Antibatterico

<p>G43 inhibits glucosyltransferase GtfB (Kd 3.7μM) and GtfC (Kd 46.9nM), and fights Streptococcus mutans in caries research.</p>

<p>Agent 46 from patent WO2013030735A1, example 9, is a potent antibacterial with research potential.</p>

<p>Gemifloxacin is a fluoronaphthyridone with strong antibacterial effect.</p>

<p>AM-8191, a bacterial topoisomerase inhibitors, has broad-spectrum antibacterial activity.</p>

<p>Tigecycline hydrate: broad-spectrum, glycylcycline antibiotic, bacteriostatic, inhibits protein synthesis, effective against resistant bacteria.</p>

<p>Sedecamycin is a 17-membered macrolide antibiotic. It is used for treating swine dysentery.</p>

<p>LEAP-2 (Human liver expressed antimicrobial peptide-2) is an antimicrobial peptide, a growth hormone-releasing peptide antagonist, and a GHS-R1a inverse agonist</p>

<p>2,2-Dithiobis(Benzothiazole) inhibits MAPK8 and Pseudomonas aeruginosa and is commonly used as an accelerator in rubber and plastic synthesis.</p>

<p>Agent 44: a new antibacterial (Patent WO2013030735A1, ex. 7) with strong activity for bacterial research.</p>

<p>Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.</p>

<p>TP2 inhibits Pks13, halting mycolic acid production and killing mycobacteria, with a 1 μM MIC against Mycobacterium tuberculosis.</p>

<p>Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections.</p>

<p>Aurodox is a biochemical.</p>

<p>Pseudouridimycin: a C-nucleoside antibiotic, inhibits bacterial RNAP, targets Gram-negative and Gram-positive bacteria.</p>

<p>Sitafloxacin: potent broad-spectrum oral fluoroquinolone effective against resistant strains.</p>

<p>Antileishmanial agent-22 (compound 15b) serves as an antiparasitic and antibacterial, exhibiting activities against Leishmania (IC50 = 0.408 μM), malaria, and</p>

<p>Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A &amp; B.</p>

<p>Arylomycin B4 is a lipidic hexapeptide antibiotic (antibiotic) targeting Gram-positive bacteria.</p>

<p>13-Deoxycarminomycin is an antitumor antibiotic.</p>

<p>ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.</p>

<p>Oxiran-2-ylmethanol exhibits antibacterial activity against Escherichia coli and can be used in related research in the field of life sciences.</p>

<p>Natural stilbene Longistyline A from Cajanus cajan leaves; antimicrobial against MRSA, MIC 1.56 μg/mL; neuroprotective.</p>

<p>Ceratotoxins B, an antibacterial peptide, is produced by sexually mature females of Ceratitis capitata (medfly).</p>

<p>IDR-1018 acetate is an innate defense regulator conjugate with a minimum inhibitory concentration (MIC) of 16 μg/mL against MRSA USA300 LAC, MRSA SAP 0017, and S. epidermidis ATCC14990. It serves a role in the synthesis of V-IDR1018 (vancomycin-innate defense regulator conjugate).</p>

<p>Amphipathic peptide LAH4 forms a-helix, binds phospholipid membranes, and shows in vitro transfection on par with commercial reagents.</p>

<p>Antibacterialagent 275 (Ⅲ1) is an antibacterial compound with a λmax value of 730 nm. It is applicable for research in antimicrobial photodynamic therapy (aPDT).</p>

<p>4-Hydroxybenzoicacid-d4 is a deuterated form of 4-Hydroxybenzoicacid, which is a phenolic derivative of benzoic acid. It is effective in inhibiting most Gram-positive bacteria and some Gram-negative bacteria with an IC50 of 160 μg/mL.</p>

<p>Ceftaroline fosamil (TAK-599) is a cephalosporin-derived MRSA antibiotic prodrug.</p>

<p>LL-37, Human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity.</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>Erythromycin dihydrate, a macrolide antibiotic from Streptomyces erythreus, targets 50S ribosomal subunits, blocking protein synthesis.</p>

<p>Pristinamycin, from Streptomyces pristinaespiralis, is a streptogramin antibiotic targeting Gram-positive and resistant bacteria like MRSA.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Carumonam, an antibiotic, could enhance the reactivity of Escherichia coli with mono- and polyclonal antisera to rough Escherichia coli J5.</p>

<p>Reveromycin D, from Streptomyces, blocks EGF in Balb/MK, halts KB/K562 growth, and shows pH-sensitive antifungal traits.</p>

<p>PhoPS is a photoactivatable β-lactamase inhibitor. Upon exposure to light, PhoPS releases the active β-lactamase inhibitor Sulbactam. This compound is capable of inhibiting the synthesis of bacterial cell walls and the formation of biofilms in Escherichia coli, thereby exhibiting antibacterial activity.</p>

<p>Anthracen-1-amine exhibits inhibitory activity against Escherichia coli.</p>

<p>(±)-Emodin bianthrone (compound 10), a naturally occurring substance, demonstrates antimalarial, antitubercular, and antifungal properties [1].</p>

<p>Heliquinomycin, a Streptomyces metabolite, inhibits DNA helicase (Ki=6.8 μM) and fights Gram-positive bacteria and various cancer cells.</p>

<p>Urdamycin B, an antibiotic derived from the metabolic products of Streptomyces fradiae, effectively inhibits fungi and bacteria, and exhibits anti-proliferative activity against mouse leukemia cells L1210. Its potential uses include research on cancer, bacterial, and fungal infections [1] [2].</p>

<p>Antibacterial agent 39 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Cephaloridine hydrate, a broad-spectrum antibacterial antibiotic, exhibits dose-related nephrotoxicity [1] [2].</p>

<p>Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo.</p>

<p>Ecubectedin (PM14), a derivative of ecteinascidins family, has antitumor and antimicrobial properties.</p>

<p>Kirromycin, an antibiotic from Streptomyces, blocks protein synthesis and stunts B. brevis growth by hindering elongation factor Tu in E. coli.</p>

<p>Wychimicin C, a spirotetronate polyketide, combats MRSA and Enterococcus (IC50: 0.125-0.5 µg/mL), from Actinocrispum MI503-AF4.</p>

<p>Antibacterial agent 132 showed antimicrobial activity against C.</p>

<p>Isepamicin (Sch 21420) is a strong aminoglycoside antibiotic, effective on Enterobacteriaceae and staphylococci, less so on other bacteria.</p>

<p>Arginomycin is a nucleoside antibiotic (antibiotic) that inhibits the growth of Gram-positive bacteria and fungi in vitro.</p>

<p>FPI-1523 inhibits β-lactamase (Kd: CTX-M-15 = 4 nM, OXA-48 = 34 nM), blocks PBP2 (IC50 = 3.2 μM), and has strong antimicrobial effects.</p>

<p>Galloyl-bis-HHDP glucose (HeT), an ellagitannin, exhibits phytoprotective effects against Pseudomonas viridiflava [1].</p>

<p>Lauryl-LF 11 displays antimicrobial activity.</p>

<p>Antofloxacin: Broad-spectrum antibiotic, potent against gyrA mutant H. pylori; mild reversible CYP1A2 inhibitor; used for bacterial infections.</p>

<p>Arylomycin B1 is a lipid hexapeptide antibiotic (antibiotic) effective against Gram-positive bacteria.</p>

<p>Dodec-1-ene is toxic to MIAPaCa2 cells, Pseudokirchneriella subcapitata, and Daphnia magna,antibacterial. It can also be used in the synthesis of surfactants.</p>

<p>Antibacterial peptide. Stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of IκBα.</p>

<p>Glutathione S-Transferase (GST) π class inhibitor is a chemical compound designed to inhibit the action of the π class of GST enzymes.</p>

<p>Calcimycin hemimagnesium is an antibiotic, ionophore, and ATPase inhibitor that boosts intracellular Ca2+, causing cell death and apoptosis.</p>

<p>Amphotericin B trihydrate, a polyene antibiotic, is derived from Streptomyces nodosus fermenter cultures. It exhibits antileishmanial properties.</p>

<p>10-Isobutyryloxy-8,9-epoxythymol isobutyrate is a major constituent of Inula helenium and Inula royleana root cultures.</p>

<p>Antibacterial Agent 33 boosts Ceftazidime's efficacy by lowering its MIC.</p>

<p>Cefazolin sodium pentahydrate: first-gen cephalosporin, treats bacterial infections, has anti-inflammatory properties, may reduce POCD.</p>

<p>ML267 (4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxypyridin-2-yl)piperazine-1-carbothioamide trifluoroacetate) is a potent inhibitor of bacterial</p>

<p>Antibacterial agent 116 is a benzophenone salicylanilide with potent activity, inhibiting peptidoglycan synthesis and labeling PBP1b to halt bacterial growth.</p>

<p>HS-291 is a HtpG inhibitor targeting Borrelia burgdorferi (Bb), composed of BX-2819 (high affinity for Bb HtpG), a PEG linker, and Verteporfin (a photoactive</p>

<p>Maximin 63, an antimicrobial peptide sourced from toad brain, exhibits potent efficacy against Staphylococcus aureus with a minimum inhibitory concentration (</p>

<p>Desferriferribactin is a biogenetic precursor of pyoverdin.</p>

<p>ST166 free acid is an inhibitor of the PhoP-DNA complex formation, with IC50 values of 18 μM and 24 μM, effectively hindering the binding of PhoP and MtrAC to DNA. Additionally, ST166 free acid exhibits antibacterial activity against Mycobacterium marinum.</p>

<p>Cloflucarban can be used as a disinfectant agent.</p>

<p>NDM-1 inhibitor-8 (Compound 18b) is a covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), with an IC50 of 7.03 μM. It effectively inhibits resistant bacterial strains and demonstrates synergistic antibacterial effects when used in combination with Meropenem. In mouse models, NDM-1 inhibitor-8 exhibits anti-infective activity.</p>

<p>DHFR-IN-8 (compound 6r), a dihydrofolate reductase (DHFR) inhibitor, disrupts purine and thymidylate biosynthesis critical for cell proliferation and growth.</p>

<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>

<p>Verruculogen, a toxin from Penicillium/Aspergillus, blocks Ca2+-K+ channels and halts mammalian M phase.</p>

<p>Zifanocycline (KBP-7072) TFA is a semi-synthetic aminomethylcycline antibiotic with oral bioavailability, targeting bacterial ribosomes to impede their function</p>

<p>Sulfamerazine sodium salt is a sulfonamide antibacterial.</p>

<p>A 26771B is an antibiotic in the class of macrolide lactone.</p>

<p>N-3-oxo-pentanoyl-L-Homoserine lactone is a quorum sensing inhibitor for E. coli at 230 nM and activates V. fischeri luminescence at 20-200 nM.</p>

<p>Pomolic Acid 3-Acetate, an antitubercular compound, exhibits a minimum inhibitory concentration (MIC) of 32 μM against Mycobacterium tuberculosis H37Rv [1].</p>

<p>Cyclothialidine is an inhibitor of DNA gyrase.</p>

<p>KU13 is an inhibitor of non-tuberculous mycobacteria (NTM), demonstrating minimum inhibitory concentrations (MIC) of 0.032-8 μg/mL against Mycobacterium and 2 μg/mL against E. coli. It is applicable in research focused on anti-infective treatments.</p>

<p>Massarigenin C from M. flavorosea inhibits neuraminidase (IC50=4.15μM) and α-glucosidase (IC50=1.25mM), reduces blood glucose in mice.</p>

<p>Daunosamnyl-daunorubicin is used as an antibody conjugate.</p>

<p>Chlortetracycline, a broad-spectrum antibiotic, halts protein synthesis in Gram-positive/negative bacteria.</p>

<p>Thiomarinol A: potent antibiotic, dithiolopyrrolone-marinolic acid hybrid with MRSA-targeting antimicrobial activity; inhibits IleRS, Ki app 19 nM.</p>

<p>Antibacterial agent 43 from patent WO2013030735A1 shows strong activity against infections and has research potential.</p>

<p>Gallichrome: an active peptide that interacts with siderophore hydroxamate; used in iron uptake research in gram-positive/negative bacteria.</p>

<p>(8'α,9'β-Dihydroxy)-3-farnesylindole exhibits significant inhibitory effectiveness (EC 50 9.8 μM) against B. subtilis.</p>

<p>Gepotidacin S enantiomer is an S enantionmer of gepotidacin.</p>

<p>4-Ethoxycoumarin has antimicrobial activity.</p>

<p>Sericin is a globular protein isolated from silkworm cocoons. It has cognitive enhancement and pain-relieving properties. Additionally, Sericin serves as a cryoprotectant, potentially replacing fetal bovine serum or dimethyl sulfoxide (DMSO). It helps reduce oxidative stress and reactive oxygen species (ROS). Sericin aids in wound repair by promoting collagen production and exhibits activities such as antioxidant, antidiabetic, antihyperlipidemic, anti-inflammatory, moisturizing, wound healing promotion, antibacterial, and antitumor effects.</p>

<p>PBP10 selectively inhibits FPR2 over FPR1, is cell-permeable, and has N-terminal rhodamine, bactericidal against gram-positive/negative bacteria.</p>

<p>β-Lactamase-IN-5, a β-lactamase inhibitor isolated from compound 720, holds significant potential for studying bacterial infections.</p>

<p>2,5-Dimethylcyclohexa-2,5-diene-1,4-dione inhibits the viability of HL60 and K562 cells and exhibits antibacterial and anticancer properties.</p>

<p>Chrysomycin B is an antibiotic isolated from Streptomyces sp.</p>

<p>CysHHC10 is a synthetic antimicrobial peptide (AMP), and exhibits strong anti-microbial properties against both Gram-positive and Gram-negative bacteria.</p>

<p>Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.</p>

<p>Nucleocidin, an antitrypanosomal antibiotic, inhibits the transfer of labeled amino acids from S-RNA to protein.</p>

<p>Ecteinascidin-Analog-1, a tetrahydroisoquinoline, is key for synthesizing ecteinascidin analogs with antitumor and antimicrobial properties.</p>

<p>LL-BM123γ2 is an antimicrobial agent that exhibits activity against various microorganisms. It is utilized in research related to antimicrobial properties.</p>

<p>Carbazomycin A: antimicrobial, antifungal, and cytotoxic; MIC 12.5-25 μg/ml; IC50 18.4-32.6 μg/ml.</p>