Recettore dei cannabinoidi
I recettori dei cannabinoidi sono GPCR che mediano gli effetti dei cannabinoidi endogeni (endocannabinoidi) e fitocannabinoidi, come quelli presenti nella cannabis. I due principali tipi di recettori dei cannabinoidi, CB1 e CB2, sono coinvolti nella regolazione di una vasta gamma di processi fisiologici, tra cui la percezione del dolore, l'appetito, l'umore e la funzione immunitaria. I modulatori dei recettori dei cannabinoidi hanno un potenziale terapeutico nel trattamento di condizioni come il dolore cronico, l'epilessia e la sclerosi multipla. Presso CymitQuimica, offriamo una vasta gamma di modulatori di recettori dei cannabinoidi di alta qualità per supportare la tua ricerca in neurofarmacologia, gestione del dolore e immunologia.
Trovati 216 prodotti di "Recettore dei cannabinoidi"
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SCH-336
CAS:SCH-336: potent, selective CB2 agonist (Ki=1.8 nM, EC50=2 nM), orally active, 100x CB2 vs. CB1 preference, reduces leukocyte migration and eosinophilia.
Formula:C23H25NO8S3Purezza:95.01%Colore e forma:SolidPeso molecolare:539.64Nonabine
CAS:Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.Formula:C25H33NO2Purezza:99.82% - 99.94%Colore e forma:SolidPeso molecolare:379.54CB1 agonist 1
CAS:CB1 agonist 1 is a potent CB1 agonist with a pIC50 value of 5.7 for CB1 receptors.CB1 agonist 1 can be used to study brain disorders, pain, and inflammation.Formula:C24H24N2O5SPurezza:98.56%Colore e forma:SolidPeso molecolare:452.52AZD1940
CAS:AZD1940 (UNII-0J0035E9FT) is a high affinity CB(1)/CB(2) receptor agonist of the cannabinoid with oral activity. Application in the study of orofacial pain.Formula:C20H29F2N3O2SPurezza:98.68%Colore e forma:SolidPeso molecolare:413.52Ref: TM-T30252
1mg130,00€5mg311,00€10mg535,00€25mg847,00€50mg1.169,00€100mg1.586,00€1mL*10mM (DMSO)344,00€CB1R antagonist 1
CAS:CB1R antagonist 1 is a potent CB1R antagonist that can be used to study diseases related to the nervous system.Formula:C18H23F3N2O3SPurezza:99.65%Colore e forma:SolidPeso molecolare:404.45O-2545 hydrochloride
CAS:O-2545 is a potent water-soluble central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptor agonist with Ki values of 1.5 and 0.32 nM, respectively. Typically, cannabinoid agonists are highly lipophilic and require solubilization through surfactant agents or binding to water miscible substances like albumin, Tween 80, or Emulphor for use. When dissolved in saline, O-2545 has shown high efficacy in mouse behavioral models, administered either intravenously or intracerebroventricularly.Formula:C26H36N2O2HClColore e forma:SolidPeso molecolare:445OMDM-5
CAS:OMDM-5 is a potent vanilloid receptor type 1 (TRPV1, EC50 = 75 nM) agonist, showing weak ligand activity at cannabinoid type 1 receptor (CB1, Ki=4.9 μM).Formula:C26H44N2O3Purezza:99.73%Colore e forma:SolidPeso molecolare:432.64Ref: TM-T12306
1mg93,00€5mg177,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€1mL*10mM (DMSO)210,00€CB-25
CAS:CB-25 is a partial agonist ligand of CB1 cannabinoid receptors, augmenting Forskolin-induced cAMP formation in cancer cells, though not affecting hCB1-CHO cellsFormula:C25H41NO3Purezza:98%Colore e forma:SolidPeso molecolare:403.6Tricosanoyl Ethanolamide
CAS:Tricosanoyl ethanolamide, a fatty N-acyl ethanolamine within the endocannabinoid family, has an ethanolamine metabolite whose significance remains to be established.Formula:C25H51NO2Colore e forma:SolidPeso molecolare:397.688Isopropyl dodec-11-enylfluorophosphonate
CAS:Isopropyl dodec-11-enylfluorophosphonate (IDEFP) is an organophosphorus ester functioning as a central cannabinoid receptor (CB1) antagonist and exhibitsFormula:C15H30FO2PPurezza:98%Colore e forma:SolidPeso molecolare:292.37O-Arachidonoyl glycidol
CAS:O-Arachidonoyl glycidol (compound 1), a 2-arachidonoylglycerol (2-AG) analog, effectively inhibits the hydrolysis of cytosolic 2-oleoylglycerol (2-OG) with an IC50 value of 4.5 µM, and also blocks 2-OG and anandamide hydrolysis in membrane fractions with IC50 values of 19 µM and 12 µM, respectively [1].Formula:C23H36O3Colore e forma:SolidPeso molecolare:360.53(R)-Monlunabant
CAS:(R)-Monlunabant ((R)-MRI-1891) serves as a CB1 receptor antagonist utilized in obesity and metabolic disease research [1].
Formula:C26H22ClF3N6O3SPurezza:98%Colore e forma:SolidPeso molecolare:591CB1 inverse agonist 1
CAS:MRL-650 is an oral, selective CB1 agonist; IC50: CB1=7.5 nM, CB2=4100 nM; anorexigenic effects noted.Formula:C25H18Cl3N3O3Purezza:99.92%Colore e forma:SolidPeso molecolare:514.79Ref: TM-T10694
1mg50,00€5mg105,00€10mg155,00€25mg224,00€50mg314,00€100mg427,00€200mg577,00€1mL*10mM (DMSO)129,00€AM841
CAS:AM841, a high-affinity electrophilic ligand, covalently interacts with a cysteine residue in helix six, thus activating the CB1 cannabinoid receptor.Formula:C26H39NO3SPurezza:98%Colore e forma:SolidPeso molecolare:445.66GSK-554418A
CAS:GSK-554418A, a novel azaindole CB(2) agonists, is used for the treatment of chronic pain. It is efficacious in the acute model and the chronic joint pain model.Formula:C19H19ClN4O2Colore e forma:SolidPeso molecolare:370.83Prostaglandin E2-1-glyceryl ester
CAS:Prostaglandin E2-1-glyceryl ester, a member of the Prostaglandin Glycerol Ester family, serves as an endocannabinoid ligand targeting the CB1 receptor. This compound triggers a swift and transient surge in intracellular free calcium levels [1] [2].Formula:C23H38O7Colore e forma:SolidPeso molecolare:426.55PF-03550096
CAS:PF-03550096, an orally active synthetic cannabinoid (CB), selectively binds to peripheral CB2 receptors with a Ki value of 7.9 nM, demonstrating analgesic activity [1].Formula:C19H28N4O4Colore e forma:SolidPeso molecolare:376.45URB447
CAS:URB447, a peripherally restricted CB1 cannabinoid antagonist with IC50 values of 313 nM for rat CB1 receptor and 41 nM for human CB2 receptor, effectively reduces food intake and body weight gain in mice. It achieves these effects without penetrating the brain or antagonizing central CB1-dependent responses, making it a potential research tool for obesity studies [1].Formula:C25H21ClN2OColore e forma:SolidPeso molecolare:400.9CAY10508
CAS:CAY10508 is a potent and selective inverse agonist for the central cannabinoid (CB1) receptor with therapeutic potential for treating obesity and drug dependence, lacking psychotropic effects. It exhibits a Ki value of 243 nM and an EC50 of 195 nM. At a concentration of 10 µM, CAY10508 displaces [3H]-CP-55,940 with 100% efficacy at the CB1 receptor and 35% at the peripheral cannabinoid (CB2) receptor. Its inverse agonist activity at the CB1 receptor was confirmed through a [35S]-GTPγS binding assay.Formula:C21H14Br2N2O2Colore e forma:SolidPeso molecolare:486.2GW405833 hydrochloride
CAS:GW405833 hydrochloride, a potent and selective agonist of the cannabinoid-2 (CB2) receptor (EC 50 = 0.65 nM; maximum inhibition = 44.6%), exhibits significant antihyperalgesic effects in various rodent pain models [1] [2] [3].Formula:C23H25Cl3N2O3Colore e forma:SolidPeso molecolare:483.82Tedalinab
CAS:Tedalinab is an effective and selective cannabinoid receptor 2 agonist.Formula:C19H21F2N3OPurezza:98%Colore e forma:SolidPeso molecolare:345.39Heptadecanoyl ethanolamide
CAS:Heptadecanoyl ethanolamide, an endogenous cannabinoid, serves as a synthetic analog of PEA, featuring an odd-numbered (17-carbon) fatty acid chain [1].Formula:C19H39NO2Colore e forma:SolidPeso molecolare:313.52CB-52
CAS:CB-52 acts as a neutral antagonist and ligand for the CB2 cannabinoid receptor [1].Formula:C26H43NO3Colore e forma:SolidPeso molecolare:417.622-Linoleoyl Glycerol
CAS:2-Arachidonoyl glycerol (2-AG), a natural endocannabinoid ligand for the CB1 receptor, was isolated from porcine brain and characterized. Its congener, 2-linoleoyl glycerol (2-LG), which has a linoleoyl group instead of an arachidonoyl group, also exists alongside 2-AG in vivo. While 2-LG exhibits low intrinsic activity, it enhances the activity of 2-AG and other endocannabinoids through an "entourage" effect, attributed to the inhibition of breakdown and reuptake pathways that typically decrease endocannabinoid levels post-release.Formula:C21H38O4Colore e forma:SolidPeso molecolare:354.531COR659
CAS:COR659: suppresses alcohol/chocolate intake in rats; enhances GABAB receptor, blocks CB1 receptor.Formula:C16H16ClNO3SPurezza:99.75%Colore e forma:SolidPeso molecolare:337.82Ref: TM-T36520
1mg38,00€5mg86,00€10mg123,00€25mg215,00€50mg299,00€100mg411,00€200mg560,00€1mL*10mM (DMSO)94,00€Hemopressin(rat) TFA
CAS:Hemopressin(rat) TFA, a nonapeptide from hemoglobin α1-chain, selectively inhibits CB1 receptors and reduces inflammatory pain.Formula:C55H78F3N13O14Colore e forma:SolidPeso molecolare:1202.28MCHB-1
CAS:MCHB-1, a potent agonist of the human cannabinoid 2 (CB2) receptor (EC50= 0.52 nM), demonstrates high selectivity for CB2 over CB1 (Kis = 3.7 and 110 nM, respectively), distinguishing itself from similar benzimidazole compounds that significantly alleviate peripheral pain while minimizing central nervous system side effects in mice.Formula:C28H37N3O2Colore e forma:SolidPeso molecolare:447.623PF 514273
CAS:PF 514273 is a CB1 receptor antagonist.Formula:C21H17Cl2F2N3O2Purezza:98%Colore e forma:SolidPeso molecolare:452.28PSB-SB1202
CAS:PSB-SB1202 (Compound 21a), a phenyl coumarin compound, acts as a CB1/CB2 agonist. It demonstrates EC50 values of 56 and 14 nM and K i values of 32 and 49 nM for CB1 and CB2 receptors, respectively [1].Formula:C23H26O4Colore e forma:SolidPeso molecolare:366.45PSNCBAM-1
CAS:PSNCBAM-1 (PSNCBAM 1) is a CB1 receptor negative allosteric modulator (EC50 = 0.1 μM) with hypophagic effects in vivo.Formula:C22H21ClN4OPurezza:99.86%Colore e forma:SolidPeso molecolare:392.88CB1 antagonist 1
CAS:CB1 antagonist 1 is a CB1 receptor antagonist, used in the research of obesity and metabolic syndrome, neuroinflammatory disorders, cognitive disorders, andFormula:C26H22Cl2N4Purezza:98%Colore e forma:SolidPeso molecolare:461.39Amauromine
CAS:Amauromine is a peripherally selective and potent cannabinoid receptor type 1 (CB1) receptor antagonist, a novel alkaloid with vasodilatory activity.Formula:C32H36N4O2Colore e forma:SolidPeso molecolare:508.65γ-Linolenoyl monoethanolamide
CAS:γ-Linolenoyl monoethanolamide, a fatty N-acyl ethanolamine, acts as an endocannabinoid [1] [2].Formula:C20H35NO2Colore e forma:SolidPeso molecolare:321.50511(Z),14(Z)-Eicosadienoic Acid Ethanolamide
CAS:11(Z),14(Z)-Eicosadienoic acid ethanolamide is an ethanolamide derivative of 11(Z),14(Z)-eicosadienoic acid.Formula:C22H41NO2Colore e forma:SolidPeso molecolare:351.57CB2R-IN-1
CAS:CB2R-IN-1 is a potent inverse agonist of the cannabinoid CB2 receptor (Ki: 0.9 nM).Formula:C23H27F3N4O6S3Purezza:98%Colore e forma:SolidPeso molecolare:608.67O-2050
CAS:O-2050: strong CB1 antagonist (Ki 2.5 nM), CB2 inhibitor (Ki 0.2 nM); reduces mouse food intake, increases activity.Formula:C23H31NO4SPurezza:98%Colore e forma:SolidPeso molecolare:417.56SAD-448
CAS:SAD-448 is a cannabinoid receptor type 1 (CB1) agonist. SAD-448 controls spasticity via action on the peripheral nerve CB1 receptor.Formula:C24H28N4O8SColore e forma:SolidPeso molecolare:532.57CB 65
CAS:CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.Formula:C22H28ClN3O3Purezza:99.53%Colore e forma:SolidPeso molecolare:417.93GSK494581A
CAS:GSK494581A is a GPR55 agonist and glycine transporter subtype 1 inhibitor.Formula:C27H28F2N2O4SPurezza:98%Colore e forma:SolidPeso molecolare:514.58GW 833972A
CAS:GW 833972A: selective CB2 agonist; reduces neural depolarization and citric acid cough in animals.
Formula:C18H14Cl2F3N5OPurezza:99.93%Colore e forma:SoildPeso molecolare:444.24GP 1a
CAS:GP 1a: potent CB2 receptor agonist (EC50=7.1), 30x CB2 over CB1 preference, boosts P-ERK1/2, aids skin healing, anti-inflammatory.
Formula:C23H22Cl2N4OPurezza:99.79%Colore e forma:SolidPeso molecolare:441.35Cannabigerovarin
CAS:Cannabigerovarin (CBGV) is a compound categorized as a phytocannabinoid.Formula:C19H28O2Peso molecolare:288.42PSB-KK1415
CAS:PSB-KK1415 is a selective agonist for the human orphan G protein-coupled receptor GPR18, with an EC50 of 19.1 nM.Formula:C24H23ClN6O2Peso molecolare:462.93MDA7
CAS:MDA7 is a selective agonist of the cannabinoid receptor 2 (CB2), demonstrating an EC50 of 128 nM in human CB2 receptors and 67.4 nM in rat CB2 receptors. The compound exhibits good affinity for CB2 receptors, with Ki values of 422 nM for humans and 238 nM for rats. In rat models, MDA7 shows analgesic activity.
Formula:C22H25NO2Colore e forma:SolidPeso molecolare:335.439BAY 38-7271
CAS:BAY 38-7271: potent neuroprotective, selective CB1/CB2 agonist, Ki of 1.85 nM (CB1) & 5.96 nM (CB2).Formula:C20H21F3O5SPurezza:98%Colore e forma:SolidPeso molecolare:430.44Bzo-poxizid
CAS:Bzo-poxizid is a synthetic cannabinoid and a psychoactive substance.Formula:C20H21N3O2Colore e forma:SolidPeso molecolare:335.40CB1/2 receptor-1
CAS:CB1/2 receptor-1 (compound 5.3) serves as an agonist for CB1/2 receptors and is utilized in angiogenesis research.Formula:C33H48O2Colore e forma:SolidPeso molecolare:476.73Taranabant
CAS:Taranabant: potent CB1 receptor inverse agonist; inhibits agonists with 0.13 nM Ki in vitro.Formula:C27H25ClF3N3O2Purezza:99.06% - 99.06%Colore e forma:SolidPeso molecolare:515.96HU 433
CAS:HU 433, a synthetic cannabinoid, acts as a CB2 receptor agonist and is an enantiomer of HU 308. It provides anti-inflammatory and neuroprotective effects by binding to the CB2 receptor, primarily found on immune cells, thereby modulating immune responses and inflammation. Additionally, HU 433 influences microglial signaling pathways, particularly LPS and IFNγ-mediated routes, affecting the phosphorylation of MAPKs, including ERK1/2, JNK, p38, and Akt. This compound is valuable in researching neuroinflammation and retinal diseases.
Formula:C27H42O3Colore e forma:SolidPeso molecolare:414.62TM38837
CAS:CB1 antagonist 4 is an inverse agonist of cannabinoid receptor 1 (CB1) with an IC50 of 0.4 nM. It can reduce body weight, improve plasma inflammatory markers, and enhance glucose homeostasis [1].
Formula:C27H20Cl2F3N7OColore e forma:SolidPeso molecolare:586.40
