Composti policiclici

<p>Applications 6-Chloro-2,3-dihydro-2-oxo-1H-indole-5-carboxylic Acid is an intermediate used in the synthesis of EPZ031686, the first orally bioavailable small molecule SMYD3 inhibitor.<br>References Mitchell, L., et al.: ACS Med. Chem. Lett. (2015)<br></p>

<p>Applications 5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.<br></p>

<p>Stability Light Sensitive<br>Applications 3,3'-Bipyridine-6,6'-dicarbonitrile<br></p>

<p>Stability Store under Argon<br>Applications 3,6-Thioxanthenediamine-10,10-dioxide (cas# 10215-25-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 9,9-Dimethyl-xanthene-3,6-diol has been used in the manufacturing of dihydroxydiaminoxanthenes as monomers for positive-working resists by treatment of dihydroxybenzenes with carbonyl compounds, nitration, and reduction.<br>References Sumitani, N.; et al.: Jpn. Kokai Tokkyo Koho 13 pp. Patent 2004 CODEN:JKXXAF<br></p>

<p>Applications 2-(pyridin-3-yl)pyrido[2,3-d]pyrimidine has been used in the preparation of divalent transition metal aminonicotinaldehyde chloride complexes, antimicrobial, antioxidant and antitumor activities, electrochemical and molecular docking with EGFR protein.<br>References Konakanchi R., et al., Res. Chem. Intermed., 44, 27-53 (2018)<br></p>

<p>Applications 2,3,3-Trimethylindolenine is an indole derivative used in the preparation of cyanine dye labelleing reagents and other imaging agents.<br>References Mujumdar, R. et al.: Cytometry, 10, 3 (1989); Mushkalko, I.L. et al.: Ukr. Khim. Zhur., 52, 509 (1986);<br></p>

<p>Applications 3,4-Dihydroisoquinoline-6,7-diol acts as a reagent for the synthesis of 6,7-dihydroxy-3,4-dihydroisoquinline, a novel inhibitor factore-kB in invitro invasion in murine mammary cells.<br>References Alvarez, F. N., et al.: Chemotherapy, 55, 175 (2009)<br></p>

<p>Applications 4,4'-Diamino-2,2'-bipyridine is a bidendate chelator.<br></p>

<p>Applications Indole derivative with anticancer activity.<br>References Lavrenov, S. et al.: Bioorgan. Med. Chem. 18, 6905 (2010)<br></p>

<p>Applications 7-chloro-4-hydroxyquinoline-3-carboxylic acid (cas# 86-47-5) is a useful research chemical.<br></p>

<p>Stability Hygroscopic<br>Applications 3-Bromo-4-fluoro-1H-indazole (cas# 885521-60-8) is a useful research chemical.<br></p>

<p>Applications 8-Hydroxyquinoline Copper Salt is used in the formulation of biocide microcapsules towards stabilized iodine-​containing compounds for protection of technical materials from degradation by microorganisms.<br>References Boettcher, A., et al.: PCT Int. Appl. (2012), WO 2012076699 A1 20120614<br></p>

<p>Applications alpha-Furil Dioxime (cas# 23789-34-6) is a useful research chemical.<br></p>

<p>Applications Methyl quinoline-4-carboxylate (cas# 21233-61-4) is a useful research chemical.<br></p>

<p>Applications Ethyl 4,6,8-trichloroquinoline-3-carboxylate<br></p>

<p>Applications 5-Chloroindole-2-carboxylic Acid is used in the synthesis of 4-(3-aminomethylphenyl)piperidine-1-carboxamides as potent, selective, and orally bioavailable inhibitors of βII tryptase. It is also a reagent used to prepare indole amides with possible antihistaminic activities.<br>References Levell, J., et al.: Bioorg. Med. Chem., 13, 2859 (2005); Battaglia, S., et al.: Eur. J. Med. Chem., 34, 93 (1999)<br></p>

<p>Applications 5-[(1R)-2-[(5,6-Diethyl-2,3-dihydro-1H-inden-2-yl)amino]-1-hydroxyethyl]-8-(phenylmethoxy)-2(1H)-quinolinone is used as a reactant in the preparation of Indacaterol (I499745), a β-adrenoreceptor agonist.<br>References Baur, Francois, et al.: J. of Med. Chem., 53(9), 3675-3684 (2010)<br></p>

<p>Applications 5-Chloroisoquinoline (cas# 5430-45-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,5,6,7-tetrahydro-1H-indazole-6-carboxylic acid (cas# 1354950-72-3) is a useful research chemical.<br></p>

<p>Applications 3-(ETHOXYCARBONYL)BICYCLO[1.1.1]PENTANE-1-CARBOXYLIC ACID (cas# 1823373-90-5) is a useful research chemical.<br></p>

<p>Applications methyl 8,8-dioxo-8lambda6-thia-2,3,5,7-tetraazatricyclo[7.4.0.0,2,6]trideca-1(13),3,5,9,11-pentaene-4-carboxylate (cas# 1311315-62-4) is a useful research chemical.<br></p>

<p>Applications 1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrochloride (cas# 5052-96-0) is a useful research chemical.<br></p>

<p>Applications 2-Azabicyclo[2.2.2]octan-3-one (cas# 3306-69-2) is a useful research chemical.<br></p>

<p>Applications 1R,3S,5R)-2-(tert-Butoxycarbonyl)-2-azabicyclo[3.1.0]hexane-3-carboxylic Acid acts as a reagent in the preparation of fused bicycles end-capped with peptide derivatives as HCV inhibitors. Synthesis of (tert-butoxycarbonyl)azabicyclohexanecarboxylic acid via stereoselective cyclopropanation of pyrroline<br>References Wang, G., et al.: Tetrahedron Lett., 54, 6722 (2013); Belema, M., et al.: From U.S. Pat. Appl. Publ. (2012), US 20120195857 A1 20120802<br></p>

<p>Applications octahydro-1H-indole-2-carboxamide (cas# 1105694-34-5) is a useful research chemical.<br></p>

<p>Applications 1-(5-Fluoropentyl)-1H-indole-3-carbonyl Chloride is an intermediate for the synthesis of Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate (M224944), which is a useful intermediate for organic synthesis.<br></p>

<p>Applications tert-​Butyl 6-​Hydroxy-​2-​azaspiro[3.3]​heptane-​2-​carboxylate is a reactant used in the synthesis of pharmaceuticals such as CNS penetrant CXCR2 antagonists for the potential treatment of CNS demyelinating.<br>References Xu, H. et al.: ACS Med. Chem. Lett., 7, 397 (2016);<br></p>

<p>Applications 4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.<br>References Fu, Y., Zhongguo Xinyao Zazhi, 22, 26 (2013); Liu, M., Adv. Mat. Res., 396, 1490 (2012); Camp, R., et al.: Cancer, 86, 2259 (1999);<br></p>

<p>Applications 5,7-Dibromoquinolin-8-ol<br></p>

<p>Applications 7-Bromoisoquinoline (cas# 58794-09-5) is a compound useful in organic synthesis. It can be used for the preparation of estrone cortistatin analogs via Suzuki-Miyaura coupling. It could also be used for the preparation of pyrazolopyrimidinamine derivatives.<br>References Sato, Y., et al.: Biosci., Biotechnol., Biochem., 72, 2992 (2008), Apsel, B., et al.: Nat. Chem. Biol., 4, 691 (2008)<br></p>

<p>Applications An indolinone derivative used for the preparation of p38α inhibitors as potential antiinflammatories.<br>References Eastwood, P., et al.: Bioorg. Med. Chem. Lett., 21, 5270 (2011),<br></p>

<p>Applications 3-AMINOQUINOLINE (cas# 580-17-6) is a useful research chemical.<br></p>

<p>Applications Protected nucleoside.<br>References Elzein, E., et al.: Bioorg. Med. Chem. Lett., 17, 161 (2007), Franchetti, P., et al.: J. Med. Chem., 52, 2393 (2009),<br></p>

<p>Applications 8,8-dimethyl-2-oxabicyclo[4.2.0]octan-7-amine (cas# 1342540-54-8) is a useful research chemical.<br></p>

<p>Applications Dichloroquinoline derivatives for use as herbicides.<br></p>

<p>Applications 4-(1-Piperazinyl)-1H-indole Dihydrochloride (cas# 84807-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Quinolin-4(1h)-one (cas# 529-37-3) is a useful research chemical.<br></p>

<p>Applications 7-Bromo-2,3-dihydro-1H-indole is a compound useful in organic synthesis.<br></p>

<p>Applications 7-Chloro-3-isoquinolinemethanol is an intermediate in the preparation of pyrrolopyrimidinones as P2X3 receptor antagonists.<br>References Bayrakdarian, M., et al.: PCT Int. Appl. (2008), WO 2008136756 A1 20081113;<br></p>

<p>Applications 3-Bromo-4-chloro-7-fluoroquinoline (cas# 1204810-31-0) is a useful research chemical.<br></p>

<p>Applications Quinoline-4-carboxylic acid (cas# 486-74-8) is a useful research chemical.<br></p>

<p>Applications 1-Hydroxyisoquinoline (cas# 491-30-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Can be used in the preparation of serotoninergic S2 antagonists.<br>References Andersen, K. et al.: J. Med. Chem. 39, 3723(1996); Perregaard, J. et al.: J. Med. Chem. 35, 1092(1992)<br></p>

<p>Applications 1-Ethyl-5-fluoroindoline-2,3-dione (cas# 776-47-6) is a useful research chemical.<br></p>

<p>Applications 2-Cyclobutenyl-3-trifluoromethyl-5-chloro-1H-indole-1-carboxylic acid ethyl ester is synthesized from 5-chloro-2-oxindole (C375030), which is used in the preparation of novel GSK-3β inhibitors as anticancer agents.<br>References Choi, M.J., et al.: Bull. Korean. Chem. Soc., 32, 2015 (2011); Otani, M., et al.: Bioorg. Med. Chem. Lett.. 20, 4259 (2010); Jhan, Y.H., et al.: Tetrahedron. Lett., 54, 1155 (2013); Hsieh, J.C., et al.: Org. Biomolec. Chem., 10, 6404 (2012);<br></p>