mTOR
Gli inibitori di mTOR sono composti che inibiscono l'attività del Bersaglio della Rapamicina nei Mammiferi (mTOR), un regolatore centrale della crescita cellulare, della proliferazione, del metabolismo e della sopravvivenza. La via di mTOR è frequentemente alterata nel cancro e in altre malattie, rendendo mTOR un bersaglio critico per l'intervento terapeutico. Gli inibitori di mTOR sono ampiamente utilizzati nella ricerca sul cancro, l'invecchiamento e i disturbi metabolici. Presso CymitQuimica, offriamo una varietà di inibitori di mTOR per supportare la tua ricerca nella trasduzione del segnale, oncologia e sviluppo terapeutico.
Trovati 162 prodotti di "mTOR"
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mTOR inhibitor-1
CAS:C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.Formula:C16H15BrN2O3Purezza:99.43%Colore e forma:SolidPeso molecolare:363.21G5-7
CAS:G5-7 is an oral JAK2 inhibitor targeting EGFR/STAT3 phosphorylation with potential for glioma research.Formula:C22H19F2NO3Purezza:97.3%Colore e forma:SolidPeso molecolare:383.39Polyphyllin I
CAS:<p>Polyphyllin D induces apoptosis via the mitochondrial apoptotic pathway as evidenced by decreased Bcl-2 expression levels, disruption of MMP and increased Bax,</p>Formula:C44H70O16Purezza:98% - 99.5%Colore e forma:SolidPeso molecolare:855.02Samotolisib
CAS:<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formula:C23H26N4O3Purezza:98.41% - 99.69%Colore e forma:SolidPeso molecolare:406.48Torin 1
CAS:<p>Torin 1 is an effective inhibitor of mTORC1/2 with (IC50: 2 nM/10 nM); has 1000-fold selectivity for mTOR than PI3K.</p>Formula:C35H28F3N5O2Purezza:98.3% - 99.33%Colore e forma:SolidPeso molecolare:607.62Apitolisib
CAS:Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formula:C23H30N8O3SPurezza:98.28% - 99.64%Colore e forma:SolidPeso molecolare:498.6Corynoxine
CAS:<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formula:C22H28N2O4Purezza:96.83% - 99.93%Colore e forma:SolidPeso molecolare:384.47Salidroside
CAS:Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.Formula:C14H20O7Purezza:97.81%Colore e forma:Red-Brown Fine PowderPeso molecolare:300.30PF-04691502
CAS:<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formula:C22H27N5O4Purezza:96.27% - ≥95%Colore e forma:SolidPeso molecolare:425.48GNE-477
CAS:<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formula:C21H28N8O3S2Purezza:98.88% - 99.55%Colore e forma:SolidPeso molecolare:504.63OSI-027
CAS:OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.Formula:C21H22N6O3Purezza:97.42%Colore e forma:SolidPeso molecolare:406.44Bimiralisib
CAS:Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formula:C17H20F3N7O2Purezza:97.58% - 98.92%Colore e forma:SolidPeso molecolare:411.38AZD-8055
CAS:<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Formula:C25H31N5O4Purezza:98% - 99.69%Colore e forma:SolidPeso molecolare:465.54Palomid 529
CAS:Palomid 529 (SG 00529) has been used in trials studying the treatment of Age-Related Macular Degeneration.Formula:C24H22O6Purezza:98.40% - 98.59%Colore e forma:SolidPeso molecolare:406.43Mito-LND
CAS:Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.Formula:C43H45BrCl2N3OPPurezza:97.25% - 98.34%Colore e forma:SolidPeso molecolare:801.62Cyclovirobuxine D
CAS:Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.Formula:C26H46N2OPurezza:97.78% - 98%Colore e forma:SolidPeso molecolare:402.6625(R,S)-Ruscogenin
CAS:<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Formula:C27H42O4Purezza:99.32% - 99.89%Colore e forma:SolidPeso molecolare:430.62NV-5138 hydrochloride
NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.Formula:C7H14ClF2NO2Colore e forma:SolidPeso molecolare:217.64Omipalisib
CAS:<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formula:C25H17F2N5O3SPurezza:98% - 99.8%Colore e forma:SolidPeso molecolare:505.5Vistusertib
CAS:Vistusertib (AZD2014) is an orally bioavailable inhibitor of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.Formula:C25H30N6O3Purezza:97.08% - 99.06%Colore e forma:SolidPeso molecolare:462.54
