Antibatterico

BTK-IN-39 (0204) is a PROTAC target protein ligand employed in the synthesis of PROTAC BTK Degrader-11.

Feglymycin, a 13-amino acid peptide, counters Gram-positive bacteria and HIV, blocks E. coli enzymes MurA & MurC.

ChlaDUB1-IN-1 (Compound 8) is an inhibitor of the Chlamydia deubiquitinase enzyme 1 (ChlaDUB1) and serves as a potential agent in antimicrobial research.

5'-Methoxynobiletin is a useful organic compound for research related to life sciences and the catalog number is T124370.

4-Trehalosamine, a microbial metabolite identified in Streptomyces, exhibits antibiotic properties.

EP5-1 is an antimicrobial peptide with antibacterial, antifungal, antitumor, and antiviral properties, notably inducing apoptosis in cancer cells and

IT-143B, a S. iakyrus metabolite, hinders OS-RC-2, ACHN cell growth; IC50s: 22, 98 μM.

Cyclo(L-Leu-L-Trp) is a diketopiperazine metabolite initially derived from Penicillium, exhibiting antibacterial (MICs = 125-1000 µg/ml) and antifungal activities (MICs = 8-64 µg/ml). It also demonstrates antioxidant properties by reducing the production of hydroxy radicals, as evidenced in an electron spin resonance (ESR) spectroscopy assay (IC50 = 1.8 µM). Additionally, Cyclo(L-Leu-L-Trp) has been identified as a bitter compound capable of quickly crossing rat taste cell membranes ex vivo at a 1 mM concentration. Furthermore, it acts as a melatonin receptor agonist in X. laevis melanophores, suppressing cAMP accumulation at a 20 µM concentration, with this effect being negated by the melatonin receptor antagonist luzindole.

Sarubicin B, an active quinone antibiotic isolated from the culture filtrate of the Streptomyces strain (Streptomyces strain) JA 2861, effectively inhibits Gram-positive bacteria while showing ineffectiveness against Gram-negative organisms.

Pseudobactin A is a nonfluorescent extracellular siderophore produced by plant growth-promoting bacterium Pseudomonas B10.

Streptimidone, a metabolite produced by Streptomyces, exhibits various biological activities, including inhibiting protein synthesis at 50 µg/ml in cell-free assays and reducing tumor growth in rat xenograft models of H.S. No. 1 human sarcoma and H.Ep. No. 3 human epidermoid carcinoma at daily doses of 12.5 and 25 mg/kg.

Meso-2,6-diaminopimelic acid is an essential precursor in the biosynthesis of the amino acid L-lysine and a critical component of peptidoglycan in the cell walls of various bacteria.

Plectasin, a peptide antibiotic derived from saprophytic fungi, can effectively kill Streptococcus pneumoniae in vitro. Additionally, it alleviates experimental peritonitis and pneumonia caused by Streptococcus pneumoniae in mice.

Decatromicin B, from Actinomadura, fights Gram-positive bacteria, like S. aureus and MRSA (MICs 0.39-0.78 μg/ml).

Neospiramycin I, a spiramycin I derivative, is an antibiotic effective against several bacteria, with varying MIC values, and protects mice from S. pneumoniae.

Flg22Pst is a peptide derived from Pseudomonas syringae pv. tabaci, acting as a potent inducer of the plant immune system. It prompts callose deposition and triggers immune responses in plants, aiding in the defense against pathogen invasion.

Deoxyviolacein, a bisindole metabolite, has anti-cancer, anti-bacterial, and anti-fungal properties.

IT-143A from Streptomyces sp. IT-143.1 kills M. luteus (MIC 6.25 μg/ml), and some fungi (MIC 12.5-25 μg/ml).

Anti bacterial agent 237 (compound Ru-8) acts as a potent antibacterial agent against Staphylococcus aureus, exhibiting minimum inhibitory concentrations (MICs) ranging from 0.78 to 1.56 μg/mL. It works by disrupting bacterial cell membranes, altering their permeability, and inducing the production of reactive oxygen species, which leads to bacterial cell death without promoting resistance. Additionally, Anti bacterial agent 237 demonstrates low hemolytic toxicity towards rabbit erythrocytes and Raw 264.7 cells. It has shown significant antibacterial activity in models of skin wound infections in mice and larval infections by the greater wax moth, effectively combating Staphylococcus aureus infections.

Enduracidin (Enramycin) is a polypeptide antibiotic produced by Streptomyces fungicides.

Lipofermata is a fatty acid transport protein (FATP) inhibitor that prevents lipid transport to melanoma cells and reduces melanoma growth and invasion.

Actinobolin ((+)-Actinobolin) is an antibiotic that inhibits protein synthesis by targeting ribosomes in both bacteria and eukaryotes. It suppresses the activity of Mycobacterium smegmatis, Escherichia coli, and rabbit reticulocyte lysate (RRL), with IC50 values of 19.2 μmol/L, 27.9 μmol/L, and 288 μmol/L, respectively.

Quaternium-15 cis-form: cosmetic preservative/antistatic, not dermal teratogen, tested in rats.

D-Octamannuronic acid: alginate from brown algae and some bacteria, studied for pain and vascular dementia research.

Antibacterialagent 180 (15g) is a substrate for type I nitroreductase (TcNTR I) and serves as a potential antitrypanosomal drug. It demonstrates non-mutagenic properties against Salmonella typhimurium strains (TA98, TA100, and TA102).

Bromamphenicol, a chloramphenicol variant, blocks protein synthesis in rats and E. coli; hampers human DNA creation; attaches to E. coli adhesin DraE.

Marstacimab (PF-06741086) is a neutralizing antibody that binds and inhibits human tissue factor pathway inhibitors.

D-Heptamannuronic acid from brown algae/bacteria is used in pain and vascular dementia research.

Isoreserpiline, an indole alkaloid discovered in R. tetraphylla, exhibits a range of biological activities. This compound enhances the antibacterial efficacy of nalidixic acid against both nalidixic acid-sensitive and -resistant E. coli strains through a synergistic effect. Additionally, at a dosage of 25 mg/kg, it mitigates amphetamine-induced hyperactivity in mice.

Furanomycin is an analog of isoleucine.

Retrocyclin-101 is an antimicrobial peptide with activity against bacterial and viral pathogens [1].

ASP-1 is a potent antistaphylococcal peptide, exhibiting minimum inhibitory concentrations (MICs) ranging from 2 μg/mL to 64 μg/mL against both S.

SAIRGA, a derivative of the phages phi3T, specifically identifies phAimR within the bacterial cytosol to initiate lysogeny [1].

Compound PDK0373, with CAS No. 841-77-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0373 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

Buforin II, from Asian toad stomach, is a strong peptide against many bacteria.

c-Met-IN-15 exhibits antibacterial activity.

Oenothein B inhibits PAR-glycohydrolase with antioxidant, anti-inflammatory, antifungal, anti-HCV, and antitumor effects.

Temporin G is an antimicrobial peptide that exhibits activity against Legionella pneumophila [1].

Abaecin, an antibacterial peptide, exhibits selective efficacy against an Apidaecin-resistant strain of Xanthomonas [1].

Drimendiol (compound 1) is a bioactive compound isolated from the leaves and branches of the winter's bark tree (D. winterii). It has inhibitory effects on biofilm formation of *Candida albicans* (C. albicans), *Staphylococcus aureus* (S. aureus), and *Staphylococcus epidermidis* (S. epidermidis), with BIC50 values of 25.5, 65.1, and 67.1 µg/ml, respectively.

Cyclo(Leu-Ala) (Cyclo(alanine-leucine)) is a compound with antimicrobial properties, isolated from microbes and effective in conjunction with other compounds against certain plant pathogens.

Glycolamide is a sulfonylurea compound containing cyclohexyl groups.

TP-271, a tetracyclines antibiotic, is used potentially for the treatment of community-acquired bacterial pneumonia (CABP).

DUB-IN-8 (Compound 8q) serves as an inhibitor of Chlamydia deubiquitinase 1 (DUB1) with an IC50 of 7.7 μM. It exhibits antibacterial properties by inhibiting Chlamydia inclusions, with an IIC50 [the concentration to induce 50% inclusion inhibition] of 8.5 μg/mL.

Antitubercula agent-45 (Compound 5g) is used as both an antifungal and antitubercular agent. It demonstrates inhibitory activity against Staphylococcus aureus, MRSA, Bacillus subtilis, Escherichia coli, and Candida albicans, with MIC values of 6.4, 10.8, 6.1, 8.4, and 8.1 μM, respectively.

Antifungalagent 88 exhibits antifungal activity, with a MIC value ranging from <0.125 μg/mL to 1 μg/mL.

Anti-MRSA agent 11 demonstrates strong activity against both fluoroquinolone-sensitive strain USA500 and resistant MRSA strain Mu50, with a MIC value of 0.39 μg/mL. It also possesses a favorable in vivo half-life and safety profile.

UH-NIP-16 exhibits antibacterial activity against Mycobacterium tuberculosis, effectively inhibiting the pathogenic mycobacterium strains H37Rv and CDC1551 with MIC50 values of 1.86 and 3.05 μM, respectively. Additionally, UH-NIP-16 synergistically enhances the antitubercular effects when used with antituberculosis agents such as Streptomycin, Isoniazid, Ethambutol, and Bedaquiline.

Tubulysin Aintermediate-1 is an intermediate in the synthesis of the cytotoxic peptide Tubulysin A. Tubulysin A (TubA) acts as an antibiotic (antibiotic), anti-microtubule toxins (anti-microtubule toxins), and apoptosis (apoptosis) inducer, which can be isolated from myxobacteria. It exhibits anti-angiogenic, anti-microtubule, anti-mitotic, and anti-proliferative properties, effectively blocking cells in the G2/M phase, inhibiting tubulin polymerization, and inducing depolymerization of isolated microtubules. Tubulysin A serves as an ADC Cytotoxin (ADC Cytotoxin) in the synthesis of ADCs.

Pap12-6 is a 12-peptide derived from the antimicrobial peptide Papiliocin, which originates from the larvae of the yellow-patterned butterfly. It exhibits potent antibacterial activity by penetrating and disrupting bacterial membranes. Additionally, Pap12-6 exerts anti-inflammatory effects through the TLR4-mediated NF-κB signaling pathway.

DHFR-IN-17 (compound j9) is an orally active SaDHFR inhibitor with an IC50 value of 0.97 nM. It exhibits antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration of 0.031 μg/mL.

DNA Gyrase-IN-10 is a potent inhibitor of DNA gyrase, exhibiting strong antibacterial activity. It effectively inhibits both Gram-positive and Gram-negative bacteria.

Anti-inflammatory agent 84 (Compound 4D) is a coumarin derivative with notable antibacterial and anti-inflammatory properties. It inhibits E. coli, Candida albicans, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA) with MIC values of 312, 156, 19, and 316 µg/mL, respectively. Additionally, it suppresses biofilm formation of S. aureus, E. coli, and MRSA, with IC50 values of 185, 321, and 99 µM, respectively. Anti-inflammatory agent 84 also reduces nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophages.

PACE4 Inhibitory peptide C23 (Compound C23) is an effective peptidomimetic inhibitor known to act against PACE4. It exhibits antiproliferative effects on PCa cell lines, with a Ki of 5 nM, and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory peptide C23 suppresses tumor growth in LNCaP xenograft mice.

Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.

SPR741 acetate, a polymyxin B derivative, enhances antibiotics against gram-negative bacteria by disrupting their outer membrane.

Sulisatin disodium salt is a laxative.

rCRAMP (rat) acetate, a cathelin-related antimicrobial peptide, exhibits antibacterial activity in rat brain peptide/protein extracts.

Colistin A sulfate hydrate: key part of antibiotic Colistin, fights against tough gram-negative infections.

CysHHC10 acetate is antibacterial; MIC: E. coli 10.1mM, P. aeruginosa 20.2mM, S. aureus 2.5mM, S. epidermidis 1.3mM.

ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.

FPI-1523 sodium, avibactam derivative; β-lactamase inhibitor (Kd: CTX-M-15, 4nM; OXA-48, 34nM); PBP2 inhibitor (IC50, 3.2μM); strong antibacterial.

pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, has antimicrobial activities and contributes to

Ro 14-1761 is a new third-generation cephalosporin.

Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.

Extracellular death factor TFA (EDF TFA) is a linear pentapeptide that communicating cells produce and release, which activates the cell death pathway.

PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor.

Lactoperoxidase is an antibacterial protein from the mammalian heme peroxidase family. It catalyzes the oxidation of its preferred halide substrates, such as I−, Br−, F−, or the pseudohalide SCN−, using H2O2.

H-Lys-Trp-Lys-OH acetate is a peptide with antibacterial and antiviral activities.

Ticarcillin disodium is a semi-synthetic, broad-spectrum penicillin, beta-lactamase resistant, inhibits cell wall synthesis, causing cell lysis.

Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.

Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting bacterial and fungal growth.

LCC-12 FA is a dimer of metformin, which reduces inflammation in mouse models of bacterial and viral infections and can be used to study metabolic diseases.

Apidaecin IB is an insect antimicrobial peptide, with MIC values of 8 μM for E. coli (O18K1H7, ML35 and ATCC 25922).

Calpurbatug is an immunoglobulin G1 (IgG1) antibody that exhibits affinity for the anti-bacterial DNA-binding protein DNABII family as well as the anti-human

Raxibacumab (ABthrax) is a humanized antibody targeting the protective antigen of Bacillus anthracis, with anti-infection activity.

F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.

ARC7 is a probe for secondary metabolites of Staphylococcus aureus, used for studying type 2 diabetes.

Setoxaximab is a chimeric humanized antibody of the IgG1-κ isotype that specifically targets Shiga toxin type 1 (Stx1).

Atidortoxumab is a human monoclonal antibody (IgG1κ) targeting Staphylococcus aureus alpha toxin [1].

Rivabazumab pegol, a pegylated Fab antibody targeting the PcrV protein, is utilized in phase II studies for chronic Pseudomonas aeruginosa infections [1].

Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] .

AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.

A unique collection of xnum species of natural products with anti-infective activity for high throughput screening (HTS) and high content screening (HCS);

Ceratotoxin A acetate is isolated from the accessory gland secretion fluid, with anti-bacterial effects.

A unique collection of 904 antibacterial bioactive compounds, a powerful tool for antibacterial drug development;

pBD-1: Endogenous AMP in pigs, expressed constitutively in mucosal epithelia for host defense.

D-Glucose-13C6,d7 is a 13C-labeled form of D-Glucose.

T3SS-IN-5 (Compound F9) is a specific inhibitor of the type III secretion system (T3SS), a virulence factor. By suppressing the expression of genes associated with T3SS, T3SS-IN-5 reduces the pathogenicity of bacteria without affecting their viability.

Brevicidine analog 22 (22) exhibits broad-spectrum antimicrobial activity and demonstrates excellent stability (t1/2 = 40.98 h), with a minimum inhibitory concentration (MIC) of 2-16 μM against both Gram-negative and Gram-positive bacteria.

Antibacterial agent 213 (compound Thy3d) exhibits antibacterial activity by disrupting the integrity of bacterial membranes, with a minimum inhibitory concentration (MIC) of 0.5 μg/ml against Staphylococcus aureus (MRSA).

Trimethoprim-d9 is the deuterated form of Trimethoprim. Trimethoprim is a bacteriostatic antibiotic and an orally active inhibitor of dihydrofolate reductase. It shows activity against a variety of Gram-positive and Gram-negative aerobic bacteria. Trimethoprim is used in studies involving urinary tract infections, shigellosis, and Pneumocystis pneumonia.

Erythromycin-d6 is a deuterated form of Erythromycin. Erythromycin, produced by actinomycetes, is a macrolide antibiotic (antibiotic) known for its broad antimicrobial activity. It functions by binding to the 50S ribosomal subunit of bacteria, thereby inhibiting RNA-dependent protein synthesis through the blockage of transpeptidation and/or translocation reactions, without affecting nucleic acid synthesis.

CF3–K11 is a stable antibiotic exhibiting significant antibacterial activity. It is particularly effective against Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus (MRSA).

Puromycin-d3 is the deuterated form of Puromycin. Derived from the bacterium Streptomyces, Puromycin belongs to the aminoglycoside class of antibiotics and acts as an inhibitor of protein synthesis.

Martinomycin is an antibiotic that inhibits Staphylococcus spp., Streptococcus spp., and Enterococcus spp., with a MIC range of 0.06 to 0.5 μg/mL.

Nonanoic acid-d2 is the deuterated form of Nonanoic acid, which is a naturally occurring saturated fatty acid with a nine-carbon structure. Nonanoic acid significantly reduces bacterial translocation, enhances antimicrobial activity, and notably increases the secretion of porcine β-defensin 1 (pBD-1) and pBD-2.

DDC18-8A is an amphiphilic dendritic polymer known for its potent antimicrobial and antibiofilm properties.

Resveratrol-13C6 is a carbon-13 labeled form of Resveratrol. Resveratrol (trans-Resveratrol; SRT501) is a natural polyphenol known for its antioxidant, anti-inflammatory, cardioprotective, and anticancer properties. It targets a variety of proteins, including mTOR, JAK, β-amyloid, Adenylyl cyclase, IKKβ, and DNA polymerase, and acts as a specific activator of SIRT1. Additionally, Resveratrol is an effective Pregnane X Receptor (PXR) inhibitor and serves as an Nrf2 activator, capable of mitigating aging-related progressive renal injury in mouse models. It also enhances nitric oxide (NO) production in endothelial cells.

Sulfanilamide-d4 is the deuterated form of Sulfanilamide. Sulfanilamide acts as an inhibitor of the bacterial enzyme dihydropteroate synthase, with an IC50 of 320 μM.

Puromycin-d3 (dihydrochloride) is the deuterated form of Puromycin dihydrochloride. Puromycin dihydrochloride (CL13900 dihydrochloride) functions as an aminonucleoside antibiotic that inhibits protein synthesis.

trans-Cinnamic acid-d7 is the deuterated form of trans-Cinnamic acid. This compound functions as a fungicide with a minimum inhibitory concentration (MIC) of 250 μg/mL against the fish pathogen Aeromonas sobria (A. sobria, SY-AS1).

Urease-IN-15 (compound 5g) is a non-competitive inhibitor of urease, exhibiting an IC50 of 3.80 µM.

Nonanoic acid-d3 is a deuterated form of Nonanoic acid. Nonanoic acid is a naturally occurring saturated fatty acid with nine carbon atoms. It significantly reduces bacterial translocation, enhances antibacterial activity, and markedly increases the secretion of pig β-defensin 1 (pBD-1) and pBD-2.

JSF-2827 is a benzothiophene compound that exhibits antibacterial activity against Enterococcus faecium.

(Rac)-Bedaquiline-d6 is a deuterium-labeled version of Bedaquiline. Bedaquiline (TMC207) is a diarylquinoline compound that targets the c and ε subunits to inhibit Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase. Levomefolic acid exhibits uncoupling activity and is used in the treatment of multidrug-resistant tuberculosis.