Antibatterico

Anti-inflammatory agent 84 (Compound 4D) is a coumarin derivative with notable antibacterial and anti-inflammatory properties. It inhibits E. coli, Candida albicans, Staphylococcus aureus, and methicillin-resistant S. aureus (MRSA) with MIC values of 312, 156, 19, and 316 µg/mL, respectively. Additionally, it suppresses biofilm formation of S. aureus, E. coli, and MRSA, with IC50 values of 185, 321, and 99 µM, respectively. Anti-inflammatory agent 84 also reduces nitric oxide production in lipopolysaccharide-stimulated RAW264.7 macrophages.

PACE4 Inhibitory peptide C23 (Compound C23) is an effective peptidomimetic inhibitor known to act against PACE4. It exhibits antiproliferative effects on PCa cell lines, with a Ki of 5 nM, and IC50 values of 25 μM and 40 μM for DU145 and LNCaP cells, respectively. Additionally, PACE4 Inhibitory peptide C23 suppresses tumor growth in LNCaP xenograft mice.

Ripasudil free base (K-115 (free base)) is a selective and potent ROCK inhibitor, is a novel and potent antiglaucoma agent.

SPR741 acetate, a polymyxin B derivative, enhances antibiotics against gram-negative bacteria by disrupting their outer membrane.

Sulisatin disodium salt is a laxative.

rCRAMP (rat) acetate, a cathelin-related antimicrobial peptide, exhibits antibacterial activity in rat brain peptide/protein extracts.

Colistin A sulfate hydrate: key part of antibiotic Colistin, fights against tough gram-negative infections.

CysHHC10 acetate is antibacterial; MIC: E. coli 10.1mM, P. aeruginosa 20.2mM, S. aureus 2.5mM, S. epidermidis 1.3mM.

ND-011992: Quinazoline inhibitor of E. coli respiratory enzymes; IC50s: 0.12-2.47 μM; potential tuberculosis research.

FPI-1523 sodium, avibactam derivative; β-lactamase inhibitor (Kd: CTX-M-15, 4nM; OXA-48, 34nM); PBP2 inhibitor (IC50, 3.2μM); strong antibacterial.

pBD-1 TFA is an endogenous and constitutively expressed antimicrobial peptide (AMP) from porcine tissues, has antimicrobial activities and contributes to

Ro 14-1761 is a new third-generation cephalosporin.

Nifurpirinol (P-7138) is an antimicrobial compound that is acutely toxic to milkfish species.

Extracellular death factor TFA (EDF TFA) is a linear pentapeptide that communicating cells produce and release, which activates the cell death pathway.

PR 39 (porcine) acetate is a noncompetitive, reversible and allosteric proteasome inhibitor.

Lactoperoxidase is an antibacterial protein from the mammalian heme peroxidase family. It catalyzes the oxidation of its preferred halide substrates, such as I−, Br−, F−, or the pseudohalide SCN−, using H2O2.

H-Lys-Trp-Lys-OH acetate is a peptide with antibacterial and antiviral activities.

Ticarcillin disodium is a semi-synthetic, broad-spectrum penicillin, beta-lactamase resistant, inhibits cell wall synthesis, causing cell lysis.

Indatuximab ravtansine (BT-062) is an antibody-drug conjugate (ADC) (Antibody-Drug Conjugates (ADCs)) that consists of a murine-human chimeric form based on B-B4, which specifically targets CD138, linked via a disulfide bond to the maytansinoid drug DM4. It exhibits antitumor activity.

Thanatin acetate is a cationic peptide with antimicrobial activity, inhibiting bacterial and fungal growth.

LCC-12 FA is a dimer of metformin, which reduces inflammation in mouse models of bacterial and viral infections and can be used to study metabolic diseases.

Apidaecin IB is an insect antimicrobial peptide, with MIC values of 8 μM for E. coli (O18K1H7, ML35 and ATCC 25922).

Calpurbatug is an immunoglobulin G1 (IgG1) antibody that exhibits affinity for the anti-bacterial DNA-binding protein DNABII family as well as the anti-human

Raxibacumab (ABthrax) is a humanized antibody targeting the protective antigen of Bacillus anthracis, with anti-infection activity.

F7H is an FZD7 antagonist, a potent ligand for the FZD7 transmembrane domain (TMD), with potential antitumor and bacteriostatic activities.

ARC7 is a probe for secondary metabolites of Staphylococcus aureus, used for studying type 2 diabetes.

Setoxaximab is a chimeric humanized antibody of the IgG1-κ isotype that specifically targets Shiga toxin type 1 (Stx1).

Atidortoxumab is a human monoclonal antibody (IgG1κ) targeting Staphylococcus aureus alpha toxin [1].

Rivabazumab pegol, a pegylated Fab antibody targeting the PcrV protein, is utilized in phase II studies for chronic Pseudomonas aeruginosa infections [1].

Rivabazumab is a recombinant antibody against Pseudomonas aeruginosa pcrV [1] .

AMXT-1501 tetrahydrochloride is an inhibitor of polyamine transport.

A unique collection of xnum species of natural products with anti-infective activity for high throughput screening (HTS) and high content screening (HCS);

Ceratotoxin A acetate is isolated from the accessory gland secretion fluid, with anti-bacterial effects.

A unique collection of 904 antibacterial bioactive compounds, a powerful tool for antibacterial drug development;

Aureothricin: DTP antibiotic from Streptomyces, broad-spectrum, inhibits HUVEC adhesion to vitronectin.

WAY-329764 is an antibacterial agent.

Erythromycin thiocyanate, a macrolide from Streptomyces erythreus, binds 50S ribosomes, halting protein synthesis in bacteria.

Methyl 3-hydroxybenzoate is a benzoic acid ester derivative commonly used as a preservative in cosmetics to inhibit microbial growth,

Golotimod hydrochloride (SCV 07 hydrochloride) is an immunomodulatory peptide with antibacterial activity.

Garenoxacin (BMS284756) is a novel oral des-fluoro(6) quinolone for the treatment of Gram-positive and Gram-negative bacterial infections.

Cefamandole is a broad-spectrum cephalosporin antibiotic with antibacterial activity against Bacillus subtilis and Escherichia coli.

Zosurabalpin (Abx MCP) is a macrolide antibiotic effective against drug-resistant Gram-negative bacteria,

Cefsulodin sodium (Sulcephalosporin) hydrate is a β lactam antibiotic.

Azlocillin sodium, an acylampicillin, is a broad-spectrum antibiotics

Bisdionin C blocks GH18 chitinase: IC50—0.2 μM for A. fumigatus, 8.3 μM for HCHT, 3.4 μM for AMCase.

1-Palmitoyl Lysophosphatidic Acid boosts antibiotics against P. aeruginosa by binding Ca2+ and Mg2+.

(rac)-Xeruborbactam ammonium is a beta-lactamase inhibitor and can be used in the study of bacterial infections.

WAY-299017 is a potent and selective UPPS inhibitor for the treatment of bacterial infections.

Cyproconazole is a triazole fungicide. It is used agriculturally for protection of crops against a wide variety of fungal pathogens.

Rhein-8-O-beta-D-glucopyranoside(Rhein-8-glucoside calcium (Rhein-8-glucoside calcium salt) salt) shows moderate bioactivity against human Protein Tyrosine