti nella regolazione di una vasta gamma di processi fisiologici, tra cui la percezione del dolore, l'appetito, l'umore e la funzione immunitaria. I modulatori dei recettori dei cannabinoidi hanno un potenziale terapeutico nel trattamento di condizioni come il dolore cronico, l'epilessia e la sclerosi multipla. Presso CymitQuimica, offriamo una vasta gamma di modulatori di recettori dei cannabinoidi di alta qualità per supportare la tua ricerca in neurofarmacologia, gestione del dolore e immunologia.
Trovati 215 prodotti di "Recettore dei cannabinoidi"
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Rimonabant hydrochloride
CAS:Rimonabant hydrochloride (SR 141716A) 是中心大麻素受体 1 的高效选择性反向激动剂， Ki 值为1.8 nM。它也能够抑制分枝杆菌膜蛋白3。Formula:C22H22Cl4N4OPurezza:98.24% - 99.5%Colore e forma:Off-White To White Crystalline PowderPeso molecolare:500.25JHU 75528
CAS:JHU 75528 (JHU-75528) is a novel PET tracer with inhibitory effects on CB that can be used to study the cannabinoid system in schizophrenic patients.Formula:C23H21Cl2N5O2Purezza:99.79%Colore e forma:SolidPeso molecolare:470.35Rimonabant
CAS:<p>Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1.</p>Formula:C22H21Cl3N4OPurezza:98% - 99.91%Colore e forma:White Or Almost White Crystalline PowderPeso molecolare:463.79EHP-101
CAS:<p>EHP-101 is a PPARγ/CB2 dual agonist with anti-inflammatory properties, inhibits fat formation, and combats diet-related obesity.</p>Formula:C28H35NO3Purezza:98.36%Colore e forma:SolidPeso molecolare:433.586-Iodopravadoline
CAS:<p>6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.</p>Formula:C23H25IN2O3Purezza:99.29%Colore e forma:Off-White SolidPeso molecolare:504.36Anandamide
CAS:<p>Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also</p>Formula:C22H37NO2Purezza:95.037% - 99.22%Colore e forma:Light Yellow OilPeso molecolare:347.53Pregnenolone
CAS:Pregnenolone (Arthenolone) is an endogenous steroid hormone synthesized from cholesterol, used in the treatment of Alzheimer's disease.Formula:C21H32O2Purezza:99.5% - 99.84%Colore e forma:SolidPeso molecolare:316.48CB1 antagonist 2
CAS:CB1 antagonist 2 (AM4113) is caimabinoid 1 (CB1) antagonist which inhibits CB1 in vivo with an IC50 of 25.5 nM.Formula:C17H12Cl3N3OPurezza:99.75%Colore e forma:SolidPeso molecolare:380.66Δ8-THC methyl ether
CAS:Δ8-THC methyl ether (compound 3) demonstrates a strong docking score of -10.167 kcal/mol for the CB2 receptor. Additionally, Δ8-THC methyl ether exhibits antinociceptive activity in mice.Formula:C22H32O2Colore e forma:SolidPeso molecolare:328.49exo-Tetrahydrocannabivarin
CAS:exo-Tetrahydrocannabivarin (Compound 12) is an analog of Δ9,11-THC. It weakly binds to cannabinoid receptors (CB) with an IC50 of 1.4 μM. In mice, exo-Tetrahydrocannabivarin exhibits activity related to both motor function and analgesia.Formula:C19H26O2Colore e forma:SolidPeso molecolare:286.418β-Hydroxy-exo-THC
CAS:<p>8β-Hydroxy-exo-THC, a cannabinoid ether analog, exhibits weak affinity for receptor sites with an IC50 of 1.2 μM.</p>Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46(±)-9-Nor-9α-hydroxy Hexahydrocannabinol
CAS:(±)-9-Nor-9α-hydroxy Hexahydrocannabinol is a cannabinoid-structured compound that exhibits potent cannabinoid-like activity in both dogs and mice.Formula:C20H30O3Colore e forma:SolidPeso molecolare:318.45Cannabigerorcin
CAS:Cannabigerorcin, a phytocannabinoid, serves as an analytical reference standard. It is designated for research and forensic applications.Formula:C17H24O2Colore e forma:SolidPeso molecolare:260.377CB2 receptor agonist 9
CAS:CB2 receptor agonist 9 (Compound 33) is an orally active agonist of cannabinoid receptor 2 (CB2 receptor) with an EC50 of 16.2 nM. It inhibits the expression of TNF-α, IL-1β, and IL-6, demonstrating anti-inflammatory activity in a DSS-induced acute colitis model in mice.Formula:C16H23N3O2SColore e forma:SolidPeso molecolare:321.44δ8-THC acetate
CAS:Delta8-THC acetate (Delta8-tetrahydrocannabinol) is a psychoactive cannabinoid that binds to the cannabinoid receptor 1 (CB1 receptor) and exhibits anti-nausea, appetite-stimulating, and anti-inflammatory effects. It may also offer neuroprotective benefits and has potential applications in research on anxiety and depression.Formula:C23H32O3Colore e forma:SolidPeso molecolare:356.5APP-FUBINACA
CAS:APP-FUBINACA is a cannabinoid receptor agonist, classified as a phenylalanine amide-based indazole-3-carboxamide derivative. It exhibits neurostimulatory effects.Formula:C24H21FN4O2Colore e forma:SolidPeso molecolare:416.45CB2R/FAAH modulator-2
CAS:CB2R/FAAH modulator-2 (compound 26) is a dual modulator targeting at CB2R and FAAH.Formula:C24H33NO2Purezza:99.15%Colore e forma:SoildPeso molecolare:367.52Δ8-THC-C8
CAS:Δ8-THC-C8 is a semi-synthetic cannabinoid. It acts as an agonist for the cannabinoid receptor 1 (CB1) with an EC50 value of 13.8 nM.Formula:C24H36O2Colore e forma:SolidPeso molecolare:356.54Cannabidivarinic acid
CAS:Cannabidivarinic acid (CBDVA), the carboxylic acid precursor to cannabidivarin (CBDV), is a non-psychoactive cannabinoid found in Cannabis and known for its anti-inflammatory properties.Formula:C20H26O4Colore e forma:SolidPeso molecolare:330.42Hemopressin(rat)
CAS:Peptide inhibitor for ep24.15, neurolysin & ACE with Ki 27.76, 3.43, 1.87 μM. Lowers blood pressure, modulates CB1 receptor, reduces pain & food intake.Formula:C53H77N13O12Purezza:98%Colore e forma:SolidPeso molecolare:1088.27CB2R/FAAH modulator-3
CAS:<p>CB2R/FAAH modulator-3 (compound 27) is a modulator targeting at CB2R and FAAH.</p>Formula:C22H31NO2Purezza:99.81%Colore e forma:SoildPeso molecolare:341.49VIP36
VIP36 is an agonist of the cannabinoid type 1 receptor (CB1) with analgesic properties. It reduces the recruitment of inhibitory proteins, thereby exerting its pain-relieving effects, and is applicable in research related to chronic pain.Formula:C27H35FN6O4Colore e forma:SolidPeso molecolare:526.603Cannabigerorcinic Acid
CAS:Cannabigerorcinic acid, structurally akin to recognized phytocannabinoids, serves as an analytical reference standard designed for research and forensic purposes.Formula:C18H24O4Colore e forma:SolidPeso molecolare:304.386Afubiata
CAS:ADB-FUBIATA is a synthetic cannabinoid studied for its metabolic profile, along with AFUBIATA, CH-FUBIATA, and CH-PIATA. This in vitro analysis by Watanabe S, et al., examines these compounds, as published in "Arch Toxicol," 2023 Dec;97(12):3085-3094.Formula:C27H29FN2OColore e forma:SolidPeso molecolare:416.53(−)-6α-hydroxy Cannabidiol
CAS:(−)-6α-Hydroxy Cannabidiol, an analytical reference standard and a phytocannabinoid metabolite, serves primarily as a metabolite of cannabidiol (CBD). This product is designed for use in research and forensic applications.Formula:C21H30O3Colore e forma:SolidPeso molecolare:330.46CB2R probe 1
CAS:<p>CB2R Probe 1, a cannabinoid 2 receptor (CB2R) fluorescent probe, exhibits both safety and environmental friendliness, boasting a dissociation constant (K i) of</p>Formula:C36H42N4O4Colore e forma:SolidPeso molecolare:594.74CB2 receptor antagonist 2
Compound 39, also known as CB2 receptor antagonist 2, is a potent CB2 antagonist exhibiting an IC50 of 0.33 μM.Colore e forma:Odour SolidHemopressin (human, mouse)
CAS:<p>Endogenous peptide, inhibits ep24.15/24.16/ACE with Ki of 27.76/3.43/1.87 μM. Lowers blood pressure, CB1 inverse agonist, reduces pain in vivo.</p>Formula:C50H79N13O12Purezza:98%Colore e forma:SolidPeso molecolare:1054.26CB1-IN-3
CB1-IN-3 (Compound 6i) is a potent inhibitor of the cannabinoid receptor type 1 (CB1). It holds potential for research in obesity, inflammation, and neurological disorders.Colore e forma:Odour Solid(R)-Zevaquenabant
(R)-Zevaquenabant ((R)-MRI-1867) is the enantiomer of Zevaquenabant. Zevaquenabant ((S)-MRI-1867) is a peripherally restricted, orally bioavailable dual antagonist of the cannabinoid CB1 receptor and inducible nitric oxide synthase (iNOS). It is beneficial in improving chronic kidney disease (CKD) caused by obesity.Colore e forma:Odour SolidDrinabant
CAS:<p>Drinabant (AVE-1625) is an orally active CB1 receptor antagonist.</p>Formula:C23H20Cl2F2N2O2SPurezza:99.8%Colore e forma:SolidPeso molecolare:497.38CB2 receptor agonist 2
CAS:<p>CB2 receptor agonist 2 (ZINC72105556): potent, Ki=8.5 nM, high selectivity for CB2.</p>Formula:C30H36N2O4Purezza:99.75%Colore e forma:SolidPeso molecolare:488.62Hemopressin(human, mouse) TFA
CAS:Hemopressin TFA: nonapeptide from hemoglobin, oral CB1 inverse agonist, eases inflammatory pain.Formula:C52H80F3N13O14Purezza:98%Colore e forma:SolidPeso molecolare:1168.27Zevaquenabant
CAS:<p>Zevaquenabant (S-MRI-1867): oral CB1/iNOS antagonist combatting obesity-induced CKD.</p>Formula:C25H21ClF3N5O2SColore e forma:SolidPeso molecolare:547.98N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide
CAS:<p>N-(1-(3,4-Dihydroxyphenyl)propan-2-yl)oleamide: binds CB1 (Ki=365 nM), activates PPARα (EC50=698 nM), reduces rat food intake, no FAAH inhibition.</p>Formula:C27H45NO3Colore e forma:SolidPeso molecolare:431.661GPR55 agonist 4
GPR55 agonist 4 (Compound 28), with an EC50 of 131 nM for hGPR55 and 1.41 nM for rGPR55, effectively induces β-arrestin recruitment to human GPR55 [1].Formula:C19H16FN5O2Colore e forma:SolidPeso molecolare:365.36GFB-024
GFB-024 is a humanized antibody targeting CB1, which can be used to study obesity.Colore e forma:LiquidPeso molecolare:145.5kDaVicasinabin
CAS:Vicasinabin: potent CB2 agonist; researches chronic pain, atherosclerosis, bone mass, neuroinflammation.Formula:C15H22N10OColore e forma:SolidPeso molecolare:358.41CB2R/FAAH modulator-1
CAS:CB2R/FAAH modulator-1: agonizes CB2R, inhibits FAAH (IC50=4 μM), alters cytokine production; used in inflammation research. Ki: CB2R=14.8 nM, CB1R=241.3 nM.Formula:C24H27NO2Purezza:99.77%Colore e forma:SoildPeso molecolare:361.48NESS 0327
CAS:NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.Formula:C24H23Cl3N4OPurezza:99.78%Colore e forma:SolidPeso molecolare:489.82RVD-Hpα
CAS:N-terminally extended form of human hemopressin that acts as a selective CB1 receptor agonist.Formula:C65H105N19O17Purezza:98%Colore e forma:SolidPeso molecolare:1424.66Tocrifluor T1117
CAS:Fluorescent form of AM 251, CB1 receptor antagonistFormula:C56H53Cl2N7O5Purezza:98%Colore e forma:SolidPeso molecolare:974.97TRPV1/CB2 agonist 1
<p>TRPV1/CB2 agonist 1 (compound 41) is a dual agonist targeting hTRPV1 and CB2 receptors, with an EC50 value of 26.8 μM for hTRPV1. It is applicable in research related to the nervous system.</p>Colore e forma:Odour SolidCB1R agonist 1
<p>CB1R agonist 1 (Compound '1350) is a potent full agonist of the cannabinoid-1 receptor (CB1R) with a Ki value of 0.95 nM. It demonstrates significant pain-relieving effects in various pain models, including acute thermal pain, inflammatory pain, and neuropathic pain.</p>Formula:C20H18F3N3O3SColore e forma:SolidPeso molecolare:437.435Noladin ether
CAS:Noladin ether (2-AG ether) is a cannabinoid CB1 receptor agonist.Formula:C23H40O3Colore e forma:SolidPeso molecolare:364.56PSB-SB-1203
CAS:<p>PSB-SB-1203 (Compound 25b) is a dual CB1/CB2 ligand that blocks the CB1 receptor and activates the CB2 receptor with a CB1 Ki of 0.244 μM, a CB2 Ki of 0.210 μM, and an EC50 of 0.054 μM. It shows potential for research in obesity and cancer.</p>Formula:C25H30O4Colore e forma:SolidPeso molecolare:394.5Cannabinol methyl ether
CAS:Cannabinol methyl ether, a phytocannabinoid, serves as an analytical reference standard. This compound can be obtained through isolation from Cannabis plants, derived from cannabinol, or synthesized. The physiological and toxicological properties of cannabinol methyl ether remain unknown. It is designed exclusively for research and forensic applications.Formula:C22H28O2Colore e forma:SolidPeso molecolare:324.5Δ9-THCH
CAS:Δ9-THCH, a phytocannabinoid analytical reference standard, is present in a Cannabis variety cultivated for medicinal use. In the United States, it is classified as a Schedule I compound. This product is designated for research and forensic applications.Formula:C22H32O2Colore e forma:SolidPeso molecolare:328.49CB1R antagonist 2
CB1R antagonist 2 (Compound 11g) functions as an antagonist of the cannabinoid receptor 1 (CB1R), inhibiting the MAPK/NF-κB signaling pathway and exhibiting anti-inflammatory properties. In RAW264.7 cells, it suppresses LPS-induced expression of IL-6, IL-1β, and TNF-α. In murine models, it improves OVA-induced allergic rhinitis.Formula:C24H26N4OColore e forma:SolidPeso molecolare:386.49CB2 PET Radioligand 1
CB2 PET Radioligand 1 (compound [18F]9) is a positron emission tomography (PET) radioligand with high affinity for the human cannabinoid receptor 2 (hCB2, Ki=7.Formula:C20H19F3N4OPurezza:98%Colore e forma:SolidPeso molecolare:388.39
