Antibatterico

JPD447, a derivative of MAC-0547630, represents a new class of UppS inhibitors designed to enhance the efficacy of β-lactam antibiotics.

VP-4604: potent anti-MRSA, inhibits S. aureus growth (MIC 4-8 μg/mL), >95% effective against MRSA.

Morinidazole has antibacterial properties for researching anaerobic infections like appendicitis and PID.

SQ609 is a dipiperidine-based drug candidate with notable in vitro anti-tuberculosis effects in mouse macrophages.

NITD-916: oral Mycobacterium InhA inhibitor (IC50: 570 nM), lipophilic 4-hydroxy-2-pyridone with antituberculosis action.

TBT1 is a first-gen MsbA ATPase activator and LPS transport blocker in Acinetobacter, EC50 at 13 μM.

Trofosfamide is a derivative of oxazaphosphorine with antineoplastic potency.

QPX7728 disodium (Xeruborbactam disodium) is a cyclic boronate inhibitor of many serine and metal-β-lactamases, exhibiting antibacterial activity.

GSK572A is a novel and potent potent inhibitor of EchA6, which can be used to treat tuberculosis.

Daldinone A (Compound 4), isolated from Nigrospora oryzae, exhibits antibacterial properties, specifically demonstrating antimicrobial potential against P. aeruginosa [1].

TP0480066 inhibits topoisomerase II, DNA gyrase (IC50=1.1nM), topo IV (IC50=62.89nM), effective against drug-resistant bacteria and N. gonorrhoeae.

A 33853 is an antibiotic isolated from culture broth of Streptomyces sp.

Avarofloxacin (JNJ-Q2) is a fluoroquinolone for treating bacterial skin infections and pneumonia.

DNA gyrase B-IN-3 (Compound A), with an IC50 of less than 10 nM, acts as an inhibitor of bacterial DNA gyrase B and exhibits antibacterial activity against Gram

Antibacterial 91: Inhibits aaRS, IC50 2.10μM vs. S. enterica ThrRS, has antibacterial properties. [1]

Quorum Sensing-IN-2 (compound 23e) is a quorum sensing inhibitor that curtails bacterial pathogenicity without impeding growth.

TMV-IN-3 is a chalcone derivative that inhibits TMV with a 120.3 μg/mL EC50, used in research on infection and cancer.

Anti-MRSA Agent 8 (Compound 7g), a derivative of DAPG, exhibits potent antibacterial properties by interacting with bacterial cell membranes and is useful for

Bassianolide, a cyclodepsipeptide insecticide produced by the fungal species B. bassiana and V. lecanii, demonstrates significant biological activity. Upon oral administration, it induces atony in B. mori silkworms at a concentration of 4 ppm and becomes lethal when concentrations exceed 8 ppm. Remarkably, atony in silkworm larvae can also be triggered by doses as low as 2 µg/larva. Further studies reveal that bassianolide (0.01-1 µM) specifically targets muscarinic receptors to inhibit contractions in isolated guinea pig smooth muscle tissue, elicited by acetylcholine, without affecting nicotinic receptor-induced contractions.

Sterculic acid methyl ester, an ester derivative of sterculic acid known for inhibiting Δ9 desaturase, has been found to adversely affect and exhibit toxicity towards R. opacus bacteria at a concentration of 0.75 mM. It not only hampers bacterial growth but also modifies fatty acid composition by reducing stearate and oleate levels, increasing the palmitate ratio, and decreasing overall fatty acid content at 0.25 or 0.5 mM concentrations. Additionally, at 50 ppm, Sterculic acid methyl ester enhances the tumor growth-promoting effects of aflatoxin Q1 in rainbow trout, indicating a synergistic interaction between the two compounds. [Matreya, LLC. Catalog No. 1236]