mTOR
Gli inibitori di mTOR sono composti che inibiscono l'attività del Bersaglio della Rapamicina nei Mammiferi (mTOR), un regolatore centrale della crescita cellulare, della proliferazione, del metabolismo e della sopravvivenza. La via di mTOR è frequentemente alterata nel cancro e in altre malattie, rendendo mTOR un bersaglio critico per l'intervento terapeutico. Gli inibitori di mTOR sono ampiamente utilizzati nella ricerca sul cancro, l'invecchiamento e i disturbi metabolici. Presso CymitQuimica, offriamo una varietà di inibitori di mTOR per supportare la tua ricerca nella trasduzione del segnale, oncologia e sviluppo terapeutico.
Trovati 163 prodotti per "mTOR".
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YB-3-17
CAS:YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)Formula:C38H39N11O6Colore e forma:SolidPeso molecolare:745.786S6K1-IN-DG2
CAS:S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.Formula:C16H17BrN6OPurezza:99.99%Colore e forma:SolidPeso molecolare:389.25Samotolisib
CAS:Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.4775BGT226
CAS:BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formula:C28H25F3N6O2Purezza:95.74% - 99.78%Colore e forma:White SolidPeso molecolare:534.5323Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurezza:98.28% - 99.64%Colore e forma:SolidPeso molecolare:498.601G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:Yellow SolidPeso molecolare:383.388Corynoxine
CAS:Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.Formula:C22H28N2O4Purezza:99.93% - 99.98%Colore e forma:Red SolidPeso molecolare:384.4687PF-04691502
CAS:PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formula:C22H27N5O4Purezza:96.27% - ≥95%Colore e forma:SolidPeso molecolare:425.48Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formula:C14H20O7Purezza:97.81% - 99.89%Colore e forma:Yellow SolidPeso molecolare:300.3044GNE-477
CAS:GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.Formula:C21H28N8O3S2Purezza:98.88% - 99.55%Colore e forma:SolidPeso molecolare:504.629PI-103
CAS:PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formula:C19H16N4O3Purezza:97.79% - 99.30%Colore e forma:Yellow SolidPeso molecolare:348.3553Omipalisib
CAS:Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formula:C25H17F2N5O3SPurezza:98% - 99.8%Colore e forma:Yellow SolidPeso molecolare:505.496AZD-8055
CAS:AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.Formula:C25H31N5O4Purezza:98% - 99.69%Colore e forma:SolidPeso molecolare:465.54mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formula:C16H15BrN2O3Purezza:99.43%Colore e forma:White SolidPeso molecolare:363.206Polyphyllin I
CAS:Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,Formula:C44H70O16Purezza:98% - 99.36%Colore e forma:SolidPeso molecolare:855.017Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Formula:C9H6O4Purezza:97.47% - 99.95%Colore e forma:SolidPeso molecolare:178.1415NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Formula:C7H14ClF2NO2Colore e forma:SolidPeso molecolare:217.64Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurezza:97.25% - 98.34%Colore e forma:SolidPeso molecolare:801.6225(R,S)-Ruscogenin
CAS:25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.Formula:C27H42O4Purezza:99.32% - 99.89%Colore e forma:White SolidPeso molecolare:430.62Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formula:C25H30N6O3Purezza:97.08% - 99.06%Colore e forma:SolidPeso molecolare:462.5441
