ATM/ATR
Gli inibitori di ATM (Ataxia Telangiectasia Mutated) e ATR (ATM and Rad3-related) prendono di mira chinasi chiave coinvolte nella risposta al danno al DNA (DDR) che vengono attivate in risposta a rotture del doppio filamento di DNA e stress da replicazione. Questi inibitori interrompono la capacità di queste chinasi di rilevare e riparare i danni al DNA, il che può portare a un aumento dell'instabilità genomica e alla morte cellulare, in particolare nelle cellule tumorali che dipendono da robusti meccanismi di riparazione del DNA per sopravvivere. Gli inibitori di ATM/ATR sono strumenti cruciali nella ricerca e nella terapia del cancro, soprattutto in combinazione con agenti che danneggiano il DNA. Presso CymitQuimica, offriamo una vasta gamma di inibitori di ATM/ATR di alta qualità per supportare la tua ricerca sulla risposta al danno al DNA, la biologia del cancro e lo sviluppo terapeutico.
Trovati 72 prodotti di "ATM/ATR"
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ATR-IN-22
CAS:ATR-IN-22 (Compound 34), an orally active ATR inhibitor, exhibits potent anti-proliferative effects on MIAPaCa-2 cells with an IC50 value of less than 1 μM andFormula:C25H31N7OPurezza:98%Colore e forma:SolidPeso molecolare:445.56Lartesertib
CAS:<p>Lartesertib (ATM Inhibitor-5) is an inhibitor of the serine/threonine protein kinase ATM with potential anticancer activity and can be used to study lung cancer</p>Formula:C23H21FN6O3Purezza:99.9%Colore e forma:SolidPeso molecolare:448.45Camonsertib
CAS:<p>Camonsertib (RP-3500) is a novel, potent and selective ATR kinase inhibitor (ATRi) that exhibits potent antitumor effects with an IC50: 1.00 nM in biochemical assays.Cost-effective and quality-assured.</p>Formula:C21H26N6O3Purezza:99.6% - 99.93%Colore e forma:SolidPeso molecolare:410.47AZ31
CAS:AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM,Formula:C24H28N4O3Purezza:98.1%Colore e forma:SolidPeso molecolare:420.5ATR-IN-14
CAS:ATR-IN-14: potent ATR kinase inhibitor; 98.03% inhibition at 25 nM; IC50 of 64 nM in LoVo cells.Formula:C20H20FN7OColore e forma:SolidPeso molecolare:393.42ATM Inhibitor-3
ATM Inhibitor-3 selectively inhibits ATM (IC50: 0.71 nM), targets PI3K kinase family, and is metabolically stable.Formula:C25H29FN6O3Colore e forma:SolidPeso molecolare:480.53ATM Inhibitor-2
ATM Inhibitor -2 is a potent and selective inhibitor of ATM (IC50<1 nM).Formula:C26H31N7O3Colore e forma:SolidPeso molecolare:489.57ATR kinase-IN-2
CAS:ATRkinase-IN-2 (Compound I-G-27) is an inhibitor of the ATR protein kinase, with a Ki value ranging from 0.01 to 1 μΜ. It is utilized in tumor research.Formula:C24H29F2N9O2Colore e forma:SolidPeso molecolare:513.54ATM Inhibitor-11
CAS:ATMInhibitor-11 (Compound 1) is an inhibitor of ATM with an IC50 of 0.32 nM. It also inhibits KAP1 phosphorylation with an IC50 of 0.97 nM. This compound exhibits high exposure in the brain, heart, and plasma of ICR mice. Furthermore, ATMInhibitor-11 demonstrates antitumor activity in the NCI-H441 xenograft mouse model.Formula:C27H33FN6O2Colore e forma:SolidPeso molecolare:492.59ATR kinase-IN-3
CAS:ATRkinase-IN-3 (Compound I-G-28) is an inhibitor of the ATR protein kinase, exhibiting a Ki value ranging from 0.01 to 1 μM, and is utilized in cancer research.Formula:C24H27F2N9O2Colore e forma:SolidPeso molecolare:511.53ATM Inhibitor-4
ATM Inhibitor -4: selective, potent (IC50: 0.32 nM), inhibits PI3K family, stable, stops mTOR at 1 μM.Formula:C26H29FN6O3Colore e forma:SolidPeso molecolare:492.55KU 59403
CAS:KU 59403 is an effective ATM inhibitor (IC50: 3 nM, 9.1 μM, and 10 μM for ATM, DNA-PK, and PI3K, respectively).Formula:C29H32N4O4S2Purezza:99.10%Colore e forma:SolidPeso molecolare:564.72ATR-IN-17
CAS:ATR-IN-17 is a potent inhibitor of ATR kinase with good anti-cancer effects in LoVo cells (IC50: 1 nM).Formula:C22H28N6O2SColore e forma:SolidPeso molecolare:440.56(S)-WSD0628
CAS:(S)-WSD0628 is the S isomer of WSD0628 and serves as an ATM inhibitor, effectively suppressing ATM phosphorylation in MCF-7 cells with an IC50 of less than 100 nM. This compound also demonstrates radiosensitizing activity and is capable of penetrating the blood-brain barrier.Formula:C23H23F2N5O2Colore e forma:SolidPeso molecolare:439.458ATR-IN-19
CAS:ATR-IN-19 (Compound 15 R-configure) is an ATR inhibitor [1].Formula:C18H19N7OSColore e forma:SolidPeso molecolare:381.45ATR-IN-12
ATR-IN-12, a potent ATR kinase inhibitor with IC50 of 0.007 μM, shows promise for drug development.Formula:C22H27N5O3SColore e forma:SolidPeso molecolare:441.55ATR-IN-11
<p>ATR-IN-11, a potent ATR kinase inhibitor, shows promise as a lead for DNA damage response-targeted cancer drugs.</p>Formula:C25H30N6O2Colore e forma:SolidPeso molecolare:446.54ATM Inhibitor-1
CAS:ATM Inhibitor-1 is a highly potent, selective and orally active ATM inhibito (IC50: 0.7 nM) anti-tumor activity.Formula:C27H36N6O3Purezza:98%Colore e forma:SolidPeso molecolare:492.61WSD0628
CAS:WSD0628 is a brain-penetrant and potent ATM inhibitor with a significant radiosensitizing effect [1].Formula:C23H23F2N5O2Colore e forma:SolidPeso molecolare:439.46Decarbamoylmitomycin C
CAS:Decarbamoylmitomycin C, an analog of Mitomycin C (MC), functions as a DNA alkylating agent. It is capable of activating chromatin relaxation by the ataxia-telangiectasia and Rad3-related protein (ATR) in a p53-independent manner.Formula:C14H17N3O4Colore e forma:SolidPeso molecolare:291.302KU-60019
CAS:<p>KU-60019 is a specific inhibitor of ATM kinase (IC50: 6.3 nM).</p>Formula:C30H33N3O5SPurezza:98.05% - 98.50%Colore e forma:SolidPeso molecolare:547.67ATR-IN-24
CAS:<p>ATR-IN-24 (Compound 1) is an ATR inhibitor with demonstrated anticancer activity [1].</p>Formula:C23H26N6O2Purezza:98%Colore e forma:SolidPeso molecolare:418.49Ref: TM-T79058
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