DHFR
La diidrofolato reduttasi (DHFR) è un enzima che svolge un ruolo cruciale nel ciclo dei folati, essenziale per la sintesi, la riparazione e la metilazione del DNA. Gli inibitori della DHFR sono ampiamente utilizzati come agenti chemioterapici nel trattamento del cancro e delle malattie autoimmuni per la loro capacità di inibire la proliferazione cellulare. Presso CymitQuimica, offriamo una varietà di inibitori della DHFR per supportare la tua ricerca in terapia del cancro, immunologia e biologia molecolare.
Trovati 32 prodotti per "DHFR".
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P 218
CAS:P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.Formula:C18H25ClN4O4Purezza:99.93%Colore e forma:White SolidPeso molecolare:396.87BION106
CAS:BION106 is a PROTAC degrader targeting dihydrofolate reductase-thymidylate synthase (DHFR-TS). It exhibits potent antimalarial activity with a Ki value of 2.68 nM against Plasmodium falciparum and a toxicity of 0.2 μM. For mammalian cells, its Ki value exceeds 100 μM and the toxicity is 44.2 μM. BION106 is suitable for antimalarial research.Formula:C57H69Cl2F2N9O9Peso molecolare:1133.13EGFR/HER2/DHFR-IN-2
EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.Purezza:98%Colore e forma:Odour SolidTH9028 TFA
TH9028 TFA is an effective MTHFD2 inhibitor (IC50=11 nM) that suppresses proliferation in HL-60 cells, AML cells, and T-ALL Jurkat cells.Formula:C18H19F3N12O7Purezza:98.94% - 99.79%Colore e forma:White SolidPeso molecolare:572.42DHFR-IN-11
DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.Colore e forma:Odour SolidDHFR-IN-16
DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.Formula:C32H34N4O4SColore e forma:SolidPeso molecolare:570.23008DHFR-IN-18
DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.Formula:C24H22ClN7Colore e forma:SolidPeso molecolare:443.16252EGFR/DHFR-IN-1
EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.Formula:C24H26N4O5S2Colore e forma:SolidPeso molecolare:514.13446DHFR-IN-21
DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.Colore e forma:Odour SolidDHFR-IN-20
DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.Colore e forma:Odour Solid4-O-Methyldopamine hydrochloride
CAS:4-O-Methyldopamine hydrochloride ,with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. 4-O-Methyldopamine hydrochloride provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Formula:C9H13NO2Colore e forma:SolidPeso molecolare:167.2CB 3705
CAS:CB 3705 is a bio-active chemical.Formula:C21H21N5O6Colore e forma:SolidPeso molecolare:439.42Anti-Dihydrofolate reductase Antibody (2V859)
Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.Colore e forma:Odour LiquidPiritrexim isethionate
CAS:Piritrexim isethionate, a fat-soluble DHFR inhibitor, shows efficacy in metastatic urothelial cancer with a 5-day oral regimen.Formula:C19H25N5O6SColore e forma:SolidPeso molecolare:451.49DHFR-IN-3
CAS:DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.Formula:C8H7BrN4Purezza:99.52% - 99.65%Colore e forma:SolidPeso molecolare:239.072Fanotaprim
CAS:Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.Formula:C19H22N8OPurezza:98.1%Colore e forma:SolidPeso molecolare:378.43Ref: TM-T36692
1mg50,00€2mg71,00€5mg110,00€1mL*10mM (DMSO)122,00€10mg170,00€25mg318,00€50mg442,00€100mg627,00€200mg845,00€WR99210
CAS:WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.Formula:C14H18Cl3N5O2Purezza:99.59%Colore e forma:SolidPeso molecolare:394.68WR99210 hydrochloride(47326-86-3 free base)
CAS:WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.Formula:C14H19Cl4N5O2Purezza:97.77% - 99.8%Colore e forma:SolidPeso molecolare:431.14Ref: TM-T17257L
1mg62,00€5mg132,00€1mL*10mM (DMSO)157,00€10mg200,00€25mg338,00€50mg497,00€100mg708,00€200mg954,00€Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
Key enzyme in folate metabolism.Colore e forma:Lyophilized PowderPeso molecolare:25.6 kDa (predicted)Ref: TM-TMPH-03535
5µg120,00€10µg195,00€20µg324,00€50µg489,00€100µg670,00€200µg964,00€500µg1.558,00€1mg2.277,00€Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
Key enzyme in folate metabolism.Colore e forma:Lyophilized PowderPeso molecolare:22.0 kDa (predicted)Ref: TM-TMPH-03581
5µg120,00€10µg195,00€20µg324,00€50µg489,00€100µg670,00€200µg964,00€500µg1.558,00€1mg2.277,00€
