Antibatterico
Gli inibitori antibatterici sono composti che prendono di mira le cellule batteriche, inibendo la loro crescita o uccidendole direttamente. Questi inibitori sono essenziali nello sviluppo di trattamenti per le infezioni batteriche e sono ampiamente utilizzati nella ricerca per studiare la fisiologia batterica, i meccanismi di resistenza e l'efficacia di nuovi agenti antibatterici. Presso CymitQuimica offriamo una gamma di inibitori antibatterici per supportare la vostra ricerca in microbiologia, malattie infettive e sviluppo di farmaci.
Trovati 3391 prodotti di "Antibatterico"
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MBL-IN-5
CAS:MBL-IN-5 is an inhibitor of metallo-β-lactamase (MBL). It effectively suppresses three clinically significant B1 subfamily MBLs: NDM-1, VIM-1, and IMP-1 with IC50 values of 0.05 nM, 14 nM, and 21 nM respectively. MBL-IN-5 notably enhances the efficacy of carbapenem antibiotics against MBL-producing clinical strains and, when combined with IPM antibiotics, significantly reduces bacterial load in a thigh infection model.Formula:C20H16ClNO3Colore e forma:SolidPeso molecolare:353.80MraY-IN-2
MraY-IN-2 (compound 6) is an effective inhibitor of bacterial transposase MraY (IC50=4.5 μ M), and can be used for antibacterial research.Formula:C16H23N3O9Colore e forma:SolidPeso molecolare:401.37Antibacterial agent 90
Antibacterial agent 90 (6n), a pleuromutilin derivative, targets Gram-positive pathogens and Mycoplasma pneumoniae.Formula:C30H42N2O6Colore e forma:SolidPeso molecolare:526.66H052
CAS:H052 is a selective inhibitor of Staphylococcus aureus α-hemolysin (Hla). It binds to the Hla monomer, disrupting its interaction with the host cell membrane, thereby blocking pore formation and inhibiting calcium influx, cytotoxicity, and inflammatory response. H052 exhibits inhibitory activity against Hla-induced calcium influx (EC50 = 30 nM in U937 cells) and holds potential for research into lung infections caused by S. aureus.Formula:C21H15ClFN3O4SColore e forma:SolidPeso molecolare:459.88OSUAB-0284
CAS:OSUAB-0284 is an inhibitor of bacterial topoisomerase. It exhibits significant activity against staphylococci, particularly methicillin-resistant Staphylococcus aureus (MRSA). The compound exerts its antibacterial effect by inhibiting bacterial topoisomerase and may be used in research on infections caused by drug-resistant bacteria, including MRSA.Formula:C22H23FN6O6Colore e forma:SolidPeso molecolare:486.45Squalamine lactate
CAS:Squalamine lactate is an aminosterol compound discovered in the tissues of the dogfish shark, with antimicrobial activity.Formula:C37H71N3O8SPurezza:98%Colore e forma:SolidPeso molecolare:718.04Antibacterial agent 278
CAS:Antibacterialagent 278 (compound B1) is an antimicrobial agent that exhibits potent inhibitory activity against Gram-positive bacteria.Formula:C24H17ClF2N4O3Colore e forma:SolidPeso molecolare:482.87ROS inducer 9
CAS:ROS inducer 9 (compound 4e) is an antibacterial agent with a minimum inhibitory concentration (MIC) of 0.25 μg/mL against Escherichia coli. It eradicates bacteria by inhibiting GSH activity and increasing ROS levels. Additionally, ROS inducer 9 exhibits low toxicity toward red blood cells and RAW 264.7 cells.Formula:C26H26BrF4N3O3Colore e forma:SolidPeso molecolare:584.401Antibacterial agent 169
CAS:Antibacterial agent 169 (Compound 28), a pyrrolamide-type GyrB/ParE inhibitor, exhibits antibacterial properties by inhibiting Gyrase and Topo IV in Staphylococcus aureus. It has IC 50 values of 49 nmol/L and 1.513 μmol/L, respectively [1].Formula:C19H25Cl2N5O3Colore e forma:SolidPeso molecolare:442.34ZG297
CAS:ZG297 is an agonist of Staphylococcus aureus ClpP (SaClpP) with an EC50 of 0.26 μM. It degrades SaFtsZ and inhibits bacterial cell division, exhibiting antistaphylococcal activity by inhibiting S. aureus 8325-4 and MRSA strains, with a MIC range of 0.063-256 μg/mL. In mouse models, ZG297 demonstrates anti-infective properties.Formula:C31H35F3N4O3Colore e forma:SolidPeso molecolare:568.63Anthelvencin A
CAS:Anthelvencin A is a pyrrolylamide metabolite with moderate antibacterial and anthelmintic activity.Formula:C19H25N9O3Colore e forma:SolidPeso molecolare:427.46Antibacterial agent 262
CAS:Antibacterialagent 262 (compound A23) is a potent antibacterial agent that inhibits the activity of Xanthomonas oryzae pv oryzae. It also disrupts the integrity of bacterial cell membranes by preventing the formation of biofilms of Xanthomonas oryzae pv oryzae.Formula:C17H18F2N6O4S3Colore e forma:SolidPeso molecolare:504.554G092
G092 is a potent inhibitor of MsbA. MsbA is an ABC transporter protein. G092 has potential for antibacterial drug research.Formula:C23H20Cl2N2O3Colore e forma:SolidPeso molecolare:443.32Thiolactomycin
CAS:Thiolactomycin is a novel reversible dual inhibitor of D-amino acid oxidase (DAO) and D-Aspartate oxidase (DDO).Formula:C11H14O2SPurezza:98%Colore e forma:SolidPeso molecolare:210.29Metallo-β-lactamase-IN-13
CAS:Metallo-β-lactamase-IN-13 (Compound 13i) serves as a pan Metallo-β-Lactamase inhibitor with extended activity against Gram-negative (GN) bacteria expressing metallo-β-lactamases. It exhibits antibacterial properties effective against P. aeruginosa [1].Formula:C15H10F3N7O2S2Colore e forma:SolidPeso molecolare:441.41trans-Clopenthixol
CAS:Trans-Clopenthixol ((E)-Clopenthixol) is an antibiotic without any sedative properties. It can be used in vitro to inhibit Pseudomonas aeruginosa and Plasmodium falciparum.Formula:C22H25ClN2OSColore e forma:SolidPeso molecolare:400.965Antibacterial agent 266
CAS:Antibacterialagent 266 (Compound C5) is an inhibitor of plant pathogenic bacteria that disrupts the integrity of bacterial cell membranes. It exhibits an EC50 of 24.1 μg/mL against Xanthomonasoryzaepvoryzae (Xoo) and 39.0 μg/mL against X. axonopodispvcitri (Xac). Antibacterialagent 266 is valuable for research in plant pathology and the development of agricultural antibacterial agents.Formula:C13H11N3OColore e forma:SolidPeso molecolare:225.246Meclocycline
CAS:Meclocycline: a tetracycline antibiotic, inhibits LDH, reduces cell toxicity from mutant huntingtin, doesn't change protein levels in PC12 cells.Formula:C22H21ClN2O8Colore e forma:SolidPeso molecolare:476.86KPC-2-IN-2
KPC-2-IN-2 (6c) inhibits KPC-2 enzyme in Klebsiella pneumoniae (Ki 0.038 μM) and boosts cefotaxime in E. coli KPC-2.Formula:C12H10BN3O2SColore e forma:SolidPeso molecolare:271.1MtTMPK-IN-8
MtTMPK-IN-8 inhibits MtbTMPK, has low cytotoxicity, shows 0.78-9.4 μM activity against Mycobacterium, useful for tuberculosis research.Formula:C24H24N6O7Colore e forma:SolidPeso molecolare:508.48DL-2-Aminopimelic Acid
CAS:DL-2-Aminopimelic Acid acts as a weak agonist for glutamate receptors and also reduces the sensitivity of leech glutamate receptors to glutamate.Formula:C7H13NO4Colore e forma:SolidPeso molecolare:175.18Aurantiogliocladin
CAS:Aurantiogliocladin is a mild antibiotic effective against Staphylococcus epidermidis, but it shows no efficacy against Staphylococcus aureus. It is also capable of inhibiting biofilm formation.Formula:C10H12O4Colore e forma:SolidPeso molecolare:196.2LolCDE-IN-2
CAS:LolCDE-IN-2 is a potent Lol protein (LolCDE) inhibitor. LolCDE-IN-2 shows antibacterial activity with a MIC of 2 μg/ml against E. coli MG1655 [1].Formula:C22H17N5OPurezza:98%Colore e forma:SolidPeso molecolare:367.40O-1269
CAS:O-1269 acts as a partial agonist for the cannabinoid receptor 1 (CB1R), with a binding affinity (Ki) of 32 nM. Additionally, it exhibits analgesic properties.Formula:C22H22Cl3N3OColore e forma:SolidPeso molecolare:450.79Lambertellin
CAS:Lambertellin, an effective antibiotic, acts as both a bactericide and fungicide. It exerts anti-inflammatory effects in LPS-stimulated RAW 264.7 macrophages by modulating the activation of MAPK and NF-κB signaling pathways.Formula:C14H8O5Colore e forma:SolidPeso molecolare:256.21Anti-MRSA agent 27
CAS:Anti-MRSA agent 27 (compound 4a) is a potent antimicrobial agent against methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 0.0975 μmol/L. It effectively disrupts MRSA biofilms and inhibits the production of hemolysins.Formula:C15H10F3N3OSColore e forma:SolidPeso molecolare:337.32Cephalosporin C
CAS:Cephalosporin C exhibits relatively weak resistance to Gram-positive and Gram-negative bacteria. It is stable against penicillinase, but can be decomposed by cephalosporinase. When hydrolyzed to remove its side chain, it yields 7-amino-cefenoic acid (7-ACA), which is an essential raw material for the production of semisynthetic cephalosporins.Formula:C16H21N3O8SColore e forma:SolidPeso molecolare:415.418QPX7728 bis-acetoxy methyl ester
CAS:QPX7728 bis-acetoxy methyl ester is an inhibitor of boronic acid β-lactamase.Formula:C15H14BFO8Purezza:98%Colore e forma:SolidPeso molecolare:352.08DHFS-IN-1
CAS:DHFS-IN-1 (Compound 3) is an inhibitor of dihydrofolate synthetase (DHFS) with an IC50 of 2.6 μM. It is applicable for research into infectious diseases related to bacterial folate synthesis.Formula:C16H16N8O2Colore e forma:SolidPeso molecolare:352.35Antibacterial agent 113
Antibacterial agent 113 targets multiple bacteria including P. aeruginosa and E. coli, showing efficacy at MIC 15625 μM.Formula:C29H18ClN5OColore e forma:SolidPeso molecolare:487.94Antibacterial agent 261
CAS:Antibacterialagent 261 (compound 43) is a potent inhibitor of the peptide deformylase (PDF) enzyme, demonstrating IC50 values of 2.5 nM against Staphylococcus aureus (S. aureus) and 10.6 nM against Escherichia coli (E. coli).Formula:C18H24N4O3S2Colore e forma:SolidPeso molecolare:408.538Alpibectir
CAS:Alpibectir has antibacterial activity [1].Formula:C12H14F6N2O2Colore e forma:SolidPeso molecolare:332.24β-Glucuronidase-IN-2
β-Glucuronidase-IN-2 is a potent inhibitor of E.Formula:C21H17Cl3O7Colore e forma:SolidPeso molecolare:487.71HT1171
CAS:HT1171 is a potent and selective inhibitor of the Mycobacterium tuberculosis proteasome. It exhibits strong antitubercular activity against Mycobacterium tuberculosis H37Rv, with a MIC90 of 2 μg/mL and MIC of 4 μg/mL. At a concentration of 100 μM, HT1171 shows an inhibition rate of 53.8% against normal human liver cells (L02). HT1171 is applicable in antituberculosis drug research.Formula:C7H4N2O4S2Colore e forma:SolidPeso molecolare:244.248Colistin adjuvant-2
Colistin adjuvant-2 is a compound that acts as a potentiation agent for colistin, effectively enhancing its activity against Gram-negative bacteria [1].Formula:C14H7Cl2F3N2OColore e forma:SolidPeso molecolare:347.12PKZ18
CAS:PKZ18 is an antibiotic that inhibits bacterial growth with a MIC value of 32-64 μg/mL against most Gram-positive bacteria. It suppresses the in vivo transcription and translation of glycyl-tRNA synthetase mRNA. PKZ18 selectively targets stem I specifier loops in Gram-positive bacteria, directly reducing T-box transcription readthrough of associated genes. It prevents codon-anticodon pairing necessary for tRNA binding and is less likely to induce resistance.Formula:C22H26N2O3SPurezza:98.08%Colore e forma:SolidPeso molecolare:398.518Ref: TM-T204863
1mgPrezzo su richiesta5mgPrezzo su richiesta25mgPrezzo su richiesta100mgPrezzo su richiesta10mg662,00€50mg1.429,00€LasR-IN-1
LasR-IN-1 (9g) strongly inhibits LasR, potent vs E. coli, with a 28.13 μM MIC against P. aeruginosa.Formula:C23H21N3O2Colore e forma:SolidPeso molecolare:371.43Pisiferic acid
CAS:Pisiferic acid is a novel PP2C activator and an an antimicrobial diterpenoidFormula:C20H28O3Colore e forma:SolidPeso molecolare:316.43RCB18350
CAS:RCB18350 is an antituberculosis agent and an isoxazole derivative. It demonstrates bacteriostatic properties by inhibiting the growth of Mycobacterium tuberculosis, with a minimum inhibitory concentration (MIC) of 1.25 μg/mL. RCB18350 is effective against multi-drug resistant Mycobacterium tuberculosis (MDR-TB) clinical isolates, Mycobacterium bovis BCG, and Mycobacterium avium, all of which are slow-growing mycobacteria.Formula:C19H18F3N3O4SColore e forma:SolidPeso molecolare:441.424InhA-IN-7
CAS:InhA-IN-7 (Compound 11), a derivative of Triclocan, shows inhibitory activity against enoyl-acyl carrier protein reductase (InhA) with an IC50 of 96 nM. It effectively inhibits the proliferation of both wildtype and mutant strains of Mycobacterium tuberculosis, exhibiting minimum inhibitory concentrations (MICs) ranging from 19 to 75 μM [1].Formula:C17H18Cl2O2Colore e forma:SolidPeso molecolare:325.23JPL
CAS:JPL is an InhA-cofactor-ligand 3FNG inhibitor and is used for the study of tuberculosis [1].Formula:C19H20Cl2O2Colore e forma:SolidPeso molecolare:351.27Antibacterial agent 66
Compound 6q, a trifluoromethylpyridine oxadiazole, targets Xanthomonas oryzae with EC50 of 7.2 μg/mL.Formula:C17H10ClF6N3O2SColore e forma:SolidPeso molecolare:469.79BRD-4592
CAS:BRD-4592 is an allosteric inhibitor targeting tryptophan synthase (TrpAB) of Mycobacterium tuberculosis. It binds at the α-β subunit interface of TrpAB, with an IC50 of 70.9 nM for the α subunit and 22.6 nM for the β subunit.Formula:C17H15FN2OColore e forma:SolidPeso molecolare:282.312MsbA-IN-3
MsbA-IN-3 is a potent and highly selective MsbA inhibitor (IC50: 2 nM). MsbA-IN-3 inhibits Escherichia coli activity (MIC: 35 μM).Formula:C24H22Cl2N2O4SColore e forma:SolidPeso molecolare:505.41ACHN-975
CAS:ACHN-975: potent LpxC inhibitor with subnanomolar activity; targets many gram-negative bacteria; MIC ≤1 μg/mL.Formula:C20H23N3O4Purezza:98%Colore e forma:SolidPeso molecolare:369.41Antibacterial agent 87
Antibacterial agent 87 is an effective antibacterial agent that acts on MRSA (MIC: 0.125 μg/ml), MRSE (MIC: 0.0625 μg/ml) and S. aureus (MIC: 0.0625 μg/ml).Formula:C31H46N2O6SColore e forma:SolidPeso molecolare:574.77Antibacterial agent 68
Antibacterial agent 68 targets drug-resistant E. coli at 0.007 mM with low cytotoxicity.Formula:C26H25BrN4O7Colore e forma:SolidPeso molecolare:585.4MurA-IN-6
CAS:MurA-IN-6 (Compound L16) is a selective MurA inhibitor with an IC50 of 26.63 μM. It exhibits antibacterial activity by inhibiting the function of MurA, a key protein essential for bacterial cell wall synthesis.Formula:C22H17N3O3SColore e forma:SolidPeso molecolare:403.454PROTAC eDHFR Degrader-2
CAS:PROTACeDHFR Degrader-2 (compound 7b) is an effective degrader targeting Escherichia coli dihydrofolate reductase (eDHFR), capable of reliably degrading eDHFR-tagged proteins.Formula:C34H40N8O9Peso molecolare:704.73Altersolanol A
CAS:Altersolanol A (Stemphylin; NSC 173943) demonstrates effective antimicrobial properties, inhibiting the growth of Bacillus subtilis and Pseudomonas aeruginosa with a minimum inhibitory concentration (MIC) ranging from 25-100 μg/mL. Additionally, it shows no phytotoxic effects on Taxus at a concentration of 4 μg/μL.Formula:C16H16O8Colore e forma:SolidPeso molecolare:336.29BAS-118
CAS:BAS-118 is a benzamide derivative exhibiting antibacterial activity. For 100 randomly selected strains of Helicobacter pylori, its MIC50, MIC90, and MIC range were ≤0.003, 0.013, and ≤0.003-0.025 mg/L, respectively. BAS-118 shows potential for research as an anti-H. pylori agent.Formula:C20H18N2O2Colore e forma:SolidPeso molecolare:318.369K13787
CAS:K13787 is an acetohydroxy acid synthase (AHAS) inhibitor with antibacterial properties. It exhibits antimicrobial activity against various non-tuberculous mycobacteria (NTM) as well as clarithromycin (CLR) resistant strains.Formula:C14H11F2N5O4SColore e forma:SolidPeso molecolare:383.33Antibacterial agent 259
CAS:Antibacterialagent 259 (K3) is a bactericide with EC50 values of 1.5, 1.7, and 4.9 mg/L against Xoo, Xoc, and Xac, respectively. It induces the production of reactive oxygen species (ROS) in pathogens, leading to their death. Antibacterialagent 259 is applicable in research for controlling bacterial diseases in plants.Formula:C7H6ClN3O2SColore e forma:SolidPeso molecolare:231.659Fenbenicillin potassium
CAS:Fenbenicillin (Phenbenicillin) potassium is a semi-synthetic penicillin with antibacterial spectrum activity.Formula:C22H22KN2O5SColore e forma:SolidPeso molecolare:465.58410(R)-hydroxy Stearic Acid
CAS:10(R)-hydroxy Stearic acid is a hydroxy fatty acid resulting from the hydroxylation of oleic acid, produced by gut microbiota.Formula:C18H36O3Colore e forma:SolidPeso molecolare:300.48Vitamin K5 hydrochloride
CAS:Vitamin K5 (hydrochloride), a naphthoquinone compound, exhibits trichomonacidal activity in vitro and can be utilized for anti-infection research [1].Formula:C11H12ClNOPeso molecolare:209.674-Hexen-3-one
CAS:4-Hexen-3-one inhibits the growth of H. pylori in the ATCC 43526 strain and TDR strain. Additionally, this compound suppresses urease activity.Formula:C6H10OColore e forma:SolidPeso molecolare:98.14Urease-IN-16
CAS:Urease-IN-16, with an IC50 of 132 µmol/L, is a urease inhibitor that coordinates with nickel atoms through the oxygen atoms of either carbonyl or boronic acid groups. This compound holds significant potential as an additive in the development of efficient fertilizers and medical applications.Formula:C14H17BN2O4SColore e forma:SolidPeso molecolare:320.17Antitubercular agent-23
Antitubercular agent-23 combats Candida albicans (MIC: 1.1 μg/ml) and M. tuberculosis (MIC: 1 μg/ml).Formula:C20H22FN5O8SColore e forma:SolidPeso molecolare:511.48AK-968-11563024
CAS:AK-968-11563024 is an inhibitor targeting marine V. vulnificus NAT [(VIBVN)NAT] with an IC50 value of 18.86 µM. In V. vulnificus, NAT (aromatic amine N-acetyltransferase) plays a role in drug metabolism, contributing to drug resistance. Thus, AK-968-11563024 can be used for research related to drug tolerance.Formula:C18H13I2N9O5Colore e forma:SolidPeso molecolare:689.162Ibafloxacine
CAS:Ibafloxacine (R835) is a fluoroquinolone antibiotic that is used exclusively in veterinary applications and shows zero good bacteriostatic effect againstFormula:C15H14FNO3Purezza:97.67%Colore e forma:SolidPeso molecolare:275.27Cefamandole lithium
CAS:Cefamandole (lithium), a second-generation broad-spectrum cephalosporin antibiotic, exhibits antimicrobial activity. Upon metabolism in the body, it releases free NMTT, which can lead to hypoprothrombinemia.Formula:C18H17LiN6O5S2Colore e forma:SolidPeso molecolare:468.444-Bromo A23187
CAS:4-Bromo A23187 is a halogenated analog of the calcium ionophore A-23187. 4-Bromo A23187 is a calcium modulator and induces apoptosis in different cells.Formula:C29H36BrN3O6Purezza:98%Colore e forma:SolidPeso molecolare:602.522-Bromo-2'-methoxyacetophenone
CAS:2-Bromo-2'-methoxyacetophenone acts as an irreversible inhibitor of MurA, effectively inhibiting MurA in E. coli with an IC50 of 0.38 μM. This compound helps inhibit bacterial cell wall synthesis, making it useful in antimicrobial research.Formula:C9H9BrO2Peso molecolare:229.07BioA-IN-1
CAS:BioA-IN-1 (Compound 15) is an inhibitor of the key enzyme BioA in the biotin biosynthesis pathway of Mycobacterium tuberculosis, with an IC50 value of 0.195 μM. It exhibits antibacterial activity without cytotoxicity.Formula:C18H17NO3SColore e forma:SolidPeso molecolare:327.397AVE-1330A sodium
CAS:AVE-1330A sodium is a beta-Lactamase inhibitor.Formula:C7H10N3NaO6SColore e forma:SolidPeso molecolare:287.23Lavendomycin
CAS:Lavendomycin can be extracted from Streptomyces lavendulae and has active against Gram-positive bacteria.Formula:C29H50N10O8Colore e forma:SolidPeso molecolare:666.77Antibacterial agent 174
CAS:Compound 174 (Compound 5g), an antibacterial agent, exhibits potent anti-infective properties in vivo along with appreciable pharmacokinetic profiles. This highly active substance demonstrates favorable biofilm removal capabilities, low hemolysis, and acceptable mammalian cell toxicity [1].Formula:C25H30FN2NaO5Colore e forma:SolidPeso molecolare:480.5MtTMPK-IN-5
MtTMPK-IN-5 inhibits Mtb TMPK with IC50 of 34 μM and fights tuberculosis with MIC of 12.5 μM, aiding TB research.Formula:C21H23N5O2Colore e forma:SolidPeso molecolare:377.44Gepotidacin hydrochloride
CAS:Gepotidacin (GSK-2140944) is a potent DNA topoisomerase inhibitor, a novel antibacterial efficacious against various anaerobes.Formula:C24H29ClN6O3Colore e forma:SolidPeso molecolare:484.98NBTIs-IN-5
CAS:NBTIs-IN-5 inhibits Mycobacterium abscessus DNA with IC50 1.5μM, halts growth at MIC90 0.4μM.Formula:C24H25F3N4O2Colore e forma:SolidPeso molecolare:458.48Diclosulam
CAS:Diclosulam (XDE 564) is an herbicide with a Ki value of less than 32 nM. It exhibits a MIC of 6.25 and 12.5 μM, and a MIC50 of 1.40 and 3.01 μM against the CBS10913 and CBS12373 strains, respectively.Formula:C13H10Cl2FN5O3SColore e forma:SolidPeso molecolare:406.229-tert-Butyldoxycycline
CAS:9-tert-Butyldoxycycline exhibits immunomodulatory activity by altering the polarization state of polymorphonuclear neutrophils and ameliorating inflammatory responses in ischemia-reperfusion injury models. Additionally, 9-tert-Butyldoxycycline serves as a ligand for the "Tet-On" inducible gene expression system.Formula:C26H32N2O8Colore e forma:SolidPeso molecolare:500.541LasR-IN-2
LasR-IN-2 blocks LasR via H-bond with TRY-56, useful in bacterial infection and CF research.Formula:C21H16ClN3O2Colore e forma:SolidPeso molecolare:377.82Kalafungin
CAS:Kalafungin inhibits various fungi, yeasts, protozoa, and gram-positive bacteria, less so for gram-negative bacteria.Formula:C16H12O6Colore e forma:SolidPeso molecolare:300.26LpxA-IN-1
CAS:LpxA-IN-1, a novel UDP-N-acetylglucosamine acyltransferase (LpxA) inhibitor exhibiting potent activity (IC 50 2 nM), effectively targets Pseudomonas aeruginosaFormula:C21H11D7F3N5O3Colore e forma:SolidPeso molecolare:452.44Antimicrobial agent-29
CAS:Antimicrobial Agent-29 (Compound C35) influences the interaction between human hemoglobin and the Staphylococcus aureus IsdB hemophore. This compound facilitates the identification of IsdB:Hb PPI inhibitors [1].Formula:C19H14N4O4SColore e forma:SolidPeso molecolare:394.4Cefclidin
CAS:Cefclidin (Cefclidine) is a cephalosporin compound.Formula:C21H26N8O6S2Colore e forma:SolidPeso molecolare:550.611Metallo-β-lactamase-IN-14
CAS:Metallo-β-lactamase-IN-14 (Compound 17e) serves as an inhibitor of Metallo-β-Lactamase, displaying inhibitory activity against VIM-1 and VIM-2. This compound also exhibits antibacterial effects on Gram-negative (GN) bacteria and P. aeruginosa [1].Formula:C20H22N8O2S2Colore e forma:SolidPeso molecolare:470.57Antibacterial agent 172
CAS:Antibacterial Agent 172 (Compound 6a), a Clostridioides difficile (Cd) SpoVD inhibitor with an IC50 value of 89 nM, effectively inhibits the sporulation of Clostridioides difficile. It is useful for research on bacterial infections [1].Formula:C21H21N9O5S2Colore e forma:SolidPeso molecolare:543.58(E)-2,6-Di-tertbutyl-4(4-(diethylamino)styryl)pyrylium TFA
CAS:(E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium TFA (Compound 4a) functions as a Gram-negative outer membrane permeabilizer by targeting Met47 in LptA to disrupt LptA/LptC interactions, exhibiting synergistic antibacterial activity. This compound, when in the form of (trifluoromethanesulfonate), enhances the efficacy of pol B against both wild-type and multi-drug resistant A. baumannii and E. coli strains. Additionally, (E)-2,6-Di-tert-butyl-4-(4-(diethylamino)styryl)pyrylium (trifluoromethanesulfonate) serves as an adjuvant for antibiotics combating multi-drug resistant Gram-negative bacteria.Formula:C26H36F3NO4SColore e forma:SolidPeso molecolare:515.629Quorum sensing-IN-9
CAS:Quorum sensing-IN-9 (Compound 7d) inhibits quorum sensing in Pseudomonas aeruginosa by binding to the PqsR protein. It suppresses the expression of quorum sensing system-related genes lasB, rhlA, and pqsA, thereby preventing the production of virulence factors elastase, pyocyanin, and rhamnolipid. Quorum sensing-IN-9 disrupts the motility of P. aeruginosa, inhibits biofilm formation, and reduces the bacterium's virulence and pathogenicity. Additionally, it exhibits anti-infective activity in the Galleria mellonella larval model.Formula:C9H10OS2Colore e forma:SolidPeso molecolare:198.305MsbA-IN-4
MsbA-IN-4 (Compound 32) is a highly selective and potent inhibitor of MsbA (IC50: 3 nM).MsbA-IN-4 inhibits Escherichia coli (MIC: 12 μM).Formula:C23H18Cl2FN5OColore e forma:SolidPeso molecolare:470.33Ph-Ph+
Ph-Ph+ is a dimerized phenanthroline derivative with antitumor, antibacterial, and antifungal effects.Formula:C24H17N4Colore e forma:SolidPeso molecolare:361.42D-CS319
CAS:D-CS319 is a potent inhibitor of metal-𝛽-lactamases (MBLs), exhibiting IC50 values of 2.0 μM for IMP-1 and 3.0 μM for IMP-78. RPX 7546 possesses antibacterial activity.Formula:C7H11NO2S3Colore e forma:SolidPeso molecolare:237.36Antibacterial agent 112
Compound 112: Powerful antibacterial, MIC 1250 μM against B. subtilis, E. coli, E. faecalis, S. typhimurium, S. aureus; also an HIV-1 antibody.Formula:C35H23N5O5Colore e forma:SolidPeso molecolare:593.59Diploicin
CAS:Diploicin is a dibenzofuran lactone compound with activity against Gram-positive bacteria, found in lichens (lichens).
Formula:C16H10Cl4O5Colore e forma:SolidPeso molecolare:424.06MsbA-IN-5
MsbA-IN-5 (compound 40) is a potent and highly selective inhibitor of MsbA (IC50: 2 nM). MsbA-IN-5 can be used in Gram-negative studies.Formula:C23H19Cl2N5OColore e forma:SolidPeso molecolare:452.34Fostriecin (free base)
CAS:Fostriecin inhibits PP2A/PP4 (IC50s = 3.2/3 nM), weakly affects topoisomerase II/PP1 (IC50s = 40/131 μM), doesn't inhibit PP2B, and may modify epigenetics.Formula:C19H27O9PColore e forma:SolidPeso molecolare:430.39844-TFM
844-TFM, a NBTI DNA gyrase blocker, IC50: 1.5 μM, kills Mycobacterium abscessus.Formula:C24H25F3N4O2Colore e forma:SolidPeso molecolare:458.48OPC-167832
CAS:OPC-167832: oral dprE1 inhibitor, IC50 0.258 μM, anti-tuberculosis, for Mycobacterium tuberculosis research.Formula:C21H20ClF3N2O4Colore e forma:SolidPeso molecolare:456.84Cilastatin ammonium salt
CAS:Cilastatin ammonium salt is an antibiotic that is particularly effective against Gram-positive cocci, with a half-life of 3-4 hours.Formula:C16H29N3O5SColore e forma:SolidPeso molecolare:375.48Levofloxacin mesylate
CAS:Levofloxacin mesylate is an orally active antibiotic effective against both Gram-positive and Gram-negative bacteria. It inhibits DNA gyrase and topoisomerase IV enzymes. Levofloxacin mesylate is employed in research related to chronic periodontitis, airway inflammation, and BK viremia. Additionally, it possesses anti-Orthopoxvirus activity.Formula:C19H24FN3O7SColore e forma:SolidPeso molecolare:457.473Carbonic anhydrase inhibitor 28
Carbonic anhydrase inhibitor28 (Compound 11) serves as an inhibitor for the Pseudomonas aeruginosa carbonic anhydrase. It exhibits antibacterial activity, with minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) values of 0.5 and 1 μg/mL, respectively, against P. aeruginosa. Carbonic anhydrase inhibitor28 is utilized in research focused on anti-infection applications.Formula:C24H24FN5O7SColore e forma:SolidPeso molecolare:545.54Antibiofilm agent-14
CAS:Antibiofilm agent-14 (compound 11) functions as an antibiofilm agent. It exhibits antifungal activity against C.albicans SC5314, with a minimum inhibitory concentration (MIC) of 50 μM.Formula:C26H30ClN3OColore e forma:SolidPeso molecolare:435.989Antitubercular agent-15
Antitubercular agent-15 (5n): low toxicity, fights M. tuberculosis strains; MIC90 values range 0.73-18.8 μg/mL.Formula:C21H29FN2Colore e forma:SolidPeso molecolare:328.47Anti-MRSA agent 23
CAS:Anti-MRSA agent 23 (compound 11) is a potent agent against methicillin-resistant Staphylococcus aureus. This compound exhibits both antibacterial and antibiofilm properties. It facilitates the healing and reconstruction of MRSA-infected skin wounds by reducing bacterial load, alleviating inflammation, and promoting angiogenesis.Formula:C20H17N5O3SColore e forma:SolidPeso molecolare:407.446Pyrromycin
CAS:Pyrromycin is a monosaccharide anthracycline which can be used to inhibit cellular RNA synthesis.Formula:C30H35NO11Colore e forma:SolidPeso molecolare:585.60MK-3402
CAS:MK-3402 is a metallo-beta-lactamase inhibitor. MK-3402can be used in the research of bacteria .Formula:C15H19N9O5S2Colore e forma:SolidPeso molecolare:469.50Palmitanilide
CAS:Palmitanilide (Palmitic acid anilide) is an antimicrobial agent effective against Gram-positive bacteria. It can electrostatically bind to components of the cell wall of Gram-positive bacteria (such as Bacillus cereus), altering the membrane structure and affecting normal cellular functions. Palmitanilide shows potential for research into infections caused by Gram-positive bacteria.Formula:C22H37NOColore e forma:SolidPeso molecolare:331.535
