DHFR
La diidrofolato reduttasi (DHFR) è un enzima che svolge un ruolo cruciale nel ciclo dei folati, essenziale per la sintesi, la riparazione e la metilazione del DNA. Gli inibitori della DHFR sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro e delle malattie autoimmuni per la loro capacità di inibire la proliferazione cellulare. Presso CymitQuimica, offriamo una varietà di inibitori della DHFR per supportare la tua ricerca in terapia del cancro, immunologia e biologia molecolare.
Trovati 34 prodotti per "DHFR".
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P 218
CAS:P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.Formula:C18H25ClN4O4Purezza:99.93%Colore e forma:White SolidPeso molecolare:396.87D-156844 hydrochloride
D-156844 (Compound 11a) hydrochloride is an SMN2 promoter activator with an EC50 of 4 nM. It enhances mRNA expression of the mouse SMN in NSC-34 cells and the human SMN2 promoter in fibroblasts from patients with severe type I spinal muscular atrophy (SMA), along with increasing full-length human SMN protein expression. D-156844 hydrochloride can overcome DHFR inhibition and is used in SMA research.PROTAC DHFR Degrader-1
CAS:PROTAC DHFR Degrader-1 is a PROTAC degrader that specifically targets the dihydrofolate reductase-thymidylate synthase (DHFR-TS) of Plasmodium falciparum, with a Ki value of 2.01 nM. It shows no inhibitory activity against human DHFR and can inhibit the growth of Plasmodium falciparum, making it useful for research on Plasmodium falciparum and malaria.Formula:C53H60Cl2F2N8O9Peso molecolare:1062.00EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.Purezza:98%Colore e forma:Odour SolidDHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Colore e forma:Odour SolidDHFR-IN-16
DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.Formula:C32H34N4O4SColore e forma:SolidPeso molecolare:570.23008DHFR-IN-18
DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.Formula:C24H22ClN7Colore e forma:SolidPeso molecolare:443.16252EGFR/DHFR-IN-1
EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.Formula:C24H26N4O5S2Colore e forma:SolidPeso molecolare:514.13446DHFR-IN-21
DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.Colore e forma:Odour SolidDHFR-IN-20
DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.Colore e forma:Odour Solid4-O-Methyldopamine hydrochloride
CAS:4-O-Methyldopamine hydrochloride ,with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-O-Methyldopamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C9H13NO2Colore e forma:SolidPeso molecolare:167.205CB 3705
CAS:CB 3705 is a bio-active chemical.Formula:C21H21N5O6Colore e forma:SolidPeso molecolare:439.42TH9028 TFA
TH9028 TFA is an effective MTHFD2 inhibitor (IC50=11 nM) that suppresses proliferation in HL-60 cells, AML cells, and T-ALL Jurkat cells.Formula:C18H19F3N12O7Purezza:98.94% - 99.79%Colore e forma:White SolidPeso molecolare:572.42BION106
CAS:BION106 is a PROTAC degrader targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS). It exhibits potent antimalarial activity with a Ki value of 2.68 nM against Plasmodium falciparum and a toxicity of 0.2 μM. For mammalian cells, its Ki value exceeds 100 μM and the toxicity is 44.2 μM. BION106 is suitable for antimalarial research.Formula:C57H69Cl2F2N9O9Peso molecolare:1133.13Anti-Dihydrofolate reductase Antibody (2V859)
Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.Colore e forma:Odour LiquidDHFR-IN-3
CAS:DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Formula:C8H7BrN4Purezza:99.52% - 99.65%Colore e forma:SolidPeso molecolare:239.072WR99210 hydrochloride
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Formula:C14H19Cl4N5O2Purezza:97.77% - 99.8%Colore e forma:SolidPeso molecolare:431.145Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Formula:C19H22N8OPurezza:98.1%Colore e forma:SolidPeso molecolare:378.431Piritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Formula:C19H25N5O6SColore e forma:SolidPeso molecolare:451.49WR99210
CAS:WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.Formula:C14H18Cl3N5O2Purezza:99.59%Colore e forma:SolidPeso molecolare:394.684
