Composti policiclici

<p>Applications 6-Hydroxyquinoline-(1H)-2-one (cas# 19315-93-6) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(prop-2-yn-1-yl)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 410538-30-6) is a useful research chemical.<br></p>

<p>Applications 5-Amino-2H-isoquinolin-1-one is a reactant used in the synthesis of glucoorticoid receptor agonists as well as PARP inhibitors used in the treatment of tumors.<br>References Berger, M. et al.: Bioorg. Med. Chem. Lett., 27, 437 (2017); Goodfellow, E. et al.: Bioorg. Med. Chem. Lett., 27, 688 (2017);<br></p>

<p>Applications 1-(4-Chlorobutyl)-7-hydroxyquinolin-2(1H)-one is a useful research chemical.<br></p>

<p>Applications 3-Hydroxyquinoline-d6 is labelled 3-Hydroxyquinoline (H953140) which is a chemical reagent used in the preparation cyclic peptides with an antitumor functionality. Quinoline derivative as a result of the metabolism by cytochrome P 450.<br>References Riego, E. et al.: Tetrahedron, 61, 1407 (2005); Kanou, M. et al.: Fund. Clin. Pharmacol., 16, 513 (2002)<br></p>

<p>Applications 4-Bromo-2,8-Bis(Trifluoromethyl)Quinoline (cas# 35853-45-3) is a useful research chemical.<br></p>

<p>Applications 6-Quinolinol is used in the preparation of potential antifungal agents containing a quinoline structure. Also used in the preparation of novel pyridocoumarins.<br>References Galariniotou, E. et al.: Tetrahedron 63, 8298 (2007); Vandekerckhove, S. et al.: Bioorg. Med. Chem. Lett., 23, 4641 (2013);<br></p>

<p>Applications 4-(ethoxymethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (cas# 18630-93-8) is a useful research chemical.<br></p>

<p>Applications 1,4-Dihydro-7-hydroxy-3(2H)-isoquinolinone, can be involved in the photocyclization of N-(chloroactyl)benzylamines to isoquinoline derivatives.<br>References Ikeda, M., et al.: Tetrahedron Lett., 13, 1181 (1974);<br></p>

<p>Applications 1,1,2-Trimethyl-1H-benzo[e]indole (cas# 41532-84-7) is a useful research chemical.<br></p>

<p>Applications 2-[3-(3,5-Dimethylphenoxy)-2-hydroxypropyl]-1H-isoindole-1,3(2H)-dione is an intermediate used in the synthesis of 1-Amino-3-(3,5-dimethylphenoxy)-2-propanol (A607300), which is a degradation product of Metaxalone (M225850); a muscle relaxant used to relax muscles and relieve pain.<br>References Rao, R.N., et al.: Biomed. Chromatogr., 27, 1733 (2013)<br></p>

<p>Applications Quinoline derivative as antibacterial agents.<br>References O'Neill, P., et al.: Pharmacol. Ther., 77, 29 (1998), Dorn, C., et al.: Bioorg. Med. Chem. Lett., 11, 259 (2001), Scozzafava, A., et al.: Curr. Med. Chem., 10, 925 (2003),<br></p>

<p>Applications 1,4-Dihydro-1-phenyl-3(2H)-isoquinolinone is used as a reagent in the synthesis of a series of 1-aryl-3-dimethylamino-1,4-dihydroisoquinolines which display anti-arthritic activity. Also used as a reagent in the synthesis of 1-aryl-1,4-dihydro-3(2H)-isoquinolinones which have potential antiserotoninergic activity.<br>References Bermudez, J., et al.: Bioorg. Med. Chem. Lett., 3, 2571 (1993); Zara-Kaczian, E., et al.: Acta Chim. Hung., 127, 607 (1990)<br></p>

<p>Applications Used for the preparation of heterocyclic sulfonamide compounds as Edg-1 antagonists useful in the treatment of cancer.<br></p>

<p>Applications α-Furil is an important industrial chemical that is used as a building block for synthesis in the pharmaceutical industry. α-Furil is also part of a group of diketones that act as skin sensitizers.<br>References Roberts, D., et al.: Contact Dermatitis, 41, 14 (1999); Wang, L., et al.: Adv. Mat. Res., 554, 764 (2012)<br></p>

<p>Applications An intermediate in the preparation of Azasetron.<br>References Baker, S., et al.: Bioorg. Med. Chem. Lett., 15, 4727 (2005), Odzak, R., et al.: Bioorg. Chem., 34, 90 (2006), Anand, R., et al.: J. Med. Chem., 52, 1602 (2009),<br></p>

<p>Applications A useful intermediate for the synthesis of pharmaceutical actives, intermediates and fine chemicals.<br>References Pezzuto, J.M., et al.: Biochem., 20, 298 (1981), Takeda, K., et al.: Chem. Pharm. Bull., 29, 1280 (1981),<br></p>

<p>Applications 2-Aminoquinoline-6-carboxylic Acid tert-Butyl ester is a substituted quinoline used in pharmaceuticals for treatment of obesity and related conditions.<br>References Bertinato, P., et al.:PCT Int. Appl. (2005), WO 2005080373 A1 20050901<br></p>

<p>Applications Isotope labelled 6-Bromopurine is a brominated derivative of purine used in various organic syntheses. Used in the synthesis of several benzo-fused scaffolds with purine or pyrimidine moietes which display antitumor and anticancer properties.<br>References Morales, F. et al.: Eur, J. Med. Chem., 76, 118 (2014); Cushing, T. et al.: J. Med. Chem., 58, 480 (2015); Jansen, R., et al.: Clin. Biochem., 38, 362 (2005),<br></p>

<p>Applications Used in the synthesis of 5-chloro-8-mercaptoquinoline and its salts.<br></p>

<p>Applications 3-Azabicyclo[3.3.0]octane Hydrochloride is a reactant in the preparation of substituted pyrimidines derivatives as novel hedgehog signaling pathway inhibitors.<br>References Xin, M. et al.: Med. Chem. Res., 23, 3784 (2014); Xin, M. et al.: Bioorg. Med. Chem. Lett., 24, 983 (2014);<br></p>

<p>Applications 7-Chloro-4-nitroquinoline is used in the synthesis of aminonitropyridine.<br></p>

<p>Applications (3S)-Aminoquinuclidine is an intermediate used in the synthesis of Palonosetron-3-ene Hydrochloride (P165825), which is an impurity of Palonosetron (P165800), a serotonin 5-HT3 receptor antagonist used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV). Antiemetic.<br>References Clark, R.D., et al.: J. Med. Chem., 36, 2645 (1993); Wong, E.H.F., et al.: Br. J. Pharmacol., 114, 851 (1995); Grunberg, S.M., et al.: Expert. Opin. Pharmacother., 4, 2297 (2003); Eisenberg, P., et al.: Ann. Oncol., 15, 330 (2004); Siddiqui, M.A.A., et al.: Drugs, 64, 1125 (2004)<br></p>

<p>Applications 8-Chloro-5-isoquinolinesulfonic Acid (cas# 1246816-17-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-Benzyl-1,2,3,4-Tetrahydroisoquinoline-3-Carboxylic Acid (cas# 54329-48-5) is a useful research chemical.<br></p>

<p>Applications Methyl-2-aminoquinoline-6-carboxylate is an organic building block of ester and amine category.<br>References Li, L., et al.: PCT Int. Appl. (2018), WO 2018196823 A1 20181101<br></p>

<p>Applications Saxagliptin hydrochloride monohydrate, an anti-diabetic drug can be synthesized using a coupling reaction of (S)-phthalimido-(3-hydroxy-adamantan-1-yl)acetic acid with (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-nitrile followed by removal of the phthalimide protecting group and treatment with HCl.<br>References Kovi, Ravishanker, et al.: Apicore, LLC, WO 2012162507 (2012)<br></p>

<p>Applications 5-Hydroxyquinolin-2(1H)-one (cas# 31570-97-5) is a compound useful in organic synthesis.<br></p>

<p>Applications 8-Hydroxyquinoline-7-carboxylic acid (cas# 19829-79-9) is a useful research chemical.<br></p>

<p>Applications Methyl 3-cyanoindole-4-carboxylate<br></p>

<p>Applications 3-Phenanthrenecarboxylic Acid is a useful building block.<br></p>

<p>Stability Moisture Sensitive<br>Applications Tricyclohexyl Phosphine is a ligand catalyst used primarily in organometallic chemistry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sanford, M. et al.: J. Am. CHem. Soc., 123, 6543 (2001);<br></p>

<p>Applications 1-Ethyl-1,4-dihydro-4-oxo-7-(4-pyridyl)quinoline-3-carboxylic Acid Ethyl Ester is an intermediate in the synthesis of Rosoxacin (R693580), an antibacterial agent used against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus and Streptococcus pneumoniae.<br>References Koba, M., et. al.: J. Mol. Modeling, 16, 327 (2010)<br></p>

<p>Applications 6-Chloro-2,3-dihydro-2-oxo-1H-indole-5-carboxylic Acid is an intermediate used in the synthesis of EPZ031686, the first orally bioavailable small molecule SMYD3 inhibitor.<br>References Mitchell, L., et al.: ACS Med. Chem. Lett. (2015)<br></p>

<p>Applications 5-Fluoro-2-oxindole (cas# 56341-41-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 9,9-Dimethyl-xanthene-3,6-diol has been used in the manufacturing of dihydroxydiaminoxanthenes as monomers for positive-working resists by treatment of dihydroxybenzenes with carbonyl compounds, nitration, and reduction.<br>References Sumitani, N.; et al.: Jpn. Kokai Tokkyo Koho 13 pp. Patent 2004 CODEN:JKXXAF<br></p>

<p>Applications 3,4-Dihydroisoquinoline-6,7-diol acts as a reagent for the synthesis of 6,7-dihydroxy-3,4-dihydroisoquinline, a novel inhibitor factore-kB in invitro invasion in murine mammary cells.<br>References Alvarez, F. N., et al.: Chemotherapy, 55, 175 (2009)<br></p>

<p>Applications 7-chloro-4-hydroxyquinoline-3-carboxylic acid (cas# 86-47-5) is a useful research chemical.<br></p>

<p>Applications 8-Hydroxyquinoline Copper Salt is used in the formulation of biocide microcapsules towards stabilized iodine-​containing compounds for protection of technical materials from degradation by microorganisms.<br>References Boettcher, A., et al.: PCT Int. Appl. (2012), WO 2012076699 A1 20120614<br></p>

<p>Applications 5-Chloroisoquinoline (cas# 5430-45-5) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications 4,5,6,7-tetrahydro-1H-indazole-6-carboxylic acid (cas# 1354950-72-3) is a useful research chemical.<br></p>

<p>Applications methyl 8,8-dioxo-8lambda6-thia-2,3,5,7-tetraazatricyclo[7.4.0.0,2,6]trideca-1(13),3,5,9,11-pentaene-4-carboxylate (cas# 1311315-62-4) is a useful research chemical.<br></p>

<p>Applications octahydro-1H-indole-2-carboxamide (cas# 1105694-34-5) is a useful research chemical.<br></p>

<p>Applications 1-(5-Fluoropentyl)-1H-indole-3-carbonyl Chloride is an intermediate for the synthesis of Methyl 2-(1-(5-Fluoropentyl)-1H-indole-3-carboxamido)-3-phenylpropanoate (M224944), which is a useful intermediate for organic synthesis.<br></p>