PI3K
Gli inibitori di PI3K sono composti che bloccano l'attività delle fosfoinositide 3-chinasi (PI3K), una famiglia di enzimi coinvolti in una vasta gamma di processi cellulari, tra cui crescita, proliferazione, sopravvivenza e metabolismo. La via PI3K/Akt/mTOR è spesso disregolata nel cancro, rendendo PI3K un obiettivo chiave per la terapia oncologica. Gli inibitori di PI3K sono strumenti critici per studiare la trasduzione del segnale, la biologia del cancro e lo sviluppo di terapie mirate. Presso CymitQuimica, offriamo una varietà di inibitori di PI3K per supportare la tua ricerca nella segnalazione cellulare, oncologia e sviluppo terapeutico.
Trovati 233 prodotti di "PI3K"
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Safingol hydrochloride
CAS:Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Formula:C18H40ClNO2Purezza:99.39% - 99.71%Colore e forma:SoildPeso molecolare:337.969Parsaclisib
CAS:<p>Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)</p>Formula:C20H22ClFN6O2Purezza:98.59%Colore e forma:SolidPeso molecolare:432.88Copanlisib dihydrochloride
CAS:Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Formula:C23H30Cl2N8O4Purezza:99.05% - 99.16%Colore e forma:SolidPeso molecolare:553.44Sophocarpine monohydrate
CAS:Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formula:C15H22N2OPurezza:99.55%Colore e forma:SolidPeso molecolare:246.35P110δ-IN-1
CAS:P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formula:C31H40N8O3SPurezza:99.75%Colore e forma:SolidPeso molecolare:604.77NSC781406
CAS:<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formula:C29H27F2N5O5S2Purezza:99.58%Colore e forma:SolidPeso molecolare:627.68Thioridazine hydrochloride
CAS:Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formula:C21H27ClN2S2Purezza:99.55% - 99.957%Colore e forma:White To Off-White SolidPeso molecolare:407.04Recilisib
CAS:Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Formula:C16H13ClO4SPurezza:98.85% - 98.96%Colore e forma:SolidPeso molecolare:336.79Ref: TM-T13862
1mg46,00€2mg59,00€5mg87,00€10mg119,00€25mg187,00€50mg311,00€100mg502,00€200mg715,00€1mL*10mM (DMSO)105,00€Pictilisib dimethanesulfonate
CAS:Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFormula:C25H35N7O9S4Purezza:99.63%Colore e forma:SolidPeso molecolare:705.85CGS 15943
CAS:CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Formula:C13H8ClN5OPurezza:97.4%Colore e forma:SolidPeso molecolare:285.69Ref: TM-T14944
2mg35,00€5mg52,00€10mg87,00€25mg156,00€50mg235,00€100mg354,00€200mg520,00€1mL*10mM (DMSO)58,00€PI4KIIIbeta-IN-10
CAS:PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formula:C22H25N3O5S2Purezza:99.76%Colore e forma:SolidPeso molecolare:475.58Ref: TM-T12468
1mg80,00€5mg164,00€10mg255,00€25mg420,00€50mg562,00€100mg792,00€200mg1.064,00€1mL*10mM (DMSO)167,00€Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formula:C23H18FN5O2Purezza:99.71%Colore e forma:SolidPeso molecolare:415.42Ref: TM-T13119
1mg38,00€2mg49,00€5mg81,00€10mg111,00€25mg188,00€50mg304,00€100mg457,00€1mL*10mM (DMSO)88,00€PI4KIIIbeta-IN-9
CAS:PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formula:C23H25N3O5S2Purezza:97.18%Colore e forma:SolidPeso molecolare:487.59Ref: TM-T12469
1mg80,00€5mg188,00€10mg283,00€25mg512,00€50mg715,00€100mg938,00€1mL*10mM (DMSO)Prezzo su richiestaInavolisib
CAS:Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Formula:C18H19F2N5O4Purezza:97.36% - 99.90%Colore e forma:SolidPeso molecolare:407.37Ref: TM-T15375
1mg88,00€5mg212,00€10mg373,00€25mg635,00€50mg1.035,00€100mg1.691,00€200mg2.262,00€1mL*10mM (DMSO)404,00€IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formula:C25H25N7O2Purezza:98.00%Colore e forma:SolidPeso molecolare:455.51Ref: TM-T15592
1mg47,00€2mg64,00€5mg104,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)113,00€GSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formula:C29H37FN6O4SPurezza:99.8%Colore e forma:SolidPeso molecolare:584.71STX-478
CAS:STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormula:C16H12F5N5O2Purezza:98.31% - 99.78%Colore e forma:SolidPeso molecolare:401.29Ref: TM-T78211
1mg88,00€5mg187,00€10mg303,00€25mg540,00€50mg815,00€100mg1.216,00€1mL*10mM (DMSO)207,00€IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formula:C22H20F2N6O4Colore e forma:SolidPeso molecolare:470.43IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFormula:C26H21F2N7O3Purezza:98%Colore e forma:SolidPeso molecolare:517.49PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withColore e forma:Odour SolidRef: TM-L1300
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaPI3Kδ-IN-14
<p>PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of</p>Formula:C26H20ClFN8OPurezza:98%Colore e forma:SolidPeso molecolare:514.94PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFormula:C45H39F2N5O12SPurezza:98%Colore e forma:SolidPeso molecolare:911.88PI3K-IN-46
CAS:<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formula:C13H9N3OSPurezza:97.51%Colore e forma:SoildPeso molecolare:255.3PI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formula:C50H46F4N8O8S2Purezza:98%Colore e forma:SolidPeso molecolare:1027.07PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Purezza:98%Colore e forma:Odour SolidPITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityPurezza:98%Colore e forma:Odour SolidDuvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formula:C22H18Cl2N6OPurezza:99.86% - 99.88%Colore e forma:SoildPeso molecolare:453.32Ref: TM-T11129L
1mg313,00€5mg758,00€10mg1.035,00€25mg1.568,00€50mg2.118,00€100mg2.783,00€1mL*10mM (DMSO)945,00€PI5P4Ks-IN-2
CAS:<p>PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.</p>Formula:C22H23N5Purezza:98.36% - 99.02%Colore e forma:SoildPeso molecolare:357.45GSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formula:C25H30N6O7SPurezza:99.52%Colore e forma:SoildPeso molecolare:558.61PI3Kα-IN-12
<p>PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values</p>Formula:C28H36F2N10O5S3Colore e forma:SolidPeso molecolare:726.84740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formula:C143H226N43O41PS3Purezza:99.92%Colore e forma:SoildPeso molecolare:3330.79WYE-687
CAS:WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formula:C28H32N8O3Purezza:99.93%Colore e forma:SolidPeso molecolare:528.61Ref: TM-T6732
5mg39,00€10mg59,00€25mg113,00€50mgPrezzo su richiesta100mgPrezzo su richiesta1mL*10mM (DMSO)50,00€Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Colore e forma:Odour SolidRef: TM-L1600
1mgPrezzo su richiesta30μL*10mM (DMSO)Prezzo su richiesta50μL*10mM (DMSO)Prezzo su richiesta100μL*10mM (DMSO)Prezzo su richiesta250μL*10mM (DMSO)Prezzo su richiestaD-106669
CAS:D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Formula:C17H18N6OColore e forma:SolidPeso molecolare:322.36BAY1082439
CAS:BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formula:C25H30N6O5Purezza:98%Colore e forma:SolidPeso molecolare:494.54IHMT-PI3Kδ-372 S-isomer
CAS:<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Formula:C26H23F2N7O2Purezza:99.97%Colore e forma:SoildPeso molecolare:503.5PROTAC PI3K/110β degrader-1
CAS:PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formula:C51H65N9O9SColore e forma:SolidPeso molecolare:980.18PI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Colore e forma:Odour SolidARUK2001607
CAS:ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formula:C14H13N3O2S2Purezza:99.75%Colore e forma:SoildPeso molecolare:319.40Umbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formula:C31H24F3N5O3Purezza:97.34%Colore e forma:SolidPeso molecolare:571.55Ref: TM-T13140
1mg187,00€5mg455,00€10mg655,00€25mg1.169,00€50mg1.510,00€100mg1.882,00€1mL*10mM (DMSO)560,00€FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Colore e forma:LiquidPROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Colore e forma:Odour SolidPI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formula:C21H19ClN4O4Colore e forma:SolidPeso molecolare:426.853(3S)-GSK-F1
CAS:(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formula:C27H18F5N5O4SPurezza:99.04%Colore e forma:SoildPeso molecolare:603.52Ref: TM-T67837
1mg73,00€5mg140,00€10mg221,00€25mg393,00€50mg562,00€100mg883,00€1mL*10mM (DMSO)192,00€PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formula:C20H15Cl2N5O3Purezza:98%Colore e forma:SolidPeso molecolare:444.27PF-06843195
CAS:PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formula:C20H25F3N8O4Purezza:98.01%Colore e forma:SolidPeso molecolare:498.46Periplocin
CAS:Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formula:C36H56O13Purezza:99.66% - 99.74%Colore e forma:SolidPeso molecolare:696.82Ref: TM-T5S1982
1mg35,00€5mg77,00€10mg106,00€25mg170,00€50mg253,00€100mg375,00€500mg892,00€1mL*10mM (DMSO)107,00€PIK-108
CAS:PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formula:C22H24N2O3Purezza:98.92%Colore e forma:SolidPeso molecolare:364.44Ref: TM-T28416
1mg40,00€2mg57,00€5mg97,00€10mg156,00€25mg255,00€50mg368,00€100mg510,00€200mg700,00€1mL*10mM (DMSO)105,00€Brevianamide F
CAS:<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formula:C16H17N3O2Purezza:97.30% - 98.82%Colore e forma:SolidPeso molecolare:283.33Alpelisib
CAS:Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Formula:C19H22F3N5O2SPurezza:98% - 99.73%Colore e forma:SolidPeso molecolare:441.47Ref: TM-T1921
2mg39,00€5mg55,00€10mg72,00€25mg87,00€50mg96,00€100mg154,00€500mg447,00€1mL*10mM (DMSO)60,00€
