gsk-3
Gli inibitori di GSK-3 sono composti che prendono di mira la Glicogeno Sintasi Chinasi 3 (GSK-3), un enzima coinvolto in numerosi processi cellulari, tra cui il metabolismo del glicogeno, la trascrizione genica e la proliferazione cellulare. GSK-3 è implicata in varie malattie, come il diabete, i disturbi neurodegenerativi e il cancro. Gli inibitori di GSK-3 sono strumenti importanti per esplorare queste vie e sviluppare potenziali terapie. Presso CymitQuimica, forniamo inibitori di GSK-3 per supportare la tua ricerca nelle malattie metaboliche, nella neurobiologia e nell'oncologia.
Trovati 110 prodotti di "gsk-3"
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PROTAC GSK-3β Degrader-1
PROTACGSK-3β Degrader-1 (compound 1) is a degrader targeting GSK-3β with an IC50 of 833 nM. This compound consists of SB-216763 (a GSK-3β inhibitor), a PEG linker, and CRBN (E3 ligase ligand). It reduces neurotoxicity induced by Aβ25-35 peptide and CuSO4 and is applicable in Alzheimer's disease research.Formula:C43H42Cl2N6O9Peso molecolare:856.239032B-(SP)
CAS:Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)Formula:C71H123N26O29PPurezza:98%Colore e forma:SolidPeso molecolare:1835.87GSK3-IN-1
CAS:<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formula:C14H10ClN3OSPurezza:99.66%Colore e forma:SolidPeso molecolare:303.77GSK-3β inhibitor 1
CAS:GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.Formula:C14H10N2OPurezza:99.40%Colore e forma:SolidPeso molecolare:222.24Ref: TM-T11467
1mg64,00€5mg137,00€10mg210,00€25mg376,00€50mg567,00€100mg777,00€200mg1.026,00€1mL*10mM (DMSO)150,00€GSK-3 inhibitor 3
CAS:GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectivelyFormula:C23H15FN6OPurezza:99.89%Colore e forma:SoildPeso molecolare:410.4GSK-3β inhibitor 22
CAS:GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.Formula:C18H12F3N3O2S2Colore e forma:SolidPeso molecolare:423.43GSK-3β inhibitor 19
GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.Formula:C15H12N4O2SColore e forma:SolidPeso molecolare:312.35GSK-3 Inhibitor 5
CAS:<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formula:C9H6BrNOPurezza:99.58%Colore e forma:Off-White To Light Yellow Crystalline PowderPeso molecolare:224.05MeBIO
CAS:MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.Formula:C17H12BrN3O2Purezza:99.64%Colore e forma:SolidPeso molecolare:370.2Ref: TM-T21966
1mg39,00€5mg74,00€10mg117,00€25mg220,00€50mg354,00€100mg520,00€500mg1.130,00€1mL*10mM (DMSO)86,00€CHIR-98023
CAS:CHIR-98023 is a bio-active chemical.Formula:C20H16Cl2N8O2Colore e forma:SolidPeso molecolare:471.30yGsy2p-IN-H23
CAS:yGsy2p-IN-H23 targets yeast GSY2 with IC50 of 875μM for hGYS1, for GSD research.Formula:C23H27N3O2Colore e forma:SolidPeso molecolare:377.488BIO-acetoxime
CAS:<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formula:C18H12BrN3O3Purezza:97.15%Colore e forma:SolidPeso molecolare:398.21Bikinin
CAS:<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formula:C9H9BrN2O3Purezza:99.86% - >99.99%Colore e forma:SolidPeso molecolare:273.08SB 415286
CAS:SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.Formula:C16H10ClN3O5Purezza:99.55%Colore e forma:SolidPeso molecolare:359.72KY19382
CAS:KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.Formula:C17H11Cl2N3O2Purezza:98.06%Colore e forma:SolidPeso molecolare:360.19Ref: TM-T9025
1mg99,00€5mg197,00€10mg350,00€25mg590,00€50mg840,00€100mg1.130,00€500mg2.308,00€1mL*10mM (DMSO)243,00€VP3.15 dihydrobromide
CAS:VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.Formula:C20H24Br2N4OSPurezza:99.67% - ≥95%Colore e forma:SolidPeso molecolare:528.3AZD1080
CAS:AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.Formula:C19H18N4O2Purezza:97.72% - 99.75%Colore e forma:SolidPeso molecolare:334.37Ref: TM-T1741
1mg43,00€2mg56,00€5mg85,00€10mg124,00€25mg219,00€50mg350,00€100mg429,00€1mL*10mM (DMSO)63,00€TDZD-8
CAS:TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.Formula:C10H10N2O2SPurezza:97.13% - 99.61%Colore e forma:White SolidPeso molecolare:222.26Indirubin-3′-oxime
CAS:<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formula:C16H11N3O2Purezza:98.34%Colore e forma:SolidPeso molecolare:277.28GSK-3β inhibitor 10
CAS:GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.Formula:C12H12N2O3SPurezza:98.06%Colore e forma:SolidPeso molecolare:264.3
